{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T12:26:22Z","timestamp":1793881582068,"version":"4.7.0"},"reference-count":203,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["ZD2024H004"],"award-info":[{"award-number":["ZD2024H004"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017366","name":"Key Research and Development Program of Heilongjiang","doi-asserted-by":"publisher","award":["2022ZX02C08"],"award-info":[{"award-number":["2022ZX02C08"]}],"id":[{"id":"10.13039\/100017366","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20512"],"award-info":[{"award-number":["U23A20512"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.phymed.2025.157219","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:17:03Z","timestamp":1757031423000},"page":"157219","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Deciphering inulin from Jerusalem artichoke: Extraction, structural characteristics, bioactivities, structure-activity relationship, modifications, pharmacokinetics and applications"],"prefix":"10.1016","volume":"147","author":[{"given":"Zihao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0201-5439","authenticated-orcid":false,"given":"Na","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunqiu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingze","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenfeng","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.phymed.2025.157219_bib0001","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/joim.13577","article-title":"Genetic and molecular architecture of familial hypercholesterolemia","volume":"293","author":"Abifadel","year":"2023","journal-title":"J. Intern. Med."},{"issue":"2","key":"10.1016\/j.phymed.2025.157219_bib0002","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/ajcn\/82.2.471","article-title":"A combination of prebiotic short- and long-chain inulin-type fructans enhances calcium absorption and bone mineralization in young adolescents","volume":"82","author":"Abrams","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"issue":"9","key":"10.1016\/j.phymed.2025.157219_bib0003","doi-asserted-by":"crossref","first-page":"855","DOI":"10.3390\/ph14090855","article-title":"Inulin and its application in drug delivery","volume":"14","author":"Afinjuomo","year":"2021","journal-title":"Pharmaceuticals"},{"issue":"1","key":"10.1016\/j.phymed.2025.157219_bib0004","article-title":"Inulin: unveiling its potential as a multifaceted biopolymer in prebiotics, drug delivery, and therapeutics","volume":"259","author":"Akram","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.phymed.2025.157219_bib0005","doi-asserted-by":"crossref","first-page":"9101","DOI":"10.1038\/s41598-024-75726-1","article-title":"Bioremoval of lead (Pb) salts from synbiotic milk by lactic acid bacteria","volume":"15","author":"Alizadeh","year":"2025","journal-title":"Sci. Rep."},{"issue":"17","key":"10.1016\/j.phymed.2025.157219_bib0006","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.3390\/nu16172935","article-title":"Health effects and mechanisms of inulin action in human metabolism","volume":"16","author":"Alonso-Allende","year":"2024","journal-title":"Nutrients"},{"issue":"Pt A","key":"10.1016\/j.phymed.2025.157219_bib0007","article-title":"Coating of betanin and carvone Co-loaded nanoliposomes with synthesized cationic inulin: a strategy for enhancing the stability and bioavailability","volume":"373","author":"Amjadi","year":"2022","journal-title":"Food Chem."},{"issue":"13","key":"10.1016\/j.phymed.2025.157219_bib0008","doi-asserted-by":"crossref","first-page":"4626","DOI":"10.1021\/ma951799f","article-title":"Molecular and crystal structures of inulin from electron diffraction data","volume":"29","author":"Andre","year":"1996","journal-title":"Macromolecules"},{"key":"10.1016\/j.phymed.2025.157219_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2020.109418","article-title":"Inulin thermal stability in prebiotic carbohydrate-enriched araticum whey beverage","volume":"128","author":"Arruda","year":"2020","journal-title":"LWT"},{"issue":"3","key":"10.1016\/j.phymed.2025.157219_bib0010","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0144-8617(98)00096-4","article-title":"Size and shape of inulin in dimethyl sulphoxide solution","volume":"38","author":"Azis","year":"1999","journal-title":"Carbohydr. Polym."},{"issue":"9","key":"10.1016\/j.phymed.2025.157219_bib0011","first-page":"1808","article-title":"Research progress on chemical constituents and pharmacological activities of Helianthus annuus L","volume":"24","author":"Bai","year":"2022","journal-title":"Mod. Chin. Med."},{"issue":"1","key":"10.1016\/j.phymed.2025.157219_bib0012","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1024\/0300-9831\/a000700","article-title":"Effects of inulin on calcium metabolism and bone health","volume":"93","author":"Bakirhan","year":"2023","journal-title":"Int. J. Vitam. Nutr. Res."},{"issue":"5","key":"10.1016\/j.phymed.2025.157219_bib0013","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1080\/10826068.2020.1827429","article-title":"Investigating the effect of different inulin-rich substrate preparations from Jerusalem artichoke (Helianthus tuberosus L.) tubers on efficient inulooligosaccharides production","volume":"51","author":"Bedzo","year":"2021","journal-title":"Prep. Bioche. Biotech."},{"issue":"11","key":"10.1016\/j.phymed.2025.157219_bib0014","doi-asserted-by":"crossref","first-page":"8916","DOI":"10.3390\/nu7115440","article-title":"Quantification of in vivo colonic short chain fatty acid production from inulin","volume":"7","author":"Boets","year":"2015","journal-title":"Nutrients"},{"issue":"5-6","key":"10.1016\/j.phymed.2025.157219_bib0015","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00217-005-0184-x","article-title":"Effect of dry heated inulin on selected intestinal bacteria","volume":"222","author":"B\u00f6hm","year":"2006","journal-title":"Eur. Food Res. Technol."},{"issue":"11","key":"10.1016\/j.phymed.2025.157219_bib0016","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1007\/s00125-007-0791-0","article-title":"Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia","volume":"50","author":"Cani","year":"2007","journal-title":"Diabetologia"},{"issue":"12","key":"10.1016\/j.phymed.2025.157219_bib0017","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1111\/pbi.13670","article-title":"Inactivation of the germacrene A synthase genes by CRISPR\/Cas9 eliminates the biosynthesis of sesquiterpene lactones in Cichorium intybus L","volume":"19","author":"Cankar","year":"2021","journal-title":"Plant Biotechnol. J."},{"issue":"8","key":"10.1016\/j.phymed.2025.157219_bib0018","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.3390\/molecules27082482","article-title":"Spaghetti enriched with inulin: Effect of polymerization degree on quality traits and \u03b1-Amylase inhibition","volume":"27","author":"Cardullo","year":"2022","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.phymed.2025.157219_bib0019","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1006\/rtph.1999.1349","article-title":"Evaluation of safety of inulin and oligofructose as dietary fiber","volume":"30","author":"Carabin","year":"1999","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"8","key":"10.1016\/j.phymed.2025.157219_bib0020","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1136\/gutjnl-2019-318424","volume":"68","author":"Chambers","year":"2019","journal-title":"Gut"},{"issue":"11","key":"10.1016\/j.phymed.2025.157219_bib0021","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1136\/gutjnl-2014-307913","article-title":"Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults","volume":"64","author":"Chambers","year":"2015","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.phymed.2025.157219_bib0022","doi-asserted-by":"crossref","DOI":"10.1111\/1541-4337.70114","article-title":"Jerusalem artichoke: a comprehensive review of nutritional composition, health benefits and emerging trends in food applications","volume":"24","author":"Chauhan","year":"2025","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"issue":"4","key":"10.1016\/j.phymed.2025.157219_bib0023","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.jfda.2019.06.005","article-title":"Impact of dietary ingredients on the interpretation of various fecal parameters in rats fed inulin","volume":"27","author":"Chen","year":"2019","journal-title":"J. Food Drug Anal."