{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:59:40Z","timestamp":1793073580006,"version":"4.5.0"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","award":["Y5100392023-01"],"award-info":[{"award-number":["Y5100392023-01"]}],"id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.phymed.2025.157091","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T23:57:48Z","timestamp":1753919868000},"page":"157091","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Columbianadin targets TRIM7 to maintain P2X7 palmitoylation, inhibiting cuproptosis in synovial M2 macrophages"],"prefix":"10.1016","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5148-3126","authenticated-orcid":false,"given":"Zihao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.157091_bib0001","first-page":"22","article-title":"Effectiveness of columbianadin, a bioactive coumarin derivative, in perturbing transient and persistent I(Na)","author":"Chang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.157091_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114918","article-title":"Immunosuppressive effect of Columbianadin on maturation, migration, allogenic T cell stimulation and phagocytosis capacity of TNF-\u03b1 induced dendritic cells","volume":"285","author":"Chen","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157091_bib0003","doi-asserted-by":"crossref","DOI":"10.1177\/23259671241298753","article-title":"Fifteen-year radiographic follow-up comparison of early versus delayed ACL reconstruction: a retrospective review of a previous prospective randomized clinical trial","volume":"12","author":"Cruz","year":"2024","journal-title":"Orthop. J. Sports Med."},{"key":"10.1016\/j.phymed.2025.157091_bib0004","doi-asserted-by":"crossref","first-page":"39064","DOI":"10.1021\/acsami.3c05861","article-title":"Apoptotic neutrophil membrane-camouflaged liposomes for dually targeting synovial macrophages and fibroblasts to attenuate osteoarthritis","volume":"15","author":"Deng","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.phymed.2025.157091_bib0005","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0005-2760(98)00130-1","article-title":"Signalling functions of protein palmitoylation","volume":"1436","author":"Dunphy","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phymed.2025.157091_bib0006","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1096\/fj.08-114637","article-title":"Palmitoylation of the P2\u00d77 receptor, an ATP-gated channel, controls its expression and association with lipid rafts","volume":"23","author":"Gonnord","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.phymed.2025.157091_bib0007","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-54762-5","article-title":"TRIM7 ubiquitinates SARS-CoV-2 membrane protein to limit apoptosis and viral replication","volume":"15","author":"Gonzalez-Orozco","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2025.157091_bib0008","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.pharmthera.2017.10.020","article-title":"Conserved structural and functional aspects of the tripartite motif gene family point towards therapeutic applications in multiple diseases","volume":"185","author":"Gushchina","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2025.157091_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155972","article-title":"Coumarins as versatile therapeutic phytomolecules: a systematic review","volume":"134","author":"Hussain","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157091_bib0010","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1016\/j.febslet.2011.07.028","article-title":"Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase","volume":"585","author":"Kokkola","year":"2011","journal-title":"FEBS Lett."},{"key":"10.1016\/j.phymed.2025.157091_bib0011","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1016\/j.cmet.2024.07.009","article-title":"Zinc transporter 1 functions in copper uptake and cuproptosis","volume":"36","author":"Li","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2025.157091_bib0012","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41420-021-00746-z","article-title":"Moderate-intensity exercise alleviates pyroptosis by promoting autophagy in osteoarthritis via the P2\u00d77\/AMPK\/mTOR axis","volume":"7","author":"LI","year":"2021","journal-title":"Cell Death. Discov."},{"key":"10.1016\/j.phymed.2025.157091_bib0013","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jep.2018.10.040","article-title":"The ethnopharmacology, phytochemistry and pharmacology of Angelica biserrata - A review","volume":"231","author":"Ma","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157091_bib0014","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.joca.2014.03.006","article-title":"Anterior Cruciate Ligament OsteoArthritis Score (ACLOAS): Longitudinal MRI-based whole joint assessment of anterior cruciate ligament injury","volume":"22","author":"Roemer","year":"2014","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.phymed.2025.157091_bib0015","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/5584_2017_59","article-title":"The P2\u00d77 Receptor","volume":"1051","author":"Sluyter","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.phymed.2025.157091_bib0016","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.phymed.2025.157091_bib0017","article-title":"Biomimic nanodrugs overcome tumor immunosuppressive microenvironment to enhance cuproptosis\/chemodynamic-induced cancer immunotherapy","volume":"12","author":"Wu","year":"2025","journal-title":"Adv. Sci. (Weinh)"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325007305?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325007305?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T13:24:19Z","timestamp":1757165059000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325007305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":17,"alternative-id":["S0944711325007305"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157091","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Columbianadin targets TRIM7 to maintain P2X7 palmitoylation, inhibiting cuproptosis in synovial M2 macrophages","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157091","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157091"}}