{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:54:18Z","timestamp":1792097658637,"version":"4.4.0"},"reference-count":144,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009004","name":"Anhui University of Chinese Medicine","doi-asserted-by":"publisher","award":["2022rcyb024"],"award-info":[{"award-number":["2022rcyb024"]}],"id":[{"id":"10.13039\/501100009004","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2024AH040146"],"award-info":[{"award-number":["2024AH040146"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2308085MH291"],"award-info":[{"award-number":["2308085MH291"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.phymed.2025.157106","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T06:09:09Z","timestamp":1753682949000},"page":"157106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Mitochondrial pathways in rheumatoid arthritis: Therapeutic roles of traditional Chinese medicine and natural products"],"prefix":"10.1016","volume":"146","author":[{"given":"Hui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinfeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5139-519X","authenticated-orcid":false,"given":"Jinchen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.157106_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2019.100940","article-title":"Mitochondria in the signaling pathways that control longevity and health span","volume":"54","author":"Akbari","year":"2019","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.phymed.2025.157106_bib0002","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s11658-024-00531-7","article-title":"Mechanistic role of quercetin as inhibitor for adenosine deaminase enzyme in rheumatoid arthritis: systematic review","volume":"29","author":"Atta","year":"2024","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.phymed.2025.157106_bib0003","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.0105-2896.2009.00859.x","article-title":"Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis","volume":"233","author":"Bartok","year":"2010","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.phymed.2025.157106_bib0004","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/s41584-022-00834-z","article-title":"The role of mitochondria in rheumatic diseases","volume":"18","author":"Becker","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.phymed.2025.157106_bib0005","doi-asserted-by":"crossref","first-page":"5372","DOI":"10.1080\/10408398.2021.1924613","article-title":"Exploring the role of polyphenols in rheumatoid arthritis","volume":"62","author":"Behl","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.phymed.2025.157106_bib0006","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.bbadis.2016.11.010","article-title":"Mitochondrial dysfunction and oxidative stress in metabolic disorders - a step towards mitochondria based therapeutic strategies","volume":"1863","author":"Bhatti","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.phymed.2025.157106_bib0007","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/j.2040-4603.2017.tb00748.x","article-title":"Calcium transport and signaling in mitochondria","volume":"7","author":"Bravo-Sagua","year":"2017","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.phymed.2025.157106_bib0008","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2022-070856","article-title":"Therapeutic advances in rheumatoid arthritis","volume":"384","author":"Brown","year":"2024","journal-title":"BMJ"},{"issue":"301","key":"10.1016\/j.phymed.2025.157106_bib0009","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1002\/ar.23798","article-title":"Reducing-autophagy derived mitochondrial dysfunction during resveratrol promotes fibroblast-like synovial cell apoptosis","volume":"2007","author":"Cao","year":"2018","journal-title":"Anat. Rec. Hoboken NJ"},{"key":"10.1016\/j.phymed.2025.157106_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10753-020-01324-8","article-title":"Focus on the multimodal role of autophagy in rheumatoid arthritis","volume":"44","author":"Chadha","year":"2021","journal-title":"Inflammation"},{"key":"10.1016\/j.phymed.2025.157106_bib0011","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.703972","article-title":"Targeting mitochondrial-derived reactive oxygen species in T cell-mediated autoimmune diseases","volume":"12","author":"Ch\u00e1vez","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2025.157106_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109407","article-title":"Rapamycin regulates osteogenic differentiation through parkin-mediated mitophagy in rheumatoid arthritis","volume":"113","author":"Chen","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2025.157106_bib0013","first-page":"1","article-title":"Neutrophil function in an inflammatory milieu of rheumatoid arthritis","volume":"2018","author":"Chen","year":"2018","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.phymed.2025.157106_bib0014","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2018.11.002","article-title":"New advances in adaptive thermogenesis: UCP1 and beyond","volume":"29","author":"Chouchani","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2025.157106_bib0015","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s11926-023-01117-6","article-title":"A review of difficult-to-treat rheumatoid arthritis: definition, clinical presentation, and management","volume":"25","author":"Conran","year":"2023","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.phymed.2025.157106_bib0016","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1093\/rheumatology\/kex041","article-title":"Neutrophil-derived