},{"issue":"3","key":"10.1016\/j.phymed.2025.157219_bib0024","first-page":"347","article-title":"Essential role of medicine and food homology in health and wellness. Chin","volume":"15","author":"Chen","year":"2023","journal-title":"Herbal Med."},{"issue":"12","key":"10.1016\/j.phymed.2025.157219_bib0025","doi-asserted-by":"crossref","first-page":"9020","DOI":"10.1111\/ijfs.17434","article-title":"Effect of phosphorylated modification on natural inulin: structural characterisation and gel properties","volume":"59","author":"Chen","year":"2024","journal-title":"Int. J. Food Sci. Technol."},{"key":"10.1016\/j.phymed.2025.157219_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.fochx.2024.101405","article-title":"Effects of inulin with different polymerization degrees on the structural and gelation properties of potato protein","volume":"22","author":"Chen","year":"2024","journal-title":"Food Chem. X."},{"issue":"2","key":"10.1016\/j.phymed.2025.157219_bib0027","doi-asserted-by":"crossref","first-page":"128669","DOI":"10.1016\/j.ijbiomac.2023.128669","article-title":"Extraction, structural characterization and biological activities of polysaccharides from mulberry leaves: a review","volume":"257","author":"Chen","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2025.157219_bib0028","article-title":"Protective effect of short-chain fructo-oligosaccharides from chicory on alcohol-induced injury in GES-1 cells via Keap1\/Nrf2 and NLRP3 inflammasome signaling pathways","volume":"11","author":"Chen","year":"2024","journal-title":"Front. Nutr."},{"issue":"2","key":"10.1016\/j.phymed.2025.157219_bib0029","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s12010-019-03215-7","article-title":"Production of short chain fructo-oligosaccharides from inulin of chicory root using fungal endoinulinase","volume":"191","author":"Chikkerur","year":"2020","journal-title":"Appl. Biochem. Biotechnol."},{"issue":"2","key":"10.1016\/j.phymed.2025.157219_bib0030","article-title":"Healthy properties of Jerusalem artichoke flour (Helianthus tuberosus L.)","volume":"8","author":"Cie\u015blik","year":"2005","journal-title":"EJPAU, Food Sci. Technol."},{"issue":"2","key":"10.1016\/j.phymed.2025.157219_bib0031","first-page":"244","article-title":"Effectiveness of inulin intake on indicators of chronic constipation; a meta-analysis of controlled randomized clinical trials","volume":"30","author":"Collado Yurrita","year":"2014","journal-title":"Nutr. Hosp."},{"issue":"5","key":"10.1016\/j.phymed.2025.157219_bib0032","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/glycob\/cwq201","article-title":"Delta inulin: a novel, immunologically active, stable packing structure comprising \u03b2-D-[2\u21921] poly(fructo-furanosyl) \u03b1-D-glucose polymers","volume":"21","author":"Cooper","year":"2011","journal-title":"Glycobiology"},{"issue":"1","key":"10.1016\/j.phymed.2025.157219_bib0033","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s40168-023-01520-2","article-title":"Inulin diet uncovers complex diet - microbiota - immune cell interactions remodeling the gut epithelium","volume":"11","author":"Corr\u00eaa","year":"2023","journal-title":"Microbiome"},{"issue":"1","key":"10.1016\/j.phymed.2025.157219_bib0034","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/jn\/136.1.117","article-title":"Dietary inulin intake and age can affect intestinal absorption of zinc and copper in rats","volume":"136","author":"Coudray","year":"2006","journal-title":"J. Nutr."},{"issue":"2","key":"10.1016\/j.phymed.2025.157219_bib0035","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00394-003-0390-x","article-title":"Effects of inulin-type fructans of different chain length and type of branching on intestinal absorption and balance of calcium and magnesium in rats","volume":"42","author":"Coudray","year":"2003","journal-title":"Eur. J. Nutr."},{"issue":"S7","key":"10.1016\/j.phymed.2025.157219_bib0036","article-title":"Inulin and oligofructose: safe intakes and legal status","volume":"129","author":"Coussement","year":"1999","journal-title":"J. Nutr."},{"issue":"9","key":"10.1016\/j.phymed.2025.157219_bib0037","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/bip.21199","article-title":"Physicochemical studies on the biopolymer inulin: a critical evaluation of its self-aggregation, aggregate-morphology, interaction with water, and thermal stability","volume":"91","author":"Dan","year":"2009","journal-title":"Biopolymers"},{"issue":"3","key":"10.1016\/j.phymed.2025.157219_bib0038","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1007\/s12602-021-09898-x","article-title":"Safety evaluation of goat milk added with the prebiotic inulin fermented with the potentially probiotic native culture Limosilactobacillus mucosae CNPC007 in co-culture with Streptococcus thermophilus QGE: analysis of acute and repeated dose oral toxicity","volume":"15","author":"de Souza Pereira","year":"2023","journal-title":"Probiotics Antimicrob. Proteins"},{"issue":"8","key":"10.1016\/j.phymed.2025.157219_bib0039","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.jnutbio.2010.05.009","article-title":"Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPAR\u03b3-related adipogenesis in the white adipose tissue of high-fat diet-fed mice","volume":"22","author":"Dewulf","year":"2011","journal-title":"J. Nutr. Biochem."},{"issue":"2","key":"10.1016\/j.phymed.2025.157219_bib0041","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s11130-023-01066-6","article-title":"Extraction, physicochemical properties, functional activities and applications of inulin polysaccharide: a review","volume":"78","author":"Du","year":"2023","journal-title":"Plant Foods Hum. Nutr."},{"issue":"2","key":"10.1016\/j.phymed.2025.157219_bib0042","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/ptr.8067","article-title":"Polysaccharides (pectin, mucilage, and fructan inulin) and their fermented products: a critical analysis of their biochemical, gut interactions, and biological functions as antidiabetic agents","volume":"38","author":"El-Nashar","year":"2024","journal-title":"Phytother. Res."},{"issue":"3","key":"10.1016\/j.phymed.2025.157219_bib0043","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00217-024-04641-6","article-title":"Jerusalem artichoke ingredient for the nutritional profile improvement of sourdough bread: techno-functional properties and consumer perception","volume":"251","author":"Franceschinis","year":"2025","journal-title":"Eur. Food Res. Technol."},{"issue":"5","key":"10.1016\/j.phymed.2025.157219_bib0044","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1080\/20014091091841","article-title":"Inulin and oligofructose as dietary fiber: a review of the evidence","volume":"41","author":"Flamm","year":"2001","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"2","key":"10.1016\/j.phymed.2025.157219_bib0045","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1007\/s10924-021-02210-6","article-title":"Inulin-niacin conjugates: preparation, characterization, kinetic and in vitro release studies","volume":"30","author":"Ganie","year":"2022","journal-title":"J. Polym. Environ."},{"key":"10.1016\/j.phymed.2025.157219_bib0046","article-title":"The impact of high polymerization inulin on body weight reduction in high-fat diet-induced obese mice: correlation with cecal","volume":"15","author":"Gan","year":"2024","journal-title":"Akkermansia. Front. Microbiol."},{"key":"10.1016\/j.phymed.2025.157219_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156436","article-title":"Unveiling polysaccharides of Houttuynia cordata Thunb.: extraction, purification, structure, bioactivities, and structure-activity relationships","volume":"138","author":"Gao","year":"2025","journal-title":"Phytomedicine"},{"issue":"7","key":"10.1016\/j.phymed.2025.157219_bib0048","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.1039\/D1FO04327G","article-title":"Pharmacokinetics, distribution and excretion of inulin-type fructan CPA after oral or intravenous administration to mice","volume":"13","author":"Guo","year":"2022","journal-title":"Food Funct."},{"issue":"1","key":"10.1016\/j.phymed.2025.157219_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.cdnut.2023.102059","article-title":"The combinational effect of inulin and resveratrol on the oxidative stress and inflammation level in a rat model of diabetic nephropathy","volume":"8","author":"Ghavidel","year":"2024","journal-title":"Curr. Dev. Nutr."