{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:51:48Z","timestamp":1790211108894,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2024YFC2510900"],"award-info":[{"award-number":["2024YFC2510900"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32300700"],"award-info":[{"award-number":["32300700"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.phymed.2025.157300","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T09:35:38Z","timestamp":1758620138000},"page":"157300","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Luteolin attenuates experimental dry eye disease via dual modulation of macrophage JAK-STAT signaling and corneal epithelial MAPK pathways"],"prefix":"10.1016","volume":"148","author":[{"given":"Zhirui","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqiao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyu","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoguo","family":"Zhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baojie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9217-5120","authenticated-orcid":false,"given":"Qian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.157300_bib0001","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.753279","article-title":"Luteolin modulates neural stem cells fate determination: in vitro study on human neural stem cells, and in vivo study on lps-induced depression mice model","volume":"9","author":"Achour","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.phymed.2025.157300_bib0002","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.701415","article-title":"Desiccation induced conjunctival monocyte recruitment and activation - implications for keratoconjunctivitis","volume":"12","author":"Alam","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2025.157300_bib0003","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1362336","article-title":"Single cell analysis of short-term dry eye induced changes in cornea immune cell populations","volume":"11","author":"Alam","year":"2024","journal-title":"Front. Med."},{"key":"10.1016\/j.phymed.2025.157300_bib0004","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s40265-017-0701-9","article-title":"JAK-STAT signaling as a target for inflammatory and autoimmune diseases: current and future prospects","volume":"77","author":"Banerjee","year":"2017","journal-title":"Drugs"},{"key":"10.1016\/j.phymed.2025.157300_bib0005","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jtos.2017.05.011","article-title":"TFOS DEWS II pathophysiology report","volume":"15","author":"Bron","year":"2017","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.phymed.2025.157300_bib0006","first-page":"311","article-title":"Zishen Huoxue decoction (ZSHX) alleviates ischemic myocardial injury (MI) via Sirt5-beta-tubulin mediated synergistic mechanism of \"mitophagy-unfolded protein response\" and mitophagy","volume":"23","author":"Chang","year":"2025","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.phymed.2025.157300_bib0007","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1002\/ptr.70008","article-title":"Potential candidates of natural antioxidants from herbs for treating lung disorders: focus on redox balance and natural products","volume":"39","author":"Chang","year":"2025","journal-title":"PhytOther Res."},{"key":"10.1016\/j.phymed.2025.157300_bib0008","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.1182\/blood.2020009023","article-title":"A JAK\/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML","volume":"137","author":"Chen","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.phymed.2025.157300_bib0009","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.taap.2018.12.019","article-title":"Myricetin inhibits NLRP3 inflammasome activation via reduction of ROS-dependent ubiquitination of ASC and promotion of ROS-independent NLRP3 ubiquitination","volume":"365","author":"Chen","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157300_bib0010","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1056\/NEJMra1407936","article-title":"Dry Eye","volume":"378","author":"Clayton","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phymed.2025.157300_bib0011","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.jtos.2017.08.003","article-title":"TFOS DEWS II report executive summary","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.phymed.2025.157300_bib0012","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/biof.1710","article-title":"Luteolin, inflammation and cancer: special emphasis on gut microbiota","volume":"47","author":"Franza","year":"2021","journal-title":"Biofactors"},{"key":"10.1016\/j.phymed.2025.157300_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155081","article-title":"Berberine ameliorate inflammation and apoptosis via modulating PI3K\/AKT\/NFkappaB and MAPK pathway on dry eye","volume":"121","author":"Han","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157300_bib0014","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1080\/14786419.2018.1460834","article-title":"A new flavonol glycoside and other flavonoids from the aerial parts of Taverniera aegyptiaca","volume":"33","author":"Hassan","year":"2019","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.phymed.2025.157300_bib0015","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23482","article-title":"From nature to therapy: luteolin's potential as an immune system modulator in inflammatory disorders","volume":"37","author":"Hussain","year":"2023","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.phymed.2025.157300_bib0016","article-title":"TFOS DEWS III management and therapy report","author":"Jones","year":"2025","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.phymed.2025.157300_bib0017","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jtos.2017.05.006","article-title":"TFOS DEWS II management and therapy report","volume":"15","author":"Jones","year":"2017","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.phymed.2025.157300_bib0018","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/biof.1687","article-title":"Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma","volume":"47","author":"Kempuraj","year":"2021","journal-title":"Biofactors"},{"key":"10.1016\/j.phymed.2025.157300_bib0019","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40662-023-00334-5","article-title":"Anti-inflammatory and antioxidative effects of gallic acid on experimental dry eye: in vitro and in vivo studies","volume":"10","author":"Li","year":"2023","journal-title":"Eye Vis."},{"key":"10.1016\/j.phymed.2025.157300_bib0020","first-page":"257","article-title":"A mouse dry eye model induced by topical administration of benzalkonium chloride","volume":"17","author":"Lin","year":"2011","journal-title":"Mol. Vis."