{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:58:36Z","timestamp":1793318316834,"version":"4.5.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009108","name":"Shandong University","doi-asserted-by":"publisher","award":["6010122050"],"award-info":[{"award-number":["6010122050"]}],"id":[{"id":"10.13039\/100009108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["2022QE275"],"award-info":[{"award-number":["2022QE275"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.phymed.2025.157292","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:10:00Z","timestamp":1758586200000},"page":"157292","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Gut microbiota metabolite Urolithin B inhibits chondrocyte ferroptosis by rewriting iron homeostasis via FGFR3\/NCOA4\/FTH1 axis, alleviating osteoarthritis"],"prefix":"10.1016","volume":"148","author":[{"given":"Yanlin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanwen","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangle","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangzhen","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunbo","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anhao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0846-2886","authenticated-orcid":false,"given":"Qingjia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.157292_bib0001","doi-asserted-by":"crossref","first-page":"10181","DOI":"10.1021\/jf9025794","article-title":"Urolithins, intestinal microbial metabolites of pomegranate ellagitannins, exhibit potent antioxidant activity in a cell-based assay","volume":"57","author":"Bialonska","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2025.157292_bib0002","doi-asserted-by":"crossref","first-page":"4784","DOI":"10.1016\/j.cell.2021.07.038","article-title":"Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations","volume":"184","author":"Boer","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2025.157292_bib0003","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1101\/gad.277137.115","article-title":"Genetic insights into the mechanisms of Fgf signaling","volume":"30","author":"Brewer","year":"2016","journal-title":"Genes Dev."},{"key":"10.1016\/j.phymed.2025.157292_bib0004","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/S0140-6736(11)60752-6","article-title":"Knee replacement","volume":"379","author":"Carr","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2025.157292_bib0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006260","article-title":"Novel genetic variants for cartilage thickness and hip osteoarthritis","volume":"12","author":"Casta\u00f1o-Betancourt","year":"2016","journal-title":"PLoS. Genet."},{"key":"10.1016\/j.phymed.2025.157292_bib0006","first-page":"10","article-title":"Whole exome sequencing with comprehensive gene set analysis identified a biparental-origin homozygous c.509G>A mutation in PPIB gene clustered in two Taiwanese families exhibiting fetal skeletal dysplasia during prenatal ultrasound","author":"Chang","year":"2020","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.phymed.2025.157292_bib0007","doi-asserted-by":"crossref","first-page":"eadf0988","DOI":"10.1126\/sciadv.adf0988","article-title":"Urchin-like ceria nanoparticles for enhanced gene therapy of osteoarthritis","volume":"9","author":"Chen","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.phymed.2025.157292_bib0008","article-title":"The gut microbiota metabolite urolithin B improves cognitive deficits by inhibiting cyt C-mediated apoptosis and promoting the survival of neurons through the PI3K pathway in aging mice","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157292_bib0009","article-title":"Recent advances and perspectives on the health benefits of Urolithin B, A bioactive natural product derived from Ellagitannins","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157292_bib0010","doi-asserted-by":"crossref","first-page":"7518","DOI":"10.1039\/D4FO02545H","article-title":"Urolithin B protects mice from diet-induced obesity, insulin resistance, and intestinal inflammation by regulating gut microbiota composition","volume":"15","author":"Chen","year":"2024","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2025.157292_bib0011","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","article-title":"Broadening horizons: the role of ferroptosis in cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.phymed.2025.157292_bib0012","doi-asserted-by":"crossref","first-page":"20509","DOI":"10.1074\/jbc.M410148200","article-title":"Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis","volume":"280","author":"Davidson","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2025.157292_bib0013","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2025.157292_bib0014","doi-asserted-by":"crossref","first-page":"10476","DOI":"10.1021\/jf0723864","article-title":"Iberian pig as a model to clarify obscure points in the bioavailability and metabolism of ellagitannins in humans","volume":"55","author":"Esp\u00edn","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2025.157292_bib0015","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41569-022-00735-4","article-title":"The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease","volume":"20","author":"Fang","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.phymed.2025.157292_bib0016","doi-asserted-by":"crossref","first-page":"5480","DOI":"10.1021\/acs.jafc.7b02049","article-title":"Gastrointestinal simulation model TWIN-SHIME shows differences between Human urolithin-metabotypes in gut microbiota composition, pomegranate polyphenol metabolism, and transport along the intestinal tract","volume":"65","author":"Garc\u00eda-Villalba","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2025.157292_bib0017","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","article-title":"Osteoarthritis","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"The Lancet"},{"key":"10.1016\/j.phymed.2025.157292_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109075","article-title":"The challenges of treating osteoarthritis pain and opportunities for novel peripherally directed therapeutic strategies","volume":"213","author":"Gon\u00e7alves","year":"2022","journal-title":"Neuropharmacology."