mitochondrial DNA promotes receptor activator of nuclear factor \u03bab and its ligand signalling in rheumatoid arthritis","volume":"56","author":"Contis","year":"2017","journal-title":"Rheumatology"},{"key":"10.1016\/j.phymed.2025.157106_bib0017","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222413670","article-title":"Shaping of monocyte-derived dendritic cell development and function by environmental factors in rheumatoid arthritis","volume":"22","author":"Coutant","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.157106_bib0018","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1136\/ard.59.9.657","article-title":"Recent aspects of gonadal hormone and neurotransmitter interactions with synovial and immune cells: implications in rheumatoid arthritis","volume":"59","author":"Cutolo","year":"2000","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.phymed.2025.157106_bib0019","first-page":"706","article-title":"Mitochondrial oxidative stress in immunopathogenesis of diseases","volume":"125","author":"Deglovic","year":"2024","journal-title":"Bratisl. Lek. Listy"},{"key":"10.1016\/j.phymed.2025.157106_bib0020","first-page":"1707","article-title":"Pathogenesis of rheumatoid arthritis: one year in review 2024","volume":"42","author":"D\u2019Orazio","year":"2024","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.phymed.2025.157106_bib0021","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/ar2481","article-title":"Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis","volume":"10","author":"Drexler","year":"2008","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.phymed.2025.157106_bib0022","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.bj.2020.06.010","article-title":"Innate immunity drives pathogenesis of rheumatoid arthritis","volume":"44","author":"Edilova","year":"2021","journal-title":"Biomed. J."},{"key":"10.1016\/j.phymed.2025.157106_bib0023","article-title":"Increased cardiovascular risk in rheumatoid arthritis: mechanisms and implications","volume":"k1036","author":"England","year":"2018","journal-title":"BMJ"},{"key":"10.1016\/j.phymed.2025.157106_bib0024","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/art.42795","article-title":"Epigenetic regulatory axis MIR22-TET3-MTRNR2L2 represses fibroblast-like synoviocyte\u2013mediated inflammation in rheumatoid arthritis","volume":"76","author":"Fang","year":"2024","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.phymed.2025.157106_bib0025","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nrrheum.2016.69","article-title":"Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis","volume":"12","author":"Fearon","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.phymed.2025.157106_bib0026","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-02167-5","article-title":"Revealing the efficacy-toxicity relationship of fuzi in treating rheumatoid arthritis by systems pharmacology","volume":"11","author":"Feng","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2025.157106_bib0027","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.pbi.2004.03.007","article-title":"Respiratory metabolism: glycolysis, the TCA cycle and mitochondrial electron transport","volume":"7","author":"Fernie","year":"2004","journal-title":"Curr. Opin. Plant Biol."},{"key":"10.1016\/j.phymed.2025.157106_bib0028","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.649693","article-title":"Neutrophils in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus: same foe different M.O","volume":"12","author":"Fresneda Alarcon","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2025.157106_bib0029","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s11655-012-1265-x","article-title":"Impairment of triptolide on liver mitochondria in isolated liver mitochondria and HL7702 cell line","volume":"19","author":"Fu","year":"2013","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.phymed.2025.157106_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115270","article-title":"Aconitine: a review of its pharmacokinetics, pharmacology, toxicology and detoxification","volume":"293","author":"Gao","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157106_bib0031","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.abb.2015.08.008","article-title":"Quercetin reduced inflammation and increased antioxidant defense in rat adjuvant arthritis","volume":"583","author":"Gardi","year":"2015","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.phymed.2025.157106_bib0032","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1152\/physrev.00041.2020","article-title":"Mitochondrial calcium exchange in physiology and disease","volume":"102","author":"Garbincius","year":"2022","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phymed.2025.157106_bib0033","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/HM9.0000000000000071","article-title":"Version updating of strategy for drug discovery based on effective constituents of traditional Chinese medicines","volume":"3","author":"Ge","year":"2023","journal-title":"Acupunct. Herb. Med."