{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:20:52Z","timestamp":1791894052513,"version":"4.3.4"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82,174,206"],"award-info":[{"award-number":["82,174,206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005153","name":"China National Funds for Distinguished Young Scientists","doi-asserted-by":"publisher","award":["82,204,804"],"award-info":[{"award-number":["82,204,804"]}],"id":[{"id":"10.13039\/501100005153","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.phymed.2025.157625","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:13:00Z","timestamp":1764202380000},"page":"157625","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Chlorogenic acid targets STING to alleviate pressure overload-induced heart failure and myocardial fibrosis"],"prefix":"10.1016","volume":"150","author":[{"given":"Kai","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Ling","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Yin","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1198-2794","authenticated-orcid":false,"given":"Fang-He","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0444-4456","authenticated-orcid":false,"given":"Shu-Zhen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.157625_bib0001","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.biopha.2016.11.067","article-title":"Chlorogenic acid ameliorates isoproterenol-induced myocardial injury in rats by stabilizing mitochondrial and lysosomal enzymes","volume":"85","author":"AKILA","year":"2017","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2025.157625_bib40","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3390\/ph12030110","article-title":"Safety pharmacological evaluation of the coffee component, caffeoylquinic acid, and its metabolites, using ex vivo and in vitro profiling assays","volume":"12","author":"AMANO","year":"2019","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.phymed.2025.157625_bib0003","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s41586-024-08008-5","article-title":"Targeting immune-fibroblast cell communication in heart failure","volume":"635","author":"AMRUTE","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2025.157625_bib0004","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1161\/CIRCRESAHA.118.314028","article-title":"Tissue Resident CCR2- and CCR2+ Cardiac Macrophages Differentially Orchestrate Monocyte Recruitment and Fate Specification Following Myocardial Injury","volume":"124","author":"BAJPAI","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2025.157625_bib0005","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/s41591-018-0059-x","article-title":"The human heart contains distinct macrophage subsets with divergent origins and functions","volume":"24","author":"BAJPAI","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2025.157625_bib39","doi-asserted-by":"crossref","first-page":"16801","DOI":"10.1038\/s41598-021-95723-y","article-title":"Cardiac macrophage subsets differentially regulate lymphatic network remodeling during pressure overload","volume":"11","author":"BIZOU","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.phymed.2025.157625_bib0006","doi-asserted-by":"crossref","first-page":"4092","DOI":"10.1093\/eurheartj\/ehaa659","article-title":"Time-to-treatment initiation of colchicine and cardiovascular outcomes after myocardial infarction in the Colchicine Cardiovascular Outcomes Trial (COLCOT)","volume":"41","author":"BOUABDALLAOUI","year":"2020","journal-title":"Eur. Heart. J."},{"key":"10.1016\/j.phymed.2025.157625_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113833","article-title":"Deciphering the effective combinatorial components from Si-Miao-Yong-An decoction regarding the intervention on myocardial hypertrophy","volume":"271","author":"CHEN","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157625_bib0008","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ijcard.2016.03.240","article-title":"Cellular, structural and functional cardiac remodelling following pressure overload and unloading","volume":"216","author":"DADSON","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.phymed.2025.157625_bib0009","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/s41577-021-00524-z","article-title":"The cGAS-STING pathway as a therapeutic target in inflammatory diseases","volume":"21","author":"DECOUT","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phymed.2025.157625_bib0010","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.immuni.2013.11.019","article-title":"Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation","volume":"40","author":"EPELMAN","year":"2014","journal-title":"Immunity."},{"key":"10.1016\/j.phymed.2025.157625_bib0011","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jep.2013.03.077","article-title":"Anti-inflammatory activity of Cymbopogon citratus leaves infusion via proteasome and nuclear factor-\u03baB pathway inhibition: contribution of chlorogenic acid","volume":"148","author":"FRANCISCO","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157625_bib41","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1161\/CIRCRESAHA.120.318539","article-title":"Molecular imaging of inflammation and fibrosis in pressure overload heart failure","volume":"129","author":"GLASENAPP","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2025.157625_bib0012","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1161\/HYPERTENSIONAHA.122.20004","article-title":"GSDMD (Gasdermin D) Mediates Pathological Cardiac Hypertrophy and Generates a Feed-Forward Amplification Cascade via Mitochondria-STING (Stimulator of Interferon Genes) Axis","volume":"79","author":"HAN","year":"2022","journal-title":"Hypertension"},{"key":"10.1016\/j.phymed.2025.157625_bib0013","doi-asserted-by":"crossref","first-page":"H1525","DOI":"10.1152\/ajpheart.00097.2020","article-title":"Cytosolic DNA sensor cGAS plays an essential pathogenetic role in pressure overload-induced heart failure","volume":"318","author":"HU","year":"2020","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"10.1016\/j.phymed.2025.157625_bib0037","first-page":"191","article-title":"Chlorogenic acid ameliorates heart failure by attenuatingcardiomyocyte ferroptosis","volume":"11","author":"HUANG","year":"2024","journal-title":"J. Tradit. Chin. Med. Sci."