},{"key":"10.1016\/j.phymed.2025.157292_bib0019","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13807","article-title":"The gut microbiota metabolite capsiate regulate SLC2A1 expression by targeting HIF-1\u03b1 to inhibit knee osteoarthritis-induced ferroptosis","volume":"22","author":"Guan","year":"2023","journal-title":"Aging Cell"},{"key":"10.1016\/j.phymed.2025.157292_bib0020","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1042\/bj2450415","article-title":"Bleomycin-detectable iron in knee-joint synovial fluid from arthritic patients and its relationship to the extracellular antioxidant activities of caeruloplasmin, transferrin and lactoferrin","volume":"245","author":"Gutteridge","year":"1987","journal-title":"Biochem. J."},{"key":"10.1016\/j.phymed.2025.157292_bib0021","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0140-6736(07)61090-3","article-title":"Achondroplasia","volume":"370","author":"Horton","year":"2007","journal-title":"The Lancet"},{"key":"10.1016\/j.phymed.2025.157292_bib0022","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1136\/annrheumdis-2019-216243","article-title":"Economic burden of rheumatoid arthritis: a systematic review of literature in biologic era","volume":"79","author":"Hsieh","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.phymed.2025.157292_bib0023","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1093\/jbmr\/zjae094","article-title":"Mechanical and structural properties of articular cartilage and subchondral bone in human osteoarthritic knees","volume":"39","author":"Hu","year":"2024","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.phymed.2025.157292_bib0024","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.joca.2018.02.906","article-title":"Osteoarthritis and stem cell therapy in humans: a systematic review","volume":"26","author":"Jevotovsky","year":"2018","journal-title":"OsteoArthritis Cartilage"},{"key":"10.1016\/j.phymed.2025.157292_bib0025","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2025.157292_bib0026","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1001\/jama.2020.22171","article-title":"Diagnosis and treatment of hip and knee osteoarthritis: a review","volume":"325","author":"Katz","year":"2021","journal-title":"JAMa"},{"key":"10.1016\/j.phymed.2025.157292_bib0027","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/art.41142","article-title":"2019 American College of Rheumatology\/Arthritis Foundation Guideline for the management of osteoarthritis of the hand, hip, and knee","volume":"72","author":"Kolasinski","year":"2020","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.phymed.2025.157292_bib0028","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.mrrev.2013.11.001","article-title":"The paradox of FGFR3 signaling in skeletal dysplasia: why chondrocytes growth arrest while other cells over proliferate","volume":"759","author":"Krejci","year":"2014","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"key":"10.1016\/j.phymed.2025.157292_bib0029","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bone.2010.03.021","article-title":"FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence","volume":"47","author":"Krejci","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.phymed.2025.157292_bib0030","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1136\/annrheumdis-2019-215696","article-title":"FGFR3 deficiency enhances CXCL12-dependent chemotaxis of macrophages via upregulating CXCR7 and aggravates joint destruction in mice","volume":"79","author":"Kuang","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.phymed.2025.157292_bib0031","first-page":"40","article-title":"Role of signaling pathways in age-related orthopedic diseases: focus on the fibroblast growth factor family","volume":"11","author":"Li","year":"2024","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.phymed.2025.157292_bib0032","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13621","article-title":"Ferritinophagy: a novel insight into the double-edged sword in ferritinophagy-ferroptosis axis and human diseases","volume":"57","author":"Li","year":"2024","journal-title":"Cell Prolif."},{"key":"10.1016\/j.phymed.2025.157292_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102175","article-title":"From biological aging to functional decline: insights into chronic inflammation and intrinsic capacity","volume":"93","author":"Li","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.phymed.2025.157292_bib0034","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13291","article-title":"Urolithin B suppressed osteoclast activation and reduced bone loss of osteoporosis via inhibiting ERK\/NF-\u03bab pathway","volume":"55","author":"Li","year":"2022","journal-title":"Cell Prolif."