{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:22:16Z","timestamp":1787314936530,"version":"build-2736575974"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013795","name":"Fujian Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071418"],"award-info":[{"award-number":["82071418"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.phymed.2025.157067","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T16:48:46Z","timestamp":1752598126000},"page":"157067","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Celastrol protected the MPTP-injected mice Parkinson's disease model via redox regulation of CDC37"],"prefix":"10.1016","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0610-1817","authenticated-orcid":false,"given":"Wanfen","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiwen","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Hafeez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinyong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3393-4497","authenticated-orcid":false,"given":"En","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.157067_bib0001","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1111\/jcmm.17784","article-title":"NF-kappaB\/NLRP3 inflammasome axis and risk of Parkinson's disease in type 2 diabetes mellitus: a narrative review and new perspective","volume":"27","author":"Alrouji","year":"2023","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.phymed.2025.157067_bib0002","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.cbpa.2018.11.002","article-title":"Cysteine reactivity across the subcellular universe","volume":"48","author":"Bak","year":"2019","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.phymed.2025.157067_bib0003","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson's disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2025.157067_bib0004","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20204976","article-title":"Hsp90 and its Co-chaperones in neurodegenerative diseases","volume":"20","author":"Bohush","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.157067_bib0005","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S1097-2765(02)00450-1","article-title":"TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90","volume":"9","author":"Chen","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.phymed.2025.157067_bib0006","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3389\/fchem.2019.00571","article-title":"Detection and characterization of catechol quinone-derived protein adducts using biomolecular mass spectrometry","volume":"7","author":"Chen","year":"2019","journal-title":"Front Chem."},{"key":"10.1016\/j.phymed.2025.157067_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155101","article-title":"Natural products for the treatment of neurodegenerative diseases","volume":"121","author":"Cui","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157067_bib0008","doi-asserted-by":"crossref","first-page":"11090","DOI":"10.1021\/bi700613w","article-title":"Quinone electrophiles selectively adduct \"electrophile binding motifs\" within cytochrome c","volume":"46","author":"Fisher","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.phymed.2025.157067_bib0009","doi-asserted-by":"crossref","DOI":"10.4061\/2011\/216298","article-title":"Transcriptional factor NF-kappaB as a target for therapy in Parkinson's Disease","author":"Flood","year":"2011","journal-title":"Parkinsons Dis"},{"key":"10.1016\/j.phymed.2025.157067_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2008.08.006","article-title":"Glutathione: overview of its protective roles, measurement, and biosynthesis","volume":"30","author":"Forman","year":"2009","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.phymed.2025.157067_bib0011","doi-asserted-by":"crossref","first-page":"18754","DOI":"10.1073\/pnas.0704908104","article-title":"Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease","volume":"104","author":"Ghosh","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.phymed.2025.157067_bib0012","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.3389\/fnins.2019.01263","article-title":"Therapeutic potential of the Hsp90\/Cdc37 interaction in neurodegenerative diseases","volume":"13","author":"Gracia","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.phymed.2025.157067_bib0013","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.freeradbiomed.2009.06.012","article-title":"Methods for the determination and quantification of the reactive thiol proteome","volume":"47","author":"Hill","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2025.157067_bib0014","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/s41467-017-01435-1","article-title":"PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress","volume":"8","author":"Huang","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2025.157067_bib0015","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26165102","article-title":"Protein adducts and Protein oxidation as molecular mechanisms of flavonoid bioactivity","volume":"26","author":"Joyner","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2025.157067_bib0016","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.molcel.2016.04.005","article-title":"Molecular mechanism of protein kinase recognition and sorting by the Hsp90 kinome-specific cochaperone Cdc37","volume":"62","author":"Keramisanou","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.phymed.2025.157067_bib0017","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jep.2015.06.028","article-title":"Celastrol blocks binding of lipopolysaccharides to a toll-like receptor4\/myeloid differentiation factor2 complex in a thiol-dependent manner","volume":"172","author":"Lee","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157067_bib0018","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1016\/j.molcel.2021.08.018","article-title":"Redox metabolism: ROS as specific molecular regulators of cell signaling and function","volume":"81","author":"Lennicke","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.phymed.2025.157067_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.104867","article-title":"Discovery