{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T02:15:39Z","timestamp":1773368139996,"version":"3.50.1"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015401","name":"Shaanxi Province Key Research and Development Projects","doi-asserted-by":"publisher","award":["2023ZDLSF-52"],"award-info":[{"award-number":["2023ZDLSF-52"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82221001-4"],"award-info":[{"award-number":["82221001-4"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071433"],"award-info":[{"award-number":["82071433"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82305137"],"award-info":[{"award-number":["82305137"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201621"],"award-info":[{"award-number":["82201621"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007847","name":"Jilin Provincial Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.phymed.2025.157369","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:12:13Z","timestamp":1760145133000},"page":"157369","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Xingnao jianshen prescription reduces mitochondrial cristae breakage by protecting GPX1 from oxidation against cerebral ischemia-reperfusion injury"],"prefix":"10.1016","volume":"148","author":[{"given":"Xinna","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7950-0953","authenticated-orcid":false,"given":"Li","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongni","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaige","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2115-8327","authenticated-orcid":false,"given":"Xiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dexi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5986-2682","authenticated-orcid":false,"given":"Qian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.157369_bib0001","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s11255-008-9407-y","article-title":"Glutathione peroxidase 1 (GPX1) genetic polymorphism, erythrocyte GPX activity, and prostate cancer risk","volume":"41","author":"Arsova-Sarafinovska","year":"2009","journal-title":"Int. Urol. Nephrol."},{"key":"10.1016\/j.phymed.2025.157369_bib0002","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pneurobio.2018.03.002","article-title":"Notch signaling and neuronal death in stroke","volume":"165-167","author":"Arumugam","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.phymed.2025.157369_bib0003","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1093\/chromsci\/bmw167","article-title":"Proteomics: technologies and their applications","volume":"55","author":"Aslam","year":"2017","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.phymed.2025.157369_bib0004","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1113\/EP088005","article-title":"Oxygen and brain death; back from the brink","volume":"104","author":"Bailey","year":"2019","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.phymed.2025.157369_bib0005","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1038\/s42255-021-00497-2","article-title":"The mitochondrial protein Opa1 promotes adipocyte browning that is dependent on urea cycle metabolites","volume":"3","author":"Bean","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.phymed.2025.157369_bib0006","first-page":"541","article-title":"Huangdi Neijing: a classic book of traditional Chinese medicine]","volume":"88","author":"Cavalieri","year":"1997","journal-title":"Recenti. Prog. Med."},{"key":"10.1016\/j.phymed.2025.157369_bib0007","doi-asserted-by":"crossref","first-page":"426","DOI":"10.7150\/ijbs.76223","article-title":"Molecular mechanisms of mitochondrial quality control in ischemic cardiomyopathy","volume":"19","author":"Chang","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.phymed.2025.157369_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104877","article-title":"Therapeutic targets of oxidative\/nitrosative stress and neuroinflammation in ischemic stroke: applications for natural product efficacy with omics and systemic biology","volume":"158","author":"Chen","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2025.157369_bib0009","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1161\/01.STR.0000221708.17159.64","article-title":"Potential contribution of NF-kappaB in neuronal cell death in the glutathione peroxidase-1 knockout mouse in response to ischemia-reperfusion injury","volume":"37","author":"Crack","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.phymed.2025.157369_bib0010","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1021\/acschemneuro.1c00314","article-title":"Schaftoside suppresses pentylenetetrazol-induced seizures in zebrafish via suppressing apoptosis, modulating inflammation, and oxidative stress","volume":"12","author":"Dang","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.phymed.2025.157369_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154214","article-title":"Scutellarin acts on the AR-NOX axis to remediate oxidative stress injury in a mouse model of cerebral ischemia\/reperfusion injury","volume":"103","author":"Deng","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157369_bib0012","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1126\/science.1124619","article-title":"Mass spectrometry and protein analysis","volume":"312","author":"Domon","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.phymed.2025.157369_bib0013","series-title":"Free Radical Biology & Medicine","first-page":"188","article-title":"The role of glutathione peroxidase-1 in health and disease","author":"E","year":"2022"},{"key":"10.1016\/j.phymed.2025.157369_bib0014","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000441085","article-title":"Update on the global burden of ischemic and hemorrhagic stroke in 1990-2013: the GBD 2013 study","volume":"45","author":"Feigin","year":"2015","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.phymed.2025.157369_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/S1474-4422(18)30499-X","article-title":"Global, regional, and national burden of neurological disorders, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"18","author":"Feigin","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phymed.2025.157369_bib0016","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1111\/ijs.12357","article-title":"Part I: frequency of depression after stroke: an updated systematic review and meta-analysis of observational studies","volume":"9","author":"Hackett","year":"2014","journal-title":"Int. J. Stroke"},{"key":"10.1016\/j.phymed.2025.157369_bib0017","article-title":"Mitochondrial