{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:36:55Z","timestamp":1792802215293,"version":"4.5.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014717","name":"National Natural Science Foundation of China National Outstanding Youth Science Fund Project","doi-asserted-by":"publisher","award":["82560922"],"award-info":[{"award-number":["82560922"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014717","name":"National Natural Science Foundation of China National Outstanding Youth Science Fund Project","doi-asserted-by":"publisher","award":["82205016"],"award-info":[{"award-number":["82205016"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","doi-asserted-by":"publisher","award":["ZYYZDXK-2023167"],"award-info":[{"award-number":["ZYYZDXK-2023167"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004924","name":"Guangxi Traditional Chinese Medical University","doi-asserted-by":"publisher","award":["2022YJKT006"],"award-info":[{"award-number":["2022YJKT006"]}],"id":[{"id":"10.13039\/501100004924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011833","name":"Guangxi University of Chinese Medicine","doi-asserted-by":"publisher","award":["2022BS028"],"award-info":[{"award-number":["2022BS028"]}],"id":[{"id":"10.13039\/501100011833","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011833","name":"Guangxi University of Chinese Medicine","doi-asserted-by":"publisher","award":["2021BS030"],"award-info":[{"award-number":["2021BS030"]}],"id":[{"id":"10.13039\/501100011833","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011833","name":"Guangxi University of Chinese Medicine","doi-asserted-by":"publisher","award":["2023JQ006"],"award-info":[{"award-number":["2023JQ006"]}],"id":[{"id":"10.13039\/501100011833","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011833","name":"Guangxi University of Chinese Medicine","doi-asserted-by":"publisher","award":["2023JQ005"],"award-info":[{"award-number":["2023JQ005"]}],"id":[{"id":"10.13039\/501100011833","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.phymed.2025.157632","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T16:41:45Z","timestamp":1764348105000},"page":"157632","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Compound Chaijin Jieyu Fang alleviates insomnia complicated with depression by reshaping actinobacteria to inhibit neuronal apoptosis"],"prefix":"10.1016","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4082-2696","authenticated-orcid":false,"given":"Yi","family":"Shu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deguo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajie","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zirong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangzi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.157632_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114079","article-title":"The microbiota drives diurnal rhythms in tryptophan metabolism in the stressed gut","volume":"43","author":"Gheorghe","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.phymed.2025.157632_bib0002","doi-asserted-by":"crossref","first-page":"505","DOI":"10.5664\/jcsm.9640","article-title":"Association of obstructive sleep apnea severity with the composition of the upper airway microbiome","volume":"18","author":"Hong","year":"2022","journal-title":"J. Clin. Sleep. Med."},{"key":"10.1016\/j.phymed.2025.157632_bib0003","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2024.1291148","article-title":"Gut bacteria: an etiological agent in human pathological conditions","volume":"14","author":"Islam","year":"2024","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1016\/j.phymed.2025.157632_bib0004","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.apsb.2024.11.009","article-title":"Gut microbiota-derived tryptophan metabolites regulated by Wuji Wan to attenuate colitis through AhR signaling activation","volume":"15","author":"Jing","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2025.157632_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2025.102048","article-title":"Sleep alterations in major depressive disorder and insomnia disorder: a network meta-analysis of polysomnographic studies","volume":"80","author":"Leitner","year":"2025","journal-title":"Sleep. Med. Rev."},{"key":"10.1016\/j.phymed.2025.157632_bib0006","doi-asserted-by":"crossref","first-page":"669","DOI":"10.3389\/fpsyt.2018.00669","article-title":"The role of microbiome in insomnia, circadian disturbance and depression","volume":"9","author":"Li","year":"2018","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.phymed.2025.157632_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2024.111141","article-title":"Pink1\/Parkin signaling mediates pineal mitochondrial autophagy dysfunction and its biological role in a comorbid rat model of depression and insomnia","volume":"220","author":"Li","year":"2025","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.phymed.2025.157632_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2024.138091","article-title":"Sleep deprivation activated AMPK\/FOXO3a signaling mediates pineal autophagy impairment to reduce melatonin secretion in CUMS + SD rats leading to depression combined with insomnia","volume":"848","author":"Li","year":"2025","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.phymed.2025.157632_bib0009","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.3390\/jcm10153377","article-title":"Effects of antidepressant treatment on neurotrophic factors (BDNF and IGF-1) in patients with major depressive disorder (MDD)","volume":"10","author":"Mosio\u0142ek","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.phymed.2025.157632_bib0010","doi-asserted-by":"crossref","first-page":"507","DOI":"10.9758\/cpn.2020.18.4.507","article-title":"Kynurenine pathway of tryptophan metabolism in neuropsychiatric disorders: pathophysiologic and therapeutic considerations","volume":"18","author":"Muneer","year":"2020","journal-title":"Clin. Psychopharmacol. Neurosci."