},{"issue":"Pt1","key":"10.1016\/j.phymed.2025.157219_bib0050","article-title":"Inulin-based formulations as an emerging therapeutic strategy for cancer: a comprehensive review","volume":"259","author":"Ghali","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2025.157219_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.121670","article-title":"Application of inulin for the formulation and delivery of bioactive molecules and live cells","volume":"327","author":"Gruskiene","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.phymed.2025.157219_bib0052","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ultsonch.2019.05.004","article-title":"High-intensity ultrasound: a novel technology for the development of probiotic and prebiotic dairy products","volume":"57","author":"Guimar\u00e3es","year":"2019","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.phymed.2025.157219_bib0054","article-title":"Effect of soluble fiber supplementation on lipid parameters in subjects with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials","volume":"176","author":"Gupta","year":"2025","journal-title":"Prostagland. Other Lipid Mediat."},{"issue":"1","key":"10.1016\/j.phymed.2025.157219_bib0055","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3390\/foods12010081","article-title":"Asparagus fructans as emerging prebiotics","volume":"12","author":"Hamdi","year":"2023","journal-title":"Foods"},{"issue":"11","key":"10.1016\/j.phymed.2025.157219_bib0056","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1038\/s41551-021-00749-2","article-title":"Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel","volume":"5","author":"Han","year":"2021","journal-title":"Nat. Biomed. Eng."},{"issue":"8","key":"10.1016\/j.phymed.2025.157219_bib0057","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1007\/s10620-013-2631-z","article-title":"Inulin-Type Fructans with Different Degrees of Polymerization Improve Lipid Metabolism but Not Glucose Metabolism in Rats Fed a High-Fat Diet Under Energy Restriction","volume":"58","author":"Han","year":"2013","journal-title":"Digest. Dis. Sci."},{"issue":"8","key":"10.1016\/j.phymed.2025.157219_bib0058","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201600635","article-title":"Dietary fat content modulates the hypolipidemic effect of dietary inulin in rats","volume":"61","author":"Han","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"issue":"2","key":"10.1016\/j.phymed.2025.157219_bib0059","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.jaci.2019.03.035","article-title":"Randomized controlled trial demonstrating the benefits of delta inulin adjuvanted immunotherapy in patients with bee venom allergy","volume":"144","author":"Heddle","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.phymed.2025.157219_bib0060","article-title":"Preparation of magnetic inulin nanocomposite and its application in the removal of methylene blue and heavy metals from aqueous solution","volume":"291","author":"Herab","year":"2022","journal-title":"Mater. Chem. Phys."},{"issue":"1","key":"10.1016\/j.phymed.2025.157219_bib0061","doi-asserted-by":"crossref","first-page":"55","DOI":"10.22358\/jafs\/189786\/2024","article-title":"Diets enriched with chicory-derived native inulin can affect kidney and liver mineral content in nursery pigs","volume":"34","author":"Herosimczyk","year":"2025","journal-title":"J. Anim. Feed Sci."},{"issue":"5","key":"10.1016\/j.phymed.2025.157219_bib0062","doi-asserted-by":"crossref","first-page":"532","DOI":"10.3390\/nu10050532","article-title":"Inulin improves postprandial hypertriglyceridemia by modulating gene expression in the small intestine","volume":"10","author":"Hiel","year":"2018","journal-title":"Nutrients"},{"issue":"12","key":"10.1016\/j.phymed.2025.157219_bib0063","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1016\/j.clnu.2020.04.005","article-title":"Link between gut microbiota and health outcomes in inulin-treated obese patients: lessons from the Food4Gut multicenter randomized placebo-controlled trial","volume":"39","author":"Hiel","year":"2020","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.phymed.2025.157219_bib0064","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.ijbiomac.2022.06.049","article-title":"Extraction, purification, structural characterization, and gut microbiota relationship of polysaccharides: a review","volume":"213","author":"Huang","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2025.157219_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118706","article-title":"Inulin as a functional ingredient and their applications in meat products","volume":"275","author":"Illippangama","year":"2022","journal-title":"Carbohydr. Polym."},{"issue":"1","key":"10.1016\/j.phymed.2025.157219_bib0066","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/fsn3.3040","article-title":"Inulin-type fructans and short-chain fructooligosaccharides - their role within the food industry as fat and sugar replacers and texture modifiers - what needs to be considered!","volume":"11","author":"Jackson","year":"2023","journal-title":"Food Sci. Nutr."},{"issue":"5","key":"10.1016\/j.phymed.2025.157219_bib0067","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.ajcnut.2023.08.016","article-title":"Inulin-type fructans and 2\u2032 fucosyllactose alter both microbial composition and appear to alleviate stress-induced mood state in a working population compared to placebo (maltodextrin): the EFFICAD trial, a randomized, controlled trial","volume":"118","author":"Jackson","year":"2023","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.phymed.2025.157219_bib0068","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ijbiomac.2022.02.031","article-title":"Genistein encapsulated inulin-stearic acid bioconjugate nanoparticles: formulation development, characterization and anticancer activity","volume":"206","author":"Jangid","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2025.157219_bib0069","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11947-007-0047-5","article-title":"Glass transition and sticky point temperatures and stability \/mobility diagram of fruit powders","volume":"2","author":"Jaya","year":"2009","journal-title":"Food Bioprocess Tech"},{"issue":"1","key":"10.1016\/j.phymed.2025.157219_bib0070","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/19476337.2020.1852314","article-title":"Effects of inulin with short and long - chain on pasting, texture and rheological properties of sweet potato starch","volume":"19","author":"Ji","year":"2021","journal-title":"CYTA-J. Food."},{"key":"10.1016\/j.phymed.2025.157219_bib0071","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.132590","article-title":"Extraction, purification, structural characterization, and biological activity of polysaccharides from Schisandra chinensis: a review","volume":"271","author":"Ji","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2025.157219_bib0072","article-title":"The role of NF - KB signaling pathway in colitis related colon cancer and the intervention of traditional chinese medicine","volume":"122","author":"Ji","year":"2018","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"23","key":"10.1016\/j.phymed.2025.157219_bib0073","first-page":"11568","article-title":"Study on the process of extracting inulin from Jerusalem artichoke by microwave method","volume":"40","author":"Jia","year":"2012","journal-title":"J. Anhui Agric. Sci."},{"issue":"16","key":"10.1016\/j.phymed.2025.157219_bib0074","first-page":"81","article-title":"Effects of inulin and composite inulin dietary fiber on inflammatory injury, oxidative stress, and intestinal flora in mice with pulmonary fibrosis","volume":"45","author":"Jiang","year":"2024","journal-title":"Food Res. Dev."},{"issue":"8","key":"10.1016\/j.phymed.2025.157219_bib0075","first-page":"98","article-title":"Optimization of the process for extracting inulin from Jerusalem artichoke by combined enzyme method","volume":"45","author":"Jiang","year":"2017","journal-title":"J. Anhui Agric. Sci."},{"key":"10.1016\/j.phymed.2025.157219_bib0076","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.jconrel.2024.10.027","article-title":"Inulin-based nanoparticles for targeted siRNA delivery in acute kidney injury","volume":"376","author":"Jogdeo","year":"2024","journal-title":"J. Control Release."