{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:54:31Z","timestamp":1783608871884,"version":"3.55.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204737"],"award-info":[{"award-number":["82204737"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474378"],"award-info":[{"award-number":["82474378"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Shanghai Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["22ZR1455900"],"award-info":[{"award-number":["22ZR1455900"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.phymed.2025.157271","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:03:57Z","timestamp":1758585837000},"page":"157271","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Alisol A 24-acetate protects against NASH-associated fibrosis via suppression of Kupffer cell-derived SPHK1\/S1P axis"],"prefix":"10.1016","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4606-1250","authenticated-orcid":false,"given":"Jia-Qi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Qi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Ming","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0380-160X","authenticated-orcid":false,"given":"Yuan-Ye","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.157271_bib0001","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.3390\/biomedicines10081945","article-title":"Pharmacological properties and molecular targets of alisol triterpenoids from alismatis rhizoma","volume":"10","author":"Bailly","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.phymed.2025.157271_bib0002","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1007\/s10753-021-01490-3","article-title":"Blocking SphK1\/S1P\/S1PR1 signaling pathway alleviates lung injury caused by sepsis in acute ethanol intoxication mice","volume":"44","author":"Chen","year":"2021","journal-title":"Inflammation"},{"key":"10.1016\/j.phymed.2025.157271_bib0003","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/hep.24341","article-title":"Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells","volume":"54","author":"Csak","year":"2011","journal-title":"Hepatol. Baltim. Md"},{"key":"10.1016\/j.phymed.2025.157271_bib0004","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1002\/ptr.6933","article-title":"Alisma genus: phytochemical constituents, biosynthesis, and biological activities","volume":"35","author":"Feng","year":"2021","journal-title":"Phytother. Res. PTR"},{"key":"10.1016\/j.phymed.2025.157271_bib0005","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1515\/jtim-2024-0023","article-title":"Prognostic prediction of m6A and ferroptosis-associated lncRNAs in liver hepatocellular carcinoma","volume":"12","author":"Gao","year":"2024","journal-title":"J. Transl. Intern. Med."},{"key":"10.1016\/j.phymed.2025.157271_bib0006","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.1176709","article-title":"Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate","volume":"325","author":"Hait","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.phymed.2025.157271_bib0007","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/s41591-023-02242-6","article-title":"Challenges and opportunities in NASH drug development","volume":"29","author":"Harrison","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2025.157271_bib0009","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.mce.2012.10.024","article-title":"Curcumin ameliorates diabetic nephropathy by inhibiting the activation of the SphK1-S1P signaling pathway","volume":"365","author":"Huang","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.phymed.2025.157271_bib0010","doi-asserted-by":"crossref","first-page":"35257","DOI":"10.1074\/jbc.M203033200","article-title":"PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA)","volume":"277","author":"Johnson","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2025.157271_bib0011","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/132436","article-title":"The inhibitory effect of alisol A 24-acetate from alisma canaliculatum on osteoclastogenesis","author":"Kim","year":"2015","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.phymed.2025.157271_bib0012","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1002\/hep.29885","article-title":"Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2","volume":"68","author":"Lan","year":"2018","journal-title":"Hepatol. Baltim. Md"},{"key":"10.1016\/j.phymed.2025.157271_bib0013","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.jhep.2010.08.028","article-title":"Sphingosine 1-phosphate (S1P)\/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility","volume":"54","author":"Li","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2025.157271_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118460","article-title":"Berberine reduces gut-vascular barrier permeability via modulation of ApoM\/S1P pathway in a model of polymicrobial sepsis","volume":"261","author":"Li","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2025.157271_bib0015","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.jhep.2023.05.007","article-title":"Therapeutic opportunities for the treatment of NASH with genetically validated targets","volume":"79","author":"Lind\u00e9n","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2025.157271_bib0016","article-title":"Salvia miltiorrhiza bge. (Danshen) in the treating non-alcoholic fatty liver disease based on the regulator of metabolic targets","volume":"9","author":"Liu","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.phymed.2025.157271_bib0017","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S1388-1981(02)00341-4","article-title":"Sphingosine kinase, sphingosine-1-phosphate, and apoptosis","volume":"1585","author":"Maceyka","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phymed.2025.157271_bib0018","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/iep.12008","article-title":"An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis","volume":"94","author":"Matsumoto","year":"2013","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.phymed.2025.157271_bib0019","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/aps.2016.119","article-title":"Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation","volume":"38","author":"Meng","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2025.157271_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2022.101523","article-title":"Sphingosine kinase 1 mediates sexual dimorphism in fibrosis in a mouse model of NASH","volume":"62","author":"Montefusco","year":"2022","journal-title":"Mol. Metab."