{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T01:03:49Z","timestamp":1772759029551,"version":"3.50.1"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["XYZX0201\\u201303"],"award-info":[{"award-number":["XYZX0201\\u201303"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82,274,345"],"award-info":[{"award-number":["82,274,345"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.phymed.2025.157075","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:23:10Z","timestamp":1752625390000},"page":"157075","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Xinyue capsule treatment on long-term outcomes in patients with stable coronary artery disease after PCI: A 10-year observational follow-up"],"prefix":"10.1016","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3728-9170","authenticated-orcid":false,"given":"Ming","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianpeng","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuye","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changgeng","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruina","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaoning","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peili","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dazhuo","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.157075_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154554","article-title":"The effectiveness and safety of Chinese Patent Medicines based on syndrome differentiation in patients following percutaneous coronary intervention due to acute coronary syndrome (CPM trial): a nationwide cohort Study","volume":"109","author":"Bai","year":"2023","journal-title":"Phytomed.: Int. J. Phytother. Phytopharmacol."},{"key":"10.1016\/j.phymed.2025.157075_bib0002","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1161\/CIRCULATIONAHA.115.019014","article-title":"Long-term safety and efficacy of lowering low-density lipoprotein cholesterol with statin therapy: 20-year follow-up of West of Scotland coronary prevention study","volume":"133","author":"Ford","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2025.157075_bib0003","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s11655-014-1881-8","article-title":"Effects of Panax quinquefolium saponin on phosphatidylinositol 3-kinase\/serine threonine kinase pathway of neonatal rat myocardial cells subjected to hypoxia","volume":"21","author":"Guo","year":"2015","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.phymed.2025.157075_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104883","article-title":"Xinyue Capsule in patients with stable coronary artery disease after percutaneous coronary intervention: a multicenter, randomized, placebo-controlled trial","volume":"158","author":"Guo","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2025.157075_bib0005","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1186\/s13063-016-1531-x","article-title":"Effect of Xinyue capsules on patients with coronary heart disease after percutaneous coronary intervention: study protocol for a randomized controlled trial","volume":"17","author":"Guo","year":"2016","journal-title":"Trials"},{"key":"10.1016\/j.phymed.2025.157075_bib0006","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1056\/NEJMoa0806470","article-title":"10-year follow-up of intensive glucose control in type 2 diabetes","volume":"359","author":"Holman","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phymed.2025.157075_bib0007","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1161\/CIRCULATIONAHA.106.625475","article-title":"Five-year follow-up of the Medicine, Angioplasty, or Surgery Study (MASS II): a randomized controlled clinical trial of 3 therapeutic strategies for multivessel coronary artery disease","volume":"115","author":"Hueb","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2025.157075_bib0008","article-title":"Efficacy and safety of xinyue capsule for coronary artery disease after percutaneous coronary intervention: a systematic review and meta-analysis of randomized clinical trials","volume":"2021","author":"Jiang","year":"2021","journal-title":"Evidence-Based Complem. Alternat. Med.: ECAM"},{"key":"10.1016\/j.phymed.2025.157075_bib0009","first-page":"1413","volume":"34","author":"Li","year":"2014","journal-title":"Biochem., Pharmacol."},{"key":"10.1016\/j.phymed.2025.157075_bib0010","article-title":"Optimization of saponin extraction from the leaves of Panax notoginseng and Panax quinquefolium and evaluation of their antioxidant, antihypertensive, hypoglycemic and anti-inflammatory activities","volume":"23","author":"Liang","year":"2024","journal-title":"Food Chem.: X"},{"key":"10.1016\/j.phymed.2025.157075_bib0011","first-page":"540","article-title":"Panax quinquefolium saponin attenuates cardiomyocyte apoptosis induced by thapsigargin through inhibition of endoplasmic reticulum stress","volume":"12","author":"Liu","year":"2015","journal-title":"J. Geriatric Cardiol.: JGC"},{"key":"10.1016\/j.phymed.2025.157075_bib0012","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.phymed.2008.07.002","article-title":"Saponins (Ginsenosides) from stems and leaves of Panax quinquefolium prevented high-fat diet-induced obesity in mice","volume":"15","author":"Liu","year":"2008","journal-title":"Phytomed.: Int. J. Phytother. Phytopharmacol."},{"key":"10.1016\/j.phymed.2025.157075_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117252","article-title":"Panax Quinquefolium Saponins enhances angiogenesis in rats with diabetes and myocardial infarction","volume":"319","author":"Pan","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157075_bib0014","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.phymed.2018.08.007","article-title":"Panax quinquefolium saponin attenuates cardiac remodeling induced by simulated microgravity","volume":"56","author":"Sun","year":"2019","journal-title":"Phytomed.: Int. J. Phytother. Phytopharmacol."},{"key":"10.1016\/j.phymed.2025.157075_bib0015","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1093\/eurheartj\/ehae177","article-title":"2024 ESC guidelines for the management of chronic coronary syndromes","volume":"45","author":"Vrints","year":"2024","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.phymed.2025.157075_bib0016","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/SHK.0b013e31823f15c4","article-title":"Panax quinquefolium saponins reduce myocardial hypoxia-reoxygenation injury by inhibiting excessive endoplasmic reticulum stress","volume":"37","author":"Wang","year":"2012","journal-title":"Shock"},{"key":"10.1016\/j.phymed.2025.157075_bib0017","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jep.2016.07.015","article-title":"Panax quinquefolium saponin combined with dual antiplatelet drugs inhibits platelet adhesion to injured HUVECs via PI3K\/AKT and COX pathways","volume":"192","author":"Wang","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157075_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111165","article-title":"Combination of Panax notoginseng saponins and aspirin potentiates platelet inhibition with alleviated gastric injury via modulating arachidonic acid metabolism","volume":"134","author":"Wang","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2025.157075_bib0019","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1056\/NEJMoa1803538","article-title":"Five-year outcomes with PCI guided by fractional flow reserve","volume":"379","author":"Xaplanteris","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phymed.2025.157075_bib0020","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s12013-024-01267-z","article-title":"Panax quinquefolius saponins and panax notoginseng saponins attenuate myocardial hypoxia-reoxygenation injury by reducing excessive mitophagy","volume":"82","author":"Xia","year":"2024","journal-title":"Cell. Biochem. Biophys."},{"key":"10.1016\/j.phymed.2025.157075_bib0021","series-title":"Combination of Neutrophil Count and Gensini Score As a Prognostic Marker in Patients with ACS and Uncontrolled T2DM Undergoing PCI","author":"Xu","year":"2023"},{"key":"10.1016\/j.phymed.2025.157075_bib0022","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1007\/s11655-015-2311-2","article-title":"Qualitative analysis of xinyue capsules by high-performance liquid chromatography: preliminary evaluation of drug quality in a Sino-Austrian joint study","volume":"21","author":"Xue","year":"2015","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.phymed.2025.157075_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112354","article-title":"The efficacy of Chinese herbal medicines on acute coronary syndrome with renal insufficiency after percutaneous coronary intervention","volume":"248","author":"Zhang","year":"2020","journal-title":"J. Ethnopharmacol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325007147?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325007147?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:10:50Z","timestamp":1772755850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325007147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":23,"alternative-id":["S0944711325007147"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157075","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Xinyue capsule treatment on long-term outcomes in patients with stable coronary artery disease after PCI: A 10-year observational follow-up","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157075","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157075"}}