},{"key":"10.1016\/j.phymed.2025.157106_bib0034","article-title":"The mitochondrial pathway of apoptosis: part I: MOMP and beyond","volume":"14","author":"Green","year":"2022","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.phymed.2025.157106_bib0035","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.jep.2011.10.010","article-title":"Anti-inflammatory activities and mechanisms of action of the petroleum ether fraction of rosa multiflora thunb. Hips","volume":"138","author":"Guo","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157106_bib0036","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12967-016-0921-x","article-title":"Guizhi-shaoyao-zhimu decoction attenuates rheumatoid arthritis partially by reversing inflammation-immune system imbalance","volume":"14","author":"Guo","year":"2016","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.phymed.2025.157106_bib0037","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1016\/j.apsb.2022.11.020","article-title":"Ultrasmall iron-quercetin metal natural product nanocomplex with antioxidant and macrophage regulation in rheumatoid arthritis","volume":"13","author":"Han","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2025.157106_bib0039","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1152\/physrev.00058.2021","article-title":"Mitochondria in health, disease, and aging","volume":"103","author":"Harrington","year":"2023","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phymed.2025.157106_bib0040","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1136\/annrheumdis-2011-200245","article-title":"Mitochondrial mutagenesis correlates with the local inflammatory environment in arthritis","volume":"71","author":"Harty","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.phymed.2025.157106_bib0041","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3109\/01480545.2014.919583","article-title":"In vitro immunosuppressive and cytotoxic activities of tripterygium wilfordii extract","volume":"38","author":"He","year":"2015","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.phymed.2025.157106_bib0042","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2025.157106_bib0043","doi-asserted-by":"crossref","first-page":"5352","DOI":"10.1002\/ptr.7144","article-title":"Quercetin and metabolic syndrome: a review","volume":"35","author":"Hosseini","year":"2021","journal-title":"Phytother. Res. PTR"},{"key":"10.1016\/j.phymed.2025.157106_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e24818","article-title":"Construction and validation of a diagnostic model for rheumatoid arthritis based on mitochondrial autophagy-related genes","volume":"10","author":"In","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.phymed.2025.157106_bib0045","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1111\/bph.16050","article-title":"Piezo1 channel activation stimulates ATP production through enhancing mitochondrial respiration and glycolysis in vascular endothelial cells","volume":"180","author":"Jiang","year":"2023","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157106_bib0046","article-title":"Function and role of regulatory T cells in rheumatoid arthritis","volume":"12","author":"Jiang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2025.157106_bib0047","article-title":"Osthole: a potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis","volume":"110","author":"Jiang","year":"2023","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.phymed.2025.157106_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106176","article-title":"8-shogaol inhibits rheumatoid arthritis through targeting TAK1","volume":"178","author":"Jo","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2025.157106_bib0049","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1177\/0271678X16680637","article-title":"Mitochondrial calcium homeostasis: implications for neurovascular and neurometabolic coupling","volume":"37","author":"Kannurpatti","year":"2017","journal-title":"J. Cereb. Blood Flow Metab. Off. J. Int. Soc. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.phymed.2025.157106_bib0050","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/imm.13412","article-title":"Crosstalk between B cells and neutrophils in rheumatoid arthritis","volume":"164","author":"Karmakar","year":"2021","journal-title":"Immunology"},{"key":"10.1016\/j.phymed.2025.157106_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2022.108965","article-title":"Interplay of redox imbalance with matrix gelatinases in neutrophils and their association with disease severity in rheumatoid arthritis patients","volume":"237","author":"Kaushal","year":"2022","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.phymed.2025.157106_bib0052","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1016\/j.devcel.2024.09.004","article-title":"Dynamic death decisions: how mitochondrial dynamics shape cellular commitment to apoptosis and ferroptosis","volume":"59","author":"Khatun","year":"2024","journal-title":"Dev. Cell"},{"key":"10.1016\/j.phymed.2025.157106_bib0053","doi-asserted-by":"crossref","first-page":"10077","DOI":"10.1007\/s11033-022-07591-y","article-title":"Inflammatory-associated apoptotic markers: are they the culprit to rheumatoid arthritis pain?","volume":"49","author":"Khir","year":"2022","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.phymed.2025.157106_bib0054","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1007\/s10067-018-4080-8","article-title":"Resveratrol as an effective adjuvant therapy in the management of rheumatoid arthritis: a clinical study","volume":"37","author":"Khojah","year":"2018","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.phymed.2025.157106_bib0056","doi-asserted-by":"crossref","first-page":"44879","DOI":"10.18632\/oncotarget.9821","article-title":"Mitochondrial