{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T19:56:24Z","timestamp":1793476584907,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007166","name":"Jiangsu Province Department of Education","doi-asserted-by":"publisher","award":["23KJD180004"],"award-info":[{"award-number":["23KJD180004"]}],"id":[{"id":"10.13039\/501100007166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008048","name":"Nanjing University","doi-asserted-by":"publisher","award":["2023-LCYJ-PY-10"],"award-info":[{"award-number":["2023-LCYJ-PY-10"]}],"id":[{"id":"10.13039\/501100008048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019155","name":"Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32100618"],"award-info":[{"award-number":["32100618"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.phymed.2025.157387","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:31:04Z","timestamp":1759991464000},"page":"157387","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Breviscapine targets EGFR and SRC to abrogate diabetes-driven GPX4 lactylation and ferroptosis resistance in gastric cancer"],"prefix":"10.1016","volume":"148","author":[{"given":"Hong Mei","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia Le","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi Han","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yu Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng Xian","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Zhong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.157387_bib0001","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.atherosclerosis.2017.06.916","article-title":"Deuterium-reinforced polyunsaturated fatty acids protect against atherosclerosis by lowering lipid peroxidation and hypercholesterolemia","volume":"264","author":"Berb\u00e9e","year":"2017","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.phymed.2025.157387_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.semcancer.2016.08.006","article-title":"Bioactive natural products in cancer prevention and therapy: progress and promise","volume":"40\u201341","author":"Bishayee","year":"2016","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.phymed.2025.157387_bib0003","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/s41586-024-07620-9","article-title":"NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance","volume":"631","author":"Chen","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2025.157387_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115774","article-title":"GCLM lactylation mediated by ACAT2 promotes ferroptosis resistance in KRASG12D-mutant cancer","volume":"44","author":"Chen","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.phymed.2025.157387_bib0005","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.2337\/dc19-0437","article-title":"Diabetes increases risk of gastric cancer after Helicobacter pylori eradication: a territory-wide study with propensity score analysis","volume":"42","author":"Cheung","year":"2019","journal-title":"Diabetes Care"},{"key":"10.1016\/j.phymed.2025.157387_bib0006","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41419-025-07498-z","article-title":"Histone lactylation enhances GCLC expression and thus promotes chemoresistance of colorectal cancer stem cells through inhibiting ferroptosis","volume":"16","author":"Deng","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2025.157387_bib0007","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s43556-024-00204-z","article-title":"Repurposing metabolic regulators: antidiabetic drugs as anticancer agents","volume":"5","author":"Dhas","year":"2024","journal-title":"Mol. Biomed."},{"key":"10.1016\/j.phymed.2025.157387_bib0008","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.freeradbiomed.2025.07.022","article-title":"Exosomes from tumor-associated neutrophils suppress ferroptosis and confer chemoresistance in gastric cancer via miR-9-3p\/ACSL4 axis","volume":"239","author":"Dong","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2025.157387_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105375","article-title":"SLC7A9 suppression increases chemosensitivity by inducing ferroptosis via the inhibition of cystine transport in gastric cancer","volume":"109","author":"Feng","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.phymed.2025.157387_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114981","article-title":"Celastrol functions as an emerging manager of lipid metabolism: mechanism and therapeutic potential","volume":"164","author":"Gu","year":"2023","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2025.157387_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.123030","article-title":"Advanced oral breviscapine sustained-release tablets for improved ischemic stroke treatment","volume":"316","author":"Hao","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.phymed.2025.157387_bib0013","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1021\/acs.langmuir.3c00119","article-title":"Differential behavior of eicosapentaenoic and docosahexaenoic acids on the organization, dynamics, and fusion of homogeneous and heterogeneous membranes","volume":"39","author":"Joardar","year":"2023","journal-title":"Langmuir"},{"key":"10.1016\/j.phymed.2025.157387_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2023.110866","article-title":"The impact of diabetes status on total and site-specific cancer risk in the elderly population: a nationwide cohort study","volume":"203","author":"Kim","year":"2023","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.phymed.2025.157387_bib0015","doi-asserted-by":"crossref","first-page":"261","DOI":"10.5650\/jos.ess24085","article-title":"Transferrin-modified Gemcitabine encapsulated polymeric nanoparticles persuaded apoptosis in U87MG cells and improved drug availability in rat brain: an active targeting strategy for treatment of glioma","volume":"74","author":"Kumar","year":"2025","journal-title":"J. Oleo Sci."