{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:49:23Z","timestamp":1787737763196,"version":"build-2784847793"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7232274"],"award-info":[{"award-number":["7232274"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274234"],"award-info":[{"award-number":["82274234"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","award":["BMU2022TSXK001"],"award-info":[{"award-number":["BMU2022TSXK001"]}],"id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.phymed.2025.157226","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T23:01:32Z","timestamp":1757026892000},"page":"157226","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["QiShenYiQi pills ameliorated aspirin and clopidogrel-induced gastric hemorrhage via multi-target regulation"],"prefix":"10.1016","volume":"147","author":[{"given":"Ru-Yu","family":"Zhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Qing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding-Zhou","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan-Kai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Shui","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2286-8076","authenticated-orcid":false,"given":"Jing-Yan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 4","key":"10.1016\/j.phymed.2025.157226_bib0001","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/jgh.12767","article-title":"Importance of cyclooxygenase-1\/prostacyclin in modulating gastric mucosal integrity under stress conditions","volume":"29","author":"Amagase","year":"2014","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"9","key":"10.1016\/j.phymed.2025.157226_bib0002","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1161\/STROKEAHA.118.021754","article-title":"Angioedema and hemorrhage after 4.5-hour tPA (tissue-type plasminogen activator) thrombolysis ameliorated by T541 via restoring brain microvascular integrity","volume":"49","author":"Chen","year":"2018","journal-title":"Stroke"},{"key":"10.1016\/j.phymed.2025.157226_bib0003","unstructured":"Chinese Pharmacopoeia Commission, 2025. Chinese Pharmacopoeia (2025 Edition), Volume I. China Medical Science Press, Beijing, p. 1012."},{"key":"10.1016\/j.phymed.2025.157226_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2025.102724","article-title":"Vitamin D3 mitigates aspirin-induced gastric injury by modulating gastrokines, E-cadherin, and inhibiting NLRP3 and NF-\u03bab\/MMP-9 signaling pathway","volume":"93","author":"El-Sayed","year":"2025","journal-title":"Tissue Cell"},{"issue":"4","key":"10.1016\/j.phymed.2025.157226_bib0005","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3390\/biom12040519","article-title":"A structural perspective on calprotectin as a ligand of receptors mediating inflammation and potential drug target","volume":"12","author":"Garcia","year":"2022","journal-title":"Biomolecules"},{"issue":"2","key":"10.1016\/j.phymed.2025.157226_bib0006","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jacc.2021.10.028","article-title":"Magnetically controlled capsule endoscopy for assessment of antiplatelet therapy-induced gastrointestinal injury","volume":"79","author":"Han","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"issue":"11","key":"10.1016\/j.phymed.2025.157226_bib0007","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.43219","article-title":"Progression of gastrointestinal injury during antiplatelet therapy after percutaneous coronary intervention: a secondary analysis of the OPT-PEACE randomized clinical trial","volume":"6","author":"He","year":"2023","journal-title":"JAMA Netw. Open"},{"issue":"9","key":"10.1016\/j.phymed.2025.157226_bib0008","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/s41422-019-0208-x","article-title":"NDUFAB1 confers cardio-protection by enhancing mitochondrial bioenergetics through coordination of respiratory complex and supercomplex assembly","volume":"29","author":"Hou","year":"2019","journal-title":"Cell Res."},{"key":"10.1016\/j.phymed.2025.157226_bib0009","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1515\/med-2019-0062","article-title":"Aspirin, a potential GLUT1 inhibitor in a vascular endothelial cell line","volume":"14","author":"Hu","year":"2019","journal-title":"Open Med. (Wars)"},{"key":"10.1016\/j.phymed.2025.157226_bib0010","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ejphar.2014.12.020","article-title":"Aspirin may influence cellular energy status","volume":"749","author":"Kamble","year":"2015","journal-title":"Eur. