{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:35:56Z","timestamp":1785339356372,"version":"3.55.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012270","name":"Shaanxi Key Science and Technology Innovation Team Project","doi-asserted-by":"publisher","award":["2023KXJ-046"],"award-info":[{"award-number":["2023KXJ-046"]}],"id":[{"id":"10.13039\/501100012270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1600400"],"award-info":[{"award-number":["2023YFD1600400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.phymed.2025.157536","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T14:58:34Z","timestamp":1762959514000},"page":"157536","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Schisandra chinensis-derived bioactive constituents loaded in pH-ROS dual-responsive polysaccharide nanoparticles for atherosclerosis treatment"],"prefix":"10.1016","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8851-5938","authenticated-orcid":false,"given":"Jinjin","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingli","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songyuan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruisi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1497-6704","authenticated-orcid":false,"given":"Jingyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dezhu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8349-7010","authenticated-orcid":false,"given":"Xiaofeng","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.157536_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2021.145525","article-title":"A haplotype of the ANGPTL3 gene is associated with CVD risk, diabetes mellitus, hypertension, obesity, metabolic syndrome, and dyslipidemia","volume":"782","author":"Aghasizadeh","year":"2021","journal-title":"Gene"},{"issue":"2","key":"10.1016\/j.phymed.2025.157536_bib0002","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/cvr\/cvs094","article-title":"Contribution of monocyte-derived macrophages and smooth muscle cells to arterial foam cell formation","volume":"95","author":"Allahverdian","year":"2012","journal-title":"Cardiovasc. Res."},{"issue":"12","key":"10.1016\/j.phymed.2025.157536_bib0003","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.3390\/biomedicines11123275","article-title":"Intraplaque neovascularization, CD68+ and iNOS2+ macrophage infiltrate intensity are associated with atherothrombosis and intraplaque hemorrhage in severe carotid atherosclerosis","volume":"11","author":"Balmos","year":"2023","journal-title":"Biomedicines"},{"issue":"Suppl 1","key":"10.1016\/j.phymed.2025.157536_bib0004","first-page":"544","article-title":"Disease interpretation of non-coding genomic elements with the GeneCards Suite","volume":"30","author":"Barshir","year":"2022","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.phymed.2025.157536_bib0005","article-title":"Advanced subclinical atherosclerosis: a novel category within the cardiovascular risk continuum with distinct treatment implications","volume":"13","author":"Blaha","year":"2023","journal-title":"Am. J. Prevent Cardiol."},{"issue":"1","key":"10.1016\/j.phymed.2025.157536_bib0006","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s00395-023-00987-2","article-title":"Matrix metalloproteinases in coronary artery disease and myocardial infarction","volume":"118","author":"Br\u00e4uninger","year":"2023","journal-title":"Basic Res. Cardiol."},{"issue":"5","key":"10.1016\/j.phymed.2025.157536_bib0007","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/MOL.0000000000000107","article-title":"Endothelial dysfunction: the role of sterol regulatory element-binding protein-induced NOD-like receptor family pyrin domain-containing protein 3 inflammasome in atherosclerosis","volume":"25","author":"Chen","year":"2014","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.phymed.2025.157536_bib0008","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.mito.2014.06.002","article-title":"Mitochondrial ROS and involvement of Bcl-2 as a mitochondrial ROS regulator","volume":"19","author":"Chong","year":"2014","journal-title":"Mitochondrion"},{"issue":"11","key":"10.1016\/j.phymed.2025.157536_bib0009","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1161\/ATVBAHA.111.231548","article-title":"Myofibroblast-mediated adventitial remodeling an underestimated player in arterial pathology","volume":"31","author":"Coen","year":"2011","journal-title":"Arterioscl. Throm. Vas."},{"issue":"2\u20133","key":"10.1016\/j.phymed.2025.157536_bib0010","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1177\/10105395241226525","article-title":"Risk factors of premature atherosclerotic cardiovascular disease in China: a Longitudinal analysis of the China health and nutrition survey cohort","volume":"36","author":"Ding","year":"2024","journal-title":"Asia-Pac J. Public He."