{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:28:28Z","timestamp":1792254508653,"version":"4.4.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012131","name":"Department of Science and Technology of Liaoning Province","doi-asserted-by":"publisher","award":["2025JH2\/101300019"],"award-info":[{"award-number":["2025JH2\/101300019"]}],"id":[{"id":"10.13039\/501100012131","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100316"],"award-info":[{"award-number":["82100316"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970357"],"award-info":[{"award-number":["81970357"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270434"],"award-info":[{"award-number":["82270434"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574406"],"award-info":[{"award-number":["82574406"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.phymed.2025.157580","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T16:22:49Z","timestamp":1764001369000},"page":"157580","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Timosaponin B-II attenuates cerebral ischemia injury by enhancing Parkin-mediated mitophagy"],"prefix":"10.1016","volume":"149","author":[{"given":"Yueyang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanxiao","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanru","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guannan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Sheng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.157580_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2024.149308","article-title":"Pathophysiology of cerebral ischemia-reperfusion injury: an overview of oxidative stress and plant-based therapeutic approaches","volume":"1847","author":"Akhtar","year":"2025","journal-title":"Brain Res."},{"key":"10.1016\/j.phymed.2025.157580_bib0002","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.jpba.2008.09.032","article-title":"A rapid and sensitive liquid chromatography-tandem mass spectrometric method for the determination of timosaponin B-II in blood plasma and a study of the pharmacokinetics of saponin in the rat","volume":"48","author":"Cai","year":"2008","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.phymed.2025.157580_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119115","article-title":"Nasal timosaponin BII dually sensitive in situ hydrogels for the prevention of Alzheimer's disease induced by lipopolysaccharides","volume":"578","author":"Chen","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.phymed.2025.157580_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2023.110631","article-title":"Parkin and mitochondrial signalling","volume":"106","author":"Connelly","year":"2023","journal-title":"Cell Signal."},{"key":"10.1016\/j.phymed.2025.157580_bib0005","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.cbi.2015.08.001","article-title":"Cardioprotective effects of timosaponin B II from Anemarrhenae asphodeloides Bge on isoproterenol-induced myocardial infarction in rats","volume":"240","author":"Deng","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.phymed.2025.157580_bib0006","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3892\/ijmm.2025.5544","article-title":"Molecular mechanisms of programmed cell death and potential targeted pharmacotherapy in ischemic stroke (Review)","volume":"56","author":"Duan","year":"2025","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.phymed.2025.157580_bib0007","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jchromb.2014.06.017","article-title":"Simultaneous determination of timosaponin B-II and A-III in rat plasma by LC-MS\/MS and its application to pharmacokinetic study","volume":"965","author":"Feng","year":"2014","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.phymed.2025.157580_bib0008","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/1472-6882-12-189","article-title":"Timosaponin-BII inhibits the up-regulation of BACE1 induced by ferric chloride in rat retina","volume":"12","author":"Huang","year":"2012","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.phymed.2025.157580_bib0009","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s10337-015-2927-6","article-title":"In-vivo and in-vitro metabolism study of timosaponin B-II Using HPLC-ESI-MSn","volume":"78","author":"Jia","year":"2015","journal-title":"Chromatographia"},{"key":"10.1016\/j.phymed.2025.157580_bib0010","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.pbb.2009.04.021","article-title":"Timosaponin AIII, a saponin isolated from Anemarrhena asphodeloides, ameliorates learning and memory deficits in mice","volume":"93","author":"Lee","year":"2009","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.phymed.2025.157580_bib0011","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkad018","article-title":"Targeting neuronal mitophagy in ischemic stroke: an update","volume":"11","author":"Li","year":"2023","journal-title":"Burns Trauma"},{"key":"10.1016\/j.phymed.2025.157580_bib0013","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.neulet.2007.04.082","article-title":"Timosaponin B-II improves memory and learning dysfunction induced by cerebral ischemia in rats","volume":"421","author":"Li","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.phymed.2025.157580_bib0014","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.yrtph.2017.09.021","article-title":"Acute toxicity, 28-day repeated-dose toxicity and toxicokinetic study of timosaponin BII in rats","volume":"90","author":"Lin","year":"2017","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157580_bib0015","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1080\/21655979.2021.2024685","article-title":"Timosaponin