},{"issue":"11","key":"10.1016\/j.phymed.2025.157219_bib0077","doi-asserted-by":"crossref","first-page":"8414","DOI":"10.1074\/jbc.M607143200","article-title":"Structural and functional insights into intramolecular fructosyl transfer by inulin fructotransferase","volume":"282","author":"Jung","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2025.157219_bib0078","first-page":"315","article-title":"Inulin-type prebiotics - a review: Part 1","volume":"13","author":"Kelly","year":"2008","journal-title":"Altern. Med. Rev."},{"issue":"12","key":"10.1016\/j.phymed.2025.157219_bib0079","first-page":"115","article-title":"Optimal process for ultrasonic-assisted extraction of inulin from Jerusalem artichoke","volume":"40","author":"Kong","year":"2013","journal-title":"Guangdong Agric. Sci."},{"issue":"5","key":"10.1016\/j.phymed.2025.157219_bib0080","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1111\/j.1439-0396.2009.00955.x","article-title":"Inulin-coated butyrate increases ileal MCT1 expression and affects mucosal morphology in the porcine ileum by reduced apoptosis","volume":"94","author":"Lacorn","year":"2010","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"10.1016\/j.phymed.2025.157219_bib0081","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118079","article-title":"Polygonum cuspidatum polysaccharide: a review of its extraction and purification, structure analysis, and biological activity","volume":"331","author":"Lai","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"21","key":"10.1016\/j.phymed.2025.157219_bib0082","doi-asserted-by":"crossref","first-page":"5067","DOI":"10.3390\/molecules25215067","article-title":"Extraction of inulin from andean plants: an approach to non-traditional crops of ecuador","volume":"25","author":"Ledesma","year":"2020","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.phymed.2025.157219_bib0083","doi-asserted-by":"crossref","DOI":"10.1111\/jfpe.12333","article-title":"Chemical, thermal and physical characterization of inulin for its technological application based on the degree of polymerization","volume":"40","author":"Leyva-Porras","year":"2017","journal-title":"J. Food Process Eng."},{"issue":"Pt B","key":"10.1016\/j.phymed.2025.157219_bib0084","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1016\/j.ijbiomac.2022.10.094","article-title":"Pressurized hot water extraction, structural properties, biological effects, and in vitro microbial fermentation characteristics of sweet tea polysaccharide","volume":"222","author":"Lei","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"3","key":"10.1016\/j.phymed.2025.157219_bib0085","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s11705-012-1295-0","article-title":"Optimization of the main liming process for inulin crude extract from Jerusalem artichoke tubers","volume":"6","author":"Li","year":"2012","journal-title":"Front. Chem. Sci. Eng."},{"issue":"4","key":"10.1016\/j.phymed.2025.157219_bib0094","first-page":"106","article-title":"Study on prebiotic properties of Jerusalem artichoke inulin with different molecular weights and the stability of its probiotic microcapsules","volume":"21","author":"Li","year":"2021","journal-title":"J. Chin. Inst. Food Sci. Technol."},{"issue":"22","key":"10.1016\/j.phymed.2025.157219_bib0086","doi-asserted-by":"crossref","first-page":"11503","DOI":"10.1039\/D2FO02051C","article-title":"Jerusalem artichoke inulin supplementation ameliorates hepatic lipid metabolism in type 2 diabetes mellitus mice by modulating the gut microbiota and fecal metabolome","volume":"13","author":"Li","year":"2022","journal-title":"Food Funct."},{"issue":"4","key":"10.1016\/j.phymed.2025.157219_bib0087","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1039\/C8FO02265H","article-title":"Dietary inulin alleviates diverse stages of type 2 diabetes mellitus via anti-inflammation and modulating gut microbiota in db\/db mice","volume":"10","author":"Li","year":"2019","journal-title":"Food Funct"},{"issue":"16","key":"10.1016\/j.phymed.2025.157219_bib0089","doi-asserted-by":"crossref","first-page":"7797","DOI":"10.1021\/acs.iecr.9b06599","article-title":"Fabrication of Ag nanosheet@TiO2 antibacterial membranes for inulin purification","volume":"59","author":"Li","year":"2020","journal-title":"Ind. Eng. Chem. Res."},{"issue":"1","key":"10.1016\/j.phymed.2025.157219_bib0090","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41538-024-00340-4","article-title":"A soluble garlic polysaccharide supplement alleviates fatigue in mice","volume":"8","author":"Li","year":"2024","journal-title":"NPJ Sci. Food."},{"key":"10.1016\/j.phymed.2025.157219_bib0088","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2021.105568","article-title":"Complexation of maltodextrin-based inulin and green tea polyphenols via different ultrasonic pretreatment","volume":"74","author":"Li","year":"2021","journal-title":"Ultrason. Sonochem."},{"issue":"9","key":"10.1016\/j.phymed.2025.157219_bib0091","first-page":"1107","article-title":"Study on the determination of inulin molecular weight by high-performance gel filtration chromatography and its changes during storage","volume":"46","author":"Li","year":"2016","journal-title":"Sci. Sin."},{"key":"10.1016\/j.phymed.2025.157219_bib0092","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.123212","article-title":"Inulin-type fructans obtained from Atractylodis macrocephalae by water\/alkali extraction and immunoregulatory evaluation","volume":"230","author":"Li","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"01","key":"10.1016\/j.phymed.2025.157219_bib0093","first-page":"201","article-title":"Effects of inulin on insulin resistance induced by trans fatty acids in mice","volume":"36","author":"Li","year":"2015","journal-title":"Food Sci"},{"key":"10.1016\/j.phymed.2025.157219_bib0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2024.114048","article-title":"Differences in physicochemical, rheological, and prebiotic properties of inulin isolated from five botanical sources and their potential applications","volume":"180","author":"Lin","year":"2024","journal-title":"Food Res. Int."},{"key":"10.1016\/j.phymed.2025.157219_bib0096","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.132420","article-title":"Advance in Hippophae rhamnoides polysaccharides: extraction, structural characteristics, pharmacological activity, structure-activity relationship and application","volume":"270","author":"Ling","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2025.157219_bib0097","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ijbiomac.2013.11.028","article-title":"Synthesis, characterization and in vitro anti-diabetic activity of catechin grafted inulin","volume":"64","author":"Liu","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"10.1016\/j.phymed.2025.157219_bib0098","first-page":"627","article-title":"Optimization of extraction process of inulin from Jerusalem artichoke by response surface methodology","volume":"36","author":"Liu","year":"2016","journal-title":"Bull. Bot. Res."},{"key":"10.1016\/j.phymed.2025.157219_bib0099","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jff.2019.02.036","article-title":"Hypoglycemic effect of inulin combined with Ganoderma lucidum polysaccharides in T2DM rats","volume":"55","author":"Liu","year":"2019","journal-title":"J. Funct. Foods."},{"key":"10.1016\/j.phymed.2025.157219_bib0100","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/j.rser.2015.10.063","article-title":"Jerusalem artichoke: a sustainable biomass feedstock for biorefinery","volume":"54","author":"Long","year":"2016","journal-title":"Renew. Sustain. Energy Rev."},{"key":"10.1016\/j.phymed.2025.157219_bib0101","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.121671","article-title":"The agavins (Agave carbohydrates) story","volume":"327","author":"L\u00f3pez","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.phymed.2025.157219_bib0102","first-page":"158","article-title":"Study on the process of extracting inulin by enzymatic method","volume":"10","author":"Lu","year":"2006","journal-title":"Sci. Technol. Food Ind."},{"key":"10.1016\/j.phymed.2025.157219_bib0103","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2021.104407","article-title":"Inulin and Lycium barbarum polysaccharides ameliorate diabetes by enhancing gut barrier via modulating gut microbiota and activating gut mucosal TLR2\u207a intraepithelial \u03b3\u03b4 T cells in rats","volume":"79","author":"Lu","year":"2021","journal-title":"J. Funct. Foods."