{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T13:22:37Z","timestamp":1793798557521,"version":"4.6.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074214"],"award-info":[{"award-number":["82074214"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004863","name":"Zhejiang Chinese Medical University","doi-asserted-by":"publisher","award":["GQD25SH12"],"award-info":[{"award-number":["GQD25SH12"]}],"id":[{"id":"10.13039\/501100004863","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004863","name":"Zhejiang Chinese Medical University","doi-asserted-by":"publisher","award":["2025FSYYZQ06"],"award-info":[{"award-number":["2025FSYYZQ06"]}],"id":[{"id":"10.13039\/501100004863","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.phymed.2025.157572","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T14:03:55Z","timestamp":1763647435000},"page":"157572","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Quzhou-sourced Fructus Aurantii ameliorates MASLD by modulating glycolysis-dependent M1 polarization in hepatic macrophages"],"prefix":"10.1016","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5014-7156","authenticated-orcid":false,"given":"Junbin","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunmeng","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1544-3093","authenticated-orcid":false,"given":"Menglu","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.157572_bib0001","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s13679-024-00574-z","article-title":"Non-invasive scores and serum biomarkers for fatty liver in the era of metabolic dysfunction-associated steatotic Liver disease (MASLD): a comprehensive review from NAFLD to MAFLD and MASLD","volume":"13","author":"Abdelhameed","year":"2024","journal-title":"Curr. Obes. Rep."},{"key":"10.1016\/j.phymed.2025.157572_bib0002","doi-asserted-by":"crossref","DOI":"10.1038\/s41577-025-01186-x","article-title":"The spatial and temporal activation of macrophages during fibrosis","author":"Behmoaras","year":"2025","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phymed.2025.157572_bib0003","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1016\/j.celrep.2017.08.096","article-title":"Metabolically activated adipose tissue macrophages perform detrimental and beneficial functions during diet-induced obesity","volume":"20","author":"Coats","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.phymed.2025.157572_bib0004","doi-asserted-by":"crossref","unstructured":"Cusi, K., Abdelmalek, M.F., Apovian, C.M., Balapattabi, K., Bannuru, R.R., Barb, D., Bardsley, J.K., Beverly, E.A., Corbin, K.D., ElSayed, N.A., Isaacs, S., Kanwal, F., Pekas, E.J., Richardson, C.R., Roden, M., Sanyal, A.J., Shubrook, J.H., Younossi, Z.M., Bajaj, M., 2025. Metabolic dysfunction-associated steatotic liver disease (MASLD) in people with diabetes: the need for screening and early intervention. A Consensus Report of the American Diabetes Association. Diabetes care.","DOI":"10.2337\/figshare.28673327"},{"key":"10.1016\/j.phymed.2025.157572_bib0005","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.apsb.2022.04.003","article-title":"Targeting macrophagic 17\u03b2-HSD7 by fenretinide for the treatment of nonalcoholic fatty liver disease","volume":"13","author":"Dong","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2025.157572_bib0006","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jhep.2020.03.039","article-title":"A new definition for metabolic dysfunction-associated fatty liver disease: an international expert consensus statement","volume":"73","author":"Eslam","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2025.157572_bib0007","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2019.11.312","article-title":"MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease","volume":"158","author":"Eslam","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phymed.2025.157572_bib0008","article-title":"Experimental pharmacology","author":"Guanhua","year":"2004","journal-title":"Experim. Pharmacol"},{"key":"10.1016\/j.phymed.2025.157572_bib0009","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.phymed.2025.157572_bib0010","doi-asserted-by":"crossref","DOI":"10.3350\/cmh.2025.0083","article-title":"Emerging therapies and real-world application of metabolic dysfunction-associated steatotic liver disease treatment","author":"Kim","year":"2025","journal-title":"Clin. Mol. Hepatol."},{"key":"10.1016\/j.phymed.2025.157572_bib0011","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/j.1476-5381.2012.01911.x","article-title":"The use of animal models in diabetes research","volume":"166","author":"King","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157572_bib0012","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jhep.2023.04.002","article-title":"Using the ELF test, FIB-4 and NAFLD fibrosis score to screen the population for liver disease","volume":"79","author":"Kjaergaard","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2025.157572_bib0013","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/hep.29544","article-title":"Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis","volume":"67","author":"Krenkel","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2025.157572_bib0014","doi-asserted-by":"crossref","first-page":"5","DOI":"10.6026\/97320630002005","article-title":"Mfuzz: a software package for soft clustering of microarray data","volume":"2","author":"Kumar","year":"2007","journal-title":"Bioinformation."