{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:35:06Z","timestamp":1787164506866,"version":"build-2736575974"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["CXTD202502034"],"award-info":[{"award-number":["CXTD202502034"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2023zdyf15"],"award-info":[{"award-number":["2023zdyf15"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2024C03171"],"award-info":[{"award-number":["2024C03171"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.phymed.2025.157221","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:37:00Z","timestamp":1756946220000},"page":"157221","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Xiaoyao San's dual efficacy in NAFLD and depression: Unraveling the mechanisms via network pharmacology and multi-omics"],"prefix":"10.1016","volume":"147","author":[{"given":"Yunxiao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4607-9979","authenticated-orcid":false,"given":"Ayesha","family":"Younas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoning","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofen","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuanghu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojian","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuxiao","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.phymed.2025.157221_bib0001","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/j.jcmgh.2021.01.012","article-title":"Transcriptional regulation of metabolic pathways via lipid-sensing nuclear receptors PPARs, FXR, and LXR in NASH","volume":"11","author":"Cariello","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol"},{"issue":"4","key":"10.1016\/j.phymed.2025.157221_bib0002","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.cnur.2021.07.009","article-title":"Obesity and non-alcoholic fatty liver disease","volume":"56","author":"Chaney","year":"2021","journal-title":"Nurs. Clin. North. Am"},{"key":"10.1016\/j.phymed.2025.157221_bib0003","article-title":"Research progress on classical traditional chinese medicine formula xiaoyaosan in the treatment of depression","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Pharmacol"},{"issue":"26","key":"10.1016\/j.phymed.2025.157221_bib0004","doi-asserted-by":"crossref","first-page":"7981","DOI":"10.1021\/acs.jafc.2c02940","article-title":"miR-143-mediated responses to Betaine supplement repress lipogenesis and hepatic gluconeogenesis by targeting MAT1a and MAPK11","volume":"70","author":"Chen","year":"2022","journal-title":"J. Agric. Food. Chem"},{"key":"10.1016\/j.phymed.2025.157221_bib0005","article-title":"Association between anxiety and depression and non-alcoholic fatty liver disease","volume":"7","author":"Choi","year":"2021","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.phymed.2025.157221_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154395","article-title":"Sinisan alleviates depression-like behaviors by regulating mitochondrial function and synaptic plasticity in maternal separation rats","volume":"106","author":"Deng","year":"2022","journal-title":"Phytomedicine"},{"issue":"7","key":"10.1016\/j.phymed.2025.157221_bib0007","first-page":"1805","article-title":"Diet-induced models of non-alcoholic fatty liver disease: food for","volume":"10","author":"Eng","year":"2021","journal-title":"Thought. Sugar. Fat. Cholest.,. Cells"},{"issue":"1","key":"10.1016\/j.phymed.2025.157221_bib0008","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-71795-0","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice","volume":"10","author":"Fling","year":"2020","journal-title":"Sci. Rep"},{"issue":"2","key":"10.1016\/j.phymed.2025.157221_bib0009","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00213-022-06302-6","article-title":"Chronic restraint stress-induced depression-like behavior is mediated by upregulation of melanopsin expression in C57BL\/6 mice retina","volume":"240","author":"Fu","year":"2023","journal-title":"Psychopharmacol. (Berl)"},{"issue":"1","key":"10.1016\/j.phymed.2025.157221_bib0010","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.tem.2021.10.005","article-title":"The menace of obesity to depression and anxiety prevalence","volume":"33","author":"Fulton","year":"2022","journal-title":"Trends. Endocrinol. Metab"},{"issue":"2","key":"10.1016\/j.phymed.2025.157221_bib0011","first-page":"117","article-title":"Adiposity in depression or depression in