},{"key":"10.1016\/j.phymed.2025.157292_bib0035","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/bmb\/lds038","article-title":"Epidemiology and burden of osteoarthritis","volume":"105","author":"Litwic","year":"2013","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.phymed.2025.157292_bib0036","doi-asserted-by":"crossref","first-page":"7038","DOI":"10.1111\/febs.16059","article-title":"Signaling pathways and defense mechanisms of ferroptosis","volume":"289","author":"Liu","year":"2022","journal-title":"FEBS. J."},{"key":"10.1016\/j.phymed.2025.157292_bib0037","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.joca.2019.05.009","article-title":"Gut microbiota and obesity-associated osteoarthritis","volume":"27","author":"Liu","year":"2019","journal-title":"OsteoArthritis Cartilage"},{"key":"10.1016\/j.phymed.2025.157292_bib0038","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1631\/jzus.B2300409","article-title":"Endoplasmic reticulum stress-induced NLRP3 inflammasome activation as a novel mechanism of polystyrene microplastics (PS-MPs)-induced pulmonary inflammation in chickens","volume":"25","author":"Lu","year":"2024","journal-title":"J. Zhejiang. Univ. Sci. B"},{"key":"10.1016\/j.phymed.2025.157292_bib0039","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrrheum.2014.157","article-title":"Repair and tissue engineering techniques for articular cartilage","volume":"11","author":"Makris","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.phymed.2025.157292_bib0040","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1093\/procel\/pwae003","article-title":"Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond","volume":"15","author":"Mao","year":"2024","journal-title":"Protein Cell"},{"key":"10.1016\/j.phymed.2025.157292_bib0041","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1080\/10717544.2021.1971798","article-title":"Targeted treatment for osteoarthritis: drugs and delivery system","volume":"28","author":"Mao","year":"2021","journal-title":"Drug Deliv."},{"key":"10.1016\/j.phymed.2025.157292_bib0042","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.redox.2017.08.015","article-title":"Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis","volume":"14","author":"Masaldan","year":"2018","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2025.157292_bib0043","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3109\/03008207.2015.1051224","article-title":"FGFR3 biology and skeletal disease","volume":"56","author":"Narayana","year":"2015","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.phymed.2025.157292_bib0044","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.1242\/dev.125.24.4977","article-title":"Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3","volume":"125","author":"Naski","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.phymed.2025.157292_bib0045","first-page":"221","article-title":"NCOA4 drives ferritin phase separation to facilitate macroferritinophagy and microferritinophagy","author":"Ohshima","year":"2022","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.phymed.2025.157292_bib0046","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/dvdy.24479","article-title":"Achondroplasia: development, pathogenesis, and therapy","volume":"246","author":"Ornitz","year":"2017","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.phymed.2025.157292_bib0047","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1101\/gad.990702","article-title":"FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease","volume":"16","author":"Ornitz","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.phymed.2025.157292_bib0048","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1101\/gad.266551.115","article-title":"Fibroblast growth factor signaling in skeletal development and disease","volume":"29","author":"Ornitz","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.phymed.2025.157292_bib0049","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.joca.2021.10.003","article-title":"Osteoarthritis year in review 2021: epidemiology & therapy","volume":"30","author":"Quicke","year":"2022","journal-title":"OsteoArthritis Cartilage"},{"key":"10.1016\/j.phymed.2025.157292_bib0050","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1136\/annrheumdis-2019-216515","article-title":"Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017","volume":"79","author":"Safiri","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.phymed.2025.157292_bib0051","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1210\/en.2011-1756","article-title":"Interleukin-1\u03b2 promotes proliferation and inhibits differentiation of chondrocytes through a mechanism involving down-regulation of FGFR-3 and p21","volume":"153","author":"Simsa-Maziel","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.phymed.2025.157292_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2020.104590","article-title":"Effect of fibroblast growth factor 2 on degenerative endplate chondrocyte: from anabolism to catabolism","volume":"118","author":"Song","year":"2021","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.phymed.2025.157292_bib0053","doi-asserted-by":"crossref","first-page":"e508","DOI":"10.1016\/S2665-9913(23)00163-7","article-title":"Global, regional, and national burden of osteoarthritis, 1990\u20132020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021","volume":"5","author":"Steinmetz","year":"2023","journal-title":"The Lancet Rheumatol."