},{"key":"10.1016\/j.phymed.2025.157219_bib0104","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.carbpol.2015.05.026","article-title":"Inulin, a flexible oligosaccharide I: review of its physicochemical characteristics","volume":"130","author":"Maarschalk","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.phymed.2025.157219_bib0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.117155","article-title":"Friend or foe? The roles of inulin-type fructans","volume":"252","author":"Man","year":"2021","journal-title":"Carbohydr. Polym."},{"issue":"23","key":"10.1016\/j.phymed.2025.157219_bib0106","doi-asserted-by":"crossref","first-page":"5195","DOI":"10.3390\/nu14235195","article-title":"Effect of inulin intervention on metabolic control and methylation of INS and IRS1 genes in patients with Type 2 Diabetes Mellitus","volume":"14","author":"Mart\u00ednez-Ram\u00edrez","year":"2022","journal-title":"Nutrients"},{"issue":"23","key":"10.1016\/j.phymed.2025.157219_bib0107","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1139\/v80-390","article-title":"Conformation and crystalline-structure of (2\u21921)-beta-d-fructofuranan (inulin)","volume":"58","author":"Marchessault","year":"1980","journal-title":"Can. J. Chem."},{"issue":"2","key":"10.1016\/j.phymed.2025.157219_bib0108","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s13197-019-04110-z","article-title":"Sequential extraction of protein and inulin from the tubers of Jerusalem artichoke (Helianthus tuberosus L.)","volume":"57","author":"Maumela","year":"2020","journal-title":"J. Food Sci. Technol."},{"issue":"6","key":"10.1016\/j.phymed.2025.157219_bib0109","doi-asserted-by":"crossref","first-page":"526","DOI":"10.30802\/AALAS-CM-99-990010","article-title":"Flow rate and apparent volume of cerebrospinal fluid in Rhesus macaques (Macaca mulatta) based on the pharmacokinetics of intrathecally administered inulin","volume":"70","author":"McCully","year":"2020","journal-title":"Comp. Med."},{"key":"10.1016\/j.phymed.2025.157219_bib0110","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.carbpol.2015.05.026","article-title":"Inulin, a flexible oligosaccharide I: review of its physicochemical characteristics","volume":"130","author":"Mensink","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.phymed.2025.157219_bib0111","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.ijbiomac.2021.03.109","article-title":"Modification of carboxymethyl inulin with heterocyclic compounds: synthesis, characterization, antioxidant and antifungal activities","volume":"181","author":"Mi","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.phymed.2025.157219_bib0112","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s13098-021-00768-8","article-title":"Dietary supplementation of inulin alleviates metabolism disorders in gestational diabetes mellitus mice via RENT\/AKT\/IRS\/GLUT4 pathway","volume":"13","author":"Miao","year":"2021","journal-title":"Diabetol. Metab. Syndr."},{"issue":"12","key":"10.1016\/j.phymed.2025.157219_bib0113","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1021\/jf030590v","article-title":"Enrichment of higher molecular weight fractions in inulin","volume":"52","author":"Moerman","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2025.157219_bib0114","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.foodchem.2012.01.027","article-title":"The effect of inulin and fructo-oligosaccharide supplementation on the textural, rheological and sensory properties of bread and their role in weight management: a review","volume":"133","author":"Morris","year":"2012","journal-title":"Food Chem."},{"issue":"7","key":"10.1016\/j.phymed.2025.157219_bib0115","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1021\/je900834c","article-title":"Viscosity and solubility behavior of the polysaccharide inulin in water, water plus dimethyl sulfoxide, and water plus isopropanol media","volume":"55","author":"Naskar","year":"2010","journal-title":"J. Chem. Eng. Data."},{"issue":"7","key":"10.1016\/j.phymed.2025.157219_bib0116","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1093\/jn\/129.7.1402S","article-title":"Inulin and oligofructose: what are they?","volume":"129","author":"Niness","year":"1999","journal-title":"J. Nutr."},{"issue":"2","key":"10.1016\/j.phymed.2025.157219_bib0117","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.biotechadv.2019.01.002","article-title":"Inulin and its enzymatic production by inulosucrase: characteristics, structural features, molecular modifications and applications","volume":"37","author":"Ni","year":"2019","journal-title":"Biotechnol. Adv."},{"issue":"32","key":"10.1016\/j.phymed.2025.157219_bib0118","doi-asserted-by":"crossref","first-page":"18100","DOI":"10.1021\/acs.jafc.4c05224","article-title":"Multistrategy engineering of an inulosucrase to enhance the activity and thermostability for efficient production of microbial inulin","volume":"72","author":"Ni","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"8","key":"10.1016\/j.phymed.2025.157219_bib0119","first-page":"61","article-title":"Chicory inulin ameliorates type 2 diabetes mellitus and suppresses JNK and MAPK pathways in vivo and in vitro","author":"Ning","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"issue":"7","key":"10.1016\/j.phymed.2025.157219_bib0120","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1080\/19420862.2017.1345834","article-title":"Pharmacokinetics of an intracerebroventricularly administered antibody in rats","volume":"9","author":"Noguchi","year":"2017","journal-title":"MABS"},{"issue":"29","key":"10.1016\/j.phymed.2025.157219_bib0121","doi-asserted-by":"crossref","first-page":"9154","DOI":"10.1021\/acs.jafc.2c03197","article-title":"Evaluation of fructo-, inulin-, and galacto-oligosaccharides on the Maillard reaction products in model systems with whey protein","volume":"70","author":"Nomi","year":"2022","journal-title":"J. Agric. Food Chem."},{"issue":"9","key":"10.1016\/j.phymed.2025.157219_bib0122","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.3109\/13880209.2015.1110597","article-title":"Hydrolysed inulin alleviates the azoxymethane-induced preneoplastic aberrant crypt foci by altering selected intestinal microbiota in Sprague-Dawley rats","volume":"54","author":"Pattananandecha","year":"2016","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.phymed.2025.157219_bib0123","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1556\/AAlim.42.2013.Suppl.7","article-title":"Jerusalem artichoke powder as a food additive in dairy products and fat replacers","volume":"42","author":"Penksza","year":"2013","journal-title":"Acta Alimentaria"},{"issue":"7","key":"10.1016\/j.phymed.2025.157219_bib0124","doi-asserted-by":"crossref","first-page":"671","DOI":"10.32604\/JRM.2018.00001","article-title":"Microwave-assisted isolation and acetylation of inulin from Helianthus tuberosus L","volume":"6","author":"Petkova","year":"2018","journal-title":"Tubers. J. Renew. Mater."},{"issue":"5","key":"10.1016\/j.phymed.2025.157219_bib0125","first-page":"1876","article-title":"Characterization of inulin from dahlia tubers isolated by microwave and ultrasound-assisted extractions","volume":"25","author":"Petkova","year":"2018","journal-title":"Int. Food Res. J."},{"issue":"7","key":"10.1016\/j.phymed.2025.157219_bib0126","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1039\/D2FO01096H","article-title":"Inulin: properties and health benefits","volume":"14","author":"Qin","year":"2023","journal-title":"Food Funct."},{"issue":"26","key":"10.1016\/j.phymed.2025.157219_bib0127","doi-asserted-by":"crossref","first-page":"9763","DOI":"10.1021\/acssuschemeng.0c02107","article-title":"Development of a robust Bacillus amyloliquefaciens cell factory for efficient poly (\u03b3-glutamic acid) production from Jerusalem artichoke","volume":"8","author":"Qiu","year":"2020","journal-title":"ACS Sustain. Chem. Eng."},{"issue":"4","key":"10.1016\/j.phymed.2025.157219_bib0128","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1111\/1541-4337.12972","article-title":"Bioactive polysaccharides and oligosaccharides from garlic (Allium sativum L.): production, physicochemical and biological properties, and structure-function relationships","volume":"21","author":"Qiu","year":"2022","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"issue":"2","key":"10.1016\/j.phymed.2025.157219_bib0129","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1017\/S000711451000036X","article-title":"Prebiotic effect of fruit and vegetable shots containing Jerusalem artichoke inulin: a human intervention study","volume":"104","author":"Ramnani","year":"2010","journal-title":"Br. J. Nutr."