{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:14:45Z","timestamp":1791332085792,"version":"4.3.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014978","name":"Hunan University of Chinese Medicine","doi-asserted-by":"publisher","award":["Z2023JBGS01"],"award-info":[{"award-number":["Z2023JBGS01"]}],"id":[{"id":"10.13039\/501100014978","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014978","name":"Hunan University of Chinese Medicine","doi-asserted-by":"publisher","award":["2024XYLH021"],"award-info":[{"award-number":["2024XYLH021"]}],"id":[{"id":"10.13039\/501100014978","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024JJ6354"],"award-info":[{"award-number":["2024JJ6354"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.phymed.2025.157065","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T16:44:19Z","timestamp":1752597859000},"page":"157065","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Shenling Tongqiao powder targets TGF-\u03b21\/Smad-Wnt\/\u03b2-catenin axis to suppress epithelial-mesenchymal transition in chronic rhinosinusitis"],"prefix":"10.1016","volume":"145","author":[{"given":"Kai","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sixin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Bin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenke","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yekui","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.157065_bib0001","doi-asserted-by":"crossref","first-page":"E34","DOI":"10.1002\/lary.28858","article-title":"Distinct clinical pathology and microbiota in chronic rhinosinusitis with nasal polyps endotypes","volume":"131","author":"Abbas","year":"2021","journal-title":"Laryngoscope"},{"key":"10.1016\/j.phymed.2025.157065_bib0002","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.mehy.2019.03.007","article-title":"Mucociliary transport as a link between chronic rhinosinusitis and trace element dysbalance","volume":"127","author":"Alekseenko","year":"2019","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.phymed.2025.157065_bib0003","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2147\/JAA.S290424","article-title":"Burden of disease in chronic rhinosinusitis with nasal polyps","volume":"14","author":"Bachert","year":"2021","journal-title":"J. Asthma Allergy"},{"key":"10.1016\/j.phymed.2025.157065_bib0004","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.iac.2024.07.005","article-title":"Biologics in chronic rhinosinusitis: current and emerging","volume":"44","author":"Boyd","year":"2024","journal-title":"Immunol. Allergy Clin. North Am."},{"key":"10.1016\/j.phymed.2025.157065_bib0005","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1093\/cid\/ciad474","article-title":"Unintended consequences: risk of opportunistic infections associated with long-term glucocorticoid therapies in adults","volume":"78","author":"Chastain","year":"2024","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.phymed.2025.157065_bib0006","article-title":"Research progress of glucocorticoid resistance in chronic rhinosinusitis with nasal polyps: a review","volume":"102","author":"Chen","year":"2023","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.phymed.2025.157065_bib0007","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1080\/03007995.2020.1815682","article-title":"Systematic literature review of the epidemiology and clinical burden of chronic rhinosinusitis with nasal polyposis","volume":"36","author":"Chen","year":"2020","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.phymed.2025.157065_bib0008","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.jaip.2019.12.021","article-title":"Phenotypes of chronic rhinosinusitis","volume":"8","author":"Cho","year":"2020","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"10.1016\/j.phymed.2025.157065_bib0009","doi-asserted-by":"crossref","first-page":"9346","DOI":"10.3390\/ijms25179346","article-title":"Advancements in plant-based therapeutics for Hepatic fibrosis: molecular mechanisms and nanoparticulate drug delivery systems","volume":"25","author":"Ciceu","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.157065_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2500\/ajra.2012.26.3716","article-title":"Acquired cilia dysfunction in chronic rhinosinusitis","volume":"26","author":"Gudis","year":"2012","journal-title":"Am. J. Rhinol. Allergy"},{"key":"10.1016\/j.phymed.2025.157065_bib0011","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1146\/annurev-physiol-022516-034348","article-title":"Macrophages and the recovery from acute and chronic inflammation","volume":"79","author":"Hamidzadeh","year":"2017","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.phymed.2025.157065_bib0012","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1111\/all.16064","article-title":"Updated epithelial barrier dysfunction in chronic rhinosinusitis: targeting pathophysiology and treatment response of tight junctions","volume":"79","author":"Huang","year":"2024","journal-title":"Allergy"},{"key":"10.1016\/j.phymed.2025.157065_bib0013","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1001\/jamaoto.2024.2705","article-title":"Chronic rhinosinusitis and mental health","volume":"150","author":"Khan","year":"2024","journal-title":"JAMA Otolaryngol. Head. Neck. Surg."},{"key":"10.1016\/j.phymed.2025.157065_bib0014","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/ar.24644","article-title":"Ancestry-based variation in maxillary sinus anatomy: implications for health disparities in sinonasal disease","volume":"305","author":"Kim","year":"2022","journal-title":"Anatomical Record (Hoboken. N.J.: 2007)"},{"key":"10.1016\/j.phymed.2025.157065_bib0015","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3389\/fcimb.2018.00168","article-title":"Heterogeneity of microbiota dysbiosis in chronic rhinosinusitis: potential clinical implications and microbial community mechanisms contributing to sinonasal inflammation","volume":"8","author":"Lee","year":"2018","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1016\/j.phymed.2025.157065_bib0016","article-title":"The signaling pathways of selected traditional Chinese medicine prescriptions and their metabolites in the treatment of diabetic cardiomyopathy: a review","volume":"15","author":"Li","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157065_bib0017","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4168\/aair.2020.12.2.176","article-title":"Chinese Society of Allergy and Chinese Society of Otorhinolaryngology-Head and Neck surgery guideline for chronic rhinosinusitis","volume":"12","author":"Liu","year":"2020","journal-title":"Allergy Asthma Immunol. Res."