function in hypoxic ischemic injury and influence of aging","volume":"157","author":"Ham","year":"2016","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.phymed.2025.157369_bib0018","first-page":"373","article-title":"Scanning electron microscopic study on mitochondrial cristae in the rat adrenal cortex","volume":"34","author":"Hanaki","year":"1985","journal-title":"J. Electron. Microsc. (Tokyo)"},{"key":"10.1016\/j.phymed.2025.157369_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111774","article-title":"Mitochondrial cristae architecture protects against mtDNA release and inflammation","volume":"41","author":"He","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.phymed.2025.157369_bib0020","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1016\/S0140-6736(24)00642-1","volume":"403","author":"Hilkens","year":"2024","journal-title":"Stroke Lancet"},{"key":"10.1016\/j.phymed.2025.157369_bib0021","article-title":"Curcumin derived from medicinal homologous foods: its main signals in immunoregulation of oxidative stress, inflammation, and apoptosis","volume":"14","author":"Hu","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2025.157369_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101223","article-title":"Taurine and its analogs in neurological disorders: focus on therapeutic potential and molecular mechanisms","volume":"24","author":"Jakaria","year":"2019","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2025.157369_bib0023","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s11655-023-3714-0","article-title":"Elemene antitumor drugs development based on \"molecular compatibility theory\" and clinical application: a retrospective and prospective outlook","volume":"30","author":"Jiang","year":"2024","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.phymed.2025.157369_bib0024","doi-asserted-by":"crossref","DOI":"10.1002\/jgm.2947","article-title":"Oxidative stress gene polymorphisms may have an impact in the development of ischemic stroke","volume":"19","author":"Karahalil","year":"2017","journal-title":"J. Gene Med."},{"key":"10.1016\/j.phymed.2025.157369_bib0025","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1161\/STROKEAHA.111.000397","article-title":"Metabolite profiling identifies a branched chain amino acid signature in acute cardioembolic stroke","volume":"44","author":"Kimberly","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.phymed.2025.157369_bib0026","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/j.apsb.2020.11.019","article-title":"Recent advances in nanomedicines for the treatment of ischemic stroke","volume":"11","author":"Li","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2025.157369_bib0027","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jconrel.2024.02.039","article-title":"Stepwise targeted strategies for improving neurological function by inhibiting oxidative stress levels and inflammation following ischemic stroke","volume":"368","author":"Li","year":"2024","journal-title":"J. Control Release"},{"key":"10.1016\/j.phymed.2025.157369_bib0028","doi-asserted-by":"crossref","first-page":"486","DOI":"10.2174\/1570159X18666200606231723","article-title":"Progress and promise of Nur77-based therapeutics for Central nervous system disorders","volume":"19","author":"Liu","year":"2021","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.phymed.2025.157369_bib0029","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.phymed.2025.157369_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112687","article-title":"Compound-based Chinese medicine formula: from discovery to compatibility mechanism","volume":"254","author":"Luan","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157369_bib0031","article-title":"Side-by-side comparison of recombinant human glutathione peroxidases identifies overlapping substrate specificities for soluble hydroperoxides","volume":"59","author":"Maria","year":"2023","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2025.157369_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.mito.2019.11.005","article-title":"Mitochondrial function and brain Metabolic Score (BMS) in ischemic stroke: evaluation of \u201cneuroprotectants\u201d safety and efficacy","volume":"50","author":"Mayevsky","year":"2020","journal-title":"Mitochondrion"},{"key":"10.1016\/j.phymed.2025.157369_bib0033","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1093\/gerona\/glu131","article-title":"Recovery of indicators of mitochondrial biogenesis, oxidative stress, and aging with (-)-epicatechin in senile mice","volume":"70","author":"Moreno-Ulloa","year":"2015","journal-title":"J. Gerontol. Biol. Sci. Med. Sci."},{"key":"10.1016\/j.phymed.2025.157369_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117665","article-title":"Antithrombin gamma attenuates macrophage\/microglial activation and brain damage after transient focal cerebral ischemia in mice","volume":"252","author":"Nakano","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2025.157369_bib0035","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0092-8674(03)00116-8","article-title":"Mitochondria: releasing power for life and unleashing the machineries of death","volume":"112","author":"Newmeyer","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2025.157369_bib0036","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0140-6736(14)60460-8","article-title":"Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"384","author":"Ng","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2025.157369_bib0037","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1161\/01.STR.0000185653.49740.c6","article-title":"Short-term administration of a new free radical scavenger, edaravone, is more effective than its long-term administration for the treatment of neonatal hypoxic-ischemic encephalopathy","volume":"36","author":"Noor","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.phymed.2025.157369_bib0038","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41392-022-01064-1","article-title":"Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions","volume":"7","author":"Qin","year":"2022","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2025.157369_bib0039","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/ncomms1722","article-title":"\u03b3-glutamylcysteine detoxifies reactive oxygen species by acting as glutathione peroxidase-1 cofactor","volume":"3","author":"Quintana-Cabrera","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2025.157369_bib0040","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1758-2946-6-13","article-title":"TCMSP: a database of systems pharmacology for drug discovery from herbal medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J. Cheminform."