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Sci."},{"key":"10.1016\/j.phymed.2025.157431_bib0106","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1089\/ars.2012.4783","article-title":"Myeloperoxidase: a leukocyte-derived protagonist of inflammation and cardiovascular disease","volume":"18","author":"Nussbaum","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.phymed.2025.157431_bib0107","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24097725","article-title":"Myeloperoxidase in health and disease","volume":"24","author":"Ortiz-Cerda","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.157431_bib0108","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22126461","article-title":"Immunofluorescence analysis of NF-kB and iNOS expression in different cell populations during early and advanced knee osteoarthritis","volume":"22","author":"Ostojic","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.157431_bib0109","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jff.2013.08.004","article-title":"Absorption and metabolism of proanthocyanidins","volume":"7","author":"Ou","year":"2014","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.phymed.2025.157431_bib0110","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nrm2125","article-title":"Matrix metalloproteinases and the regulation of tissue remodelling","volume":"8","author":"Page-McCaw","year":"2007","journal-title":"Nat. Rev. Mol. 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Res."},{"key":"10.1016\/j.phymed.2025.157431_bib0113","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104555","article-title":"Programming changes in GLUT1 mediated the accumulation of AGEs and matrix degradation in the articular cartilage of female adult rats after prenatal caffeine exposure","volume":"151","author":"Qing-Xian","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2025.157431_bib0114","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41392-023-01399-3","article-title":"Small molecule metabolites: discovery of biomarkers and therapeutic targets","volume":"8","author":"Qiu","year":"2023","journal-title":"Signal. Transduct. Target Ther."},{"key":"10.1016\/j.phymed.2025.157431_bib0115","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1002\/jcb.24532","article-title":"Expression and function of K(ATP) channels in normal and osteoarthritic human chondrocytes: possible role in glucose sensing","volume":"114","author":"Rufino","year":"2013","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.phymed.2025.157431_bib0116","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1006\/abbi.1998.0772","article-title":"Myeloperoxidase and horseradish peroxidase catalyze tyrosine nitration in proteins from nitrite and hydrogen peroxide","volume":"356","author":"Sampson","year":"1998","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.phymed.2025.157431_bib0117","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/cr.1998.17","article-title":"Complex role of matrix metalloproteinases in angiogenesis","volume":"8","author":"Sang","year":"1998","journal-title":"Cell Res."},{"key":"10.1016\/j.phymed.2025.157431_bib0118","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1101\/gad.934301","article-title":"Hypoxia in cartilage: hIF-1alpha is essential for chondrocyte growth arrest and survival","volume":"15","author":"Schipani","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.phymed.2025.157431_bib0119","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s11101-014-9376-y","article-title":"Phytochemical profile of Paulownia tomentosa (Thunb). Steud","volume":"14","author":"Schneiderov\u00e1","year":"2015","journal-title":"Phytochem. 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