Adiposity? The role of immune-inflammatory-microbial overlap","volume":"11","author":"Gawlik-Kotelnicka","year":"2021","journal-title":"Life. (Basel)"},{"key":"10.1016\/j.phymed.2025.157221_bib0012","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1389967","article-title":"Associations between systemic inflammation indicators and non-alcoholic fatty liver disease: evidence from a prospective study","volume":"15","author":"Gong","year":"2024","journal-title":"Front. Immunol"},{"key":"10.1016\/j.phymed.2025.157221_bib0013","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jad.2021.12.128","article-title":"Association between non-alcoholic fatty liver disease and depression: a systematic review and meta-analysis of observational studies","volume":"301","author":"Gu","year":"2022","journal-title":"J. Affect. Disord"},{"issue":"10","key":"10.1016\/j.phymed.2025.157221_bib0014","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/s41575-023-00807-x","article-title":"Hepatic inflammatory responses in liver fibrosis","volume":"20","author":"Hammerich","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol"},{"key":"10.1016\/j.phymed.2025.157221_bib0015","doi-asserted-by":"crossref","unstructured":"Hassamal S. Chronic stress, neuroinflammation, and depression: an overview of pathophysiological mechanisms and emerging anti-inflammatories. Front Psychiatry. 2023;14:1130989.doi:10.3389\/fpsyt.2023.1130989.","DOI":"10.3389\/fpsyt.2023.1130989"},{"issue":"7","key":"10.1016\/j.phymed.2025.157221_bib0016","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.1002\/tox.24239","article-title":"Picein alleviates oxidative stress and promotes bone regeneration in osteoporotic bone defect by inhibiting ferroptosis via Nrf2\/HO-1\/GPX4 pathway","volume":"39","author":"Huang","year":"2024","journal-title":"Env. Toxicol"},{"issue":"4","key":"10.1016\/j.phymed.2025.157221_bib0017","doi-asserted-by":"crossref","first-page":"4199","DOI":"10.3390\/ijms24044199","article-title":"The greater impact of paternal, compared to maternal, hereditary background on depressive-like behavior in wistar Kyoto rats with different amino acid metabolism in the pup brain","volume":"24","author":"Ihara","year":"2023","journal-title":"Int. J. Mol. Sci"},{"issue":"5","key":"10.1016\/j.phymed.2025.157221_bib0018","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.aohep.2019.11.007","article-title":"Peroxisomal footprint in the pathogenesis of non-alcoholic steatohepatitis","volume":"19","author":"Islam","year":"2020","journal-title":"Ann. Hepatol"},{"issue":"5","key":"10.1016\/j.phymed.2025.157221_bib0019","first-page":"755","article-title":"Impact of standard treatment on the quality of life of non-alcoholic fatty liver disease patients","volume":"16","author":"Jamali","year":"2021","journal-title":"J. Taibah. Univ. Med. Sci"},{"key":"10.1016\/j.phymed.2025.157221_bib0020","article-title":"Angel or devil: the dual roles of 2,3,5,4\u2032-tetrahydroxystilbene-2-O-\u03b2-d-glucopyranoside in the development of liver injury based on integrating pharmacological techniques: a systematic review","volume":"16","author":"Jiang","year":"2025","journal-title":"Front. Pharmacol"},{"key":"10.1016\/j.phymed.2025.157221_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102963","article-title":"Arbutin alleviates fatty liver by inhibiting ferroptosis via FTO\/SLC7A11 pathway","volume":"68","author":"Jiang","year":"2023","journal-title":"Redox. Biol"},{"key":"10.1016\/j.phymed.2025.157221_bib0022","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.bbrc.2022.12.014","article-title":"The natural flavone acacetin protects against high-fat diet-induced lipid accumulation in the liver via the endoplasmic reticulum stress\/ferroptosis pathway","volume":"640","author":"Jiang","year":"2023","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1016\/j.phymed.2025.157221_bib0023","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.2147\/NDT.S302443","article-title":"Traditional Chinese formula xiaoyaosan alleviates depressive-like behavior in CUMS mice by regulating PEBP1-GPX4-mediated ferroptosis in the hippocampus","volume":"17","author":"Jiao","year":"2021","journal-title":"Neuropsychiatr. Dis. Treat"},{"issue":"9","key":"10.1016\/j.phymed.2025.157221_bib0024","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202002556RRR","article-title":"Melatonin induces Nrf2-HO-1 reprogramming and corrections in hepatic core