of novel celastrol-triazole derivatives with Hsp90-Cdc37 disruption to induce tumor cell apoptosis","volume":"111","author":"Li","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.phymed.2025.157067_bib0020","doi-asserted-by":"crossref","first-page":"815","DOI":"10.14336\/AD.2021.1115","article-title":"Neuroprotective effects of celastrol in neurodegenerative diseases-unscramble its major mechanisms of action and targets","volume":"13","author":"Liu","year":"2022","journal-title":"Aging Dis"},{"key":"10.1016\/j.phymed.2025.157067_bib0021","article-title":"NF-kappaB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2025.157067_bib0022","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0140-6736(23)01478-2","article-title":"The pathogenesis of Parkinson's disease","volume":"403","author":"Morris","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2025.157067_bib0023","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2174\/1874609808666150520111109","article-title":"Withaferin A regulates LRRK2 levels by interfering with the Hsp90- Cdc37 chaperone complex","volume":"8","author":"Narayan","year":"2015","journal-title":"Curr. Aging. Sci."},{"key":"10.1016\/j.phymed.2025.157067_bib0024","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3233\/JPD-160779","article-title":"Implication of alpha-synuclein phosphorylation at S129 in synucleinopathies: what have we learned in the last decade?","volume":"6","author":"Oueslati","year":"2016","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.phymed.2025.157067_bib0025","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nchembio.1212","article-title":"ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system","volume":"9","author":"Polier","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.phymed.2025.157067_bib0026","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1016\/S0968-0896(99)00234-5","article-title":"Helenanolide type sesquiterpene lactones. Part 5: the role of glutathione addition under physiological conditions","volume":"7","author":"Schmidt","year":"1999","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.phymed.2025.157067_bib0027","doi-asserted-by":"crossref","DOI":"10.3791\/52434-v","article-title":"Use of the Open field maze to measure locomotor and anxiety-like behavior in mice","author":"Seibenhener","year":"2015","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.phymed.2025.157067_bib0028","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000520726","article-title":"Prevalence of Parkinson's Disease in adults aged 65 years and older in China: a multicenter population-based survey","volume":"56","author":"Song","year":"2022","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.phymed.2025.157067_bib0029","doi-asserted-by":"crossref","first-page":"5853","DOI":"10.1002\/anie.200900929","article-title":"Molecular mechanism of inhibition of the human protein complex Hsp90-Cdc37, a kinome chaperone-cochaperone, by triterpene celastrol","volume":"48","author":"Sreeramulu","year":"2009","journal-title":"Angew. Chem. Int. Ed Engl."},{"key":"10.1016\/j.phymed.2025.157067_bib0030","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.cell.2012.06.047","article-title":"Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition","volume":"150","author":"Taipale","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2025.157067_bib0031","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1091\/mbc.e07-10-1004","article-title":"Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule","volume":"19","author":"Trott","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.phymed.2025.157067_bib0032","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1042\/EBC20190053","article-title":"Mechanisms and consequences of protein cysteine oxidation: the role of the initial short-lived intermediates","volume":"64","author":"Turell","year":"2020","journal-title":"Essays Biochem."},{"key":"10.1016\/j.phymed.2025.157067_bib0033","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.tibs.2017.07.002","article-title":"How Hsp90 and Cdc37 lubricate kinase molecular switches","volume":"42","author":"Verba","year":"2017","journal-title":"Trends Biochem. Sci"},{"key":"10.1016\/j.phymed.2025.157067_bib0034","doi-asserted-by":"crossref","first-page":"12871","DOI":"10.1039\/C8CC06140H","article-title":"Celastrol binds to its target protein via specific noncovalent interactions and reversible covalent bonds","volume":"54","author":"Zhang","year":"2018","journal-title":"Chem. Commun. (Camb.)"},{"key":"10.1016\/j.phymed.2025.157067_bib0035","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.2174\/1389450123666220408101544","article-title":"The therapeutic potential of targeting Hsp90-Cdc37 interactions in several diseases","volume":"23","author":"Zhang","year":"2022","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.phymed.2025.157067_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102290","article-title":"Hsp90 S-nitrosylation at Cys521, as a conformational switch, modulates cycling of Hsp90-AHA1-CDC37 chaperone machine to aggravate atherosclerosis","volume":"52","author":"Zhao","year":"2022","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2025.157067_bib0037","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1039\/C6MB00691D","article-title":"Competitive profiling of celastrol targets in human cervical cancer HeLa cells via quantitative chemical proteomics","volume":"13","author":"Zhou","year":"2016","journal-title":"Mol. Biosyst."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325007068?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325007068?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,10]],"date-time":"2025-08-10T06:37:38Z","timestamp":1754807858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325007068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":37,"alternative-id":["S0944711325007068"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157067","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Celastrol protected the MPTP-injected mice Parkinson's disease model via redox regulation of CDC37","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157067"}}