{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:48:12Z","timestamp":1791654492510,"version":"4.3.4"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100020205","name":"Jiangxi Province Health Commission","doi-asserted-by":"publisher","award":["202310886"],"award-info":[{"award-number":["202310886"]}],"id":[{"id":"10.13039\/501100020205","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009102","name":"Education Department of Jiangxi Province","doi-asserted-by":"publisher","award":["GJJ2403619"],"award-info":[{"award-number":["GJJ2403619"]}],"id":[{"id":"10.13039\/501100009102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404050"],"award-info":[{"award-number":["82404050"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.phymed.2025.157459","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T23:01:29Z","timestamp":1761433289000},"page":"157459","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Tongxie Yaofang attenuates ulcerative colitis by modulating gut microbiota and IL-10RA\/NF-\u03baB-mediated macrophage polarization"],"prefix":"10.1016","volume":"148","author":[{"given":"Zhao","family":"Shang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0907-8485","authenticated-orcid":false,"given":"Li","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengke","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feixiang","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4787-0378","authenticated-orcid":false,"given":"Yanglin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4684-0318","authenticated-orcid":false,"given":"Dan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.157459_bib0001","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1159\/000354699","article-title":"Risks of inflammatory bowel disease treatment with glucocorticosteroids and aminosalicylates","volume":"31","author":"Curkovic","year":"2013","journal-title":"Dig. Dis."},{"key":"10.1016\/j.phymed.2025.157459_bib0002","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1681\/ASN.2017091044","article-title":"IL-10 receptor signaling empowers regulatory T cells to control Th17 responses and protect from GN","volume":"29","author":"Diefenhardt","year":"2018","journal-title":"JASN"},{"key":"10.1016\/j.phymed.2025.157459_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113571","article-title":"Gegen qinlian decoction ameliorates murine colitis by inhibiting the expansion of enterobacteriaceae through activating PPAR-\u03b3 signaling","volume":"154","author":"Hu","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2025.157459_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2024.01.008","article-title":"Paeoniflorin ameliorates chronic colitis via the DR3 signaling pathway in group 3 innate lymphoid cells","volume":"14","author":"Huang","year":"2024","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.phymed.2025.157459_bib0005","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev-immunol-070119-115104","article-title":"Interaction between the microbiota, epithelia, and immune cells in the intestine","volume":"38","author":"Kayama","year":"2020","journal-title":"Annu. Rev. Immunol"},{"key":"10.1016\/j.phymed.2025.157459_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117691","article-title":"Network pharmacology mechanisms and experimental verification of licorice in the treatment of ulcerative colitis","author":"Kong","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157459_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154052","article-title":"Huangqin decoction ameliorates DSS-induced ulcerative colitis: Role of gut microbiota and amino acid metabolism, mTOR pathway and intestinal epithelial barrier","volume":"100","author":"Li","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157459_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.130863","article-title":"Sporisorium reilianum polysaccharides improve DSS-induced ulcerative colitis by regulating intestinal barrier function and metabolites","volume":"265","author":"Liu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2025.157459_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117990","article-title":"Banxia xiexin decoction modulates gut microbiota and gut microbiota metabolism to alleviate DSS-induced ulcerative colitis","volume":"326","author":"Luo","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157459_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155336","article-title":"Forsythia suspensa polyphenols regulate macrophage M1 polarization to alleviate intestinal inflammation in mice","volume":"125","author":"Lv","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157459_bib0011","article-title":"The gut microbiota-immune-brain axis: Therapeutic implications","volume":"6","author":"O'Riordan","year":"2025","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.phymed.2025.157459_bib0012","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3390\/biology11101377","article-title":"Interleukin-10 deficiency impacts on TNF-induced NF\u03baB regulated responses in vivo","volume":"11","author":"Papoutsopoulou","year":"2022","journal-title":"Biology"},{"key":"10.1016\/j.phymed.2025.157459_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156836","article-title":"Regulation of inflammation by chaihu-shugan-san: Targeting the IL-17\/NF-\u03baB pathway to combat breast cancer-related depression","author":"Qu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157459_bib0014","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41416-024-02893-3","article-title":"IL-10RA governor the expression of IDO in the instruction of lymphocyte immunity","volume":"132","author":"Tai","year":"2025","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.phymed.2025.157459_bib0015","article-title":"Structural elucidation of polysaccharide from fresh areca catechu L. and its mitigation effect on DSS-induced colitis in mice","volume":"318","author":"Wang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2025.157459_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118740","article-title":"In vivo and in vitro study on the regulatory mechanism of XiaoChaiHu decoction on PANoptosis in sepsis-induced cardiomyopathy","volume":"336","author":"Wang","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157459_bib0017","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-024-03220-6","article-title":"Preoperative gut microbiota of POCD patients induces pre- and postoperative cognitive impairment and systemic inflammation in rats","volume":"21","author":"Wei","year":"2024","journal-title":"J. Neuroinflammation."},{"key":"10.1016\/j.phymed.2025.157459_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104489","article-title":"Phloretin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by regulating the gut microbiota","volume":"150","author":"Wu","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2025.157459_bib0019","doi-asserted-by":"crossref","first-page":"24449","DOI":"10.1021\/acs.jafc.4c05365","article-title":"Pueraria extract ameliorates alcoholic liver disease via the liver\u2013gut\u2013brain axis: Focus on restoring the intestinal barrier and inhibiting alcohol metabolism","volume":"72","author":"Wu","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2025.157459_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118541","article-title":"Tong-xie-yao-fang induces mitophagy in colonic epithelial cells to inhibit colitis-associated colorectal cancer","volume":"334","author":"Xu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157459_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105576","article-title":"A sweet spot for macrophages: Focusing on polarization","volume":"167","author":"Yang","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2025.157459_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154455","article-title":"Tongxie-yaofang formula regulated macrophage polarization to ameliorate DSS-induced colitis via NF-\u03baB\/NLRP3 signaling pathway","volume":"107","author":"Zhang","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157459_bib0023","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41538-025-00378-y","article-title":"Network pharmacology study on the mechanism of berberine in alzheimer's disease model","volume":"9","author":"Zhang","year":"2025","journal-title":"NPJ. Sci. Food"},{"key":"10.1016\/j.phymed.2025.157459_bib0024","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202400785","article-title":"Therapeutic potential of vanillic acid in ulcerative colitis through microbiota and macrophage modulation","volume":"69","author":"Zhao","year":"2025","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.phymed.2025.157459_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2025.106937","article-title":"Mechanisms of corn silk polysaccharide in promoting colorectal cancer progression: A multi-omics approach to microbiota, metabolomics, and transcriptomics","volume":"130","author":"Zhou","year":"2025","journal-title":"J. Funct. Foods"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325010967?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325010967?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:44:25Z","timestamp":1773308665000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325010967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":25,"alternative-id":["S0944711325010967"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157459","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tongxie Yaofang attenuates ulcerative colitis by modulating gut microbiota and IL-10RA\/NF-\u03baB-mediated macrophage polarization","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157459","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157459"}}