clock oscillations in non-alcoholic fatty liver disease","volume":"35","author":"Joshi","year":"2021","journal-title":"FASEB. J"},{"issue":"4","key":"10.1016\/j.phymed.2025.157221_bib0025","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00210-018-1466-8","article-title":"Metformin potentiates cognitive and antidepressant effects of fluoxetine in rats exposed to chronic restraint stress and high fat diet: potential involvement of hippocampal c-Jun repression","volume":"391","author":"Khedr","year":"2018","journal-title":"Naunyn. Schmiedeb. Arch. Pharmacol"},{"key":"10.1016\/j.phymed.2025.157221_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101600","article-title":"Curcumin blunts epithelial-mesenchymal transition of hepatocytes to alleviate hepatic fibrosis through regulating oxidative stress and autophagy","volume":"36","author":"Kong","year":"2020","journal-title":"Redox. Biol"},{"issue":"6","key":"10.1016\/j.phymed.2025.157221_bib0027","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1161\/ATVBAHA.107.142638","article-title":"Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptors","volume":"27","author":"Kr\u00f6nke","year":"2007","journal-title":"Arter. Thromb. Vasc. Biol"},{"issue":"11","key":"10.1016\/j.phymed.2025.157221_bib0028","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1134\/S0006297924110130","article-title":"Role of MMP-2 and MMP-9 in the relationship between inflammation, fibrosis, and apoptosis during progression of non-alcoholic fatty liver disease and diagnostic significance of plasma levels of their active forms","volume":"89","author":"Kurbatova","year":"2024","journal-title":"Biochem. (Mosc)"},{"issue":"9","key":"10.1016\/j.phymed.2025.157221_bib0029","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1002\/hep4.1541","article-title":"Non-alcoholic fatty liver disease increases the risk of anxiety and depression","volume":"4","author":"Labenz","year":"2020","journal-title":"Hepatol. Commun"},{"issue":"4","key":"10.1016\/j.phymed.2025.157221_bib0030","doi-asserted-by":"crossref","first-page":"841","DOI":"10.3350\/cmh.2022.0239","article-title":"Forecasted 2040 global prevalence of non-alcoholic fatty liver disease using hierarchical bayesian approach","volume":"28","author":"Le","year":"2022","journal-title":"Clin. Mol. Hepatol"},{"issue":"5","key":"10.1016\/j.phymed.2025.157221_bib0031","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202300355","article-title":"Folate deficiency and\/or the genetic variant Mthfr677C >T can drive hepatic fibrosis or steatosis in mice, in a sex-specific manner","volume":"68","author":"Leclerc","year":"2024","journal-title":"Mol. Nutr. Food. Res"},{"key":"10.1016\/j.phymed.2025.157221_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2023.110773","article-title":"Inhibition of ferroptosis alleviates chronic unpredictable mild stress-induced depression in mice via tsRNA-3029b","volume":"204","author":"Li","year":"2023","journal-title":"Brain. Res. Bull"},{"issue":"1","key":"10.1016\/j.phymed.2025.157221_bib0033","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s41065-024-00322-2","article-title":"Exploring the mechanism of dendrobine in treating metabolic associated fatty liver disease based on network pharmacology and experimental validation","volume":"161","author":"Li","year":"2024","journal-title":"Hereditas"},{"issue":"23","key":"10.1016\/j.phymed.2025.157221_bib0034","doi-asserted-by":"crossref","first-page":"7936","DOI":"10.3390\/molecules28237936","article-title":"Mechanism and progress of natural products in the treatment of NAFLD-related fibrosis","volume":"28","author":"Li","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2025.157221_bib0035","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jad.2024.02.074","article-title":"Depression and NAFLD risk: a meta-analysis and mendelian randomization study","volume":"352","author":"Li","year":"2024","journal-title":"J. Affect. Disord"},{"issue":"11","key":"10.1016\/j.phymed.2025.157221_bib0036","doi-asserted-by":"crossref","first-page":"6263","DOI":"10.3390\/ijms23116263","article-title":"Betaine alleviates high-fat diet-induced disruptionof hepatic lipid and iron homeostasis in mice","volume":"23","author":"Li","year":"2022","journal-title":"Int. J. Mol. Sci"},{"issue":"5","key":"10.1016\/j.phymed.2025.157221_bib0037","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/j.gendis.2022.03.019","article-title":"Nicotinamide