},{"issue":"4","key":"10.1016\/j.phymed.2025.157219_bib0130","first-page":"1104","article-title":"Optimization of hydrothermal extraction process of inulin from Jerusalem artichoke in plateau area","volume":"52","author":"Ren","year":"2023","journal-title":"Appl. Chem. Ind."},{"issue":"1","key":"10.1016\/j.phymed.2025.157219_bib0131","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2178796","article-title":"Inulin increases the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota","volume":"15","author":"R\u00e9gnier","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.phymed.2025.157219_bib0132","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.foodres.2018.04.032","article-title":"Infrared spectroscopy as an alternative methodology to evaluate the effect of structural features on the physical-chemical properties of inulins","volume":"109","author":"Romano","year":"2018","journal-title":"Food Res. Int."},{"issue":"2","key":"10.1016\/j.phymed.2025.157219_bib0133","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11483-007-9034-7","article-title":"Characterization of the physical state of spray-dried inulin","author":"Ronkart","year":"2007","journal-title":"Food Biophys"},{"issue":"2","key":"10.1016\/j.phymed.2025.157219_bib0134","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.aoas.2022.11.001","article-title":"Physicochemical and rheological characterization of dumpling's dough fortified with Jerusalem artichoke (Helianthus tuberosus) powder","volume":"67","author":"Rushchitc","year":"2022","journal-title":"Ann. Agric. Sci."},{"key":"10.1016\/j.phymed.2025.157219_bib0135","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.foodres.2014.02.024","article-title":"In vitro prebiotic activity of inulin-rich carbohydrates extracted from Jerusalem artichoke (Helianthus tuberosus L.) tubers at different storage times by Lactobacillus paracasei","volume":"62","author":"Rubel","year":"2014","journal-title":"Food Res. Int."},{"key":"10.1016\/j.phymed.2025.157219_bib0136","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.foodres.2017.10.041","article-title":"Inulin rich carbohydrates extraction from Jerusalem artichoke (Helianthus tuberosus L.) tubers and application of different drying methods","volume":"103","author":"Rubel","year":"2018","journal-title":"Food Res. Int."},{"key":"10.1016\/j.phymed.2025.157219_bib0137","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jfoodeng.2005.09.025","article-title":"Evaluating water activity and glass transition concepts for food stability","volume":"78","author":"Sablani","year":"2007","journal-title":"J. Food Eng."},{"issue":"14","key":"10.1016\/j.phymed.2025.157219_bib0138","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.2174\/138945011614151119130426","article-title":"Inulin derivatives obtained via enhanced microwave synthesis for nucleic acid based drug delivery","volume":"16","author":"Sardo","year":"2015","journal-title":"Curr. Drug Targets."},{"issue":"8","key":"10.1016\/j.phymed.2025.157219_bib0139","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1007\/s13346-022-01135-4","article-title":"Inulin-g-poly-D,L-lactide, a sustainable amphiphilic copolymer for nano-therapeutics","volume":"12","author":"Sardo","year":"2022","journal-title":"Drug Deliv. Transl. Res."},{"issue":"4","key":"10.1016\/j.phymed.2025.157219_bib0140","doi-asserted-by":"crossref","first-page":"160","DOI":"10.14715\/cmb\/2020.66.4.20","article-title":"Jerusalem artichoke (Helianthus tuberosus L.) as a medicinal plant and its natural products","volume":"66","author":"Sawicka","year":"2020","journal-title":"Cell. Mol. Biol. (Noisy-le-grand)"},{"key":"10.1016\/j.phymed.2025.157219_bib0141","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2023.1111110","article-title":"A comparison of three different delivery methods for achieving CRISPR\/Cas9 mediated genome editing in Cichorium intybus L","volume":"14","author":"Salvagnin","year":"2023","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.phymed.2025.157219_bib0142","doi-asserted-by":"crossref","first-page":"118951","DOI":"10.1016\/j.carbpol.2021.118951","article-title":"Structural elucidation of the fucose containing polysaccharide of Paenibacillus polymyxa DSM 365","volume":"278","author":"Schilling","year":"2021","journal-title":"Carbohydr. Polym."},{"issue":"1","key":"10.1016\/j.phymed.2025.157219_bib0143","doi-asserted-by":"crossref","first-page":"e3387","DOI":"10.1002\/brb3.3387","article-title":"Inulin alters gut microbiota to alleviate post-stroke depressive-like behavior associated with the IGF-1-mediated MAPK signaling pathway","volume":"14","author":"Shao","year":"2024","journal-title":"Brain Behav."},{"issue":"5","key":"10.1016\/j.phymed.2025.157219_bib0144","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s10719-021-10011-1","article-title":"Enhanced antitumor activity of inulin-capped Se nanoparticles synthesized using Jerusalem artichoke tubers","volume":"38","author":"Shao","year":"2021","journal-title":"Glycoconj. J."},{"key":"10.1016\/j.phymed.2025.157219_bib0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.carres.2021.108422","article-title":"Preparation and characterization of sulfated inulin-type fructans from Jerusalem artichoke tubers and their antitumor activity","volume":"509","author":"Shao","year":"2021","journal-title":"Carbohydr. Res."},{"issue":"3","key":"10.1016\/j.phymed.2025.157219_bib0146","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1017\/S0007114519002332","article-title":"Inulin from Jerusalem artichoke tubers alleviates hyperglycaemia in high-fat-diet-induced diabetes mice through the intestinal microflora improvement","volume":"123","author":"Shao","year":"2020","journal-title":"Br. J. Nutr."},{"issue":"11","key":"10.1016\/j.phymed.2025.157219_bib0147","first-page":"1","article-title":"Research progress of inulin in higher plants","volume":"31","author":"Shang","year":"2019","journal-title":"Strait Pharm. J."},{"key":"10.1016\/j.phymed.2025.157219_bib0148","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.carbpol.2016.04.020","article-title":"Inulin: properties, health benefits and food applications","volume":"147","author":"Shoaib","year":"2016","journal-title":"Carbohydr. Polym."},{"issue":"4","key":"10.1016\/j.phymed.2025.157219_bib0149","doi-asserted-by":"crossref","DOI":"10.1002\/fsn3.70046","article-title":"Inulin protects Caco-2 cells against lipopolysaccharide-induced epithelial barrier dysfunction","volume":"13","author":"Skinner","year":"2025","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.phymed.2025.157219_bib0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.141385","article-title":"Extraction, optimization, purification and characterization of inulin from chicory roots using conventional and greener extraction techniques","volume":"306","author":"Singh","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"6","key":"10.1016\/j.phymed.2025.157219_bib0151","doi-asserted-by":"crossref","first-page":"608","DOI":"10.3390\/vaccines12060608","article-title":"Dietary inulin to improve SARS-CoV-2 vaccine response in kidney transplant recipients: The RIVASTIM-inulin randomised controlled trial","volume":"12","author":"Singer","year":"2024","journal-title":"Vaccines"},{"issue":"1","key":"10.1016\/j.phymed.2025.157219_bib0152","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/bm005642t","article-title":"Chemical modification of inulin, a valuable renewable resource, and its industrial applications","volume":"2","author":"Stevens","year":"2001","journal-title":"Biomacromolecules"},{"issue":"2","key":"10.1016\/j.phymed.2025.157219_bib0153","doi-asserted-by":"crossref","DOI":"10.1111\/apha.14262","article-title":"Prebiotics as modulators of colonic calcium and magnesium uptake","volume":"241","author":"Stumpff","year":"2025","journal-title":"Acta Physiol."},{"key":"10.1016\/j.phymed.2025.157219_bib0154","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.135217","article-title":"Gamma-irradiation of inulin improves its biological functionality and feasibility as a functional ingredient in synbiotic food","volume":"408","author":"Sudesh","year":"2023","journal-title":"Food Chem"},{"issue":"3","key":"10.1016\/j.phymed.2025.157219_bib0155","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.3390\/cimb45030168","article-title":"The effect of a diet enriched with Jerusalem artichoke, inulin, and fluoxetine on cognitive functions, neurogenesis, and the composition of the intestinal microbiota in mice","volume":"45","author":"Szewczyk","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.phymed.2025.157219_bib0156","doi-asserted-by":"crossref","first-page":"7870","DOI":"10.29219\/fnr.v66.7870","article-title":"Administration of Jerusalem artichoke reduces the postprandial plasma glucose and glucose-dependent insulinotropic polypeptide (GIP) concentrations in humans","volume":"66","author":"Takahashi","year":"2022","journal-title":"Food Nutr. Res."