},{"key":"10.1016\/j.phymed.2025.157536_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.ntm.2025.100083","article-title":"Nanoparticles for drug delivery: insight into in vitro and in vivo drug release from nanomedicines","volume":"4","author":"Ewii","year":"2025","journal-title":"Nano TransMed."},{"issue":"12","key":"10.1016\/j.phymed.2025.157536_bib0012","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1161\/CIRCRESAHA.118.311362","article-title":"NLRP3 inflammasome and the IL-1 pathway in atherosclerosis","volume":"122","author":"Grebe","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2025.157536_bib0013","doi-asserted-by":"crossref","first-page":"D514","DOI":"10.1093\/nar\/gki033","article-title":"Online mendelian inheritance in man (OMIM), a knowledgebase of human genes and genetic disorders","volume":"33","author":"Hamosh","year":"2005","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.phymed.2025.157536_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2025.123639","article-title":"Konjac glucomannan\/Bletilla polysaccharide composite hydrogel: a promising anti-inflammatory dressing for accelerated wound healing","volume":"361","author":"Hao","year":"2025","journal-title":"Carbohyd. Polym."},{"key":"10.1016\/j.phymed.2025.157536_bib0015","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.lfs.2018.09.024","article-title":"Metformin ameliorates Ox-LDL-induced foam cell formation in raw264.7 cells by promoting ABCG-1 mediated cholesterol efflux","volume":"216","author":"He","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2025.157536_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105447","article-title":"Pyroptosis is a critical immune-inflammatory response involved in atherosclerosis","volume":"165","author":"He","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2025.157536_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.140234","article-title":"Antioxidant and hepatic fibrosis-alleviating effects of selenium-modified Bletilla striata polysaccharide","volume":"301","author":"Jiang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.phymed.2025.157536_bib0018","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3390\/polym15010116","article-title":"The dual modification of PNIPAM and \u03b2-Cyclodextrin grafted on hyaluronic acid as self-assembled nanogel for curcumin delivery","volume":"15","author":"Kaewruethai","year":"2023","journal-title":"Polymers-Basel"},{"key":"10.1016\/j.phymed.2025.157536_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119550","article-title":"Targeted delivery of anti-inflammatory cytokine by nanocarrier reduces atherosclerosis in ApoE\u2212\/\u2212 mice","volume":"226","author":"Kim","year":"2020","journal-title":"Biomater"},{"issue":"18","key":"10.1016\/j.phymed.2025.157536_bib0020","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/j.jacc.2010.12.026","article-title":"Stroke risk after coronary artery bypass graft surgery and extent of cerebral artery atherosclerosis","volume":"57","author":"Lee","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.phymed.2025.157536_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.133262","article-title":"A NIR pH sensitive fluorescent strategy for ratiometric detection of reactive oxygen species and its application in the imaging of arthritis","volume":"379","author":"Liu","year":"2023","journal-title":"Sensor Actuat B-Chem."},{"key":"10.1016\/j.phymed.2025.157536_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155372","article-title":"Schisandrin a alleviates renal fibrosis by inhibiting PKC\u03b2 and oxidative stress","volume":"126","author":"Liu","year":"2024","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.phymed.2025.157536_bib0023","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1002\/bab.2602","article-title":"The inhibitory impact of Schisandrin on inflammation and oxidative stress alleviates LPS-induced acute kidney injury","volume":"71","author":"Liu","year":"2024","journal-title":"Biotechnol. Appl. Bioc."},{"issue":"6","key":"10.1016\/j.phymed.2025.157536_bib0024","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.tcm.2008.11.004","article-title":"Monocyte-endothelial cell interactions in the development of atherosclerosis","volume":"18","author":"Mestas","year":"2008","journal-title":"Trends Cardiovas. Med."},{"issue":"16","key":"10.1016\/j.phymed.2025.157536_bib0025","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241612949","article-title":"In silico analysis, anticonvulsant activity, and toxicity evaluation of schisandrin B in zebrafish larvae and mice","volume":"24","author":"Nieoczym","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.phymed.2025.157536_bib0026","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1080\/08916934.2022.2103801","article-title":"Immunoenhancement activity of Bletilla striata polysaccharide through MAPK and NF-\u03baB signalling pathways in vivo and in vitro","volume":"55","author":"Niu","year":"2022","journal-title":"Autoimmunity"},{"key":"10.1016\/j.phymed.2025.157536_bib0027","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jiec.2020.08.034","article-title":"In vivo imaging of reactive oxygen species (ROS)-producing pro-inflammatory macrophages in murine carotid atheromas using a CD44-targetable and ROS-responsive nanosensor","volume":"92","author":"Park","year":"2020","journal-title":"J. Ind. Eng. Chem."