N-methyltransferase and liver diseases","volume":"10","author":"Liang","year":"2022","journal-title":"Genes. Dis"},{"issue":"11","key":"10.1016\/j.phymed.2025.157221_bib0039","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1007\/s00432-011-1037-6","article-title":"Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K\/mTOR pathway","volume":"137","author":"Liu","year":"2011","journal-title":"J. Cancer. Res. Clin. Oncol"},{"issue":"2","key":"10.1016\/j.phymed.2025.157221_bib0041","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/dom.14877","article-title":"Non-alcoholic fatty liver disease and complications in type 1 and type 2 diabetes: a mendelian randomization study","volume":"25","author":"Liu","year":"2023","journal-title":"Diabetes. Obes. Metab"},{"key":"10.1016\/j.phymed.2025.157221_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.114999","article-title":"Xiaoyao Powder in the treatment of non-alcoholic fatty liver disease: a systematic review and meta-analysis","volume":"288","author":"Liu","year":"2022","journal-title":"J. Ethnopharmacol"},{"key":"10.1016\/j.phymed.2025.157221_bib0044","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.biopha.2016.10.098","article-title":"Potential involvement of JNK1 repression in the hepatic effect of sitagliptin and metformin in rats subjected to high fat diet and chronic mild distress","volume":"85","author":"Magdy","year":"2017","journal-title":"Biomed. Pharmacother"},{"issue":"9","key":"10.1016\/j.phymed.2025.157221_bib0045","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.2337\/dc22-2373","article-title":"Bidirectional mendelian randomization and multiphenotype GWAS show causality and shared pathophysiology between depression and type 2 diabetes","volume":"46","author":"Maina","year":"2023","journal-title":"Diabetes. Care"},{"issue":"2","key":"10.1016\/j.phymed.2025.157221_bib0046","doi-asserted-by":"crossref","DOI":"10.1177\/03000605221075816","article-title":"Validity of chronic restraint stress for modeling anhedonic-like behavior in rodents: a systematic review and meta-analysis","volume":"50","author":"Mao","year":"2022","journal-title":"J. Int. Med. Res"},{"key":"10.1016\/j.phymed.2025.157221_bib0047","article-title":"NAFLD, insulin resistance, and diabetes mellitus type 2","volume":"2021","author":"Maru\u0161i\u0107","year":"2021","journal-title":"Can. J. Gastroenterol. Hepatol"},{"issue":"12","key":"10.1016\/j.phymed.2025.157221_bib0048","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1002\/jat.4374","article-title":"A hypothesis concerning the role of PPAR family on cardiac energetics in Adriamycin-induced cardiomyopathy","volume":"42","author":"Mohan","year":"2022","journal-title":"J. Appl. Toxicol"},{"issue":"22","key":"10.1016\/j.phymed.2025.157221_bib0049","doi-asserted-by":"crossref","first-page":"3986","DOI":"10.1021\/acschemneuro.3c00499","article-title":"Effects of anesthetic administration on rat hypothalamus and cerebral cortex peptidome","volume":"14","author":"Mousavi","year":"2023","journal-title":"ACS. Chem. Neurosci"},{"issue":"4","key":"10.1016\/j.phymed.2025.157221_bib0050","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1111\/his.13665","article-title":"Extracellular matrix components indicate remodelling activity in different fibrosis stages of human non-alcoholic fatty liver disease","volume":"73","author":"Munsterman","year":"2018","journal-title":"Histopathology"},{"key":"10.1016\/j.phymed.2025.157221_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122109","article-title":"Spermidine suppresses oxidative stress and ferroptosis by Nrf2\/HO-1\/GPX4 and Akt\/FHC\/ACSL4 pathway to alleviate ovarian damage","volume":"332","author":"Niu","year":"2023","journal-title":"Life. Sci"},{"key":"10.1016\/j.phymed.2025.157221_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2023.105484","article-title":"Impact of non-alcoholic fatty liver disease-related metabolic state on depression","volume":"163","author":"Ntona","year":"2023","journal-title":"Neurochem. Int"},{"key":"10.1016\/j.phymed.2025.157221_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.121145","article-title":"The hepatoprotective effects of n3-polyunsaturated fatty acids against non-alcoholic fatty liver disease in diabetic rats through the FOXO1\/PPAR\u03b1\/GABARAPL1 signalling