dysfunction and oxidative stress in aging and cancer","volume":"7","author":"Kudryavtseva","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.phymed.2025.157106_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103511","article-title":"Andrographolide: chemical modification and its effect on biological activities","volume":"95","author":"Kumar","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.phymed.2025.157106_bib0058","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s13075-024-03329-2","article-title":"Plasma mtDNA as a possible contributor to and biomarker of inflammation in rheumatoid arthritis","volume":"26","author":"Lehmann","year":"2024","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.phymed.2025.157106_bib0059","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1021\/acsnano.2c09834","article-title":"Ultrasound-remote selected activation mitophagy for precise treatment of rheumatoid arthritis by two-dimensional piezoelectric nanosheets","volume":"17","author":"Li","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.phymed.2025.157106_bib0060","article-title":"Shikonin induces programmed death of fibroblast synovial cells in rheumatoid arthritis by inhibiting energy pathways","volume":"11","author":"Li","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2025.157106_bib0061","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12906-021-03311-4","article-title":"Network analysis indicating the pharmacological mechanism of yunpi-qufeng-chushi-prescription in prophylactic treatment of rheumatoid arthritis","volume":"21","author":"Li","year":"2021","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.phymed.2025.157106_bib0062","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12906-023-03836-w","article-title":"Screening of major hepatotoxic components of tripterygium wilfordii based on hepatotoxic injury patterns","volume":"23","author":"Li","year":"2023","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.phymed.2025.157106_bib0063","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101981","article-title":"Prevention and treatment of inflammatory arthritis with traditional Chinese medicine: underlying mechanisms based on cell and molecular targets","volume":"89","author":"Li","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.phymed.2025.157106_bib0064","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000501163","article-title":"Tangeretin inhibits oxidative stress and inflammation via upregulating nrf-2 signaling pathway in collagen-induced arthritic rats","volume":"104","author":"Li","year":"2019","journal-title":"Pharmacology"},{"key":"10.1016\/j.phymed.2025.157106_bib0065","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jep.2014.06.006","article-title":"Triptolide: progress on research in pharmacodynamics and toxicology","volume":"155","author":"Li","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157106_bib0066","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jep.2015.01.004","article-title":"Investigation of the active components in tripterygium wilfordii leading to its acute hepatotoxicty and nephrotoxicity","volume":"162","author":"Li","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157106_bib0067","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1080\/15548627.2018.1522467","article-title":"Mir223 restrains autophagy and promotes CNS inflammation by targeting ATG16L1","volume":"15","author":"Li","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2025.157106_bib0068","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3390\/cells9040880","article-title":"Update on the pathomechanism, diagnosis, and treatment options for rheumatoid arthritis","volume":"9","author":"Lin","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2025.157106_bib0069","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S1471-4892(03)00037-7","article-title":"The role of apoptosis in rheumatoid arthritis","volume":"3","author":"Liu","year":"2003","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157106_bib0070","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.3109\/13880209.2014.960945","article-title":"The effects of arctigenin on human rheumatoid arthritis fibroblast-like synoviocytes","volume":"53","author":"Liu","year":"2015","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.phymed.2025.157106_bib0071","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.119307","article-title":"Wutou decoction: a latest review on molecular mechanisms, clinical studies, quality control, pharmacokinetic studies, pharmacological effects, toxicity, and target prediction","volume":"341","author":"Liu","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157106_bib0072","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115915","article-title":"Hezi inhibits tiebangchui-induced cardiotoxicity and preserves its anti-rheumatoid arthritis effects by regulating the pharmacokinetics of aconitine and deoxyaconitine","volume":"302","author":"Liu","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157106_bib0073","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1007\/s10787-023-01196-y","article-title":"Mechanism of action of quercetin in rheumatoid arthritis models: meta-analysis and systematic review of animal studies","volume":"31","author":"Liu","year":"2023","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.phymed.2025.157106_bib0074","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.3390\/antiox11061151","article-title":"Mitochondrial