},{"issue":"1","key":"10.1016\/j.phymed.2025.157219_bib0157","article-title":"Study of the structural characterization, physicochemical properties and antioxidant activities of phosphorylated long-chain inulin with different degrees of substitution","volume":"263","author":"Tang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"10.1016\/j.phymed.2025.157219_bib0158","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1039\/D2FO03687H","article-title":"Structural elucidation and hypoglycemic effect of an inulin-type fructan extracted from Stevia rebaudiana roots","volume":"14","author":"Tang","year":"2023","journal-title":"Food Funct"},{"key":"10.1016\/j.phymed.2025.157219_bib0159","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.ijbiomac.2021.03.038","article-title":"Microencapsulation of Lactobacillus casei and Lactobacillus rhamnosus in pectin and pectin-inulin microgel particles: effect on bacterial survival under storage conditions","volume":"179","author":"Tarifa","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"issue":"12","key":"10.1016\/j.phymed.2025.157219_bib0160","doi-asserted-by":"crossref","first-page":"640","DOI":"10.3390\/fermentation10120640","article-title":"Microbial conversion of inulin to valuable products: the biorefinery concept","volume":"10","author":"Tsigoriyna","year":"2024","journal-title":"Fermentation"},{"issue":"1","key":"10.1016\/j.phymed.2025.157219_bib0161","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2478\/pjvs-2014-0008","article-title":"Alternative for improving gut microbiota: use of Jerusalem artichoke and probiotics in diet of weaned piglets","volume":"17","author":"Valdovska","year":"2014","journal-title":"Pol. J. Vet. Sci."},{"issue":"11","key":"10.1016\/j.phymed.2025.157219_bib0162","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1136\/gutjnl-2016-313271","article-title":"Prebiotic inulin-type fructans induce specific changes in the human gut microbiota","volume":"66","author":"Vandeputte","year":"2017","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.phymed.2025.157219_bib0163","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.3390\/nu12061552","article-title":"In vitro evaluation of prebiotic properties of a commercial artichoke inflorescence extract revealed bifidogenic effects","volume":"12","author":"van den Abbeele","year":"2020","journal-title":"Nutrients"},{"issue":"12","key":"10.1016\/j.phymed.2025.157219_bib0164","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1038\/s41366-024-01590-8","article-title":"Enhancing gut microbiota and microbial function with inulin supplementation in children with obesity","volume":"48","author":"Visuthranukul","year":"2024","journal-title":"Int. J. Obes."},{"issue":"6","key":"10.1016\/j.phymed.2025.157219_bib0165","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1021\/acsomega.9b03957","article-title":"Novel inulin electrospun composite nanofibers: prebiotic and antibacterial Activities","volume":"5","author":"Wahbi","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.phymed.2025.157219_bib0166","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.116589","article-title":"The physiological functions and pharmaceutical applications of inulin: a review","volume":"246","author":"Wan","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.phymed.2025.157219_bib0172","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119742","article-title":"An inulin-type fructan (AMP1-1) from Atractylodes macrocephala with anti-weightlessness bone loss activity","volume":"294","author":"Wang","year":"2022","journal-title":"Carbohydr. Polym."},{"issue":"3","key":"10.1016\/j.phymed.2025.157219_bib0167","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.chmed.2023.05.002","article-title":"Research and application of leek roots in medicinal field","volume":"15","author":"Wang","year":"2023","journal-title":"Chin. Herbal Med."},{"issue":"1","key":"10.1016\/j.phymed.2025.157219_bib0168","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/11263504.2013.856961","article-title":"Direct production of bioethanol from Jerusalem artichoke inulin by gene - engineering Saccharomyces cerevisiae 6525 with exoinulinase gene","volume":"148","author":"Wang","year":"2014","journal-title":"Plant Biosyst."},{"key":"10.1016\/j.phymed.2025.157219_bib0173","first-page":"1408","article-title":"Enzymatic extraction of inulin from Jerusalem artichoke pulp and its composition and antioxidant activity analysis","volume":"31","author":"Wang","year":"2019","journal-title":"Nat. Prod. Res. Dev."},{"issue":"4","key":"10.1016\/j.phymed.2025.157219_bib0170","first-page":"340","article-title":"Study on the technological conditions for extracting inulin from Jerusalem artichoke by ultrasonic method","volume":"13","author":"Wang","year":"2014","journal-title":"Ningxia Eng. Technol."},{"key":"10.1016\/j.phymed.2025.157219_bib0171","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.bbrc.2022.02.033","article-title":"Inulin activates FXR - FGF15 signaling and further increases bile acids excretion in non - alcoholic fatty liver disease mice","volume":"600","author":"Wang","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.phymed.2025.157219_bib0169","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1186\/s12967-019-02159-0","article-title":"Inulin-type fructans supplementation improves glycemic control for the prediabetes and type 2 diabetes populations: results from a GRADE-assessed systematic review and dose-response meta-analysis of 33 randomized controlled trials","volume":"17","author":"Wang","year":"2019","journal-title":"J. Transl. Med."},{"issue":"4","key":"10.1016\/j.phymed.2025.157219_bib0174","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.aninu.2020.09.001","article-title":"Nutritional value, bioactivity, and application potential of Jerusalem artichoke (Helianthus tuberosus L.) as a neotype feed resource","volume":"6","author":"Wang","year":"2020","journal-title":"Anim. Nutr."},{"issue":"S1","key":"10.1016\/j.phymed.2025.157219_bib0175","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1079\/BJN20041357","article-title":"Inulin, oligofructose and immunomodulation","volume":"93","author":"Watzl","year":"2005","journal-title":"Br. J. Nutr."},{"issue":"3","key":"10.1016\/j.phymed.2025.157219_bib0176","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.jfoodeng.2006.03.028","article-title":"Studies on the extracting technical conditions of inulin from Jerusalem artichoke tubers","volume":"79","author":"Wei","year":"2007","journal-title":"J. Food Eng."},{"issue":"11","key":"10.1016\/j.phymed.2025.157219_bib0177","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1080\/10408398.2019.1602823","article-title":"Combination of emerging technologies for the extraction of bioactive compounds","volume":"60","author":"Wen","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"1","key":"10.1016\/j.phymed.2025.157219_bib0178","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/advances\/nmab114","article-title":"The effects of prebiotics, synbiotics, and short-chain fatty acids on respiratory tract infections and immune function: a systematic review and meta-analysis","volume":"13","author":"Williams","year":"2022","journal-title":"Adv. Nutr."},{"issue":"1","key":"10.1016\/j.phymed.2025.157219_bib0179","doi-asserted-by":"crossref","DOI":"10.1016\/j.dsx.2021.102354","article-title":"Pre-meal high-performance inulin supplementation reduce post-prandial glycaemic response in healthy subjects: a repeated single-arm clinical trial","volume":"16","author":"Wijaya","year":"2022","journal-title":"Diabetes Metab. Syndr.-Clin. Res. Rev."},{"issue":"2","key":"10.1016\/j.phymed.2025.157219_bib0180","first-page":"172","article-title":"Systematic review of the effects of inulin-type fructans on blood lipid profiles: a meta-analysis","volume":"39","author":"Wu","year":"2010","journal-title":"J. Hyg. Res."