pathway","volume":"311","author":"Ramadan","year":"2022","journal-title":"Life. Sci"},{"key":"10.1016\/j.phymed.2025.157221_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2022.101452","article-title":"Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction","volume":"58","author":"Rome","year":"2022","journal-title":"Mol. Metab"},{"issue":"11","key":"10.1016\/j.phymed.2025.157221_bib0055","doi-asserted-by":"crossref","first-page":"4932","DOI":"10.1002\/ptr.7959","article-title":"Extracellular matrix turnover: phytochemicals target and modulate the dual role of matrix metalloproteinases (MMPs) in liver fibrosis","volume":"37","author":"Sabir","year":"2023","journal-title":"Phytother. Res"},{"issue":"11","key":"10.1016\/j.phymed.2025.157221_bib0056","first-page":"1697","article-title":"Non-alcoholic fatty liver disease (NAFLD) and potential links to depression","volume":"9","author":"Shea","year":"2021","journal-title":"Anxiety. Chronic. Stress,. Biomed."},{"key":"10.1016\/j.phymed.2025.157221_bib0057","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1357664","article-title":"Non-alcoholic fatty liver disease and coexisting depression, anxiety and\/or stress in adults: a systematic review and meta-analysis","volume":"15","author":"Shea","year":"2024","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.phymed.2025.157221_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2023.148715","article-title":"Acupuncture alleviates CUMS-induced depression-like behaviors of rats by regulating oxidative stress, neuroinflammation and ferroptosis","volume":"1826","author":"Shen","year":"2024","journal-title":"Brain. Res"},{"issue":"6","key":"10.1016\/j.phymed.2025.157221_bib0059","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1111\/jog.14753","article-title":"Role of FOXO protein's abnormal activation through PI3K\/AKT pathway in platinum resistance of ovarian cancer","volume":"47","author":"Shi","year":"2021","journal-title":"J. Obs. Gynaecol. Res"},{"key":"10.1016\/j.phymed.2025.157221_bib0060","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/8063897","article-title":"Attenuation by time-restricted feeding of high-fat and high-fructose diet-induced NASH in mice is related to Per2 and ferroptosis","volume":"2022","author":"Shu","year":"2022","journal-title":"Oxid. Med. Cell. Longev"},{"key":"10.1016\/j.phymed.2025.157221_bib0061","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ajem.2022.10.041","article-title":"Resource equation method for sample size calculation in animal studies","volume":"63","author":"Sohn","year":"2023","journal-title":"Am. J. Emerg. Med"},{"issue":"4","key":"10.1016\/j.phymed.2025.157221_bib0062","doi-asserted-by":"crossref","first-page":"8334","DOI":"10.1080\/21655979.2022.2051858","article-title":"Liraglutide attenuates hepatic iron levels and ferroptosis in db\/db mice","volume":"13","author":"Song","year":"2022","journal-title":"Bioengineered"},{"issue":"1","key":"10.1016\/j.phymed.2025.157221_bib0063","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s12916-020-01713-8","article-title":"Non-alcoholic fatty liver disease (NAFLD) as a neglected metabolic companion of psychiatric disorders: common pathways and future approaches","volume":"18","author":"Soto-Angona","year":"2020","journal-title":"BMC. Med"},{"issue":"4","key":"10.1016\/j.phymed.2025.157221_bib0064","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.21873\/invivo.13618","article-title":"Depression exacerbates hepatic steatosis in C57BL\/6J mice by activating the hypothalamic-pituitary-adrenal axis","volume":"38","author":"Su","year":"2024","journal-title":"In. Vivo. (Brooklyn)"},{"key":"10.1016\/j.phymed.2025.157221_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2024.155953","article-title":"Targeting the regulation of iron homeostasis as a potential therapeutic strategy for non-alcoholic fatty liver disease","volume":"157","author":"Sui","year":"2024","journal-title":"Metabolism"},{"key":"10.1016\/j.phymed.2025.157221_bib0066","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1496639","article-title":"Clopidogrel ameliorates high-fat diet-induced hepatic steatosis in mice through activation of the AMPK signaling pathway and beyond","volume":"15","author":"Tai","year":"2024","journal-title":"Front. Pharmacol"},{"issue":"1","key":"10.1016\/j.phymed.2025.157221_bib0067","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3109\/1354750X.2012.738249","article-title":"Higher hepatic gene expression and serum levels of matrix metalloproteinase-2 are