dysfunction and oxidative stress in rheumatoid arthritis","volume":"11","author":"L\u00f3pez-Armada","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2025.157106_bib0075","first-page":"463","article-title":"Resveratrol alleviates inflammatory injury and enhances the apoptosis of fibroblast\u2011like synoviocytes via mitochondrial dysfunction and ER stress in rats with adjuvant arthritis","volume":"20","author":"Lu","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.phymed.2025.157106_bib0076","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1080\/13880209.2022.2107018","article-title":"Danggui niantong granules ameliorate rheumatoid arthritis by regulating intestinal flora and promoting mitochondrial apoptosis","volume":"60","author":"Lu","year":"2022","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.phymed.2025.157106_bib0077","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2020.108984","article-title":"Andrographolide ameliorates oxidative stress, inflammation and histological outcome in complete freund\u2019s adjuvant-induced arthritis","volume":"319","author":"Luo","year":"2020","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.phymed.2025.157106_bib0078","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/978-981-10-6674-0_6","article-title":"Roles of mitochondrial DNA in energy metabolism","volume":"1038","author":"Lv","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.phymed.2025.157106_bib0079","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.3390\/biom12091216","article-title":"Mitochondrial dysfunction in rheumatoid arthritis","volume":"12","author":"Ma","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.phymed.2025.157106_bib0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.mito.2024.101854","article-title":"Mitochondrial functioning in rheumatoid arthritis modulated by estrogen: evidence-based insight into the sex-based influence on mitochondria and disease","volume":"76","author":"Malik","year":"2024","journal-title":"Mitochondrion"},{"key":"10.1016\/j.phymed.2025.157106_bib0081","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154216","article-title":"A promising drug combination of mangiferin and glycyrrhizic acid ameliorates disease severity of rheumatoid arthritis by reversing the disturbance of thermogenesis and energy metabolism","volume":"104","author":"Mao","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157106_bib0082","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1586\/1744666X.2014.907744","article-title":"Regulation of B lymphocytes and plasma cells by innate immune mechanisms and stromal cells in rheumatoid arthritis","volume":"10","author":"Maseda","year":"2014","journal-title":"Expert Rev. Clin. Immunol."},{"key":"10.1016\/j.phymed.2025.157106_bib0083","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1056\/NEJMra1004965","article-title":"The pathogenesis of rheumatoid arthritis","volume":"365","author":"McInnes","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phymed.2025.157106_bib0084","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202149675","article-title":"Targeting B cells and plasma cells in autoimmune diseases: from established treatments to novel therapeutic approaches","volume":"53","author":"Merino-Vico","year":"2023","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.phymed.2025.157106_bib0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174504","article-title":"The pharmacological assessment of resveratrol on preclinical models of rheumatoid arthritis through a systematic review and meta-analysis","volume":"910","author":"Mittal","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157106_bib0086","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/s42255-023-00783-1","article-title":"Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction","volume":"5","author":"Monzel","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.phymed.2025.157106_bib0087","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00296-010-1598-8","article-title":"Resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells in a sirtuin 1-dependent manner","volume":"32","author":"Nakayama","year":"2012","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.phymed.2025.157106_bib0088","doi-asserted-by":"crossref","first-page":"5650","DOI":"10.3390\/ijms23105650","article-title":"TNF-\u03b1 induces mitophagy in rheumatoid arthritis synovial fibroblasts, and mitophagy inhibition alleviates synovitis in collagen antibody-induced arthritis","volume":"23","author":"Nam","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.157106_bib0089","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","article-title":"Mitochondria: in sickness and in health","volume":"148","author":"Nunnari","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2025.157106_bib0090","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/s41584-020-0413-5","article-title":"Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes","volume":"16","author":"Nygaard","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.phymed.2025.157106_bib0091","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1002\/jsfa.8664","article-title":"Anti-inflammatory effects of polyphenols in arthritis","volume":"98","author":"Oliviero","year":"2018","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.phymed.2025.157106_bib0092","article-title":"Guizhi shaoyao zhimu decoction alleviates rheumatoid arthritis by inhibiting inflammation by targeting