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.phymed.2025.157226_bib0011","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1002\/ijc.31022","article-title":"By inhibiting PFKFB3, aspirin overcomes sorafenib resistance in hepatocellular carcinoma","volume":"141","author":"Li","year":"2017","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.phymed.2025.157226_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117610","article-title":"QiShenYiQi pills preserve endothelial barrier integrity to mitigate sepsis-induced acute lung injury by inhibiting ferroptosis","volume":"322","author":"Li","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.phymed.2025.157226_bib0013","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.bbalip.2012.04.002","article-title":"Insight into NSAID-induced membrane alterations, pathogenesis and therapeutics: characterization of interaction of NSAIDs with phosphatidylcholine","volume":"1821","author":"Lichtenberger","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phymed.2025.157226_bib0014","doi-asserted-by":"crossref","unstructured":"Lip, G.Y.H., Collet, J.P., Haude, M., Byrne, R., Chung, E.H., Fauchier, L., Halvorsen, S., Lau, D., Lopez-Cabanillas, N., Lettino, M., Marin, F., Obel, I., Rubboli, A., Storey, R.F., Valgimigli, M., Huber, K., ESC Scientific Document Group, 2019. 2018 joint European consensus document on the management of antithrombotic therapy in atrial fibrillation patients presenting with acute coronary syndrome and\/or undergoing percutaneous cardiovascular interventions: a joint consensus document of the European heart rhythm association (EHRA), European society of cardiology working group on thrombosis, European association of percutaneous cardiovascular interventions (EAPCI), and European association of acute cardiac care (ACCA) endorsed by the heart rhythm society (HRS), Asia-Pacific heart rhythm society (APHRS), Latin America heart rhythm society (LAHRS), and cardiac arrhythmia society of Southern Africa (CASSA). Europace. 21(2), 192\u2013193.","DOI":"10.1093\/europace\/euy174"},{"key":"10.1016\/j.phymed.2025.157226_bib0015","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nrgastro.2017.117","article-title":"Proton-pump inhibitors: understanding the complications and risks","volume":"14","author":"Malfertheiner","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2025.157226_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2025.149702","article-title":"Unlocking the cellular mystery: how proton pump inhibitors may alter the dementia landscape","volume":"1861","author":"Mohan","year":"2025","journal-title":"Brain Res."},{"issue":"4","key":"10.1016\/j.phymed.2025.157226_bib0017","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1159\/000079152","article-title":"Lactobacillus acidophilus protects tight junctions from aspirin damage in HT-29 cells","volume":"69","author":"Montalto","year":"2004","journal-title":"Digestion"},{"issue":"8","key":"10.1016\/j.phymed.2025.157226_bib0018","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1179\/1607845414Y.0000000226","article-title":"Association between expression of MMP-2 and MMP-9 genes and pathogenesis of intracranial hemorrhage in severe coagulation factor XIII deficiency","volume":"20","author":"Naderi","year":"2015","journal-title":"Hematology"},{"issue":"4 Pt 2","key":"10.1016\/j.phymed.2025.157226_bib0019","first-page":"H1462","article-title":"Initiation of hyperpermeability in energy-depleted coronary endothelial monolayers","volume":"268","author":"Noll","year":"1995","journal-title":"Am. J. Physiol."},{"issue":"3","key":"10.1016\/j.phymed.2025.157226_bib0020","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.ajhg.2018.01.020","article-title":"Biallelic mutations in ATP5F1D, which encodes a subunit of ATP synthase, cause a metabolic disorder","volume":"102","author":"Ol\u00e1hov\u00e1","year":"2018","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.phymed.2025.157226_bib0021","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.753761","article-title":"QiShenYiQi pills attenuates ischemia\/reperfusion-induced cardiac microvascular hyperpermeability implicating Src\/Caveolin-1 and RhoA\/ROCK\/MLC signaling","volume":"12","author":"Pan","year":"2021","journal-title":"Front. Physiol."},{"issue":"7","key":"10.1016\/j.phymed.2025.157226_bib0022","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1093\/chromsci\/bmu210","article-title":"Liquid chromatographic method for simultaneous quantitation of clopidogrel, aspirin and atorvastatin in rat plasma and its application to the pharmacokinetic study","volume":"53","author":"Porwal","year":"2015","journal-title":"J. Chromatogr. Sci."},{"issue":"13","key":"10.1016\/j.phymed.2025.157226_bib0023","first-page":"e771","article-title":"2025 ACC\/AHA\/ACEP\/NAEMSP\/SCAI guideline for the management of patients with acute coronary syndromes: a report of the American college of cardiology\/American heart association joint committee on clinical practice guidelines","volume":"151","author":"Rao","year":"2025","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.phymed.2025.157226_bib0024","first-page":"e256","article-title":"Role of proton pump inhibitors in prevention of upper gastrointestinal bleeding in patients on dual antiplatelet therapy: systematic review and meta-analysis","volume":"32","author":"Saeed","year":"2025","journal-title":"Am. J. Ther."