{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:02:13Z","timestamp":1786114933140,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82,372,154"],"award-info":[{"award-number":["82,372,154"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.phymed.2025.157641","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T23:41:24Z","timestamp":1764459684000},"page":"157641","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Xuebijing injection alleviates sepsis-induced acute lung injury by triggering ferroptosis of CCR2hi monocytes"],"prefix":"10.1016","volume":"150","author":[{"given":"Jing","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8213-5019","authenticated-orcid":false,"given":"Huirong","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junlong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhen","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0530-6749","authenticated-orcid":false,"given":"Jianbo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.157641_bib0001","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.immuni.2022.08.010","article-title":"Biology of lung macrophages in health and disease","volume":"55","author":"Aegerter","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.phymed.2025.157641_bib0002","doi-asserted-by":"crossref","first-page":"eade9585","DOI":"10.1126\/sciadv.ade9585","article-title":"NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8","volume":"9","author":"Anandhan","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.phymed.2025.157641_bib0003","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s11658-024-00613-6","article-title":"Emerging role of glutathione peroxidase 4 in myeloid cell lineage development and acute myeloid leukemia","volume":"29","author":"Auberger","year":"2024","journal-title":"Cell Mol. Biol. Lett."},{"key":"10.1016\/j.phymed.2025.157641_bib0004","doi-asserted-by":"crossref","first-page":"21105","DOI":"10.1073\/pnas.1111919109","article-title":"Human monocytes are severely impaired in base and DNA double-strand break repair that renders them vulnerable to oxidative stress","volume":"108","author":"Bauer","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U S. A"},{"key":"10.1016\/j.phymed.2025.157641_bib0005","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.immuni.2024.03.019","article-title":"Ironing out the role of ferroptosis in immunity","volume":"57","author":"Bell","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.phymed.2025.157641_bib0006","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41577-020-00491-x","article-title":"Regulation of inflammation by the antioxidant haem oxygenase 1","volume":"21","author":"Campbell","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phymed.2025.157641_bib0007","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00018-023-05007-z","article-title":"Emerging roles and mechanisms of ERK pathway mechanosensing","volume":"80","author":"Crozet","year":"2023","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.phymed.2025.157641_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156573","article-title":"Herbal-based Xuebijing injection ameliorated vascular endothelial dysfunction via inhibiting ACLY\/MYB\/RIG-I axis in sepsis-associated lung injury","volume":"140","author":"Cui","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157641_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101107","article-title":"NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis","volume":"23","author":"Dodson","year":"2019","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2025.157641_bib0010","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41590-023-01660-5","article-title":"The pathophysiology of sepsis and precision-medicine-based immunotherapy","volume":"25","author":"Giamarellos-Bourboulis","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.phymed.2025.157641_bib0011","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.freeradbiomed.2024.11.007","article-title":"Ginsenoside Rb1 targets to HO-1 to improve sepsis by inhibiting ferroptosis","volume":"226","author":"He","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2025.157641_bib0012","first-page":"5","article-title":"Single cell RNA sequencing identifies an early monocyte gene signature in acute respiratory distress syndrome","author":"Jiang","year":"2020","journal-title":"JCI. Insight."},{"key":"10.1016\/j.phymed.2025.157641_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109163","article-title":"GC\/MS-based metabonomics approach reveals effects of Xuebijing injection in CLP induced septic rats","volume":"117","author":"Jiang","year":"2019","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2025.157641_bib0014","doi-asserted-by":"crossref","first-page":"eadl6162","DOI":"10.1126\/sciadv.adl6162","article-title":"Lung-innervating nociceptor sensory neurons promote pneumonic sepsis during carbapenem-resistant Klebsiella pneumoniae lung infection","volume":"10","author":"Joshi","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.phymed.2025.157641_bib0015","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/s41589-019-0462-8","article-title":"Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death","volume":"16","author":"Kapralov","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.phymed.2025.157641_bib0016","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s44254-023-00009-3","article-title":"Perspective from anesthesiologists on the therapy of critically ill patients with COVID-19","volume":"1","author":"Li","year":"2023","journal-title":"Anesth. Perioper. Sci."},{"key":"10.1016\/j.phymed.2025.157641_bib0017","first-page":"14","article-title":"Identifying Baicalein as a key bioactive compound in XueBiJing targeting KEAP1: implications for antioxidant effects","author":"Lin","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2025.157641_bib0018","doi-asserted-by":"crossref","first-page":"7717","DOI":"10.2147\/JIR.S523991","article-title":"Xuebijing injection alleviates sepsis-induced acute lung injury by inhibition of cell apoptosis and inflammation through the Hippo pathway","volume":"18","author":"Ling","year":"2025","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.phymed.2025.157641_bib0019","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1001\/jamainternmed.2023.0780","article-title":"Effect of an herbal-based injection on 28-day mortality in patients with sepsis: the EXIT-SEP randomized clinical trial","volume":"183","author":"Liu","year":"2023","journal-title":"JAMa Intern. Med."