{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:45:05Z","timestamp":1792457105020,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100022773","name":"Scientific Research and Technological Development Council of Veracruz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022773","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174150"],"award-info":[{"award-number":["82174150"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20799"],"award-info":[{"award-number":["U24A20799"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2024ZY01016"],"award-info":[{"award-number":["2024ZY01016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.phymed.2025.157122","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T17:42:15Z","timestamp":1754415735000},"page":"157122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["The Tanyu Tongzhi Formula enhances IL-10 expression and macrophage efferocytosis to alleviate atherosclerosis in mice"],"prefix":"10.1016","volume":"146","author":[{"given":"Chenxia","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4002-4762","authenticated-orcid":false,"given":"Tiantian","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9328-4273","authenticated-orcid":false,"given":"Zhengtian","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingshuang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luoxia","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youjin","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5084-1071","authenticated-orcid":false,"given":"Zheng","family":"Rong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7005-8628","authenticated-orcid":false,"given":"Chenchen","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3914-8793","authenticated-orcid":false,"given":"Xinbin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0956-8869","authenticated-orcid":false,"given":"Tingting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9662-1570","authenticated-orcid":false,"given":"Hongqiang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.157122_bib0001","doi-asserted-by":"crossref","DOI":"10.1038\/s41569-024-01037-7","article-title":"Efferocytosis in atherosclerosis","author":"Adkar","year":"2024","journal-title":"Nat Rev Cardiol"},{"issue":"1\u20132","key":"10.1016\/j.phymed.2025.157122_bib0003","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/BF03402102","article-title":"Interleukin-10 deficiency increases atherosclerosis, thrombosis, and low-density lipoproteins in apolipoprotein E knockout mice","volume":"9","author":"Caligiuri","year":"2003","journal-title":"Mol Med"},{"issue":"8","key":"10.1016\/j.phymed.2025.157122_bib0004","doi-asserted-by":"crossref","first-page":"4733","DOI":"10.4049\/jimmunol.172.8.4733","article-title":"A toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-fos in dendritic cells","volume":"172","author":"Dillon","year":"2004","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.phymed.2025.157122_bib0005","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00395-023-01023-z","article-title":"Macrophage profiling in atherosclerosis: understanding the unstable plaque","volume":"119","author":"Gianopoulos","year":"2024","journal-title":"Basic Res Cardiol"},{"issue":"5","key":"10.1016\/j.phymed.2025.157122_bib0006","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.immuni.2007.03.012","article-title":"C-type lectin DC-SIGN modulates toll-like receptor signaling via raf-1 kinase-dependent acetylation of transcription factor NF-kappaB","volume":"26","author":"Gringhuis","year":"2007","journal-title":"Immunity"},{"issue":"47","key":"10.1016\/j.phymed.2025.157122_bib0007","doi-asserted-by":"crossref","first-page":"32950","DOI":"10.1074\/jbc.M109.040899","article-title":"Interleukin-10 facilitates both cholesterol uptake and efflux in macrophages","volume":"284","author":"Han","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.phymed.2025.157122_bib0002","article-title":"Effects of the containing serum of synchronic treating phlegm and blood stasis on neovascularization of vascular endothelial cells by regulating ppar\u03b3\/NF-\u03bab pathway","volume":"38","author":"Hong-wen","year":"2023","journal-title":"China Journal of Traditional Chinese Medicine and Pharmacy"},{"key":"10.1016\/j.phymed.2025.157122_bib0008","article-title":"Macrophage WEE1 directly binds to and phosphorylates NF-\u03bab p65 subunit to induce inflammatory response and drive atherosclerosis","author":"Huang","year":"2025","journal-title":"Adv Sci (Weinh)"},{"issue":"6337","key":"10.1016\/j.phymed.2025.157122_bib0009","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1126\/science.aal3535","article-title":"Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages","volume":"356","author":"Ip","year":"2017","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.phymed.2025.157122_bib0010","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1084\/jem.20091059","article-title":"TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells","volume":"206","author":"Kaiser","year":"2009","journal-title":"J Exp