{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:11:06Z","timestamp":1790428266407,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["LQ23H260006"],"award-info":[{"award-number":["LQ23H260006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373354"],"award-info":[{"award-number":["82373354"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017599","name":"Science and Technology Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2024ZL1183"],"award-info":[{"award-number":["2024ZL1183"]}],"id":[{"id":"10.13039\/501100017599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017599","name":"Science and Technology Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2023-3-111"],"award-info":[{"award-number":["2023-3-111"]}],"id":[{"id":"10.13039\/501100017599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017599","name":"Science and Technology Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2024-03-004"],"award-info":[{"award-number":["2024-03-004"]}],"id":[{"id":"10.13039\/501100017599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LTGY23H160025"],"award-info":[{"award-number":["LTGY23H160025"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.phymed.2025.157564","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T14:04:00Z","timestamp":1763647440000},"page":"157564","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Atractylenolide I activates the DNA damage-apoptosis axis in colorectal cancer patient-derived organoids by dual-targeting XRCC5 and CLTC"],"prefix":"10.1016","volume":"149","author":[{"given":"Lin","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4196-3965","authenticated-orcid":false,"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1047-0041","authenticated-orcid":false,"given":"Xuewei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7564-1417","authenticated-orcid":false,"given":"Yuqing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0725-5685","authenticated-orcid":false,"given":"Yi","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxuan","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuochen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8377-8421","authenticated-orcid":false,"given":"Kangfu","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlin","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4655-4968","authenticated-orcid":false,"given":"Wenxia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.phymed.2025.157564_bib0001","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1158\/1541-7786.MCR-18-0178","article-title":"Spindle assembly disruption and cancer cell apoptosis with a CLTC-binding compound","volume":"16","author":"Bond","year":"2018","journal-title":"Mol. Cancer Res. MCR"},{"issue":"13","key":"10.1016\/j.phymed.2025.157564_bib0002","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1039\/D5LC00062A","article-title":"Patient-derived organotypic tumor spheroids, tumoroids, and organoids: advancing immunotherapy using state-of-the-art 3D tumor model systems","volume":"25","author":"Bozym","year":"2025","journal-title":"Lab Chip"},{"issue":"7","key":"10.1016\/j.phymed.2025.157564_bib0003","doi-asserted-by":"crossref","first-page":"4935","DOI":"10.1245\/s10434-025-17299-5","article-title":"The Landmark Series: neoadjuvant therapy for locally advanced rectal cancer","volume":"32","author":"Bunjo","year":"2025","journal-title":"Ann. Surg. Oncol."},{"issue":"3","key":"10.1016\/j.phymed.2025.157564_bib0004","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.21037\/jgo-21-230","article-title":"Effects of molecular markers on the treatment decision and prognosis of colorectal cancer: a narrative review","volume":"12","author":"Cao","year":"2021","journal-title":"J. Gastrointest. Oncol."},{"issue":"10","key":"10.1016\/j.phymed.2025.157564_bib0005","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1007\/s11427-024-2888-8","article-title":"Endocrine cancer organoids in basic and translational medical research","volume":"68","author":"Chen","year":"2025","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.phymed.2025.157564_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2022.123260","article-title":"Specific metabolic response of patient-derived organoids to curcumin of colorectal cancer","volume":"1203","author":"Chen","year":"2022","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"issue":"7","key":"10.1016\/j.phymed.2025.157564_bib0008","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s12272-021-01342-6","article-title":"Atractylenolides (I, II, and III): a review of their pharmacology and pharmacokinetics","volume":"44","author":"Deng","year":"2021","journal-title":"Arch. Pharm. Res."},{"issue":"1","key":"10.1016\/j.phymed.2025.157564_bib0010","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s11064-024-04258-x","article-title":"Atractylenolide-I attenuates MPTP\/MPP+\u2011mediated oxidative stress in Parkinson\u2019s disease through SIRT1\/PGC\u20111\u03b1\/Nrf2 axis","volume":"50","author":"Gao","year":"2024","journal-title":"Neurochem. Res."},{"issue":"1","key":"10.1016\/j.phymed.2025.157564_bib0011","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13020-025-01086-1","article-title":"Atractylenolide I ameliorated the growth and enzalutamide resistance of castration-resistant prostate cancer by targeting KIF15","volume":"20","author":"Han","year":"2025","journal-title":"Chin. Med."},{"issue":"5","key":"10.1016\/j.phymed.2025.157564_bib0012","doi-asserted-by":"crossref","first-page":"5939","DOI":"10.1002\/cam4.5387","article-title":"Regulation of DNA-PK activity promotes the progression of TNBC via enhancing the immunosuppressive function of myeloid-derived suppressor cells","volume":"12","author":"Han","year":"2023","journal-title":"Cancer Med."