B-II alleviates osteoarthritis-related inflammation and extracellular matrix degradation through inhibition of mitogen-activated protein kinases and nuclear factor-kappaB pathways in vitro","volume":"13","author":"Liu","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.phymed.2025.157580_bib0016","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s00018-023-04792-x","article-title":"Phosphorylation of STAT3 at Tyr705 contributes to TFEB-mediated autophagy-lysosomal pathway dysfunction and leads to ischemic injury in rats","volume":"80","author":"Liu","year":"2023","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.phymed.2025.157580_bib0017","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1161\/STROKEAHA.120.032749","article-title":"CAPN1 (Calpain1)-mediated impairment of autophagic flux contributes to cerebral ischemia-induced neuronal damage","volume":"52","author":"Liu","year":"2021","journal-title":"Stroke"},{"key":"10.1016\/j.phymed.2025.157580_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2024.108721","article-title":"Potential application of natural compounds in ischaemic stroke: focusing on the mechanisms underlying \"lysosomocentric\" dysfunction of the autophagy-lysosomal pathway","volume":"263","author":"Liu","year":"2024","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2025.157580_bib0019","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/15548627.2018.1531196","article-title":"Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia","volume":"15","author":"Liu","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2025.157580_bib0020","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1002\/rcm.6299","article-title":"Metabolism profile of timosaponin B-II in urine after oral administration to rats by ultrahigh-performance liquid chromatography\/quadrupole-time-of-flight mass spectrometry","volume":"26","author":"Liu","year":"2012","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.phymed.2025.157580_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116186","article-title":"The role of oxidative stress in blood-brain barrier disruption during ischemic stroke: antioxidants in clinical trials","volume":"228","author":"Lochhead","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157580_bib0022","doi-asserted-by":"crossref","first-page":"31684","DOI":"10.1074\/jbc.M110.202531","article-title":"Activation of autophagy of aggregation-prone ubiquitinated proteins by timosaponin A-III","volume":"286","author":"Lok","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2025.157580_bib0023","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.phymed.2025.157580_bib0024","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1007\/s12272-009-1916-4","article-title":"Timosaponin B-II inhibits pro-inflammatory cytokine induction by lipopolysaccharide in BV2 cells","volume":"32","author":"Lu","year":"2009","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.phymed.2025.157580_bib0025","doi-asserted-by":"crossref","first-page":"736","DOI":"10.7150\/thno.79876","article-title":"Cellular mitophagy: mechanism, roles in diseases and small molecule pharmacological regulation","volume":"13","author":"Lu","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2025.157580_bib0026","doi-asserted-by":"crossref","DOI":"10.1177\/26331055241292600","article-title":"Ischemic stroke: pathophysiology and evolving treatment approaches","volume":"19","author":"Majumder","year":"2024","journal-title":"Neurosci. Insights"},{"key":"10.1016\/j.phymed.2025.157580_bib0027","doi-asserted-by":"crossref","first-page":"7653","DOI":"10.7150\/thno.112608","article-title":"Multi-dimensional data-driven computational drug repurposing strategy for screening novel neuroprotective agents in ischemic stroke","volume":"15","author":"Meng","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2025.157580_bib0028","first-page":"214","article-title":"A quinolinyl analog of resveratrol improves neuronal damage after ischemic stroke by promoting Parkin-mediated mitophagy","volume":"23","author":"Meng","year":"2025","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.phymed.2025.157580_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155406","article-title":"Kellerin alleviates cerebral ischemic injury by inhibiting ferroptosis via targeting Akt-mediated transcriptional activation of Nrf2","volume":"128","author":"Mi","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157580_bib0030","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/s41580-024-00757-5","article-title":"Mechanisms of autophagy-lysosome dysfunction in neurodegenerative diseases","volume":"25","author":"Nixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2025.157580_bib0031","first-page":"121","article-title":"Effects of timosaponins on learning and memory abilities of rats with dementia induced by lateral cerebral ventricular injection of amyloid beta- peptide","volume":"25","author":"Ouyang","year":"2005","journal-title":"Di Yi Jun Yi Da Xue Xue Bao"},{"key":"10.1016\/j.phymed.2025.157580_bib0032","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1038\/s42255-023-00930-8","article-title":"Mitophagy in human health, ageing and disease","volume":"5","author":"Picca","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.phymed.2025.157580_bib0033","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41392-022-01064-1","article-title":"Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions","volume":"7","author":"Qin","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2025.157580_bib0034","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3119649","article-title":"Docosahexaenoic