{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:11:15Z","timestamp":1794003075497,"version":"4.8.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019981","name":"South-Central University for Nationalities","doi-asserted-by":"publisher","award":["CZQ23027"],"award-info":[{"award-number":["CZQ23027"]}],"id":[{"id":"10.13039\/501100019981","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22177138"],"award-info":[{"award-number":["22177138"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473797"],"award-info":[{"award-number":["82473797"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.phymed.2025.157276","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:03:47Z","timestamp":1758585827000},"page":"157276","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Grifolin-4-l-ergothioneine from Albatrellus dispansus ameliorates CCl4-induced liver injury via activating SIRT1\/AMPK\/NRF2 signaling in hepatocytes"],"prefix":"10.1016","volume":"148","author":[{"given":"Guang-Qiong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Tian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1284-0288","authenticated-orcid":false,"given":"Zheng-Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Kun","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Kai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.157276_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2019.126808","article-title":"Isolation of three new meroterpenoids and seven known compounds from Albatrellus yasudae and their A\u03b2-aggregation inhibitory activity","volume":"30","author":"Akiba","year":"2020","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.phymed.2025.157276_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112445","article-title":"SanWeiGanJiang San relieves liver injury via Nrf2\/Bach1","volume":"251","author":"Chen","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157276_bib0003","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.fct.2012.11.022","article-title":"Antioxidant and hepatoprotective effects of Schisandra chinensis pollen extract on CCl4-induced acute liver damage in mice","volume":"55","author":"Cheng","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.phymed.2025.157276_bib0004","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.redox.2013.01.005","article-title":"Competition of nuclear factor-erythroid 2 factors related transcription factor isoforms, Nrf1 and Nrf2, in antioxidant enzyme induction","volume":"1","author":"Chepelev","year":"2013","journal-title":"Redox Biol."},{"key":"10.1016\/j.phymed.2025.157276_bib0005","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1021\/np200001x","article-title":"Protective effects of hyperoside against carbon tetrachloride-induced liver damage in mice","volume":"74","author":"Choi","year":"2011","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phymed.2025.157276_bib0006","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.apsb.2022.08.019","article-title":"SIRT1 activation synergizes with FXR agonism in hepatoprotection via governing nucleocytoplasmic shuttling and degradation of FXR","volume":"13","author":"Cui","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2025.157276_bib0007","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0261-5614(03)00108-0","article-title":"L-ergothioneine modulates oxidative damage in the kidney and liver of rats in vivo: studies upon the profile of polyunsaturated fatty acids","volume":"23","author":"Deiana","year":"2004","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.phymed.2025.157276_bib0008","doi-asserted-by":"crossref","first-page":"e804","DOI":"10.1038\/cddis.2013.324","article-title":"Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K\/Akt signaling pathway","volume":"4","author":"Deng","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2025.157276_bib0009","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1021\/ja01392a021","article-title":"Biochemistry of sulfur. II. The isolation of ergothioneine from ergot of rye","volume":"50","author":"Eagles","year":"1928","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.phymed.2025.157276_bib0010","doi-asserted-by":"crossref","first-page":"6466","DOI":"10.1021\/jf071328f","article-title":"Dietary sources and antioxidant effects of ergothioneine","volume":"55","author":"Ey","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2025.157276_bib0011","article-title":"Ergothioneine as a natural antioxidant against oxidative stress-related diseases","volume":"13","author":"Fu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157276_bib0012","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1080\/10286020.2014.951925","article-title":"One new ergostane-type steroid and three new phthalide derivatives from cultures of the basidiomycete Albatrellus confluens","volume":"17","author":"Guo","year":"2015","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.phymed.2025.157276_bib0013","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.apsb.2016.06.003","article-title":"The modification of natural products for medical use","volume":"7","author":"Guo","year":"2017","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2025.157276_bib0014","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s12906-024-04486-2","article-title":"Luteolin attenuates CCl4-induced hepatic injury by inhibiting ferroptosis via SLC7A11","volume":"24","author":"Han","year":"2024","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.phymed.2025.157276_bib0015","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jhep.2019.04.001","article-title":"Ursodeoxycholic acid therapy and liver transplant-free survival in patients with primary