},{"issue":"1","key":"10.1016\/j.phymed.2025.157564_bib0013","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s11302-022-09854-6","article-title":"P2X7 receptor involved in antitumor activity of atractylenolide I in human cervical cancer cells","volume":"19","author":"Han","year":"2023","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.phymed.2025.157564_bib0014","doi-asserted-by":"crossref","first-page":"3840","DOI":"10.1038\/srep03840","article-title":"Atractylenolide-I sensitizes human ovarian cancer cells to paclitaxel by blocking activation of TLR4\/MyD88-dependent pathway","volume":"4","author":"Huang","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2025.157564_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106957","article-title":"Discovery of plant-derived anti-tumor natural products: potential leads for anti-tumor drug discovery","volume":"142","author":"Hui","year":"2024","journal-title":"Bioorg. Chem."},{"issue":"24","key":"10.1016\/j.phymed.2025.157564_bib0016","doi-asserted-by":"crossref","first-page":"6083","DOI":"10.1016\/j.bmcl.2004.09.060","article-title":"Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries","volume":"14","author":"Leahy","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"5","key":"10.1016\/j.phymed.2025.157564_bib0017","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3390\/metabo15050329","article-title":"Atractylenolide I inhibits nicotine-induced macrophage pyroptosis and alleviates atherogenesis by suppressing the TLR4\/ROS\/TXNIP\/NLRP3 pathway","volume":"15","author":"Li","year":"2025","journal-title":"Metabolites"},{"issue":"3","key":"10.1016\/j.phymed.2025.157564_bib0018","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1080\/15548627.2024.2421699","article-title":"Atractylenolide I inhibits angiogenesis and reverses sunitinib resistance in clear cell renal cell carcinoma through ATP6V0D2-mediated autophagic degradation of EPAS1\/HIF2\u03b1","volume":"21","author":"Li","year":"2025","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2025.157564_bib0019","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3389\/fphar.2020.00273","article-title":"Atractylenolide I induces apoptosis and suppresses glycolysis by blocking the JAK2\/STAT3 signaling pathway in colorectal cancer cells","volume":"11","author":"Li","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157564_bib0020","doi-asserted-by":"crossref","DOI":"10.1177\/09636897251314645","article-title":"Patient-derived tumor organoids: a platform for precision therapy of colorectal cancer","volume":"34","author":"Li","year":"2025","journal-title":"Cell Transplant"},{"issue":"17","key":"10.1016\/j.phymed.2025.157564_bib0021","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.2174\/0118715206366543250213071529","article-title":"Atractylenolide I inhibits the growth of esophageal cancer cells by inhibiting the wnt\/\u0392-catenin pathway","volume":"25","author":"Lian","year":"2025","journal-title":"Anticancer Agents Med. Chem."},{"issue":"1","key":"10.1016\/j.phymed.2025.157564_bib0022","first-page":"94","article-title":"USP10\/XAB2\/ANXA2 axis promotes DNA damage repair to enhance chemoresistance to oxaliplatin in colorectal cancer","volume":"44","author":"Liu","year":"2025","journal-title":"J. Exp. Clin. Cancer Res. CR"},{"issue":"6141","key":"10.1016\/j.phymed.2025.157564_bib0023","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.1233606","article-title":"Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay","volume":"341","author":"Martinez Molina","year":"2013","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.phymed.2025.157564_bib0025","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/s41568-024-00706-6","article-title":"Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment","volume":"24","author":"Polak","year":"2024","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.phymed.2025.157564_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113760","article-title":"Phytotherapeutic applications of alkaloids in treating breast cancer","volume":"155","author":"Rampogu","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"11","key":"10.1016\/j.phymed.2025.157564_bib0028","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1038\/nprot.2017.100","article-title":"Measuring protein structural changes on a proteome-wide scale using limited proteolysis-coupled mass spectrometry","volume":"12","author":"Schopper","year":"2017","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.phymed.2025.157564_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119868","article-title":"Ganoderic acid A: an in-depth review of pharmacological effects and molecular docking analysis","volume":"349","author":"Sui","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2025.157564_bib0030","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3892\/ijmm.2025.5545","article-title":"Precision oncolytic viral therapy in colorectal cancer: genetic targeting and immune modulation for personalized treatment (Review)","volume":"56","author":"Sultan","year":"2025","journal-title":"Int. J. Mol. Med."},{"issue":"5","key":"10.1016\/j.phymed.2025.157564_bib0031","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.21037\/jgo-22-910","article-title":"Atractylenolide I inhibited the development of malignant colorectal cancer cells and enhanced oxaliplatin sensitivity through the PDK1-FoxO1 axis","volume":"13","author":"Sun","year":"2022","journal-title":"J. Gastrointest. Oncol."},{"issue":"5","key":"10.1016\/j.phymed.2025.157564_bib0032","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70195","article-title":"Organoid-guided precision medicine: from bench to bedside","volume":"6","author":"Tao","year":"2025","journal-title":"MedComm"},{"issue":"8","key":"10.1016\/j.phymed.2025.157564_bib0033","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1093\/annonc\/mdw235","article-title":"ESMO consensus guidelines for the management of patients with metastatic colorectal cancer","volume":"27","author":"Van Cutsem","year":"2016","journal-title":"Annal. Oncol. Off. J. Eur. Soc. Med. Oncol."