},{"key":"10.1016\/j.phymed.2025.157625_bib0014","article-title":"Chlorogenic acid attenuates cardiac hypertrophy and fibrosis by downregulating galectin 3","volume":"15","author":"KIM","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2025.157625_bib0015","doi-asserted-by":"crossref","first-page":"16029","DOI":"10.1073\/pnas.1406508111","article-title":"Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart","volume":"111","author":"LAVINE","year":"2014","journal-title":"Proc. Natl. Acad. Sci. u S. a"},{"key":"10.1016\/j.phymed.2025.157625_bib0016","doi-asserted-by":"crossref","first-page":"E4661","DOI":"10.1073\/pnas.1720065115","article-title":"Distinct roles of resident and nonresident macrophages in nonischemic cardiomyopathy","volume":"115","author":"LIAO","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"10.1016\/j.phymed.2025.157625_bib0017","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1111\/1541-4337.12620","article-title":"Chlorogenic acid: a comprehensive review of the dietary sources, processing effects, bioavailability, beneficial properties, mechanisms of action, and future directions","volume":"19","author":"LU","year":"2020","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"10.1016\/j.phymed.2025.157625_bib0018","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"MCDONAGH","year":"2021","journal-title":"Eur. Heart. J."},{"key":"10.1016\/j.phymed.2025.157625_bib0019","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.jacc.2020.01.014","article-title":"Inflammation in Heart Failure: JACC State-of-the-Art Review","volume":"75","author":"MURPHY","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.phymed.2025.157625_bib0020","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.biopha.2017.10.064","article-title":"Chlorogenic acid (CGA): a pharmacological review and call for further research","volume":"97","author":"NAVEED","year":"2018","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2025.157625_bib0021","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cell.2020.08.031","article-title":"A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart","volume":"183","author":"NICOL\u00e1S-\u00c1VILA","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2025.157625_bib0022","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jacbts.2017.12.006","article-title":"CCR2(+) Monocyte-Derived Infiltrating Macrophages Are Required for Adverse Cardiac Remodeling During Pressure Overload","volume":"3","author":"PATEL","year":"2018","journal-title":"JACC. Basic Transl. Sci."},{"key":"10.1016\/j.phymed.2025.157625_bib0023","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1002\/ehf2.14707","article-title":"Chlorogenic acid attenuates cardiac hypertrophy via up-regulating Sphingosine-1-phosphate receptor1 to inhibit endoplasmic reticulum stress","volume":"11","author":"PING","year":"2024","journal-title":"ESC. Heart. Fail."},{"key":"10.1016\/j.phymed.2025.157625_bib0024","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202000810","article-title":"Chlorogenic Acid Alleviates Hyperglycemia-Induced Cardiac Fibrosis through Activation of the NO\/cGMP\/PKG Pathway in Cardiac Fibroblasts","volume":"65","author":"QIN","year":"2021","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.phymed.2025.157625_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104318","article-title":"Si-Miao-Yong-An decoction ameliorates cardiac function through restoring the equilibrium of SOD and NOX2 in heart failure mice","volume":"146","author":"REN","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2025.157625_bib0026","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1161\/CIRCRESAHA.121.319737","article-title":"Cardiac Resident Macrophages Prevent Fibrosis and Stimulate Angiogenesis","volume":"129","author":"REVELO","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2025.157625_bib0027","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease","volume":"377","author":"RIDKER","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phymed.2025.157625_bib0028","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1161\/CIRCULATIONAHA.115.020502","article-title":"Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload-Induced Mitochondrial Dysfunction and Heart Failure","volume":"133","author":"SHIRAKABE","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2025.157625_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110132","article-title":"Si-Miao-Yong-An decoction attenuates cardiac fibrosis via suppressing TGF-\u03b21 pathway and interfering with MMP-TIMPs expression","volume":"127","author":"SU","year":"2020","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2025.157625_bib0030","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1161\/CIRCULATIONAHA.118.034621","article-title":"Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca(2+)\/Calmodulin-Dependent Protein Kinase II \u03b4 Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling","volume":"138","author":"SUETOMI","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2025.157625_bib0031","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/s41419-020-02777-3","article-title":"Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload","volume":"11","author":"WANG","year":"2020","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.phymed.2025.157625_bib0032","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41392-025-02220-z","article-title":"The immune system in cardiovascular diseases: from basic mechanisms to therapeutic implications","volume":"10","author":"WANG","year":"2025","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2025.157625_bib0033","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1080\/10641960600798655","article-title":"The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension","volume":"28","author":"WATANABE","year":"2006","journal-title":"Clin. Exp. Hypertens"},{"key":"10.1016\/j.phymed.2025.157625_bib0034","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40360-022-00631-0","article-title":"GAS-STING signaling plays an essential pathogenetic role in Doxorubicin-Induced Cardiotoxicity","volume":"24","author":"XIAO","year":"2023","journal-title":"BMC. Pharmacol. Toxicol."},{"key":"10.1016\/j.phymed.2025.157625_bib0035","doi-asserted-by":"crossref","DOI":"10.3791\/55293","article-title":"Minimally Invasive Transverse Aortic Constriction in Mice","author":"ZAW","year":"2017","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.phymed.2025.157625_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110022","article-title":"STING is an essential regulator of heart inflammation and fibrosis in mice with pathological cardiac hypertrophy via endoplasmic reticulum (ER) stress","volume":"125","author":"ZHANG","year":"2020","journal-title":"Biomed. PharmacOther"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325012607?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325012607?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T01:06:39Z","timestamp":1773882399000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325012607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":39,"alternative-id":["S0944711325012607"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157625","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chlorogenic acid targets STING to alleviate pressure overload-induced heart failure and myocardial fibrosis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157625","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"157625"}}