{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T23:53:17Z","timestamp":1789343597136,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100014717","name":"National Natural Science Foundation of China National Outstanding Youth Science Fund Project","doi-asserted-by":"publisher","award":["82304503"],"award-info":[{"award-number":["82304503"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017128","name":"Science Fund for Distinguished Young Scholars of Anhui Province","doi-asserted-by":"publisher","award":["2308085QH305"],"award-info":[{"award-number":["2308085QH305"]}],"id":[{"id":"10.13039\/100017128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.phymed.2025.157400","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T22:50:16Z","timestamp":1760223016000},"page":"157400","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Perillyl alcohol ameliorates high-fat diet-induced obesity in mice by modulating gut microbiota and activating IRF4-mediated brown fat thermogenesis"],"prefix":"10.1016","volume":"148","author":[{"given":"Shasha","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songning","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruru","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenzhong","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8000-4305","authenticated-orcid":false,"given":"Shuang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.157400_bib0001","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1021\/acschemneuro.1c00550","article-title":"Perillyl alcohol attenuates NLRP3 inflammasome activation and rescues dopaminergic neurons in experimental In vitro and In vivo models of Parkinson's Disease","volume":"13","author":"Ahmed","year":"2022","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.phymed.2025.157400_bib0002","doi-asserted-by":"crossref","DOI":"10.3390\/nu15112610","article-title":"Collagen peptide exerts an anti-obesity effect by influencing the firmicutes\/bacteroidetes ratio in the gut","volume":"15","author":"Baek","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2025.157400_bib0003","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1007\/s00210-023-02398-5","article-title":"Perillyl alcohol (PA) mitigates inflammatory, oxidative, and histopathological consequences of allergic asthma in rats","volume":"396","author":"Bejeshk","year":"2023","journal-title":"Naunyn Schmiedeb. Arch. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157400_bib0004","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/jcsm.13391","article-title":"Obesity worsens mitochondrial quality control and does not protect against skeletal muscle wasting in murine cancer cachexia","volume":"15","author":"Cardaci","year":"2024","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.phymed.2025.157400_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105291","article-title":"Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and \u03b23-AR activation","volume":"164","author":"Chen","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2025.157400_bib0006","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1002\/ptr.7462","article-title":"Rutin-activated adipose tissue thermogenesis is correlated with increased intestinal short-chain fatty acid levels","volume":"36","author":"Cheng","year":"2022","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2025.157400_bib0007","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2018.11.002","article-title":"New advances in adaptive thermogenesis: UCP1 and beyond","volume":"29","author":"Chouchani","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2025.157400_bib0008","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2337\/diabetes.53.3.577","article-title":"Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis","volume":"53","author":"Christoffolete","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.phymed.2025.157400_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2024.127648","article-title":"Distribution and roles of ligilactobacillus murinus in hosts","volume":"282","author":"Chuandong","year":"2024","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.phymed.2025.157400_bib0010","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/s41556-023-01180-2","article-title":"Arf1 coordinates fatty acid metabolism and mitochondrial homeostasis","volume":"25","author":"Enkler","year":"2023","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.phymed.2025.157400_bib0011","doi-asserted-by":"crossref","first-page":"108","DOI":"10.4274\/jcrpe.galenos.2023.2023-3-2","article-title":"Current treatments for patients with genetic obesity","volume":"15","author":"Faccioli","year":"2023","journal-title":"J. Clin. Res. Pediatr. Endocrinol."},{"key":"10.1016\/j.phymed.2025.157400_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108525","article-title":"Novel mechanism by which extracellular vesicles derived from Lactobacillus murinus alleviates deoxynivalenol-induced intestinal barrier disruption","volume":"185","author":"Fan","year":"2024","journal-title":"Env. Int."},{"key":"10.1016\/j.phymed.2025.157400_bib0013","first-page":"469","article-title":"[beta 2 microglobulin as marker for isolating human tumoral antigens]","volume":"128","author":"Gold","year":"1977","journal-title":"Ann. Immunol. (Paris)"},{"key":"10.1016\/j.phymed.2025.157400_bib0014","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21082890","article-title":"Microbial medicine: prebiotic and probiotic functional foods to target obesity and metabolic syndrome","volume":"21","author":"Green","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.157400_bib0015","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.1038\/s41467-023-39710-z","article-title":"The muscle-enriched myokine Musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1\/PKA signaling in male mice","volume":"14","author":"Jin","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2025.157400_bib0016","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cell.2014.04.049","article-title":"IRF4 is a key thermogenic transcriptional partner of PGC-1\u03b1","volume":"158","author":"Kong","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2025.157400_bib0017","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1038\/s42255-024-01143-3","article-title":"Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress","volume":"6","author":"Korobkina","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.phymed.2025.157400_bib0018","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1039\/D1FO03147C","article-title":"Seabuckthorn polysaccharide ameliorates high-fat diet-induced obesity by gut microbiota-SCFAs-liver axis","volume":"13","author":"Lan","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2025.157400_bib0020","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.cmet.2014.02.007","article-title":"Central neural regulation of brown adipose tissue thermogenesis and energy expenditure","volume":"19","author":"Morrison","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2025.157400_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2020.154396","article-title":"UCP1-dependent and UCP1-independent metabolic changes induced by acute cold exposure in brown adipose tissue of mice","volume":"113","author":"Okamatsu-Ogura","year":"2020","journal-title":"Metabolism"},{"key":"10.1016\/j.phymed.2025.157400_bib0022","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/BF00841984","article-title":"Sensitive control of heart rate in monkeys using burst stimulation of the vagus nerve]","volume":"104","author":"Pokrovski\u012d","year":"1987","journal-title":"Biull. Eksp. Biol. Med."