{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T21:10:36Z","timestamp":1780434636459,"version":"3.54.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFD1801000"],"award-info":[{"award-number":["2021YFD1801000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20242"],"award-info":[{"award-number":["U23A20242"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010211","name":"Education Department of Jilin Province","doi-asserted-by":"publisher","award":["JJKH20250160BS"],"award-info":[{"award-number":["JJKH20250160BS"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004032","name":"Jilin University","doi-asserted-by":"publisher","award":["2024KC168"],"award-info":[{"award-number":["2024KC168"]}],"id":[{"id":"10.13039\/501100004032","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.phymed.2025.157278","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:04:24Z","timestamp":1758585864000},"page":"157278","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Daphnetin as a novel polyphosphate kinase inhibitor to combat Salmonella infection"],"prefix":"10.1016","volume":"148","author":[{"given":"Shufang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfa","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazhang","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuming","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8311-0894","authenticated-orcid":false,"given":"Jianfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.157278_bib0001","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1475-2859-10-63","article-title":"Polyphosphate\u2013an ancient energy source and active metabolic regulator","volume":"10","author":"ACHBERGEROVA","year":"2011","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.phymed.2025.157278_bib0002","first-page":"17","article-title":"Global research landscape on two coumarin derivatives: a scientometric study of trends and innovations from 1990 to 2022","author":"ADETUNJI","year":"2024","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.phymed.2025.157278_bib0003","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002558","article-title":"Polyphosphate kinase regulates LPS structure and polymyxin resistance during starvation in E. coli","volume":"22","author":"BAIJAL","year":"2024","journal-title":"PLoS Biol."},{"key":"10.1016\/j.phymed.2025.157278_bib0004","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2309664121","article-title":"Polyphosphate kinase-1 regulates bacterial and host metabolic pathways involved in pathogenesis of mycobacterium tuberculosis","volume":"121","author":"CHUGH","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.phymed.2025.157278_bib0005","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1038\/s41467-023-38902-x","article-title":"A global genomic analysis of salmonella concord reveals lineages with high antimicrobial resistance in Ethiopia","volume":"14","author":"CUYPERS","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2025.157278_bib0006","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00294-020-01148-x","article-title":"Model systems for studying polyphosphate biology: a focus on microorganisms","volume":"67","author":"DENONCOURT","year":"2021","journal-title":"Curr. Genet."},{"key":"10.1016\/j.phymed.2025.157278_bib0007","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1098\/rstb.2009.0179","article-title":"Evolution of acidocalcisomes and their role in polyphosphate storage and osmoregulation in eukaryotic microbes","volume":"365","author":"DOCAMPO","year":"2010","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.phymed.2025.157278_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.coi.2023.102306","article-title":"Determinants of persistent salmonella infections","volume":"82","author":"EHRHARDT","year":"2023","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.phymed.2025.157278_bib0009","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.1016\/j.jmb.2018.07.026","article-title":"Functional amyloid and other protein fibers in the biofilm matrix","volume":"430","author":"ERSKINE","year":"2018","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.phymed.2025.157278_bib0010","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1093\/cid\/ciac035","article-title":"Invasive non-typhoidal salmonella (iNTS) infections","volume":"75","author":"FIERER","year":"2022","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.phymed.2025.157278_bib0011","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.molcel.2014.01.012","article-title":"Polyphosphate is a primordial chaperone","volume":"53","author":"GRAY","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.phymed.2025.157278_bib0012","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3389\/fimmu.2014.00481","article-title":"Salmonella-host interactions - modulation of the host innate immune system","volume":"5","author":"HURLEY","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2025.157278_bib0013","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.993562","article-title":"Daphnetin: a bioactive natural coumarin with diverse therapeutic potentials","volume":"13","author":"JAVED","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157278_bib0014","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3389\/fcimb.2017.00335","article-title":"What the SIF is happening-the role of intracellular salmonella-induced filaments","volume":"7","author":"KNUFF","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.phymed.2025.157278_bib0015","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s44280-023-00001-3","article-title":"Antimicrobial resistance profiles of salmonella isolates from human diarrhea cases in China: an eight-year surveilance study","volume":"1","author":"LI","year":"2023","journal-title":"One Health Adv."