biliary cholangitis","volume":"71","author":"Harms","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2025.157276_bib0016","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0021-9258(19)51132-2","article-title":"Grifolin, an antibiotic from a basidiomycete","volume":"184","author":"Hirata","year":"1950","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2025.157276_bib0017","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/jpp\/rgab164","article-title":"Specnuezhenide reduces carbon tetrachloride-induced liver injury in mice through inhibition of oxidative stress and hepatocyte apoptosis","volume":"74","author":"Hu","year":"2022","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157276_bib0018","doi-asserted-by":"crossref","first-page":"e2637","DOI":"10.1038\/cddis.2017.62","article-title":"Endogenous AMPK acts as a detrimental factor in fulminant hepatitis via potentiating JNK-dependent hepatocyte apoptosis","volume":"8","author":"Hu","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2025.157276_bib0019","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1248\/cpb.36.2918","article-title":"Studies on the constituents of Polyporus dispansus and P. confluens","volume":"36","author":"Ishii","year":"1988","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.phymed.2025.157276_bib0020","doi-asserted-by":"crossref","first-page":"3414","DOI":"10.1016\/j.apsb.2023.05.001","article-title":"A new class of potent liver injury protective compounds: structural elucidation, total synthesis and bioactivity study","volume":"13","author":"Ji","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2025.157276_bib0021","doi-asserted-by":"crossref","first-page":"13080","DOI":"10.1021\/acs.jafc.1c05213","article-title":"Erythritol improves nonalcoholic fatty liver disease by activating Nrf2 antioxidant capacity","volume":"69","author":"Jin","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2025.157276_bib0022","doi-asserted-by":"crossref","first-page":"9909","DOI":"10.1038\/s41598-023-35228-y","article-title":"Amelioration of CCl4-induced oxidative stress and hepatotoxicity by ganoderma lucidum in Long Evans rats","volume":"13","author":"Johra","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2025.157276_bib0023","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242317033","article-title":"Forsythiaside A activates AMP-activated protein kinase and regulates oxidative stress via Nrf2 signaling","volume":"24","author":"Kim","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.157276_bib0024","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.3390\/nu15133006","article-title":"Dihydro-resveratrol attenuates oxidative stress, adipogenesis and insulin resistance in in vitro models and high-fat diet-induced mouse model via AMPK activation","volume":"15","author":"Lam","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2025.157276_bib0025","doi-asserted-by":"crossref","first-page":"6900","DOI":"10.3390\/ijms24086900","article-title":"Kaempferol suppresses carbon tetrachloride-induced liver damage in rats via the MAPKs\/NF-\u03baB and AMPK\/Nrf2 signaling pathways","volume":"24","author":"Lee","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.157276_bib0026","doi-asserted-by":"crossref","first-page":"3938","DOI":"10.3390\/nu14193938","article-title":"Ginsenosides restore lipid and redox homeostasis in mice with intrahepatic cholestasis through SIRT1\/AMPK pathways","volume":"14","author":"Li","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2025.157276_bib0027","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.phytol.2023.09.011","article-title":"Five new chemical constituents from the mushroom Albatrellus dispansus","volume":"58","author":"Li","year":"2023","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.phymed.2025.157276_bib0028","doi-asserted-by":"crossref","first-page":"4450","DOI":"10.1007\/s12035-023-03364-1","article-title":"Neuroprotective effects of oxymatrine via triggering autophagy and inhibiting apoptosis following spinal cord injury in rats","volume":"60","author":"Li","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2025.157276_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115113","article-title":"Kaempferol attenuates nonalcoholic fatty liver disease in type 2 diabetic mice via the Sirt1\/AMPK signaling pathway","volume":"165","author":"Li","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2025.157276_bib0030","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1039\/C7FO00355B","article-title":"The hepatoprotective effect of the probiotic clostridium butyricum against carbon tetrachloride-induced acute liver damage in mice","volume":"8","author":"Liu","year":"2017","journal-title":"Food. Funct."},{"key":"10.1016\/j.phymed.2025.157276_bib0031","first-page":"755","article-title":"Breviscapine ameliorates CCl4induced liver injury in mice through inhibiting inflammatory apoptotic response and ROS generation","volume":"42","author":"Liu","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.phymed.2025.157276_bib0032","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1021\/acs.molpharmaceut.6b00562","article-title":"Nrf2 knockdown disrupts the protective effect of curcumin on alcohol-induced hepatocyte necroptosis","volume":"13","author":"Lu","year":"2016","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.phymed.2025.157276_bib0033","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1053\/j.gastro.2014.07.018","article-title":"Cell death and cell death responses in liver disease: mechanisms and clinical