{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:45:44Z","timestamp":1789130744957,"version":"build-2803163510"},"reference-count":101,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82002764"],"award-info":[{"award-number":["82002764"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172717"],"award-info":[{"award-number":["82172717"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.phymed.2025.157648","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T08:18:12Z","timestamp":1764749892000},"page":"157648","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Cucurbitacin I induces immunogenic cell death and synergistically potentiates cisplatin efficacy in epithelial ovarian cancer"],"prefix":"10.1016","volume":"150","author":[{"given":"Geyang","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingbo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanjie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.157648_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2021.102224","article-title":"Recent advancements of antiangiogenic combination therapies in ovarian cancer","volume":"98","author":"An","year":"2021","journal-title":"Cancer Treat. Rev."},{"issue":"9","key":"10.1016\/j.phymed.2025.157648_bib0002","doi-asserted-by":"crossref","first-page":"972","DOI":"10.6004\/jnccn.2022.0047","article-title":"NCCN Guidelines\u00ae insights: ovarian cancer, version 3.2022","volume":"20","author":"Armstrong","year":"2022","journal-title":"J. Natl. Compr. Canc. Netw."},{"issue":"6","key":"10.1016\/j.phymed.2025.157648_bib0003","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1002\/ptr.7842","article-title":"Molecular mechanisms of action and chemosensitization of tumor cells in ovarian cancer by phytochemicals: a narrative review on pre-clinical and clinical studies","volume":"37","author":"Barboza","year":"2023","journal-title":"Phytother. Res."},{"issue":"8","key":"10.1016\/j.phymed.2025.157648_bib0004","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1038\/s41418-017-0044-9","article-title":"eIF2\u03b1 phosphorylation is pathognomonic for immunogenic cell death","volume":"25","author":"Bezu","year":"2018","journal-title":"Cell Death Differ"},{"issue":"12","key":"10.1016\/j.phymed.2025.157648_bib0005","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1158\/1078-0432.CCR-15-2657","article-title":"Neoadjuvant chemotherapy modulates the immune microenvironment in metastases of tubo-ovarian high-grade serous carcinoma","volume":"22","author":"B\u00f6hm","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.phymed.2025.157648_bib0006","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/978-1-4939-7000-1_26","article-title":"Protein Data Bank (PDB): the single global macromolecular structure archive","volume":"1607","author":"Burley","year":"2017","journal-title":"Methods Mol. Biol."},{"issue":"15","key":"10.1016\/j.phymed.2025.157648_bib0007","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.7150\/jca.20314","article-title":"Immune cell population in ovarian tumor microenvironment","volume":"8","author":"Cai","year":"2017","journal-title":"J. Cancer."},{"issue":"2","key":"10.1016\/j.phymed.2025.157648_bib0008","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.3892\/or.2016.4892","article-title":"Cucurbitacin B reverses multidrug resistance by targeting CIP2A to reactivate protein phosphatase 2A in MCF-7\/adriamycin cells","volume":"36","author":"Cai","year":"2016","journal-title":"Oncol. Rep."},{"issue":"16","key":"10.1016\/j.phymed.2025.157648_bib0009","doi-asserted-by":"crossref","first-page":"11351","DOI":"10.1021\/acs.jmedchem.3c00836","article-title":"Platinum(IV) complexes as inhibitors of STAT3 and regulators of the tumor microenvironment to control breast cancer","volume":"66","author":"Cai","year":"2023","journal-title":"J. Med. Chem."},{"issue":"22","key":"10.1016\/j.phymed.2025.157648_bib0010","doi-asserted-by":"crossref","first-page":"6555","DOI":"10.1158\/1078-0432.CCR-07-1610","article-title":"The epidermal growth factor receptor: a role in repair of radiation-induced DNA damage","volume":"13","author":"Chen","year":"2007","journal-title":"Clin. Cancer Res."},{"issue":"17","key":"10.1016\/j.phymed.2025.157648_bib0011","doi-asserted-by":"crossref","first-page":"9656","DOI":"10.1039\/D0CP00831A","article-title":"The application of the MM\/GBSA method in the binding pose prediction of FGFR inhibitors","volume":"22","author":"Chen","year":"2020","journal-title":"Phys. Chem. Chem. Phys."