SLPI","volume":"139","author":"Pan","year":"2025","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.phymed.2025.157106_bib0094","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s10522-010-9294-3","article-title":"Mitochondrial function, mitochondrial DNA and ageing: a reappraisal","volume":"11","author":"Passarino","year":"2010","journal-title":"Biogerontology"},{"key":"10.1016\/j.phymed.2025.157106_bib0095","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.mito.2023.10.004","article-title":"Role of mitochondrial dysfunction in the pathogenesis of rheumatoid arthritis: looking closely at fibroblast- like synoviocytes","volume":"73","author":"Promila","year":"2023","journal-title":"Mitochondrion"},{"key":"10.1016\/j.phymed.2025.157106_bib0096","first-page":"6545","article-title":"Quercetin: its antioxidant mechanism, antibacterial properties and potential application in prevention and control of toxipathy","volume":"27","author":"Qi","year":"2022","journal-title":"Mol. Basel Switz."},{"key":"10.1016\/j.phymed.2025.157106_bib0097","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s13075-024-03343-4","article-title":"Targeting pathogenic fibroblast-like synoviocyte subsets in rheumatoid arthritis","volume":"26","author":"Qian","year":"2024","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.phymed.2025.157106_bib0099","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108858","article-title":"Emerging therapeutic potential of regulatory T (treg) cells for rheumatoid arthritis: new insights and challenges","volume":"108","author":"Rezaei Kahmini","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2025.157106_bib0100","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.cmet.2022.02.016","article-title":"Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue","volume":"34","author":"Rosina","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2025.157106_bib0101","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1093\/rheumatology\/keaa686","article-title":"Dendritic cell integrin expression patterns regulate inflammation in the rheumatoid arthritis joint","volume":"60","author":"Schittenhelm","year":"2021","journal-title":"Rheumatology"},{"key":"10.1016\/j.phymed.2025.157106_bib0102","doi-asserted-by":"crossref","first-page":"728","DOI":"10.3390\/nu13030728","article-title":"Immunomodulatory effects of dietary polyphenols","volume":"13","author":"Shakoor","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2025.157106_bib0103","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bcp.2019.03.029","article-title":"The many facets of macrophages in rheumatoid arthritis","volume":"165","author":"Siouti","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157106_bib0104","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2025.157106_bib0105","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.578129","article-title":"Neutrophil extracellular traps tied to rheumatoid arthritis: points to ponder","volume":"11","author":"Song","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2025.157106_bib0106","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.toxlet.2013.08.014","article-title":"Triptolide alters barrier function in renal proximal tubular cells in rats","volume":"223","author":"Sun","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.phymed.2025.157106_bib0107","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.pneurobio.2013.04.004","article-title":"Mitochondrial dysfunction and oxidative stress in Parkinson\u2019s disease","volume":"106\u2013107","author":"Subramaniam","year":"2013","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.phymed.2025.157106_bib0108","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.3390\/ijms18071576","article-title":"Interaction of mitochondria with the endoplasmic reticulum and plasma membrane in calcium homeostasis, lipid trafficking and mitochondrial structure","volume":"18","author":"Szyma\u0144ski","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.157106_bib0109","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.2147\/DDDT.S364759","article-title":"Pharmacological aspects of natural quercetin in rheumatoid arthritis","volume":"16","author":"Tang","year":"2022","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.phymed.2025.157106_bib0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.coph.2022.102304","article-title":"Targeting fibroblast-like synoviocytes in rheumatoid arthritis","volume":"67","author":"Tsaltskan","year":"2022","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157106_bib0111","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.114912","article-title":"Glytabastan B, a coumestan isolated from glycine tabacina, alleviated synovial inflammation, osteoclastogenesis and collagen-induced arthritis through inhibiting MAPK and PI3K\/AKT pathways","volume":"197","author":"Tu","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157106_bib0112","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jep.2019.03.035","article-title":"Glycine tabacina ethanol extract ameliorates collagen-induced arthritis in rats via inhibiting pro-inflammatory cytokines and oxidation","volume":"237","author":"Tu","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157106_bib0114","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3390\/ijms24010238","article-title":"Regulation of myeloid dendritic cells by synthetic and natural compounds for the treatment of rheumatoid