},{"key":"10.1016\/j.phymed.2025.157369_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107695","article-title":"Natural medicine in neuroprotection for ischemic stroke: challenges and prospective","volume":"216","author":"Tao","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2025.157369_bib0042","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jns.2015.05.036","article-title":"Neuroprotective effect of microRNA-99a against focal cerebral ischemia-reperfusion injury in mice","volume":"355","author":"Tao","year":"2015","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.phymed.2025.157369_bib0043","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1080\/19390210802519739","article-title":"Essential concepts and vocabulary in herbal medicine","volume":"5","author":"Tillotson","year":"2008","journal-title":"J. Diet. Suppl."},{"key":"10.1016\/j.phymed.2025.157369_bib0044","first-page":"2021","article-title":"Classical active ingredients and extracts of Chinese herbal medicines: pharmacokinetics, pharmacodynamics, and molecular mechanisms for ischemic stroke","author":"Ting","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.phymed.2025.157369_bib0045","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.nbd.2016.03.015","article-title":"Mic60\/mitofilin overexpression alters mitochondrial dynamics and attenuates vulnerability of dopaminergic cells to dopamine and rotenone","volume":"91","author":"Van Laar","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.phymed.2025.157369_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.wneu.2016.11.006","article-title":"Patterns of stroke between University Hospitals and Nonuniversity Hospitals in China's mainland: prospective multicenter hospital-based registry study","volume":"98","author":"Wang","year":"2017","journal-title":"World Neurosurg."},{"key":"10.1016\/j.phymed.2025.157369_bib0047","doi-asserted-by":"crossref","first-page":"5145","DOI":"10.7150\/ijbs.96748","article-title":"Exploring the mechanism of ferroptosis induction by Sappanone A in cancer: insights into the mitochondrial dysfunction mediated by NRF2\/xCT\/GPX4 axis","volume":"20","author":"Wang","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.phymed.2025.157369_bib0048","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1039\/C2MB25224D","article-title":"(1)H NMR-based metabolomics exploring biomarkers in rat cerebrospinal fluid after cerebral ischemia\/reperfusion","volume":"9","author":"Wang","year":"2013","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.phymed.2025.157369_bib0049","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13020-017-0141-1","article-title":"A research on syndrome element differentiation based on phenomenology and mathematical method","volume":"12","author":"Yan","year":"2017","journal-title":"Chin. Med."},{"key":"10.1016\/j.phymed.2025.157369_bib0050","doi-asserted-by":"crossref","first-page":"C135","DOI":"10.1152\/ajpcell.00136.2018","article-title":"Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke","volume":"316","author":"Yang","year":"2019","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.phymed.2025.157369_bib0051","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.02.008","article-title":"The possible damaged mechanism and the preventive effect of monosialotetrahexosylganglioside in a rat model of cerebral ischemia-reperfusion injury","volume":"24","author":"Zhang","year":"2015","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.phymed.2025.157369_bib0052","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.brainres.2014.07.002","article-title":"Glycyrrhizin protects brain against ischemia-reperfusion injury in mice through HMGB1-TLR4-IL-17A signaling pathway","volume":"1582","author":"Zhang","year":"2014","journal-title":"Brain Res."},{"key":"10.1016\/j.phymed.2025.157369_bib0053","article-title":"Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2025.157369_bib0054","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jmgm.2017.05.021","article-title":"In silico modeling on ADME properties of natural products: classification models for blood-brain barrier permeability, its application to traditional Chinese medicine and in vitro experimental validation","volume":"75","author":"Zhang","year":"2017","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.phymed.2025.157369_bib0055","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1007\/s00204-023-03599-w","article-title":"Involvement of mitochondrial dynamics and mitophagy in diabetic endothelial dysfunction and cardiac microvascular injury","volume":"97","author":"Zhang","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.phymed.2025.157369_bib0056","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1007\/s10495-023-01824-6","article-title":"Anti-apoptosis effect of traditional Chinese medicine in the treatment of cerebral ischemia-reperfusion injury","volume":"28","author":"Zhao","year":"2023","journal-title":"Apoptosis"},{"key":"10.1016\/j.phymed.2025.157369_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphs.2018.08.002","article-title":"Chrysophanol attenuates nitrosative\/oxidative stress injury in a mouse model of focal cerebral ischemia\/reperfusion","volume":"138","author":"Zhao","year":"2018","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.phymed.2025.157369_bib0058","article-title":"Neuronal injuries in cerebral infarction and ischemic stroke: from mechanisms to treatment (Review)","volume":"49","author":"Zhao","year":"2022","journal-title":"Int. J. Mol. Med."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325010074?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325010074?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:28:17Z","timestamp":1773325697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325010074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":58,"alternative-id":["S0944711325010074"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157369","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Xingnao jianshen prescription reduces mitochondrial cristae breakage by protecting GPX1 from oxidation against cerebral ischemia-reperfusion injury","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157369","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"157369"}}