},{"issue":"6165","key":"10.1016\/j.phymed.2025.157648_bib0012","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1126\/science.342.6165.1432","article-title":"Breakthrough of the year 2013. Cancer immunotherapy","volume":"342","author":"Couzin-Frankel","year":"2013","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.phymed.2025.157648_bib0013","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1001\/jamaoncol.2018.6258","article-title":"Efficacy and safety of avelumab for patients with recurrent or refractory ovarian cancer: phase 1b results from the JAVELIN solid tumor trial","volume":"5","author":"Disis","year":"2019","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.phymed.2025.157648_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217738","article-title":"A necrosis inducer promotes an immunogenic response and destroys ovarian cancers in mouse xenografts and patient ascites organoids","volume":"625","author":"Duraki","year":"2025","journal-title":"Cancer lett"},{"key":"10.1016\/j.phymed.2025.157648_bib0016","series-title":"GAUSSIAN 09, Revision D.01","first-page":"201","author":"Frisch","year":"2009"},{"issue":"2","key":"10.1016\/j.phymed.2025.157648_bib0017","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nri.2016.107","article-title":"Immunogenic cell death in cancer and infectious disease","volume":"17","author":"Galluzzi","year":"2017","journal-title":"Nat. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.phymed.2025.157648_bib0018","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/s41573-024-00920-9","article-title":"Targeting immunogenic cell stress and death for cancer therapy","volume":"23","author":"Galluzzi","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.phymed.2025.157648_bib0019","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12967-023-04017-6","article-title":"Immunogenic cell death in cancer: concept and therapeutic implications","volume":"21","author":"Galluzzi","year":"2023","journal-title":"J. Transl. Med."},{"issue":"3","key":"10.1016\/j.phymed.2025.157648_bib0020","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ"},{"issue":"1","key":"10.1016\/j.phymed.2025.157648_bib0021","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2019-000337","article-title":"Consensus guidelines for the definition, detection and interpretation of immunogenic cell death","volume":"8","author":"Galluzzi","year":"2020","journal-title":"J. Immunother. Cancer."},{"issue":"1","key":"10.1016\/j.phymed.2025.157648_bib0022","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/s41392-022-01046-3","article-title":"Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy","volume":"7","author":"Gao","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2025.157648_bib0023","doi-asserted-by":"crossref","first-page":"588","DOI":"10.3389\/fimmu.2015.00588","article-title":"Molecular and translational classifications of DAMPs in immunogenic cell death","volume":"6","author":"Garg","year":"2015","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.phymed.2025.157648_bib0024","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1186\/s12964-025-02322-9","article-title":"Phosphorylated IRF3 promotes GSDME-mediated pyroptosis through RIPK1\/FADD\/caspase-8 complex formation during mitotic arrest in ovarian cancer","volume":"23","author":"Gong","year":"2025","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.phymed.2025.157648_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.150508","article-title":"Cucurbitacin I exerts its anticancer effects by inducing cell cycle arrest via the KAT2a-ube2C\/E2F1 pathway and inhibiting HepG2-induced macrophage M2 polarization","volume":"738","author":"Gong","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phymed.2025.157648_bib0026","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.701968","article-title":"Enhanced antitumor response to immune checkpoint blockade exerted by cisplatin-induced mutagenesis in a murine melanoma model","volume":"11","author":"Gorgun","year":"2021","journal-title":"Front. Oncol."},{"issue":"7","key":"10.1016\/j.phymed.2025.157648_bib0027","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1161\/01.ATV.0000223900.67024.15","article-title":"Nitric oxide and endoplasmic reticulum stress","volume":"26","author":"Gotoh","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"13","key":"10.1016\/j.phymed.2025.157648_bib0028","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1038\/s41388-018-0581-9","article-title":"Cisplatin-induced immune modulation in ovarian cancer mouse models with distinct inflammation profiles","volume":"38","author":"Grabosch","year":"2019","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.phymed.2025.157648_bib0029","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.ccell.2023.04.015","article-title":"Calreticulin exposure orchestrates innate immunosurveillance","volume":"41","author":"Guilbaud","year":"2023","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.phymed.2025.157648_bib0030","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20210789","article-title":"WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway","volume":"219","author":"Guo","year":"2022","journal-title":"J. Exp. Med."