},{"key":"10.1016\/j.phymed.2025.157536_bib0028","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.carbpol.2014.02.042","article-title":"Structure and immunobiological activity of a new polysaccharide from Bletilla striata","volume":"107","author":"Peng","year":"2014","journal-title":"Carbohyd. Polym."},{"issue":"D1","key":"10.1016\/j.phymed.2025.157536_bib0029","doi-asserted-by":"crossref","first-page":"D833","DOI":"10.1093\/nar\/gkw943","article-title":"DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants","volume":"45","author":"Pi\u00f1ero","year":"2017","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.phymed.2025.157536_bib0030","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1758-2946-6-13","article-title":"TCMSP: a database of systems pharmacology for drug discovery from herbal medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J. Cheminformatics"},{"issue":"D1","key":"10.1016\/j.phymed.2025.157536_bib0031","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic. Acids. Res."},{"issue":"2","key":"10.1016\/j.phymed.2025.157536_bib0032","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"Software news and update AutoDock vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.phymed.2025.157536_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117680","article-title":"Bletilla striata polysaccharide attenuated the progression of pulmonary fibrosis by inhibiting TGF-\u03b21\/Smad signaling pathway","volume":"323","author":"Wang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157536_bib0034","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.fitote.2013.10.008","article-title":"A new glucomannan from: structural and anti-fibrosis effects","volume":"92","author":"Wang","year":"2014","journal-title":"Fitoterapia"},{"issue":"27","key":"10.1016\/j.phymed.2025.157536_bib0035","doi-asserted-by":"crossref","first-page":"35421","DOI":"10.1021\/acsami.4c01540","article-title":"\u03b2-Cyclodextrin and hyaluronic acid-modified targeted nanodelivery system for atherosclerosis prevention","volume":"16","author":"Yu","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"38","key":"10.1016\/j.phymed.2025.157536_bib0036","doi-asserted-by":"crossref","first-page":"10046","DOI":"10.1016\/j.biomaterials.2014.09.007","article-title":"Targeted depletion of tumour-associated macrophages by an alendronate-glucomannan conjugate for cancer immunotherapy","volume":"35","author":"Zhan","year":"2014","journal-title":"Biomater"},{"key":"10.1016\/j.phymed.2025.157536_bib0037","article-title":"A self-healing hydrogel wound dressing based on oxidized polysaccharide and cationic gelatin for skin trauma treatment","volume":"253","author":"Zhang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"6","key":"10.1016\/j.phymed.2025.157536_bib0038","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/jphp.12888","article-title":"characterization of pH-sensitive Bletilla Striata polysaccharide copolymer micelles and enhanced tumour suppression","volume":"70","author":"Zhao","year":"2018","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157536_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115749","article-title":"Recent advances of traditional Chinese medicine for the prevention and treatment of atherosclerosis","volume":"301","author":"Zhi","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"D1","key":"10.1016\/j.phymed.2025.157536_bib0040","doi-asserted-by":"crossref","first-page":"D1465","DOI":"10.1093\/nar\/gkad751","article-title":"TTD: therapeutic target database describing target druggability information","volume":"52","author":"Zhou","year":"2024","journal-title":"Nucleic. Acids. Res."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325011729?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325011729?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T11:32:35Z","timestamp":1766662355000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325011729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":40,"alternative-id":["S0944711325011729"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157536","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Schisandra chinensis-derived bioactive constituents loaded in pH-ROS dual-responsive polysaccharide nanoparticles for atherosclerosis treatment","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157536","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157536"}}