},{"key":"10.1016\/j.phymed.2025.157632_bib0011","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.jpsychires.2011.01.010","article-title":"Severe insomnia is associated with more severe presentation and greater functional deficits in depression","volume":"45","author":"O\u2019Brien","year":"2011","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.phymed.2025.157632_bib0012","doi-asserted-by":"crossref","first-page":"9946","DOI":"10.1074\/jbc.M112.436451","article-title":"Novel tryptophan metabolism by a potential gene cluster that is widely distributed among actinomycetes","volume":"288","author":"Ozaki","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2025.157632_bib0013","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s12529-020-09903-7","article-title":"The role of emotion regulation difficulties in the relation between insomnia and depressive symptoms","volume":"27","author":"Predatu","year":"2020","journal-title":"Int. J. Behav. Med."},{"key":"10.1016\/j.phymed.2025.157632_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2025.114881","article-title":"The relationship between \u201cmicrobiota-gut-brain\u201d axis and depression: chronic stress-induced inflammation","volume":"294","author":"Wang","year":"2025","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.phymed.2025.157632_bib0015","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1038\/s41380-024-02867-0","article-title":"Gut microbiota regulate insomnia-like behaviors via gut-brain metabolic axis","volume":"30","author":"Wang","year":"2025","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.phymed.2025.157632_bib0016","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/ptr.6799","article-title":"Schisandra chinensis ameliorates depressive-like behaviors by regulating microbiota-gut-brain axis via its anti-inflammation activity","volume":"35","author":"Yan","year":"2021","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2025.157632_bib0017","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41574-025-01090-3","article-title":"Tryptophan metabolism, exercise and depression","volume":"21","author":"Yates","year":"2025","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.phymed.2025.157632_bib0018","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jpsychires.2025.01.035","article-title":"Insomnia patients have a poor intestinal prognosis: accompanied by microbiota-derived short chain fatty acids, diet and zonulin","volume":"183","author":"Yerlikaya","year":"2025","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.phymed.2025.157632_bib0019","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.dcmed.2022.10.007","article-title":"Compound Chaijin Jieyu tablets ameliorating insomnia complicated with depression by improving synaptic plasticity via regulating orexin A, melatonin, and acetylcholine contents","volume":"5","author":"Han","year":"2022","journal-title":"Digit. Chin. Med."},{"key":"10.1016\/j.phymed.2025.157632_bib0020","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/jcp.29832","article-title":"The aryl hydrocarbon receptor ligand ITE inhibits cell proliferation and migration and enhances sensitivity to drug-resistance in hepatocellular carcinoma","volume":"236","author":"Zhang","year":"2021","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.phymed.2025.157632_bib0021","doi-asserted-by":"crossref","first-page":"3298","DOI":"10.1016\/j.apsb.2022.02.032","article-title":"Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota","volume":"12","author":"Zhang","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2025.157632_bib0022","article-title":"Psychobiotic Lactobacillus plantarum JYLP-326 relieves anxiety, depression, and insomnia symptoms in test anxious college via modulating the gut microbiota and its metabolism","volume":"14","author":"Zhu","year":"2023","journal-title":"Front. Immunol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132501267X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132501267X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:18:35Z","timestamp":1773865115000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471132501267X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":22,"alternative-id":["S094471132501267X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157632","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Compound Chaijin Jieyu Fang alleviates insomnia complicated with depression by reshaping actinobacteria to inhibit neuronal apoptosis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157632","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"157632"}}