},{"key":"10.1016\/j.phymed.2025.157271_bib0021","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1101\/gad.262816.115","article-title":"A YAP\/TAZ-induced feedback mechanism regulates hippo pathway homeostasis","volume":"29","author":"Moroishi","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.phymed.2025.157271_bib0022","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1158\/0008-5472.CAN-17-1423","article-title":"Targeting the SphK1\/S1P\/S1PR1 axis that links obesity, chronic inflammation, and breast cancer metastasis","volume":"78","author":"Nagahashi","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.phymed.2025.157271_bib0023","doi-asserted-by":"crossref","first-page":"6325","DOI":"10.1021\/acs.biochem.7b00859","article-title":"Resveratrol exerts antioxidant effects by activating SIRT2 to deacetylate Prx1","volume":"56","author":"Pan","year":"2017","journal-title":"Biochemistry"},{"key":"10.1016\/j.phymed.2025.157271_bib0024","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mam.2018.09.002","article-title":"Liver fibrosis: pathophysiology, pathogenetic targets and clinical issues","volume":"65","author":"Parola","year":"2019","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.phymed.2025.157271_bib0025","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1158\/1078-0432.CCR-21-1258","article-title":"NASH and hepatocellular carcinoma: immunology and immunotherapy","volume":"29","author":"Pinter","year":"2023","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"key":"10.1016\/j.phymed.2025.157271_bib0026","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jhep.2017.11.012","article-title":"Determinants of fibrosis progression and regression in NASH","volume":"68","author":"Schuppan","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2025.157271_bib0027","first-page":"600","article-title":"Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration","volume":"25","author":"Strub","year":"2011","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.phymed.2025.157271_bib0028","doi-asserted-by":"crossref","first-page":"729","DOI":"10.21037\/atm-20-4354","article-title":"Non-alcoholic fatty liver disease (NAFLD)\/non-alcoholic steatohepatitis (NASH)-related liver fibrosis: mechanisms, treatment and prevention","volume":"9","author":"Tacke","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.phymed.2025.157271_bib0029","first-page":"225","article-title":"A bibliometric analysis of immune-related adverse events in cancer patients and a meta-analysis of immune-related adverse events in patients with hepatocellular carcinoma","volume":"12","author":"Wang","year":"2024","journal-title":"J. Transl. Intern. Med."},{"key":"10.1016\/j.phymed.2025.157271_bib0030","first-page":"172","article-title":"Alisol A 24-acetate and Alisol B 23-acetate induced autophagy mediates apoptosis and nephrotoxicity in human renal proximal tubular cells","volume":"8","author":"Wang","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157271_bib0031","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3389\/fchem.2020.00363","article-title":"Triterpenoids from Alisma species: phytochemistry, structure modification, and bioactivities","volume":"8","author":"Wang","year":"2020","journal-title":"Front. Chem."},{"key":"10.1016\/j.phymed.2025.157271_bib0032","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.3389\/fimmu.2019.01706","article-title":"Sphingosine-1-phosphate and macrophage biology-how the Sphinx tames the big eater","volume":"10","author":"Weigert","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2025.157271_bib0033","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cbi.2018.06.005","article-title":"Alisol A 24-acetate ameliorates nonalcoholic steatohepatitis by inhibiting oxidative stress and stimulating autophagy through the AMPK\/mTOR pathway","volume":"291","author":"Wu","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.phymed.2025.157271_bib0034","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jhep.2013.02.021","article-title":"Sphingosine kinase\/sphingosine 1-phosphate (S1P)\/S1P receptor axis is involved in liver fibrosis-associated angiogenesis","volume":"59","author":"Yang","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2025.157271_bib0035","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2025.157271_bib0036","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatol. Baltim. Md"},{"key":"10.1016\/j.phymed.2025.157271_bib0037","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2022.881848","article-title":"Targeting acid ceramidase ameliorates fibrosis in mouse models of non-alcoholic steatohepatitis","volume":"9","author":"Yu","year":"2022","journal-title":"Front. Med."},{"key":"10.1016\/j.phymed.2025.157271_bib0038","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.cell.2024.02.007","article-title":"Regulation of the hippo-YAP pathway by G-protein-coupled receptor signaling","volume":"187","author":"Yu","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2025.157271_bib0039","article-title":"Curcumin attenuates ulcerative colitis via regulation of sphingosine kinases 1\/NF-\u03bab signaling pathway","volume":"51","author":"Zhang","year":"2025","journal-title":"BioFactors Oxf. Engl."},{"key":"10.1016\/j.phymed.2025.157271_bib0040","doi-asserted-by":"crossref","first-page":"3826","DOI":"10.1080\/14786419.2022.2149520","article-title":"Mechanism of triterpenoids from Alismatis Rhizoma against liver fibrosis based on an integrated approach using network pharmacology, molecular docking, and luciferase assay","volume":"37","author":"Zhang","year":"2023","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.phymed.2025.157271_bib0041","article-title":"Application of herbs and active ingredients ameliorate non-alcoholic fatty liver disease under the guidance of traditional Chinese medicine","volume":"13","author":"Zhou","year":"2022","journal-title":"Front. Endocrinol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325009109?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325009109?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T06:18:14Z","timestamp":1773123494000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325009109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":40,"alternative-id":["S0944711325009109"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157271","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alisol A 24-acetate protects against NASH-associated fibrosis via suppression of Kupffer cell-derived SPHK1\/S1P axis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157271","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157271"}}