arthritis","volume":"24","author":"Umbreen","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.157106_bib0115","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.berh.2018.10.005","article-title":"Update on the epidemiology, risk factors, and disease outcomes of rheumatoid arthritis","volume":"32","author":"Van Der Woude","year":"2018","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.phymed.2025.157106_bib0116","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/s41418-022-01094-w","article-title":"Mitochondria and cell death-associated inflammation","volume":"30","author":"Vringer","year":"2023","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.phymed.2025.157106_bib0117","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.2147\/JIR.S398690","article-title":"PINK1\/parkin-mediated mitochondrial autophagy participates in H2O2-induced abnormal proliferation of fibroblast-like synoviocytes in rheumatoid arthritis","volume":"16","author":"Wang","year":"2023","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.phymed.2025.157106_bib0118","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/biof.1599","article-title":"Resveratrol ameliorates rheumatoid arthritis via activation of SIRT1-Nrf2 signaling pathway","volume":"46","author":"Wang","year":"2020","journal-title":"BioFactors Oxf. Engl."},{"key":"10.1016\/j.phymed.2025.157106_bib0119","article-title":"Antimicrobial peptides mediate apoptosis by changing mitochondrial membrane permeability","volume":"23","author":"Wang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.157106_bib0120","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/j.jep.2011.08.004","article-title":"The analgesic and anti-rheumatic effects of thladiantha dubia fruit crude polysaccharide fraction in mice and rats","volume":"137","author":"Wang","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157106_bib0122","article-title":"Advantages of Chinese herbal medicine in treating rheumatoid arthritis: a focus on its anti-inflammatory and anti-oxidative effects","volume":"11","author":"Wang","year":"2024","journal-title":"Front. Med."},{"key":"10.1016\/j.phymed.2025.157106_bib0123","article-title":"Shikonin suppresses rheumatoid arthritis by inducing apoptosis and autophagy via modulation of the AMPK\/mTOR\/ULK-1 signaling pathway","volume":"128","author":"Wang","year":"2024","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.phymed.2025.157106_bib0124","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114368","article-title":"Traditional herbal medicine: therapeutic potential in rheumatoid arthritis","volume":"279","author":"Wang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157106_bib0125","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s13075-023-03159-8","article-title":"The mechanism of dendritic cell-T cell crosstalk in rheumatoid arthritis","volume":"25","author":"Wang","year":"2023","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.phymed.2025.157106_bib0126","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/cei.13256","article-title":"Dendritic cells, T cells and their interaction in rheumatoid arthritis","volume":"196","author":"Wehr","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.phymed.2025.157106_bib0127","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41590-020-00816-x","article-title":"The immunology of rheumatoid arthritis","volume":"22","author":"Weyand","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.phymed.2025.157106_bib0128","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00011-017-1116-5","article-title":"Intracellular apoptotic pathways: a potential target for reducing joint damage in rheumatoid arthritis","volume":"67","author":"Williams","year":"2018","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.phymed.2025.157106_bib0129","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1038\/s41590-021-01065-2","article-title":"Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation","volume":"22","author":"Wu","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.phymed.2025.157106_bib0130","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1051082","article-title":"Systemic complications of rheumatoid arthritis: focus on pathogenesis and treatment","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2025.157106_bib0131","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jep.2014.09.026","article-title":"Petroleum ether extractive of the hips of rosa multiflora ameliorates collagen-induced arthritis in rats","volume":"157","author":"Wu","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157106_bib0132","article-title":"Aconiti lateralis radix praeparata total alkaloids exert anti-RA effects by regulating NF-\u03bab and JAK\/STAT signaling pathways and promoting apoptosis","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157106_bib0133","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153522","article-title":"Wutou decoction ameliorates experimental rheumatoid arthritis via regulating NF-kB and Nrf2: integrating efficacy-oriented compatibility of traditional Chinese medicine","volume":"85","author":"Xie","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157106_bib0134","article-title":"Yishen tongbi decoction attenuates inflammation and bone destruction in rheumatoid arthritis by regulating JAK\/STAT3\/SOCS3 pathway","volume":"15","author":"Xu","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2025.157106_bib0135","article-title":"Kunduan yimu decoction affected Th17\/treg balance through microRNA-124 to improve rheumatoid arthritis