},{"issue":"34","key":"10.1016\/j.phymed.2025.157648_bib0031","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.1200\/JCO.2015.62.3397","article-title":"Safety and antitumor activity of anti-PD-1 antibody, nivolumab, in patients with platinum-resistant ovarian cancer","volume":"33","author":"Hamanishi","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.phymed.2025.157648_bib0032","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.intimp.2018.06.001","article-title":"Immune checkpoint blockade therapy for cancer: an overview of FDA-approved immune checkpoint inhibitors","volume":"62","author":"Hargadon","year":"2018","journal-title":"Int. Immunopharmacol."},{"issue":"12","key":"10.1016\/j.phymed.2025.157648_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2021.101217","article-title":"Cisplatin increases immune activity of monocytes and cytotoxic T-cells in a murine model of epithelial ovarian cancer","volume":"14","author":"Hopkins","year":"2021","journal-title":"Transl. Oncol."},{"issue":"1","key":"10.1016\/j.phymed.2025.157648_bib0034","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1021\/ci100275a","article-title":"Assessing the performance of the MM\/PBSA and MM\/GBSA methods. 1. The accuracy of binding free energy calculations based on molecular dynamics simulations","volume":"51","author":"Hou","year":"2011","journal-title":"J. Chem. Inf. Model."},{"issue":"3","key":"10.1016\/j.phymed.2025.157648_bib0035","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/s41419-021-03516-y","article-title":"Induction of ferroptosis in human nasopharyngeal cancer cells by cucurbitacin B: molecular mechanism and therapeutic potential","volume":"12","author":"Huang","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.phymed.2025.157648_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107082","article-title":"Identification of Fasudil as a collaborator to promote the antitumor effect of lenvatinib in hepatocellular carcinoma by inhibiting GLI2-mediated hedgehog signaling pathway","volume":"200","author":"Huang","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2025.157648_bib0037","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41420-020-00349-0","article-title":"The caspase-3\/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer","volume":"6","author":"Jiang","year":"2020","journal-title":"Cell Death Discov"},{"issue":"D1","key":"10.1016\/j.phymed.2025.157648_bib0038","doi-asserted-by":"crossref","first-page":"D1202","DOI":"10.1093\/nar\/gkv951","article-title":"PubChem substance and compound databases","volume":"44","author":"Kim","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"10.1016\/j.phymed.2025.157648_bib0039","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/1096-987X(20010415)22:5<501::AID-JCC1021>3.0.CO;2-V","article-title":"A fast SHAKE algorithm to solve distance constraint equations for small molecules in molecular dynamics simulations","volume":"22","author":"Kr\u00fcttler","year":"2001","journal-title":"J. Comput. Chem."},{"issue":"1","key":"10.1016\/j.phymed.2025.157648_bib0040","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1016\/S1470-2045(18)30786-1","article-title":"Exploring and comparing adverse events between PARP inhibitors","volume":"20","author":"LaFargue","year":"2019","journal-title":"Lancet Oncol"},{"issue":"5795","key":"10.1016\/j.phymed.2025.157648_bib0041","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1126\/science.1132939","article-title":"The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease","volume":"313","author":"Lamb","year":"2006","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.phymed.2025.157648_bib0042","doi-asserted-by":"crossref","DOI":"10.1063\/1.2464095","article-title":"Langevin stabilization of molecular-dynamics simulations of polymers by means of quasisymplectic algorithms","volume":"126","author":"Larini","year":"2007","journal-title":"J. Chem. Phys."},{"issue":"8","key":"10.1016\/j.phymed.2025.157648_bib0043","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1158\/2326-6066.CIR-19-0616","article-title":"Paclitaxel induces immunogenic cell death in ovarian cancer via TLR4\/IKK2\/SNARE-dependent exocytosis","volume":"8","author":"Lau","year":"2020","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.phymed.2025.157648_bib0044","doi-asserted-by":"crossref","DOI":"10.1177\/17588359211039899","article-title":"Immune checkpoint inhibitors in ovarian cancer: where do we stand?","volume":"13","author":"Leary","year":"2021","journal-title":"Ther. Adv. Med. Oncol."},{"key":"10.1016\/j.phymed.2025.157648_bib110","doi-asserted-by":"crossref","first-page":"102089","DOI":"10.1016\/j.redox.2021.102089","article-title":"Role of acetylation in doxorubicin-induced cardiotoxicity","volume":"46","author":"Li","year":"2021","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.phymed.2025.157648_bib0047","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41392-022-01131-7","article-title":"Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing MAPK hyperactivation","volume":"7","author":"Li","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"2","key":"10.1016\/j.phymed.2025.157648_bib0048","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1002\/jcb.27570","article-title":"Cucurbitacin I induces cancer cell death through the endoplasmic reticulum stress