},{"key":"10.1016\/j.phymed.2025.157387_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctcp.2022.101657","article-title":"Are herbal medicines alone or in combination for diabetic peripheral neuropathy more effective than methylcobalamin alone? A systematic review and meta-analysis","volume":"49","author":"Lee","year":"2022","journal-title":"Complement. Ther. Clin. Pract."},{"key":"10.1016\/j.phymed.2025.157387_bib0017","doi-asserted-by":"crossref","first-page":"5826","DOI":"10.7150\/thno.100080","article-title":"Ferroptosis at the nexus of metabolism and metabolic diseases","volume":"14","author":"Li","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2025.157387_bib0018","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s00125-022-05854-8","article-title":"Inequalities in cancer mortality trends in people with type 2 diabetes: 20 year population-based study in England","volume":"66","author":"Ling","year":"2023","journal-title":"Diabetologia"},{"key":"10.1016\/j.phymed.2025.157387_bib0019","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.3892\/etm.2016.3483","article-title":"Effect of breviscapine injection on clinical parameters in diabetic nephropathy: a meta-analysis of randomized controlled trials","volume":"12","author":"Liu","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.phymed.2025.157387_bib0020","first-page":"755","article-title":"Breviscapine ameliorates CCl4\u2011induced liver injury in mice through inhibiting inflammatory apoptotic response and ROS generation","volume":"42","author":"Liu","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.phymed.2025.157387_bib0021","doi-asserted-by":"crossref","first-page":"6178","DOI":"10.1021\/acs.jafc.3c05243","article-title":"Myricetin induces ferroptosis and inhibits gastric cancer progression by targeting NOX4","volume":"72","author":"Lu","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2025.157387_bib0022","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ijpharm.2008.03.047","article-title":"Comparative pharmacokinetics of breviscapine liposomes in dogs, rabbits and rats","volume":"359","author":"Lv","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.phymed.2025.157387_bib0023","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.756193","article-title":"Characterization of two ferroptosis subtypes with distinct immune infiltration and gender difference in gastric cancer","volume":"8","author":"Ma","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.phymed.2025.157387_bib0024","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.957483","article-title":"The efficacy and safety of mecobalamin combined with Chinese medicine injections in the treatment of diabetic peripheral neuropathy: a systematic review and bayesian network meta-analysis of randomized controlled trials","volume":"13","author":"Ma","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157387_bib0025","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12847","article-title":"Melatonin ameliorates myocardial infarction in obese diabetic individuals: the possible involvement of macrophage apoptotic factors","volume":"74","author":"Maity","year":"2023","journal-title":"J. Pineal. Res."},{"key":"10.1016\/j.phymed.2025.157387_bib0026","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.681338","article-title":"Levobupivacaine induces ferroptosis by miR-489-3p\/SLC7A11 signaling in gastric cancer","volume":"12","author":"Mao","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157387_bib0027","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/s41423-022-00894-x","article-title":"Glucose metabolism controls human \u03b3\u03b4 T-cell-mediated tumor immunosurveillance in diabetes","volume":"19","author":"Mu","year":"2022","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.phymed.2025.157387_bib0028","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1111\/jdi.14232","article-title":"Causes of death in Japanese patients with diabetes based on the results of a survey of 68,555 cases during 2011-2020: committee report on causes of death in diabetes mellitus, Japan Diabetes Society (English version)","volume":"15","author":"Nakamura","year":"2024","journal-title":"J. Diabetes. Investig."},{"key":"10.1016\/j.phymed.2025.157387_bib0029","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phymed.2025.157387_bib0030","doi-asserted-by":"crossref","first-page":"9674","DOI":"10.1038\/s41598-023-33792-x","article-title":"Breviscapine regulates the proliferation, migration, invasion, and apoptosis of colorectal cancer cells via the PI3K\/AKT pathway","volume":"13","author":"Niu","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2025.157387_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102317","article-title":"Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer","volume":"52","author":"Ouyang","year":"2022","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2025.157387_bib0032","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s43556-025-00275-6","article-title":"Histone and non-histone lactylation: molecular mechanisms, biological functions, diseases, and therapeutic targets","volume":"6","author":"Peng","year":"2025","journal-title":"Mol. Biomed."},{"key":"10.1016\/j.phymed.2025.157387_bib0033","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/s41419-024-06618-5","article-title":"POLQ inhibition attenuates the stemness and ferroptosis resistance in gastric cancer cells via downregulation of dihydroorotate dehydrogenase","volume":"15","author":"Peng","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2025.157387_bib0034","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12933-018-0672-5","article-title":"Relationship between polyunsaturated fatty acid composition in serum phospholipids, systemic low-grade inflammation, and glycemic control in patients with type 2 diabetes and atherosclerotic cardiovascular disease","volume":"17","author":"Poreba","year":"2018","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.phymed.2025.157387_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2019.107843","article-title":"Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition","volume":"157","author":"Saeedi","year":"2019","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.phymed.2025.157387_bib0036","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/s42003-020-01367-5","article-title":"Fatty-acid-induced FABP5\/HIF-1 reprograms lipid metabolism and enhances the proliferation of liver cancer cells","volume":"3","author":"Seo","year":"2020","journal-title":"Commun. Biol."