},{"key":"10.1016\/j.phymed.2025.157065_bib0018","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.jaci.2014.08.031","article-title":"Increased noneosinophilic nasal polyps in chronic rhinosinusitis in US second-generation Asians suggest genetic regulation of eosinophilia","volume":"135","author":"Mahdavinia","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.phymed.2025.157065_bib0019","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3390\/healthcare9030257","article-title":"Understanding traditional Chinese Medicine therapeutics: an overview of the basics and clinical applications","volume":"9","author":"Matos","year":"2021","journal-title":"Healthcare"},{"key":"10.1016\/j.phymed.2025.157065_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112491","article-title":"Shanghuo\" increases disease susceptibility: modern significance of an old TCM theory","volume":"250","author":"Pan","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157065_bib0021","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s40463-015-0064-8","article-title":"Chronic rhinosinusitis: an under-researched epidemic","volume":"44","author":"Rudmik","year":"2015","journal-title":"J. Otolaryngol. Head. Neck. Surg."},{"key":"10.1016\/j.phymed.2025.157065_bib0022","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/ACI.0000000000000701","article-title":"Epithelial-to-mesenchymal transition in neutrophilic chronic rhinosinusitis","volume":"21","author":"Ryu","year":"2021","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"10.1016\/j.phymed.2025.157065_bib0023","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1146\/annurev-pathol-052016-100401","article-title":"Immunopathogenesis of chronic rhinosinusitis and nasal polyposis","volume":"12","author":"Schleimer","year":"2017","journal-title":"Annu Rev. Pathol."},{"key":"10.1016\/j.phymed.2025.157065_bib0024","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.jaip.2022.01.016","article-title":"Epidemiology of chronic rhinosinusitis: prevalence and risk factors","volume":"10","author":"Sedaghat","year":"2022","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"10.1016\/j.phymed.2025.157065_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111998","article-title":"The mechanisms and clinical application of Traditional Chinese Medicine Lianhua-Qingwen capsule","volume":"142","author":"Shen","year":"2021","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.phymed.2025.157065_bib0026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MOO.0000000000000595","article-title":"The relationship of chronic rhinosinusitis and depression","volume":"28","author":"Smith","year":"2020","journal-title":"Curr. Opin. Otolaryngol. Head. Neck. Surg."},{"key":"10.1016\/j.phymed.2025.157065_bib0027","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1038\/s41467-023-38360-5","article-title":"Spatially resolved multi-omics highlights cell-specific metabolic remodeling and interactions in gastric cancer","volume":"14","author":"Sun","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2025.157065_bib0028","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111709","article-title":"Epithelial-cell-derived extracellular vesicles in pathophysiology of Epithelial injury and repair in chronic rhinosinusitis: connecting immunology in research lab to biomarkers in clinics","volume":"22","author":"Takahashi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.157065_bib0029","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1136\/postgradmedj-2019-136519","article-title":"What is the most appropriate treatment for chronic rhinosinusitis","volume":"95","author":"Walker","year":"2019","journal-title":"Postgrad. Med. J."},{"key":"10.1016\/j.phymed.2025.157065_bib0030","doi-asserted-by":"crossref","first-page":"450","DOI":"10.2500\/aap.2021.42.210080","article-title":"Treatment options for chronic rhinosinusitis with nasal polyps","volume":"42","author":"Wallace","year":"2021","journal-title":"Allergy Asthma Proc."},{"key":"10.1016\/j.phymed.2025.157065_bib0031","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1080\/1744666X.2023.2232113","article-title":"Epithelial cell dysfunction in chronic rhinosinusitis: the epithelial-mesenchymal transition","volume":"19","author":"Yuan","year":"2023","journal-title":"Expert. Rev. Clin. Immunol."},{"key":"10.1016\/j.phymed.2025.157065_bib0032","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4687788","article-title":"Mechanism of Peitu Shengjin Formula Shenlingbaizhu powder in treating bronchial asthma and allergic colitis through different diseases with simultaneous treatment based on network pharmacology and molecular docking","volume":"2022","author":"Zeng","year":"2022","journal-title":"Evid. Based. Complement. Altern. Med."},{"key":"10.1016\/j.phymed.2025.157065_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156658","article-title":"Traditional Chinese medicine in chronic rhinosinusitis: mechanisms and postoperative recovery","volume":"141","author":"Zhang","year":"2025","journal-title":"Phytomedicine"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325007044?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325007044?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:47:52Z","timestamp":1777592872000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325007044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":33,"alternative-id":["S0944711325007044"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157065","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Shenling Tongqiao powder targets TGF-\u03b21\/Smad-Wnt\/\u03b2-catenin axis to suppress epithelial-mesenchymal transition in chronic rhinosinusitis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157065","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"157065"}}