},{"key":"10.1016\/j.phymed.2025.157641_bib0020","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/imr.13330","article-title":"Interferons and epigenetic mechanisms in training, priming and tolerance of monocytes and hematopoietic progenitors","volume":"323","author":"Mishra","year":"2024","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.phymed.2025.157641_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120370","article-title":"Xuebijing alleviates sepsis-induced acute lung injury by inhibiting alveolar epithelial cell apoptosis via cAMP\/PKA signaling pathway","volume":"353","author":"Ren","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157641_bib0022","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2025.157641_bib0023","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1054176","article-title":"Xuebijing injection inhibited neutrophil extracellular traps to reverse lung injury in sepsis mice via reducing Gasdermin D","volume":"13","author":"Shang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157641_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167480","article-title":"Electroacupuncture pretreatment maintains mitochondrial quality control via HO-1\/MIC60 signaling pathway to alleviate endotoxin-induced acute lung injury","volume":"1870","author":"Shi","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Basis. Dis."},{"key":"10.1016\/j.phymed.2025.157641_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101954","article-title":"Dexmedetomidine ameliorates endotoxin-induced acute lung injury in vivo and in vitro by preserving mitochondrial dynamic equilibrium through the HIF-1a\/HO-1 signaling pathway","volume":"41","author":"Shi","year":"2021","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2025.157641_bib0026","doi-asserted-by":"crossref","first-page":"9306","DOI":"10.1007\/s12035-025-04832-6","article-title":"Retinal pigment epithelium and monocytes' Mitochondrial control of ferroptosis and its relevance to age-related macular degeneration","volume":"62","author":"Singh","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2025.157641_bib0027","doi-asserted-by":"crossref","first-page":"e735","DOI":"10.1097\/CCM.0000000000003842","article-title":"XueBiJing injection versus placebo for critically ill patients with severe community-acquired pneumonia: A randomized controlled trial","volume":"47","author":"Song","year":"2019","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.phymed.2025.157641_bib0028","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev-physiol-061121-040214","article-title":"Sepsis-induced immunosuppression","volume":"84","author":"Torres","year":"2022","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.phymed.2025.157641_bib0029","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1016\/j.immuni.2021.10.012","article-title":"The immunology of sepsis","volume":"54","author":"van der Poll","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.phymed.2025.157641_bib0030","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s00204-023-03476-6","article-title":"ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis","volume":"97","author":"Wang","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.phymed.2025.157641_bib0031","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12423","article-title":"Endothelial cell-derived extracellular vesicles expressing surface VCAM1 promote sepsis-related acute lung injury by targeting and reprogramming monocytes","volume":"13","author":"Wang","year":"2024","journal-title":"J. ExtraCell Vesicles."},{"key":"10.1016\/j.phymed.2025.157641_bib0032","article-title":"Three ingredients of safflower alleviate acute lung injury and inhibit NET release induced by lipopolysaccharide","author":"Wang","year":"2020","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.phymed.2025.157641_bib0033","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.1016\/j.apsb.2023.06.001","article-title":"Potential herb\u2012drug interactions between anti-COVID-19 drugs and traditional Chinese medicine","volume":"13","author":"Ye","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2025.157641_bib0034","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.freeradbiomed.2024.06.025","article-title":"A Streptococcus pneumoniae endolysin mutant protein DeltaA146Ply elicits rapid broad-spectrum mucosal protection in mice via upregulation of GPX4 through TLR4\/IRG1\/NRF2 to alleviate macrophage ferroptosis","volume":"222","author":"Yuan","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2025.157641_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120280","article-title":"Modulation of the CEACAM1\/TIM3 pathway by traditional Chinese medicine Xuebijing alleviates sepsis-induced acute lung injury through inhibition of NETs formation","volume":"353","author":"Zhang","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157641_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102985","article-title":"Identification of ZIP8-induced ferroptosis as a major type of cell death in monocytes under sepsis conditions","volume":"69","author":"Zhang","year":"2024","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2025.157641_bib0037","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.2147\/JIR.S497418","article-title":"Integrating bulk and single-cell transcriptomic data to identify ferroptosis-associated inflammatory gene in Alzheimer's disease","volume":"18","author":"Zhou","year":"2025","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.phymed.2025.157641_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118732","article-title":"XueBiJing injection improves the symptoms of sepsis-induced acute lung injury by mitigating oxidative stress and ferroptosis","volume":"337","author":"Zou","year":"2025","journal-title":"J. Ethnopharmacol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325012760?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325012760?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T23:21:35Z","timestamp":1785972095000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325012760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":38,"alternative-id":["S0944711325012760"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157641","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Xuebijing injection alleviates sepsis-induced acute lung injury by triggering ferroptosis of CCR2hi monocytes","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157641","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157641"}}