Med"},{"issue":"1","key":"10.1016\/j.phymed.2025.157122_bib0011","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.atherosclerosis.2010.07.029","article-title":"AAV\/hSTAT3-gene delivery lowers aortic inflammatory cell infiltration in LDLR KO mice on high cholesterol","volume":"213","author":"Khan","year":"2010","journal-title":"Atherosclerosis"},{"issue":"4","key":"10.1016\/j.phymed.2025.157122_bib0012","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.phymed.2025.157122_bib0013","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinformatics"},{"issue":"5","key":"10.1016\/j.phymed.2025.157122_bib0014","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/bioinformatics\/btn025","article-title":"SOAP: short oligonucleotide alignment program","volume":"24","author":"Li","year":"2008","journal-title":"Bioinformatics"},{"issue":"4","key":"10.1016\/j.phymed.2025.157122_bib0015","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1161\/ATVBAHA.116.307344","article-title":"Inhibition of Orai1 store-operated calcium channel prevents foam cell formation and atherosclerosis","volume":"36","author":"Liang","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"7855","key":"10.1016\/j.phymed.2025.157122_bib0016","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/s41586-021-03392-8","article-title":"The changing landscape of atherosclerosis","volume":"592","author":"Libby","year":"2021","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.phymed.2025.157122_bib0017","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.7150\/thno.41028","article-title":"TMEM16A ameliorates vascular remodeling by suppressing autophagy via inhibiting bcl-2-p62 complex formation","volume":"10","author":"Lv","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2025.157122_bib0019","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jep.2018.11.043","article-title":"Compatibility principle in the Tanyu Tongzhi Formula revealed by a cell-based analysis","volume":"231","author":"Ma","year":"2019","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.phymed.2025.157122_bib0018","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.734589","article-title":"Tanyu Tongzhi formula delays atherosclerotic plaque progression by promoting alternative macrophage activation via PPAR\u03b3 and AKT\/ERK signal pathway in ApoE knock-out mice","volume":"12","author":"Ma","year":"2021","journal-title":"Front Pharmacol"},{"issue":"9","key":"10.1016\/j.phymed.2025.157122_bib0020","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1161\/CIRCRESAHA.120.315930","article-title":"Sex as a biological variable in atherosclerosis","volume":"126","author":"Man","year":"2020","journal-title":"Circ Res"},{"issue":"1","key":"10.1016\/j.phymed.2025.157122_bib0021","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.atherosclerosis.2003.08.032","article-title":"Intramuscular gene transfer of interleukin-10 cDNA reduces atherosclerosis in apolipoprotein E-knockout mice","volume":"172","author":"Namiki","year":"2004","journal-title":"Atherosclerosis"},{"issue":"4","key":"10.1016\/j.phymed.2025.157122_bib0022","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.immuni.2019.03.020","article-title":"IL-10 Family Cytokines IL-10 and IL-22: from basic science to clinical translation","volume":"50","author":"Ouyang","year":"2019","journal-title":"Immunity"},{"issue":"10","key":"10.1016\/j.phymed.2025.157122_bib0023","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1161\/01.RES.0000018941.10726.FA","article-title":"Overexpression of interleukin-10 by activated T lymphocytes inhibits atherosclerosis in LDL receptor-deficient mice by altering lymphocyte and macrophage phenotypes","volume":"90","author":"Pinderski","year":"2002","journal-title":"Circ Res"},{"issue":"8","key":"10.1016\/j.phymed.2025.157122_bib0024","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1161\/01.ATV.0000134378.86443.cd","article-title":"Leukocyte-derived interleukin 10 is required for protection against atherosclerosis in low-density lipoprotein receptor knockout mice","volume":"24","author":"Potteaux","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"10","key":"10.1016\/j.phymed.2025.157122_bib0025","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/s41569-021-00538-z","article-title":"High-density lipoproteins, reverse cholesterol transport and atherogenesis","volume":"18","author":"Pownall","year":"2021","journal-title":"Nat Rev Cardiol"},{"issue":"4","key":"10.1016\/j.phymed.2025.157122_bib0026","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.immuni.2018.07.015","article-title":"Regulatory T cells promote macrophage efferocytosis during inflammation resolution","volume":"49","author":"Proto","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.phymed.2025.157122_bib0027","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1146\/annurev-biochem-081720-114505","article-title":"MAPK-activated protein kinases: servant or partner?","volume":"91","author":"Ronkina","year":"2022","journal-title":"Annu Rev Biochem"},{"issue":"3","key":"10.1016\/j.phymed.2025.157122_bib0029","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nri2711","article-title":"The