relevance","volume":"147","author":"Luedde","year":"2014","journal-title":"Gastroenterol"},{"key":"10.1016\/j.phymed.2025.157276_bib0034","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.apsb.2020.11.006","article-title":"S-Allylmercaptocysteine improves alcoholic liver disease partly through a direct modulation of insulin receptor signaling","volume":"11","author":"Luo","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2025.157276_bib0035","doi-asserted-by":"crossref","first-page":"68708","DOI":"10.18632\/oncotarget.11929","article-title":"Grifolin inhibits tumor cells adhesion and migration via suppressing interplay between PGC1\u03b1 and Fra-1\/LSF-MMP2\/CD44 axes","volume":"7","author":"Luo","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.phymed.2025.157276_bib0036","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1186\/s12944-024-02382-9","article-title":"Ergothioneine ameliorates metabolic dysfunction-associated steatotic liver disease (MASLD) by enhancing autophagy, inhibiting oxidative damage and inflammation","volume":"23","author":"Lv","year":"2024","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.phymed.2025.157276_bib0037","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0955-2863(03)00003-2","article-title":"Vitamin E supplementation in the mitigation of carbon tetrachloride induced oxidative stress in rats","volume":"14","author":"MacDonald-Wicks","year":"2003","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.phymed.2025.157276_bib0038","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/jat.2550150111","article-title":"Protective effect of colchicine on acute liver damage induced by CCl4. Role of cytochrome p-450","volume":"15","author":"Mart\u00ednez","year":"1995","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.phymed.2025.157276_bib0039","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1021\/acs.jnatprod.0c01329","article-title":"Inhibition of BACE1 and amyloid-\u03b2 aggregation by meroterpenoids from the mushroom Albatrellus yasudae","volume":"84","author":"Masuda","year":"2021","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phymed.2025.157276_bib0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911407","article-title":"Hepatoprotective Effects of a natural flavanol 3,3\u2032-diindolylmethane against CCl4-induced chronic liver injury in mice and TGF\u03b21-Induced EMT in mouse hepatocytes via activation of Nrf2 cascade","volume":"23","author":"Munakarmi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.157276_bib0041","doi-asserted-by":"crossref","first-page":"13291","DOI":"10.1074\/jbc.R900010200","article-title":"The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress","volume":"284","author":"Nguyen","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2025.157276_bib0042","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0031-9422(02)00050-X","article-title":"Neogrifolin derivatives possessing anti-oxidative activity from the mushroom Albatrellus ovinus","volume":"59","author":"Nukata","year":"2002","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phymed.2025.157276_bib0043","doi-asserted-by":"crossref","first-page":"4068","DOI":"10.1039\/C5GC00403A","article-title":"Iodine catalyzed cross-dehydrogenative C\u2013S coupling by C (sp2)\u2013H bond activation: direct access to aryl sulfides from aryl thiols","volume":"17","author":"Parumala","year":"2015","journal-title":"Green Chem."},{"key":"10.1016\/j.phymed.2025.157276_bib0044","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1021\/acs.jnatprod.5b00942","article-title":"Pelianthinarubins A and B, red pyrroloquinoline alkaloids from the fruiting bodies of the mushroom Mycena pelianthina","volume":"79","author":"Pulte","year":"2016","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phymed.2025.157276_bib0045","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/763257","article-title":"Role of the Nrf2-ARE pathway in liver diseases","volume":"2013","author":"Shin","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phymed.2025.157276_bib0046","doi-asserted-by":"crossref","first-page":"11686","DOI":"10.1039\/D1FO02657G","article-title":"Piperine inhibits AML-12 hepatocyte EMT and LX-2 HSC activation and alleviates mouse liver fibrosis provoked by CCl4: roles in the activation of the Nrf2 cascade and subsequent suppression of the TGF-\u03b21\/Smad axis","volume":"12","author":"Shu","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2025.157276_bib0047","doi-asserted-by":"crossref","first-page":"10591","DOI":"10.1039\/D3FO03643J","article-title":"Ergothioneine suppresses hepatic stellate cell activation via promoting Foxa3-dependent potentiation of the Hint1\/Smad7 cascade and improves CCl4-induced liver fibrosis in mice","volume":"14","author":"Shu","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2025.157276_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175964","article-title":"Theaflavine inhibits hepatic stellate cell activation through modulating PKA\/LKB1\/AMPK\/GSK3\u03b2 cascade and subsequent enhancement of Nrf2 signaling","volume":"956","author":"Shu","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157276_bib0049","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41419-023-05896-9","article-title":"TRIB1 regulates liver regeneration by antagonizing the NRF2-mediated antioxidant response","volume":"14","author":"Sun","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2025.157276_bib0050","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.jhep.2009.02.023","article-title":"Silybin, a component of sylimarin, exerts anti-inflammatory and anti-fibrogenic effects on human hepatic stellate cells","volume":"50","author":"Trappoliere","year":"2009","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2025.157276_bib0051","doi-asserted-by":"crossref","first-page":"104","DOI":"10.11646\/phytotaxa.317.2.2","article-title":"First