},{"key":"10.1016\/j.phymed.2025.157292_bib0054","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.phymed.2025.157292_bib0055","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1002\/art.39739","article-title":"Fibroblast growth factor receptor 3 inhibits osteoarthritis progression in the knee joints of adult mice","volume":"68","author":"Tang","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.phymed.2025.157292_bib0056","doi-asserted-by":"crossref","first-page":"9179","DOI":"10.1002\/jcp.26954","article-title":"Ferritinophagy\/ferroptosis: iron-related newcomers in human diseases","volume":"233","author":"Tang","year":"2018","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.phymed.2025.157292_bib0057","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41413-022-00226-9","article-title":"Current understanding of osteoarthritis pathogenesis and relevant new approaches","volume":"10","author":"Tong","year":"2022","journal-title":"Bone Res."},{"key":"10.1016\/j.phymed.2025.157292_bib0058","article-title":"Unveiling the interplay of MAPK\/NF-\u03bab\/MLKL axis in brain health: omega-3 as a promising candidates against copper neurotoxicity","volume":"370","author":"Wang","year":"2024","journal-title":"J. Environ. Manage"},{"key":"10.1016\/j.phymed.2025.157292_bib0059","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113572","article-title":"Dexmedetomidine attenuates myocardial ischemia\/reperfusion-induced ferroptosis via AMPK\/GSK-3\u03b2\/Nrf2 axis","volume":"154","author":"Wang","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.phymed.2025.157292_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104892","article-title":"Association between gut microbiome-related metabolites and symptomatic hand osteoarthritis in two independent cohorts","volume":"98","author":"Wei","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.phymed.2025.157292_bib0061","doi-asserted-by":"crossref","first-page":"24912","DOI":"10.1074\/jbc.M116.730093","article-title":"Chondrocyte FGFR3 regulates bone mass by inhibiting osteogenesis","volume":"291","author":"Wen","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2025.157292_bib0062","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1080\/15548627.2023.2170960","article-title":"ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4","volume":"19","author":"Wu","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2025.157292_bib0063","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00223-014-9917-9","article-title":"Osteoarthritis pathogenesis: a review of molecular mechanisms","volume":"95","author":"Xia","year":"2014","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.phymed.2025.157292_bib0064","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00204-023-03660-8","article-title":"Ferroptosis regulation through Nrf2 and implications for neurodegenerative diseases","volume":"98","author":"Xiang","year":"2024","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.phymed.2025.157292_bib0065","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1080\/13548506.2021.1971725","article-title":"Health-related quality of life in osteoarthritis patients: a systematic review and meta-analysis","volume":"27","author":"Yan","year":"2022","journal-title":"Psychol. Health Med."},{"key":"10.1016\/j.phymed.2025.157292_bib0066","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41392-020-00428-9","article-title":"Ferroptosis: mechanisms and links with diseases","volume":"6","author":"Yan","year":"2021","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2025.157292_bib0067","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jot.2020.09.006","article-title":"Chondrocyte ferroptosis contribute to the progression of osteoarthritis","volume":"27","author":"Yao","year":"2021","journal-title":"J. Orthop. Translat."},{"key":"10.1016\/j.phymed.2025.157292_bib0068","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2023.105761","article-title":"Assessing and mitigating foodborne acetochlor exposure induced ileum toxicity in broiler chicks: the role of omega-3 polyunsaturated fatty acids supplementation and molecular pathways analysis","volume":"199","author":"Zhang","year":"2024","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.phymed.2025.157292_bib0069","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104655","article-title":"Urolithin B, a gut microbiota metabolite, protects against myocardial ischemia\/reperfusion injury via p62\/Keap1\/Nrf2 signaling pathway","volume":"153","author":"Zheng","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2025.157292_bib0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101249","article-title":"The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis","volume":"66","author":"Zheng","year":"2021","journal-title":"Ageing Res. Rev."}],"updated-by":[{"DOI":"10.1016\/j.phymed.2026.158449","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000}}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325009316?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325009316?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:48:38Z","timestamp":1782852518000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325009316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":70,"alternative-id":["S0944711325009316"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157292","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gut microbiota metabolite Urolithin B inhibits chondrocyte ferroptosis by rewriting iron homeostasis via FGFR3\/NCOA4\/FTH1 axis, alleviating osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157292","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157292"}}