acid alleviates brain damage by promoting mitophagy in mice with ischaemic stroke","volume":"2022","author":"Sun","year":"2022","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.phymed.2025.157580_bib0035","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/8474303","article-title":"Parkin protects against oxygen-glucose deprivation\/reperfusion insult by promoting Drp1 degradation","author":"Tang","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.phymed.2025.157580_bib0036","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.freeradbiomed.2021.05.014","article-title":"Timosaponin BII improved osteoporosis caused by hyperglycemia through promoting autophagy of osteoblasts via suppressing the mTOR\/NFkappaB signaling pathway","volume":"171","author":"Wang","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2025.157580_bib0037","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/s41419-021-03900-8","article-title":"Hypoxic postconditioning promotes mitophagy against transient global cerebral ischemia via PINK1\/Parkin-induced mitochondrial ubiquitination in adult rats","volume":"12","author":"Wen","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2025.157580_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157026","article-title":"Ethanol extract of Periploca forrestii Schltr. and chlorogenic acid alleviate ischemic stroke by inhibiting TLR4-mediated neuroinflammation","volume":"145","author":"Wu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157580_bib0040","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1080\/15548627.2020.1802089","article-title":"BNIP3L\/NIX degradation leads to mitophagy deficiency in ischemic brains","volume":"17","author":"Wu","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2025.157580_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102842","article-title":"Bidirectional regulation of neuronal autophagy in ischemic stroke: mechanisms and therapeutic potential","volume":"111","author":"Wu","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.phymed.2025.157580_bib0042","doi-asserted-by":"crossref","first-page":"e4321","DOI":"10.1002\/bmc.4321","article-title":"Protective effects of timosaponin BII on oxidative stress damage in PC12 cells based on metabolomics","volume":"32","author":"Xie","year":"2018","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.phymed.2025.157580_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153288","article-title":"Cardioprotective effect exerted by Timosaponin B\u2161 through the regulation of endoplasmic stress-induced apoptosis","volume":"78","author":"Xing","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157580_bib0044","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/bmc.3109","article-title":"A novel LC-MS\/MS method for determination of tissue distribution and excretion of timosaponin B-II in rat biological matrices","volume":"28","author":"Xu","year":"2014","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.phymed.2025.157580_bib0045","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-019-1693-z","article-title":"Dectin-1\/Syk signaling triggers neuroinflammation after ischemic stroke in mice","volume":"17","author":"Ye","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.phymed.2025.157580_bib0046","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3109\/15376516.2015.1045652","article-title":"Timosaponin B-II inhibits lipopolysaccharide-induced acute lung toxicity via TLR\/NF-kappaB pathway","volume":"25","author":"Zhang","year":"2015","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.phymed.2025.157580_bib0047","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.4161\/auto.25132","article-title":"Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance","volume":"9","author":"Zhang","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2025.157580_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107527","article-title":"The therapeutic effects of salvianolic acids on ischemic stroke: from molecular mechanisms to clinical applications","volume":"210","author":"Zhao","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2025.157580_bib0049","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1007\/s11011-016-9877-z","article-title":"Timosaponin B-II ameliorates scopolamine-induced cognition deficits by attenuating acetylcholinesterase activity and brain oxidative damage in mice","volume":"31","author":"Zhao","year":"2016","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.phymed.2025.157580_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2023.105520","article-title":"Umbelliferone protects against cerebral ischemic injury through selective autophagy of mitochondria","volume":"165","author":"Zhou","year":"2023","journal-title":"Neurochem. Int."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325012164?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325012164?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:12:08Z","timestamp":1773864728000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325012164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":48,"alternative-id":["S0944711325012164"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157580","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Timosaponin B-II attenuates cerebral ischemia injury by enhancing Parkin-mediated mitophagy","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157580","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"157580"}}