},{"issue":"5","key":"10.1016\/j.phymed.2025.157219_bib0181","first-page":"178","article-title":"Research progress on the characteristics and extraction process of inulin","volume":"48","author":"Xia","year":"2023","journal-title":"Food Sci. Technol."},{"issue":"10","key":"10.1016\/j.phymed.2025.157219_bib0182","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.3390\/foods11101467","article-title":"Inulin-modified liposomes as a novel delivery system for cinnamaldehyde","volume":"11","author":"Xue","year":"2022","journal-title":"Foods"},{"key":"10.1016\/j.phymed.2025.157219_bib0183","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.ijbiomac.2015.10.082","article-title":"Structural characterization and anti-tumor effects of an inulin-type fructan from Atractylodes chinensis","volume":"82","author":"Xu","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"issue":"8","key":"10.1016\/j.phymed.2025.157219_bib0184","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1080\/1028415X.2021.1889452","article-title":"Apolipoprotein E genotype-dependent nutrigenetic effects to prebiotic inulin for modulating systemic metabolism and neuroprotection in mice via gut-brain axis","volume":"25","author":"Yanckello","year":"2022","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.phymed.2025.157219_bib0185","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1743-7075-9-112","article-title":"Jerusalem artichoke and chungkookjang additively improve insulin secretion and sensitivity in diabetic rats","volume":"9","author":"Yang","year":"2012","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.phymed.2025.157219_bib0186","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.molcatb.2016.10.020","article-title":"Genetic modification and optimization of endo-inulinase for the enzymatic production of oligofructose from inulin","volume":"134","author":"Yang","year":"2016","journal-title":"J. Mol. Catal. B"},{"issue":"4","key":"10.1016\/j.phymed.2025.157219_bib0187","first-page":"106","article-title":"Study on prebiotic properties of Jerusalem artichoke inulin with different molecular weights and the stability of its probiotic microcapsules","volume":"21","author":"Yang","year":"2021","journal-title":"J. Chin. Inst. Food Sci. Technol."},{"issue":"2","key":"10.1016\/j.phymed.2025.157219_bib0188","first-page":"180","article-title":"Chinese herbal medicines for treating ulcerative colitis via regulating gut microbiota-intestinal immunity axis","volume":"15","author":"Yang","year":"2023","journal-title":"Chin. Herbal Med."},{"issue":"2","key":"10.1016\/j.phymed.2025.157219_bib0189","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1053\/j.gastro.2023.10.012","article-title":"High soluble fiber promotes colorectal tumorigenesis through modulating gut microbiota and metabolites in mice","volume":"166","author":"Yang","year":"2024","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phymed.2025.157219_bib0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2025.115934","article-title":"Ultrasound-assisted fermentation effectively alleviates the weakening of wheat gluten network caused by long-chain inulin and the underlying mechanism","volume":"204","author":"Yue","year":"2025","journal-title":"Food Res. Int."},{"issue":"Pt 8","key":"10.1016\/j.phymed.2025.157219_bib0191","article-title":"Modification methods, biological activities and applications of pectin: a review","volume":"253","author":"Yue","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2025.157219_bib0192","article-title":"Inulin alleviates atherosclerosis through improving lipid metabolism, inflammation, and gut microbiota in ApoE-knockout mice: the short-chain is more efficacious","volume":"15","author":"Zeng","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2025.157219_bib0197","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s40538-024-00667-w","article-title":"Recent advances in inulin polysaccharides research: extraction, purification, structure, and bioactivities","volume":"11","author":"Zhang","year":"2024","journal-title":"Chem. Biol. Technol. Agric."},{"issue":"5","key":"10.1016\/j.phymed.2025.157219_bib0193","first-page":"1137","article-title":"Optimization of the decolorization process of inulin from Jerusalem artichoke","volume":"52","author":"Zhang","year":"2013","journal-title":"Hubei Agric. Sci."},{"issue":"1","key":"10.1016\/j.phymed.2025.157219_bib0194","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1039\/D3FO02223D","article-title":"Maternal inulin alleviates high - fat diet - induced lipid disorder in offspring by epigenetically modulating hypothalamus feeding circuit - related genes","volume":"15","author":"Zhang","year":"2024","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2025.157219_bib0195","doi-asserted-by":"crossref","first-page":"e4446","DOI":"10.7717\/peerj.4446","article-title":"Inulin-type fructan improves diabetic phenotype and gut microbiota profiles in rats","volume":"6","author":"Zhang","year":"2018","journal-title":"PeerJ"},{"issue":"14","key":"10.1016\/j.phymed.2025.157219_bib0196","doi-asserted-by":"crossref","first-page":"12048","DOI":"10.1021\/acsomega.2c00302","article-title":"Extraction and purification of inulin from Jerusalem artichoke with response surface method and ion exchange resins","volume":"7","author":"Zhang","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.phymed.2025.157219_bib0198","series-title":"Study on the Extraction, Isolation, Purification and Analysis of Polysaccharides from Jerusalem Artichoke","author":"Zhang","year":"2015"},{"issue":"2","key":"10.1016\/j.phymed.2025.157219_bib0199","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrendo.2017.151","article-title":"Global aetiology and epidemiology of type 2 diabetes mellitus and its complications","volume":"14","author":"Zheng","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"issue":"3","key":"10.1016\/j.phymed.2025.157219_bib0200","first-page":"249","article-title":"An inulin-type fructan CP-A from Codonopsis pilosula attenuates experimental colitis in mice by promoting autophagy-mediated inactivation of NLRP3 inflammasome","volume":"22","author":"Zhou","year":"2024","journal-title":"Chin. J. Nat. Med."},{"issue":"19","key":"10.1016\/j.phymed.2025.157219_bib0201","first-page":"6522","article-title":"Physiological response characteristics of fructan metabolism in Helianthus tuberosus L. under drought stress","volume":"20","author":"Zhou","year":"2022","journal-title":"Mol. Plant Breed."},{"issue":"3","key":"10.1016\/j.phymed.2025.157219_bib0202","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3390\/coatings12030385","article-title":"Extraction and characterization of pectin from Jerusalem artichoke residue and its application in blueberry preservation","volume":"12","author":"Zhou","year":"2022","journal-title":"Coatings"},{"key":"10.1016\/j.phymed.2025.157219_bib0203","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2021.110846","article-title":"Global genome and comparative transcriptomic analysis reveal the inulin consumption strategy of Lactiplantibacillus plantarum QS7T","volume":"151","author":"Zhu","year":"2022","journal-title":"Food Res. Int."},{"issue":"8","key":"10.1016\/j.phymed.2025.157219_bib0204","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.3390\/foods13081241","article-title":"Exploration and improvement of acid hydrolysis conditions for inulin-type fructans monosaccharide composition analysis: monosaccharide recovery and by-product identification","volume":"13","author":"Zong","year":"2024","journal-title":"Foods"},{"issue":"1","key":"10.1016\/j.phymed.2025.157219_bib0205","article-title":"Optimized acid hydrolysis conditions for better characterization of the structure of inulin-type fructan from Polygonatum sibiricum","volume":"256","author":"Zong","year":"2024","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132500858X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132500858X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:36:36Z","timestamp":1773419796000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471132500858X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":203,"alternative-id":["S094471132500858X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157219","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deciphering inulin from Jerusalem artichoke: Extraction, structural characteristics, bioactivities, structure-activity relationship, modifications, pharmacokinetics and applications","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157219","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157219"}}