},{"issue":"2","key":"10.1016\/j.phymed.2025.157226_bib0025","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1093\/eurjpc\/zwab213","article-title":"Burden of ischemic heart disease and its attributable risk factors in 204 countries and territories, 1990-2019","volume":"29","author":"Safiri","year":"2022","journal-title":"Eur. J. Prev. Cardiol."},{"key":"10.1016\/j.phymed.2025.157226_bib0026","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/828354","article-title":"S100A8 and S100A9: dAMPs at the crossroads between innate immunity, traditional risk factors, and cardiovascular disease","volume":"2013","author":"Schiopu","year":"2013","journal-title":"Mediators Inflamm."},{"issue":"1","key":"10.1016\/j.phymed.2025.157226_bib0027","first-page":"35","article-title":"Gastrointestinal adverse events after dual antiplatelet therapy: clopidogrel is safer than ticagrelor, but prasugrel data are lacking or inconclusive","volume":"126","author":"Serebruany","year":"2013","journal-title":"Cardiol"},{"issue":"2","key":"10.1016\/j.phymed.2025.157226_bib0028","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1006\/taap.1997.8313","article-title":"Role of the mitochondrial permeability transition in salicylate toxicity to cultured rat hepatocytes: implications for the pathogenesis of Reye's syndrome","volume":"147","author":"Trost","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"12","key":"10.1016\/j.phymed.2025.157226_bib0029","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1515\/cclm-2019-0380","article-title":"The role of platelets in bleeding in patients with thrombocytopenia and hematological disease","volume":"57","author":"Vinholt","year":"2019","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.phymed.2025.157226_bib0030","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.molimm.2025.01.015","article-title":"Protective effect of dendrobium officinale extract on aspirin-induced gastric lesions in rats","volume":"179","author":"Wang","year":"2025","journal-title":"Mol. Immunol."},{"issue":"32","key":"10.1016\/j.phymed.2025.157226_bib0031","doi-asserted-by":"crossref","first-page":"9914","DOI":"10.1073\/pnas.1509047112","article-title":"Endothelial depletion of murine SRF\/MRTF provokes intracerebral hemorrhagic stroke","volume":"112","author":"Weinl","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"5","key":"10.1016\/j.phymed.2025.157226_bib0032","first-page":"1741","article-title":"Role of MKP-5-p38\/MAPK pathway in clopidogrel-induced gastric mucosal epithelial cells apoptosis and tight junction dysfunction","volume":"12","author":"Wu","year":"2020","journal-title":"Am. J. Transl. Res."},{"issue":"3","key":"10.1016\/j.phymed.2025.157226_bib0033","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/imm.13722","article-title":"Roles of S100A8, S100A9 and S100A12 in infection, inflammation and immunity","volume":"171","author":"Xia","year":"2024","journal-title":"Immunology."},{"issue":"1","key":"10.1016\/j.phymed.2025.157226_bib0034","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41421-024-00744-2","article-title":"TPM4 condensates glycolytic enzymes and facilitates actin reorganization under hyperosmotic stress","volume":"10","author":"Yang","year":"2024","journal-title":"Cell Discov."},{"key":"10.1016\/j.phymed.2025.157226_bib0035","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.759027","article-title":"QiShenYiQi inhibits tissue plasminogen activator-induced brain edema and hemorrhage after ischemic stroke in mice","volume":"12","author":"Ye","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.phymed.2025.157226_bib0036","doi-asserted-by":"crossref","first-page":"256","DOI":"10.31083\/ph.2021.0926","article-title":"MiR-877-5p targets PDK-1 to promote aspirin-induced apoptosis in gastric mucosal cells","volume":"76","author":"Yuyu","year":"2021","journal-title":"Pharmazie"},{"issue":"1","key":"10.1016\/j.phymed.2025.157226_bib0037","first-page":"28","article-title":"A meta-analysis of proton pump inhibitor exposure and the risk of adverse outcomes in patients with inflammatory bowel disease","volume":"43","author":"Zhang","year":"2025","journal-title":"Dig. Dis."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325008657?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325008657?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:18:26Z","timestamp":1778559506000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325008657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":37,"alternative-id":["S0944711325008657"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157226","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"QiShenYiQi pills ameliorated aspirin and clopidogrel-induced gastric hemorrhage via multi-target regulation","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157226","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157226"}}