record of Albatrellus (Russulales, Albatrellaceae) from Thailand","volume":"317","author":"Vadthanarat","year":"2017","journal-title":"Phytotaxa"},{"key":"10.1016\/j.phymed.2025.157276_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155124","article-title":"Wedelolactone alleviates cholestatic liver injury by regulating FXR-bile acid-NF-\u03baB\/NRF2 axis to reduce bile acid accumulation and its subsequent inflammation and oxidative stress","volume":"122","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157276_bib0053","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/s42255-021-00366-y","article-title":"Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation","volume":"3","author":"Weng","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.phymed.2025.157276_bib0054","article-title":"Co-treatment with resveratrol and FGF1 protects against acute liver toxicity after doxorubicin treatment via the AMPK\/NRF2 pathway","volume":"13","author":"Xu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157276_bib0055","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.3748\/wjg.v12.i9.1379","article-title":"In vitro and in vivo protective effects of proteoglycan isolated from mycelia of ganoderma lucidum on carbon tetrachloride-induced liver injury","volume":"12","author":"Yang","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phymed.2025.157276_bib0056","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.phrs.2018.03.017","article-title":"Dioscin alleviates non-alcoholic fatty liver disease through adjusting lipid metabolism via SIRT1\/AMPK signaling pathway","volume":"131","author":"Yao","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2025.157276_bib0057","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41420-021-00579-w","article-title":"Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases","volume":"7","author":"Yu","year":"2021","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.phymed.2025.157276_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2019.05.041","article-title":"Transcriptomic analyses reveal the molecular mechanisms of schisandrin B alleviates CCl4-induced liver fibrosis in rats by RNA-sequencing","volume":"309","author":"Zhang","year":"2019","journal-title":"Chem.-Biol. Interact."},{"key":"10.1016\/j.phymed.2025.157276_bib0059","doi-asserted-by":"crossref","first-page":"10158","DOI":"10.1021\/acs.joc.8b01420","article-title":"Heterocyclic compounds from the mushroom Albatrellus confluens and their inhibitions against lipopolysaccharides-induced B lymphocyte cell proliferation","volume":"83","author":"Zhang","year":"2018","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.phymed.2025.157276_bib0060","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1016\/j.tetlet.2018.07.033","article-title":"Confluenines A\u2013F, N-oxidized l-isoleucine derivatives from the edible mushroom Albatrellus confluens","volume":"59","author":"Zhang","year":"2018","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.phymed.2025.157276_bib0061","article-title":"Water extract of earthworms mitigates mouse liver fibrosis by potentiating hepatic LKB1\/Nrf2 axis to inhibit HSC activation and hepatocyte death","volume":"321","author":"Zhang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157276_bib0062","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.781856","article-title":"Protective effects and mechanisms of polyethylene glycol loxenatide against hyperglycemia and liver injury in db\/db diabetic mice","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157276_bib0063","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111307","article-title":"RNA-Seq analysis of the protection by dendrobium nobile alkaloids against carbon tetrachloride hepatotoxicity in mice","volume":"137","author":"Zhang","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2025.157276_bib0064","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/s41420-022-01173-4","article-title":"Regulating Nrf2-GPx4 axis by bicyclol can prevent ferroptosis in carbon tetrachloride-induced acute liver injury in mice","volume":"8","author":"Zhao","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2025.157276_bib0065","first-page":"870","article-title":"The roles played by crucial free radicals like lipid free radicals, nitric oxide, and enzymes NOS and NADPH in CCl4-induced acute liver injury of mice. Free Radic","volume":"29","author":"Zhu","year":"2000","journal-title":"Biol. Med."},{"key":"10.1016\/j.phymed.2025.157276_bib0066","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2023.113585","article-title":"Identification of antioxidant peptides targeting Keap1\u2212Nrf2\u2212ARE pathway from in vitro digestion of pork sausage with partial substitution of NaCl by KCl","volume":"174","author":"Zou","year":"2023","journal-title":"Food Res. Int."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325009158?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325009158?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T22:23:24Z","timestamp":1769811804000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325009158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":66,"alternative-id":["S0944711325009158"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157276","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Grifolin-4-l-ergothioneine from Albatrellus dispansus ameliorates CCl4-induced liver injury via activating SIRT1\/AMPK\/NRF2 signaling in hepatocytes","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157276","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157276"}}