},{"key":"10.1016\/j.phymed.2025.157572_bib0015","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.cmet.2016.06.004","article-title":"Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation","volume":"24","author":"Lampropoulou","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2025.157572_bib0016","doi-asserted-by":"crossref","first-page":"938","DOI":"10.15252\/msb.20177703","article-title":"Network analyses identify liver-specific targets for treating liver diseases","volume":"13","author":"Lee","year":"2017","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.phymed.2025.157572_bib0017","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1038\/s41401-024-01389-3","article-title":"SGLT2 inhibitors ameliorate NAFLD in mice via downregulating PFKFB3, suppressing glycolysis and modulating macrophage polarization","volume":"45","author":"Lin","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phymed.2025.157572_bib0018","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phymed.2025.157572_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2022.101642","article-title":"Adipose tissue macrophages: regulators of adipose tissue immunometabolism during obesity","volume":"66","author":"Nance","year":"2022","journal-title":"Mol. Metab."},{"key":"10.1016\/j.phymed.2025.157572_bib0020","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/ni.2852","article-title":"Glycolytic reprogramming by TLRs in dendritic cells","volume":"15","author":"O'Neill","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.phymed.2025.157572_bib0021","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/s42255-023-00800-3","article-title":"Mitochondrial pyruvate carrier-mediated metabolism is dispensable for the classical activation of macrophages","volume":"5","author":"Ran","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.phymed.2025.157572_bib0022","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.jhep.2023.06.003","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"79","author":"Rinella","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2025.157572_bib0023","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.jhep.2024.06.016","article-title":"Inflammasomes in chronic liver disease: hepatic injury, fibrosis progression and systemic inflammation","volume":"81","author":"Taru","year":"2024","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2025.157572_bib0024","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41575-020-0316-6","article-title":"From NAFLD to MAFLD: when pathophysiology succeeds","volume":"17","author":"Tilg","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2025.157572_bib0025","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/3-540-26573-2_12","article-title":"Handbook of Experimental Pharmacology","volume":"168","author":"Vaughan","year":"2005","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157572_bib0026","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jhep.2017.11.013","article-title":"Non-invasive assessment of non-alcoholic fatty liver disease: clinical prediction rules and blood-based biomarkers","volume":"68","author":"Vilar-Gomez","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2025.157572_bib0027","doi-asserted-by":"crossref","first-page":"e2792","DOI":"10.1038\/cddis.2017.10","article-title":"MiR-130a-3p attenuates activation and induces apoptosis of hepatic stellate cells in nonalcoholic fibrosing steatohepatitis by directly targeting TGFBR1 and TGFBR2","volume":"8","author":"Wang","year":"2017","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.phymed.2025.157572_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155924","article-title":"Mechanistic study of fructus aurantii (Quzhou origin) in regulating ileal reg3g in the treatment for NASH","volume":"133","author":"Yan","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157572_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154944","article-title":"Pure total flavonoids from citrus alleviate oxidative stress and inflammation in nonalcoholic fatty liver disease by regulating the miR-137-3p\/NOXA2\/NOX2 pathway","volume":"118","author":"Yan","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157572_bib0030","first-page":"739","article-title":"Global prevalence, incidence, and outcomes of non-obese or lean non-alcoholic fatty liver disease: a systematic review and meta-analysis. The lancet","volume":"5","author":"Ye","year":"2020","journal-title":"Gastroenterol. Hepatol. (N. Y)"},{"key":"10.1016\/j.phymed.2025.157572_bib0031","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2025.157572_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.tem.2025.03.009","article-title":"Targeting PKLR in liver diseases","author":"Yuan","year":"2025","journal-title":"Trends. Endocrinol. Metab."},{"key":"10.1016\/j.phymed.2025.157572_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156439","article-title":"Zhuyu pill attenuates metabolic-associated fatty liver disease by regulating macrophage polarization through TLR4 signaling pathway","volume":"138","author":"Zhao","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157572_bib0034","doi-asserted-by":"crossref","DOI":"10.1111\/liv.70155","article-title":"Global burden of chronic liver disease and temporal trends: a population-based analysis from 1990 to 2021 with projections to 2050","volume":"45","author":"Zhao","year":"2025","journal-title":"Liver. Int."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325012085?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325012085?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T16:33:55Z","timestamp":1773938035000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325012085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":34,"alternative-id":["S0944711325012085"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157572","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quzhou-sourced Fructus Aurantii ameliorates MASLD by modulating glycolysis-dependent M1 polarization in hepatic macrophages","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157572","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157572"}}