},{"key":"10.1016\/j.phymed.2025.157278_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2024.128013","article-title":"Salmonella: infection mechanism and control strategies","volume":"292","author":"LU","year":"2025","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.phymed.2025.157278_bib0017","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12879-025-10478-5","article-title":"Combatting salmonella: a focus on antimicrobial resistance and the need for effective vaccination","volume":"25","author":"NAZIR","year":"2025","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.phymed.2025.157278_bib0018","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00592-21","article-title":"A dual-specificity inhibitor targets polyphosphate kinase 1 and 2 enzymes to attenuate virulence of pseudomonas aeruginosa","volume":"12","author":"NEVILLE","year":"2021","journal-title":"mBio"},{"key":"10.1016\/j.phymed.2025.157278_bib0019","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1021\/jf048693g","article-title":"Interaction of flavonoids with bovine serum albumin: a fluorescence quenching study","volume":"53","author":"PAPADOPOULOU","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2025.157278_bib0020","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1128\/JB.187.9.3088-3099.2005","article-title":"Polyphosphate kinase protects salmonella enterica from weak organic acid stress","volume":"187","author":"PRICE-CARTER","year":"2005","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.phymed.2025.157278_bib0021","first-page":"12","article-title":"The antimicrobial peptide octopromycin suppresses biofilm formation and quorum sensing in acinetobacter baumannii","author":"RAJAPAKSHA","year":"2023","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.phymed.2025.157278_bib0022","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1128\/JB.182.1.225-227.2000","article-title":"Inorganic polyphosphate is required for motility of bacterial pathogens","volume":"182","author":"RASHID","year":"2000","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.phymed.2025.157278_bib0023","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.764733","article-title":"Broad-spectrum inhibitor of bacterial polyphosphate homeostasis attenuates virulence factors and helps reveal novel physiology of klebsiella pneumoniae and acinetobacter baumannii","volume":"12","author":"ROBERGE","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.phymed.2025.157278_bib0024","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1038\/s41467-020-17639-x","article-title":"Bacterial polyphosphates interfere with the innate host defense to infection","volume":"11","author":"ROEWE","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2025.157278_bib0025","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1128\/JB.00038-13","article-title":"Polyphosphate deficiency in mycobacterium tuberculosis is associated with enhanced drug susceptibility and impaired growth in guinea pigs","volume":"195","author":"SINGH","year":"2013","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.phymed.2025.157278_bib0026","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.01195-20","article-title":"The polyphosphate kinase of Escherichia coli is required for full production of the genotoxin colibactin","volume":"5","author":"TANG-FICHAUX","year":"2020","journal-title":"mSphere"},{"key":"10.1016\/j.phymed.2025.157278_bib0027","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fcimb.2018.00008","article-title":"Inorganic polyphosphate is essential for Salmonella typhimurium virulence and survival in dictyostelium discoideum","volume":"8","author":"VARAS","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.phymed.2025.157278_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156357","article-title":"Effect of daphnetin, the coumarin derivative isolated from daphne genus, on helicobacter pylori adhesion to gastric epithelial cells","volume":"137","author":"WANG","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157278_bib0029","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.cell.2008.09.024","article-title":"Bleach activates a redox-regulated chaperone by oxidative protein unfolding","volume":"135","author":"WINTER","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2025.157278_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinf.2025.106421","article-title":"An MDR Salmonella enteritidis sublineage associated with gastroenteritis outbreaks and invasive disease in China","volume":"90","author":"ZHENG","year":"2025","journal-title":"J. Infect."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325009171?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325009171?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T07:40:01Z","timestamp":1773128401000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325009171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":30,"alternative-id":["S0944711325009171"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157278","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Daphnetin as a novel polyphosphate kinase inhibitor to combat Salmonella infection","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157278","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157278"}}