},{"key":"10.1016\/j.phymed.2025.157387_bib0037","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/s41388-024-03243-6","article-title":"Delactylase effects of SIRT1 on a positive feedback loop involving the H19-glycolysis-histone lactylation in gastric cancer","volume":"44","author":"Tsukihara","year":"2025","journal-title":"Oncogene"},{"key":"10.1016\/j.phymed.2025.157387_bib0038","doi-asserted-by":"crossref","first-page":"4729","DOI":"10.1021\/acs.molpharmaceut.3c00477","article-title":"Molecular-level structural analysis of siRNA-loaded lipid nanoparticles by 1H NMR relaxometry: impact of lipid composition on their structural properties","volume":"20","author":"Ueda","year":"2023","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.phymed.2025.157387_bib0039","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3274084","article-title":"Advanced glycation end products increase MDM2 expression via transcription factor KLF5","author":"Wang","year":"2018","journal-title":"J. Diabetes. Res."},{"key":"10.1016\/j.phymed.2025.157387_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2022.100916","article-title":"Overcoming cancer chemotherapy resistance by the induction of ferroptosis","volume":"66","author":"Wang","year":"2023","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.phymed.2025.157387_bib0041","doi-asserted-by":"crossref","DOI":"10.1007\/s12265-025-10628-9","article-title":"Hypoxia\/reoxygenation-induced glycolysis mediates myocardial ischemia-reperfusion injury through promoting the lactylation of GPX4","author":"Wang","year":"2025","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.phymed.2025.157387_bib0042","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1142\/S0192415X21500646","article-title":"Breviscapine: a review on its phytochemistry, pharmacokinetics and therapeutic effects","volume":"49","author":"Wen","year":"2021","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.phymed.2025.157387_bib0043","doi-asserted-by":"crossref","first-page":"4184","DOI":"10.1039\/D2BM00678B","article-title":"A glutathione-responsive sulfur dioxide polymer prodrug selectively induces ferroptosis in gastric cancer therapy","volume":"10","author":"Xia","year":"2022","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.phymed.2025.157387_bib0044","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3109\/10717544.2010.528068","article-title":"Characterization, biodistribution and targeting evaluation of breviscapine lipid emulsions following intravenous injection in mice","volume":"18","author":"Xiong","year":"2011","journal-title":"Drug Deliv."},{"key":"10.1016\/j.phymed.2025.157387_bib0045","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1186\/s12935-023-03162-8","article-title":"Glucose transporter 3 (GLUT3) promotes lactylation modifications by regulating lactate dehydrogenase A (LDHA) in gastric cancer","volume":"23","author":"Yang","year":"2023","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.phymed.2025.157387_bib0046","doi-asserted-by":"crossref","unstructured":"Yang, J., Jin, W., Zhang, X., Chang, P., Zheng, D., 2021. Breviscapine participates in the progression of prostate cancer by inhibiting ZFP91 expression through upregulation of MicroRNA-129-5p Evid based Complement Alternat Med 2021, 1511607. https:\/\/doi.org\/10.1155\/2021\/1511607.","DOI":"10.1155\/2021\/1511607"},{"key":"10.1016\/j.phymed.2025.157387_bib0047","article-title":"Lactylation of HDAC1 confers resistance to ferroptosis in colorectal cancer","volume":"12","author":"Yang","year":"2025","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.phymed.2025.157387_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102670","article-title":"Lactylation: the metabolic accomplice shaping cancer\u2019s response to radiotherapy and immunotherapy","volume":"104","author":"Yu","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.phymed.2025.157387_bib0049","doi-asserted-by":"crossref","first-page":"11535","DOI":"10.1021\/acs.jafc.5c02530","article-title":"Engineering PUFA synthase for enhanced production of polyunsaturated fatty acids: insights and applications","volume":"73","author":"Zhang","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2025.157387_bib0050","doi-asserted-by":"crossref","first-page":"6114","DOI":"10.7150\/ijbs.74924","article-title":"Stearoyl-CoA Desaturase-1 dependent lipid droplets accumulation in cancer-associated fibroblasts facilitates the progression of lung cancer","volume":"18","author":"Zhang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.phymed.2025.157387_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102678","article-title":"Accumulated cholesterol protects tumours from elevated lipid peroxidation in the microenvironment","volume":"62","author":"Zhao","year":"2023","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2025.157387_bib0053","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41392-024-01769-5","article-title":"Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies","volume":"9","author":"Zhou","year":"2024","journal-title":"Signal. Transduct. Target. Ther."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325010256?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325010256?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:08:30Z","timestamp":1773270510000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325010256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":51,"alternative-id":["S0944711325010256"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157387","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Breviscapine targets EGFR and SRC to abrogate diabetes-driven GPX4 lactylation and ferroptosis resistance in gastric cancer","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157387","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157387"}}