associated with steatohepatitis in non-alcoholic fatty liver diseases","volume":"18","author":"Toyoda","year":"2013","journal-title":"Biomarkers"},{"key":"10.1016\/j.phymed.2025.157221_bib0068","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1213506","article-title":"Molecular subtypes and scoring tools related to Foxo signaling pathway for assessing hepatocellular carcinoma prognosis and treatment responsiveness","volume":"14","author":"Tu","year":"2023","journal-title":"Front. Pharmacol"},{"key":"10.1016\/j.phymed.2025.157221_bib0070","article-title":"Research on Xiaoyao Powder in the treatment of depression based on epigenetics and quality markers","volume":"17","author":"Wang","year":"2023","journal-title":"Front. Neurosci"},{"issue":"5","key":"10.1016\/j.phymed.2025.157221_bib0071","doi-asserted-by":"crossref","DOI":"10.1136\/gpsych-2023-101072","article-title":"Targeting the ferroptosis crosstalk: novel alternative strategies for the treatment of major depressive disorder","volume":"36","author":"Wang","year":"2023","journal-title":"Gen. Psychiatr"},{"issue":"5","key":"10.1016\/j.phymed.2025.157221_bib0072","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s12263-013-0333-y","article-title":"Timed high-fat diet in the evening affects the hepatic circadian clock and PPAR\u03b1-mediated lipogenic gene expressions in mice","volume":"8","author":"Wang","year":"2013","journal-title":"Genes. Nutr"},{"issue":"6","key":"10.1016\/j.phymed.2025.157221_bib0073","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.3390\/ijms21062061","article-title":"PPARs as metabolic regulators in the liver: lessons from liver-specific PPAR-null mice","volume":"21","author":"Wang","year":"2020","journal-title":"Int. J. Mol. Sci"},{"key":"10.1016\/j.phymed.2025.157221_bib0074","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102131","article-title":"Fibroblast growth factor 21 attenuates iron overload-induced liver injury and fibrosis by inhibiting ferroptosis","volume":"46","author":"Wu","year":"2021","journal-title":"Redox. Biol"},{"key":"10.1016\/j.phymed.2025.157221_bib0075","doi-asserted-by":"crossref","first-page":"5027","DOI":"10.2147\/IDR.S484103","article-title":"Hepcidin exacerbates iron metabolism imbalance in septic mice","volume":"17","author":"Wu","year":"2024","journal-title":"Infect. Drug. Resist"},{"key":"10.1016\/j.phymed.2025.157221_bib0076","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.1033129","article-title":"Protective effect of traditional Chinese medicine on non-alcoholic fatty liver disease and liver cancer by targeting ferroptosis","volume":"9","author":"Wu","year":"2022","journal-title":"Front. Nutr"},{"issue":"2","key":"10.1016\/j.phymed.2025.157221_bib0077","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s10753-015-0286-y","article-title":"BML-111 attenuates renal ischemia\/reperfusion injury via peroxisome proliferator-activated receptor-\u03b1-regulated heme oxygenase-1","volume":"39","author":"Wu","year":"2016","journal-title":"Inflammation"},{"issue":"38","key":"10.1016\/j.phymed.2025.157221_bib0078","doi-asserted-by":"crossref","first-page":"23791","DOI":"10.1039\/D1RA04438A","article-title":"Untargeted metabolomic and lipid metabolism-related gene expression analyses of the effects and mechanism of aged Liupao tea treatment in HFD-induced obese mice","volume":"11","author":"Wu","year":"2021","journal-title":"RSC. Adv"},{"key":"10.1016\/j.phymed.2025.157221_bib0079","article-title":"Effects of Huolisu oral Solution on depression-like behavior in rats: neurotransmitter and HPA axis","volume":"13","author":"Xiao","year":"2022","journal-title":"Front. Pharmacol"},{"issue":"2","key":"10.1016\/j.phymed.2025.157221_bib0080","first-page":"273","article-title":"Osteopontin promotes macrophage M1 polarization by activation of the JAK1\/STAT1\/HMGB1 signaling pathway in non-alcoholic fatty liver disease","volume":"11","author":"Xu","year":"2023","journal-title":"J. Clin. Transl. Hepatol"},{"issue":"8","key":"10.1016\/j.phymed.2025.157221_bib0081","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.3390\/nu15081904","article-title":"Vegetable oil-peroxidation product 'Hydroxynonenal' Causes hepatocyte injury and steatosis via Hsp70.1 and BHMT disorders in the monkey liver","volume":"15","author":"Yamashima","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2025.157221_bib0082","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/6363748","article-title":"Sijunzi, Lizhong, and