pathology","volume":"135","author":"Xu","year":"2024","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.phymed.2025.157106_bib0136","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1136\/ard-2022-223645","article-title":"Immunomics analysis of rheumatoid arthritis identified precursor dendritic cells as a key cell subset of treatment resistance","volume":"82","author":"Yamada","year":"2023","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.phymed.2025.157106_bib0137","doi-asserted-by":"crossref","first-page":"12953","DOI":"10.1021\/acs.jafc.8b05047","article-title":"Resveratrol alleviates rheumatoid arthritis via reducing ROS and inflammation, inhibiting MAPK signaling pathways, and suppressing angiogenesis","volume":"66","author":"Yang","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2025.157106_bib0138","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1002\/JLB.4RU0619-197R","article-title":"Th17 cell pathogenicity and plasticity in rheumatoid arthritis","volume":"106","author":"Yang","year":"2019","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.phymed.2025.157106_bib0139","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154967","article-title":"Guizhi shaoyao zhimu granules attenuate bone destruction in mice with collagen-induced arthritis by promoting mitophagy of osteoclast precursors to inhibit osteoclastogenesis","volume":"118","author":"Yao","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157106_bib0140","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1248\/bpb.31.592","article-title":"Involvement of mitochondrial pathway in triptolide-induced cytotoxicity in human normal liver L-02 cells","volume":"31","author":"Yao","year":"2008","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.phymed.2025.157106_bib0141","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/ptr.5763","article-title":"Anti-rheumatoid arthritis effect of kaejadan via analgesic and antiinflammatory activity in vivo and in vitro: anti-rheumatoid arthritis effect of kaejadan","volume":"31","author":"Yoon","year":"2017","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2025.157106_bib0142","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114952","article-title":"Qingluotongbi formula regulates the lxr\u03b1-ERS-SREBP-1c pathway in hepatocytes to alleviate the liver injury caused by tripterygium wilfordii hook. F","volume":"287","author":"Yu","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157106_bib0143","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/ptr.7324","article-title":"Andrographolide: a review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches","volume":"36","author":"Zeng","year":"2022","journal-title":"Phytother. Res. PTR"},{"key":"10.1016\/j.phymed.2025.157106_bib0144","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1039\/C7FO01748K","article-title":"Apoptosis effects of imperatorin on synoviocytes in rheumatoid arthritis through mitochondrial\/caspase-mediated pathways","volume":"9","author":"Zhai","year":"2018","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2025.157106_bib0145","article-title":"Augmenting regulatory T cells: new therapeutic strategy for rheumatoid arthritis","volume":"15","author":"Zhang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2025.157106_bib0146","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1507\/endocrj.EJ11-0407","article-title":"Effect of triptolide on estradiol release from cultured rat granulosa cells","volume":"59","author":"Zhang","year":"2012","journal-title":"Endocr. J."},{"key":"10.1016\/j.phymed.2025.157106_bib0147","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.14336\/AD.2024.0514","article-title":"Redefinition of synovial fibroblasts in rheumatoid arthritis","volume":"16","author":"Zhang","year":"2024","journal-title":"Aging Dis."},{"key":"10.1016\/j.phymed.2025.157106_bib0148","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/nyas.14196","article-title":"Nrf2\u2013Keap1 pathway\u2013mediated effects of resveratrol on oxidative stress and apoptosis in hydrogen peroxide\u2013treated rheumatoid arthritis fibroblast-like synoviocytes","volume":"1457","author":"Zhang","year":"2019","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.phymed.2025.157106_bib0150","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1309835","article-title":"The neutrophil-lymphocyte ratio predicts all-cause and cardiovascular mortality among U.S. adults with rheumatoid arthritis: results from NHANES 1999-2020","volume":"14","author":"Zhou","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2025.157106_bib0151","article-title":"Identifying immune cell infiltration and effective diagnostic biomarkers in rheumatoid arthritis by bioinformatics analysis","volume":"12","author":"Zhou","year":"2021","journal-title":"Front. Immunol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325007457?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325007457?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T08:50:37Z","timestamp":1762332637000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325007457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":144,"alternative-id":["S0944711325007457"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157106","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial pathways in rheumatoid arthritis: Therapeutic roles of traditional Chinese medicine and natural products","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157106","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157106"}}