},{"key":"10.1016\/j.phymed.2025.157300_bib0021","doi-asserted-by":"crossref","first-page":"25377","DOI":"10.1021\/acsnano.3c08869","article-title":"Multifunctional hydrogel eye drops for synergistic treatment of ocular inflammatory disease","volume":"17","author":"Liu","year":"2023","journal-title":"ACS. Nano"},{"key":"10.1016\/j.phymed.2025.157300_bib0022","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.mucimm.2023.11.008","article-title":"Single-cell landscape reveals the epithelial cell-centric pro-inflammatory immune microenvironment in dry eye development","volume":"17","author":"Liu","year":"2024","journal-title":"Mucosal. Immunol."},{"key":"10.1016\/j.phymed.2025.157300_bib0023","doi-asserted-by":"crossref","first-page":"692","DOI":"10.3389\/fphar.2017.00692","article-title":"Luteolin: a Flavonoid that Has Multiple Cardio-Protective Effects and Its Molecular Mechanisms","volume":"8","author":"Luo","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157300_bib0024","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.4103\/IJO.IJO_2986_22","article-title":"Ocular surface immune cell diversity in dry eye disease","volume":"71","author":"Nair","year":"2023","journal-title":"Indian J. Ophthalmol."},{"key":"10.1016\/j.phymed.2025.157300_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108294","article-title":"Inflammatory basis for dry eye disease flares","volume":"201","author":"Perez","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.phymed.2025.157300_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156982","article-title":"Tanshinone IIA modulates Sirt5 and Metll3 interaction to govern mitochondria-endoplasmic reticulum unfolded protein response in coronary microvascular injury","volume":"145","author":"Pu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157300_bib0027","doi-asserted-by":"crossref","first-page":"3776","DOI":"10.1167\/iovs.19-26928","article-title":"Therapeutic Effects of STAT3 Inhibition on Experimental Murine Dry Eye","volume":"60","author":"Qu","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.phymed.2025.157300_bib0028","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3109\/08820538.2016.1154168","article-title":"A comprehensive review of sex disparities in symptoms, pathophysiology, and epidemiology of dry eye syndrome","volume":"31","author":"Rapoport","year":"2016","journal-title":"Semin. Ophthalmol."},{"key":"10.1016\/j.phymed.2025.157300_bib0029","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.foodchem.2018.04.039","article-title":"Phenolic compounds as beneficial phytochemicals in pomegranate (Punica granatum L.) peel: a review","volume":"261","author":"Singh","year":"2018","journal-title":"Food Chem."},{"key":"10.1016\/j.phymed.2025.157300_bib0030","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","article-title":"TFOS DEWS II epidemiology report","volume":"15","author":"Stapleton","year":"2017","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.phymed.2025.157300_bib0031","article-title":"TFOS DEWS III digest report","author":"Stapleton","year":"2025","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.phymed.2025.157300_bib0032","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1001\/archophthalmol.2011.364","article-title":"Dry eye disease: an immune-mediated ocular surface disorder","volume":"130","author":"Stevenson","year":"2012","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.phymed.2025.157300_bib0033","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.3892\/mmr.2016.5052","article-title":"Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease model","volume":"13","author":"Wang","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.phymed.2025.157300_bib0034","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12929-022-00821-2","article-title":"Interleukin-20 is involved in dry eye disease and is a potential therapeutic target","volume":"29","author":"Wang","year":"2022","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.phymed.2025.157300_bib0035","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1186\/s12951-025-03420-z","article-title":"Ligustrazine nano-drug delivery system ameliorates doxorubicin-mediated myocardial injury via piezo-type mechanosensitive ion channel component 1-prohibitin 2-mediated mitochondrial quality surveillance","volume":"23","author":"Wang","year":"2025","journal-title":"J. Nanobiotechn."},{"key":"10.1016\/j.phymed.2025.157300_bib0036","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.2174\/0929867327666200713184138","article-title":"Recent research on flavonoids and their biomedical applications","volume":"28","author":"Wen","year":"2021","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.phymed.2025.157300_bib0037","doi-asserted-by":"crossref","first-page":"261","DOI":"10.18632\/aging.204479","article-title":"The protective effect of luteolin on the depression-related dry eye disorder through Sirt1\/NF-kappaB\/NLRP3 pathway","volume":"15","author":"Xie","year":"2023","journal-title":"Aging"},{"key":"10.1016\/j.phymed.2025.157300_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110996","article-title":"Luteolin ameliorates DSS-induced colitis in mice via suppressing macrophage activation and chemotaxis","volume":"124","author":"Xue","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2025.157300_bib0039","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s00005-015-0335-0","article-title":"Macrophage phenotype in the ocular surface of experimental murine dry eye disease","volume":"63","author":"You","year":"2015","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"10.1016\/j.phymed.2025.157300_bib0040","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.exer.2015.02.013","article-title":"Reactive oxygen species activated NLRP3 inflammasomes initiate inflammation in hyperosmolarity stressed human corneal epithelial cells and environment-induced dry eye patients","volume":"134","author":"Zheng","year":"2015","journal-title":"Exp. Eye Res."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325009390?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325009390?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T07:49:03Z","timestamp":1773128943000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325009390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":40,"alternative-id":["S0944711325009390"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157300","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Luteolin attenuates experimental dry eye disease via dual modulation of macrophage JAK-STAT signaling and corneal epithelial MAPK pathways","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157300","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157300"}}