},{"key":"10.1016\/j.phymed.2025.157564_bib0034","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2025.1569337","article-title":"Organoids technology in cancer research: from basic applications to advanced ex vivo models","volume":"13","author":"Varinelli","year":"2025","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.phymed.2025.157564_bib0035","article-title":"Atractylenolide I inhibits colorectal cancer cell proliferation by affecting metabolism and stemness via AKT\/mTOR signaling","volume":"68","author":"Wang","year":"2020","journal-title":"Phytomed. Int. J.f Phytother. Phytopharmacol."},{"key":"10.1016\/j.phymed.2025.157564_bib0036","article-title":"Atractylenolide-I sensitizes triple-negative breast cancer cells to paclitaxel by blocking CTGF expression and fibroblast activation","volume":"11","author":"Wang","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.phymed.2025.157564_bib0037","article-title":"Atractylenolide-I alleviates hyperglycemia-induced heart developmental malformations through direct and indirect modulation of the STAT3 pathway","volume":"129","author":"Wang","year":"2024","journal-title":"Phytomed. Int. J.f Phytother. Phytopharmacol."},{"key":"10.1016\/j.phymed.2025.157564_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105728","article-title":"Metabolic reprogramming by traditional Chinese medicine and its role in effective cancer therapy","volume":"170","author":"Wang","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"7","key":"10.1016\/j.phymed.2025.157564_bib0039","doi-asserted-by":"crossref","first-page":"e613","DOI":"10.1002\/mco2.613","article-title":"The multifaceted functions of DNA-PKcs: implications for the therapy of human diseases","volume":"5","author":"Wu","year":"2024","journal-title":"MedComm"},{"issue":"6","key":"10.1016\/j.phymed.2025.157564_bib0040","first-page":"1213","article-title":"Atractylenolide I regulates colorectal cancer cells\u2019 biological processes and glycolysis via KRT7","volume":"37","author":"Xie","year":"2024","journal-title":"Pak. J. Pharm. Sci."},{"issue":"10","key":"10.1016\/j.phymed.2025.157564_bib0041","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.3390\/molecules28103987","article-title":"Chemical Constitution, pharmacological effects and the underlying mechanism of atractylenolides: a review","volume":"28","author":"Xie","year":"2023","journal-title":"Molecules"},{"issue":"10","key":"10.1016\/j.phymed.2025.157564_bib0042","doi-asserted-by":"crossref","DOI":"10.1172\/JCI146832","article-title":"Atractylenolide I enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation","volume":"131","author":"Xu","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.phymed.2025.157564_bib0043","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3892\/ol.2025.15118","article-title":"Atractylenolide I inhibits the growth, proliferation and migration of B16 melanoma cells via the PI3K\/AKT\/mTOR pathway","volume":"30","author":"Xu","year":"2025","journal-title":"Oncol. Lett."},{"issue":"11","key":"10.1016\/j.phymed.2025.157564_bib0044","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1111\/cas.13792","article-title":"Tumor suppressive role for kinases phosphorylating p53 in DNA damage-induced apoptosis","volume":"109","author":"Yogosawa","year":"2018","journal-title":"Cancer Sci."},{"issue":"9","key":"10.1016\/j.phymed.2025.157564_bib0045","doi-asserted-by":"crossref","first-page":"7037","DOI":"10.1007\/s12035-024-04025-7","article-title":"Atractylenolide I suppresses A1 astrocyte activation to improve depression in mice","volume":"61","author":"Zhai","year":"2024","journal-title":"Mol. Neurobiol."},{"issue":"23","key":"10.1016\/j.phymed.2025.157564_bib0046","first-page":"6512","article-title":"Evidence map for randomized controlled trials of traditional Chinese medicine in prevention and treatment of colorectal cancer]","volume":"49","author":"Zhang","year":"2024","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"issue":"4","key":"10.1016\/j.phymed.2025.157564_bib0048","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s13577-025-01224-9","article-title":"Screening of pivotal oncogenes modulated by DNA methylation in hepatocellular carcinoma and identification of atractylenolide I as an anti-cancer drug","volume":"38","author":"Zhi","year":"2025","journal-title":"Hum. Cell"},{"key":"10.1016\/j.phymed.2025.157564_bib0049","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jep.2018.08.023","article-title":"The traditional uses, phytochemistry, and pharmacology of atractylodes macrocephala koidz.: a review","volume":"226","author":"Zhu","year":"2018","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"10.1016\/j.phymed.2025.157564_bib0050","doi-asserted-by":"crossref","first-page":"C148","DOI":"10.1152\/ajpcell.00302.2024","article-title":"The contribution of the novel CLTC-VMP1 fusion gene to autophagy regulation and energy metabolism in cisplatin-resistant osteosarcoma","volume":"328","author":"Zou","year":"2025","journal-title":"Am. J. Physiol. Cell Physiol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325012000?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325012000?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T11:29:57Z","timestamp":1766662197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325012000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":45,"alternative-id":["S0944711325012000"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157564","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Atractylenolide I activates the DNA damage-apoptosis axis in colorectal cancer patient-derived organoids by dual-targeting XRCC5 and CLTC","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157564","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157564"}}