Fuzilizhong decoction alleviate non-alcoholic fatty liver disease through activation of PPAR pathway","volume":"2020","author":"Yang","year":"2020","journal-title":"Evid. Based. Complement. Altern. Med"},{"key":"10.1016\/j.phymed.2025.157221_bib0083","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118165","article-title":"Xiaozhi formula attenuates non-alcoholic fatty liver disease by regulating lipid metabolism via activation of AMPK and PPAR pathways","volume":"329","author":"You","year":"2024","journal-title":"J. Ethnopharmacol"},{"issue":"3","key":"10.1016\/j.phymed.2025.157221_bib0084","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.13138","article-title":"Royal jelly attenuates non-alcoholic fatty liver disease by inhibiting oxidative stress and regulating the expression of circadian genes in ovariectomized rats","volume":"44","author":"You","year":"2020","journal-title":"J. Food. Biochem"},{"key":"10.1016\/j.phymed.2025.157221_bib0085","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1339057","article-title":"Ferroptosis: a new antidepressant pharmacological mechanism","volume":"14","author":"Zhang","year":"2024","journal-title":"Front. Pharmacol"},{"issue":"1","key":"10.1016\/j.phymed.2025.157221_bib0086","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0317295","article-title":"Dapagliflozin inhibits ferroptosis to improve chronic heart failure by regulating Nrf2\/HO-1\/GPX4 signaling pathway","volume":"20","author":"Zhang","year":"2025","journal-title":"PLoS. One"},{"key":"10.1016\/j.phymed.2025.157221_bib0087","article-title":"Iron overload accelerated lipid metabolism disorder and liver injury in rats with non-alcoholic fatty liver disease","volume":"9","author":"Zhang","year":"2022","journal-title":"Front. Nutr"},{"issue":"1","key":"10.1016\/j.phymed.2025.157221_bib0088","doi-asserted-by":"crossref","first-page":"4172","DOI":"10.1038\/s41598-023-30582-3","article-title":"Mangiferin relieves CCl4-induced liver fibrosis in mice","volume":"13","author":"Zhang","year":"2023","journal-title":"Sci. Rep"},{"key":"10.1016\/j.phymed.2025.157221_bib0089","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jpsychires.2024.07.054","article-title":"Change in the global burden of depression from 1990 to 2019 and its prediction for 2030","volume":"178","author":"Zhang","year":"2024","journal-title":"J. Psychiatr. Res"},{"key":"10.1016\/j.phymed.2025.157221_bib0090","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.590457","article-title":"An integrative pharmacology-based pattern to uncover the pharmacological mechanism of ginsenoside H dripping pills in the treatment of depression","volume":"11","author":"Zhao","year":"2021","journal-title":"Front. Pharmacol"},{"issue":"12","key":"10.1016\/j.phymed.2025.157221_bib0091","doi-asserted-by":"crossref","first-page":"332","DOI":"10.31083\/j.fbl2812332","article-title":"Lipid peroxidation in ferroptosis and association with non-alcoholic fatty liver disease","volume":"28","author":"Zhao","year":"2023","journal-title":"Front. Biosci. (Landmark. Ed)"},{"issue":"1","key":"10.1016\/j.phymed.2025.157221_bib0092","article-title":"Association of depression with severe non-alcoholic fatty liver disease: evidence from the UK Biobank study and mendelian randomization analysis","volume":"14","author":"Zhou","year":"2024","journal-title":"Sci. Rep"},{"key":"10.1016\/j.phymed.2025.157221_bib0093","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174351","article-title":"Thymosin beta 4 alleviates non-alcoholic fatty liver by inhibiting ferroptosis via up-regulation of GPX4","volume":"908","author":"Zhu","year":"2021","journal-title":"Eur. J. Pharmacol"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325008608?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325008608?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:27:49Z","timestamp":1773419269000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325008608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":89,"alternative-id":["S0944711325008608"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157221","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Xiaoyao San's dual efficacy in NAFLD and depression: Unraveling the mechanisms via network pharmacology and multi-omics","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157221","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"157221"}}