regulation of IL-10 production by immune cells","volume":"10","author":"Saraiva","year":"2010","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"10.1016\/j.phymed.2025.157122_bib0028","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.4049\/jimmunol.175.2.1041","article-title":"Identification of a macrophage-specific chromatin signature in the IL-10 locus","volume":"175","author":"Saraiva","year":"2005","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.phymed.2025.157122_bib0030","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/imr.13214","article-title":"The role of efferocytosis-fueled macrophage metabolism in the resolution of inflammation","volume":"319","author":"Schilperoort","year":"2023","journal-title":"Immunol Rev"},{"issue":"3","key":"10.1016\/j.phymed.2025.157122_bib0031","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1161\/CIRCRESAHA.119.316461","article-title":"Regulatory T cells license macrophage pro-resolving functions during atherosclerosis regression","volume":"127","author":"Sharma","year":"2020","journal-title":"Circ Res"},{"issue":"3","key":"10.1016\/j.phymed.2025.157122_bib0032","first-page":"565","article-title":"Deleting myeloid IL-10 receptor signalling attenuates atherosclerosis in LDLR-\/- mice by altering intestinal cholesterol fluxes","volume":"116","author":"St\u00f6ger","year":"2016","journal-title":"Thromb Haemost"},{"issue":"5","key":"10.1016\/j.phymed.2025.157122_bib0033","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/s41419-019-1599-9","article-title":"MicroRNA-181a-5p and microRNA-181a-3p cooperatively restrict vascular inflammation and atherosclerosis","volume":"10","author":"Su","year":"2019","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.phymed.2025.157122_bib0034","doi-asserted-by":"crossref","DOI":"10.1172\/JCI148559","article-title":"Addressing dyslipidemic risk beyond LDL-cholesterol","volume":"132","author":"Tall","year":"2022","journal-title":"J Clin Invest"},{"issue":"5","key":"10.1016\/j.phymed.2025.157122_bib0035","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1093\/cvr\/cvaf024","article-title":"Endothelial c-REL orchestrates atherosclerosis at regions of disturbed flow through crosstalk with TXNIP-p38 and non-canonical NF-\u03bab pathways","volume":"121","author":"Tardajos Ayllon","year":"2025","journal-title":"Cardiovasc Res"},{"issue":"8","key":"10.1016\/j.phymed.2025.157122_bib0036","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1161\/CIR.0000000000001123","article-title":"Heart Disease and Stroke statistics-2023 update: a report from the American Heart Association","volume":"147","author":"Tsao","year":"2023","journal-title":"Circulation"},{"issue":"14","key":"10.1016\/j.phymed.2025.157122_bib0037","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1096\/fj.01-0483fje","article-title":"Attenuation of atherogenesis by systemic and local adenovirus-mediated gene transfer of interleukin-10 in LDLr-\/- mice","volume":"15","author":"Von Der Th\u00fcsen","year":"2001","journal-title":"Faseb j"},{"key":"10.1016\/j.phymed.2025.157122_bib0038","article-title":"Effect of Tanyu Tongzhi Recipe on angiogenesis in atherosclerosis plaque rats by regulating ppar\u03b3\/NF-\u03bab pathways","volume":"37","author":"Wei","year":"2017","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine"},{"issue":"1","key":"10.1016\/j.phymed.2025.157122_bib0039","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1161\/ATVBAHA.123.319663","article-title":"Protein tyrosine phosphatase SHP2 in macrophages acts as an antiatherosclerotic regulator in mice","volume":"44","author":"Wu","year":"2024","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"8004","key":"10.1016\/j.phymed.2025.157122_bib0040","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/s41586-024-07098-5","article-title":"IL-10 constrains sphingolipid metabolism to limit inflammation","volume":"627","author":"York","year":"2024","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.phymed.2025.157122_bib0041","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.cmet.2020.01.001","article-title":"Macrophage metabolism of apoptotic cell-derived arginine promotes continual efferocytosis and resolution of injury","volume":"31","author":"Yurdagul","year":"2020","journal-title":"Cell Metab"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325007615?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325007615?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:48:03Z","timestamp":1777592883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325007615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":41,"alternative-id":["S0944711325007615"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157122","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Tanyu Tongzhi Formula enhances IL-10 expression and macrophage efferocytosis to alleviate atherosclerosis in mice","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157122","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"157122"}}