},{"key":"10.1016\/j.phymed.2025.157400_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154415","article-title":"Perillyl alcohol attenuates chronic restraint stress aggravated dextran sulfate sodium-induced ulcerative colitis by modulating TLR4\/NF-\u03bab and JAK2\/STAT3 signaling pathways","volume":"106","author":"Puppala","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157400_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.153926","article-title":"Perillyl alcohol attenuates rheumatoid arthritis via regulating TLR4\/NF-\u03bab and Keap1\/Nrf2 signaling pathways: a comprehensive study onin-vitro and in-vivo experimental models","volume":"97","author":"Puppala","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157400_bib0025","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.cmet.2022.02.016","article-title":"Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue","volume":"34","author":"Rosina","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2025.157400_bib0026","first-page":"283","article-title":"Linking gut microbiota and inflammation to obesity and insulin resistance","volume":"31","author":"Saad","year":"2016","journal-title":"Physiol. (Bethesda)"},{"key":"10.1016\/j.phymed.2025.157400_bib0027","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201949828","article-title":"The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT-liver communication","volume":"21","author":"Sponton","year":"2020","journal-title":"EMBO Rep."},{"key":"10.1016\/j.phymed.2025.157400_bib0028","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/s42255-022-00590-0","article-title":"Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation","volume":"4","author":"Sugimoto","year":"2022","journal-title":"Nat. Metab."},{"key":"10.1016\/j.phymed.2025.157400_bib0029","doi-asserted-by":"crossref","first-page":"14513","DOI":"10.1021\/acs.jafc.0c06138","article-title":"3\u2032-Hydroxydaidzein improves obesity through the induced browning of beige adipose and modulation of gut microbiota in mice with obesity induced by a high-fat diet","volume":"68","author":"Tung","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2025.157400_bib0030","article-title":"Glabridin ameliorates alcohol-caused liver damage by reducing oxidative stress and inflammation via p38 MAPK\/Nrf2\/NF-\u03bab pathway","volume":"15","author":"Wang","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2025.157400_bib0031","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41418-024-01397-0","article-title":"SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice","volume":"32","author":"Wang","year":"2025","journal-title":"Cell Death. Differ."},{"key":"10.1016\/j.phymed.2025.157400_bib0032","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/j.cmet.2021.08.012","article-title":"The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy","volume":"33","author":"Wei","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2025.157400_bib0033","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1136\/gutjnl-2017-315458","article-title":"Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis","volume":"68","author":"Wu","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.phymed.2025.157400_bib0034","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1038\/s41467-023-38141-0","article-title":"Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice","volume":"14","author":"Xiao","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2025.157400_bib0035","doi-asserted-by":"crossref","DOI":"10.3390\/nu15030743","article-title":"Sulforaphane ameliorates nonalcoholic fatty liver disease induced by high-fat and high-fructose diet via LPS\/TLR4 in the gut-liver axis","volume":"15","author":"Xu","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2025.157400_bib0036","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.7150\/ijbs.62556","article-title":"Berberine modulates deacetylation of ppar\u03b3 to promote adipose tissue remodeling and thermogenesis via AMPK\/SIRT1 pathway","volume":"17","author":"Xu","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.phymed.2025.157400_bib0037","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1186\/s12967-023-04790-4","article-title":"Didymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis","volume":"21","author":"Yang","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.phymed.2025.157400_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155826","article-title":"Molecular pharmacology and therapeutic advances of monoterpene perillyl alcohol","volume":"132","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157400_bib0039","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.jhep.2020.07.034","article-title":"Reduced Nogo expression inhibits diet-induced metabolic disorders by regulating ChREBP and insulin activity","volume":"73","author":"Zhang","year":"2020","journal-title":"J. Hepatol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325010384?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325010384?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T22:23:45Z","timestamp":1769811825000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325010384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":38,"alternative-id":["S0944711325010384"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157400","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perillyl alcohol ameliorates high-fat diet-induced obesity in mice by modulating gut microbiota and activating IRF4-mediated brown fat thermogenesis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157400","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157400"}}