pathway","volume":"120","author":"Li","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.phymed.2025.157648_bib0050","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.3892\/mmr.2020.11327","article-title":"Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B\u2011Rac1 signaling axis","volume":"22","author":"Li","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.phymed.2025.157648_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156898","article-title":"Gene signature-guided isolation identifies cucurbitacins as STAT3 inhibitors from Picria fel-terrae Lour","volume":"144","author":"Li","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157648_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115707","article-title":"Potential of cucurbitacin as an anticancer drug","volume":"168","author":"Li","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"17","key":"10.1016\/j.phymed.2025.157648_bib0045","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.3390\/cancers17172827","article-title":"Liposomal doxorubicin, but not platinum-taxane, supports MHC-II expression and immune maturation in the ovarian tumor microenvironment","volume":"17","author":"Lee","year":"2025","journal-title":"Cancers (Basel)"},{"issue":"10177","key":"10.1016\/j.phymed.2025.157648_bib0053","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/S0140-6736(18)32552-2","article-title":"Epithelial ovarian cancer","volume":"393","author":"Lheureux","year":"2019","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.phymed.2025.157648_bib0054","doi-asserted-by":"crossref","first-page":"512","DOI":"10.6004\/jnccn.2024.0052","article-title":"NCCN Guidelines\u00ae insights: ovarian cancer\/fallopian tube cancer\/primary peritoneal cancer, version 3.2024","volume":"22","author":"Liu","year":"2024","journal-title":"J. Natl. Compr. Canc. Netw."},{"issue":"3","key":"10.1016\/j.phymed.2025.157648_bib0055","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3390\/molecules24030647","article-title":"Cucurbitacin B induces the lysosomal degradation of EGFR and suppresses the CIP2A\/PP2A\/akt signaling axis in gefitinib-resistant Non-small cell Lung cancer","volume":"24","author":"Liu","year":"2019","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.phymed.2025.157648_bib0056","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s41573-021-00154-z","article-title":"Channelling inflammation: gasdermins in physiology and disease","volume":"20","author":"Liu","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"issue":"8","key":"10.1016\/j.phymed.2025.157648_bib0057","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1021\/acscentsci.2c00107","article-title":"Allosteric regulation of IGF2BP1 as a novel strategy for the activation of tumor immune microenvironment","volume":"8","author":"Liu","year":"2022","journal-title":"ACS Cent. Sci."},{"issue":"19","key":"10.1016\/j.phymed.2025.157648_bib0058","doi-asserted-by":"crossref","first-page":"6042","DOI":"10.1158\/1078-0432.CCR-07-4923","article-title":"Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators","volume":"14","author":"Lo","year":"2008","journal-title":"Clin. Cancer Res."},{"issue":"8","key":"10.1016\/j.phymed.2025.157648_bib0060","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1021\/acs.jctc.5b00255","article-title":"ff14SB: improving the accuracy of protein side chain and backbone parameters from ff99SB","volume":"11","author":"Maier","year":"2015","journal-title":"J. Chem. Theory Comput."},{"issue":"2","key":"10.1016\/j.phymed.2025.157648_bib0061","doi-asserted-by":"crossref","first-page":"148","DOI":"10.2478\/raon-2019-0018","article-title":"Cisplatin and beyond: molecular mechanisms of action and drug resistance development in cancer chemotherapy","volume":"53","author":"Makovec","year":"2019","journal-title":"Radiol. Oncol."},{"issue":"43","key":"10.1016\/j.phymed.2025.157648_bib0062","doi-asserted-by":"crossref","first-page":"9954","DOI":"10.1021\/jp003020w","article-title":"Structure and dynamics of the TIP3P, SPC, and SPC\/E water models at 298 K","volume":"105","author":"Mark","year":"2001","journal-title":"J. Phys. Chem. A."},{"issue":"7","key":"10.1016\/j.phymed.2025.157648_bib0063","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1093\/annonc\/mdz135","article-title":"Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: results from the phase II KEYNOTE-100 study","volume":"30","author":"Matulonis","year":"2019","journal-title":"Ann. Oncol."},{"issue":"10290","key":"10.1016\/j.phymed.2025.157648_bib0065","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1016\/S0140-6736(21)00731-5","article-title":"Ovarian cancer population screening and mortality after long-term follow-up in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial","volume":"397","author":"Menon","year":"2021","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.phymed.2025.157648_bib0066","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.ccell.2021.11.010","article-title":"Toward a better understanding of T cells in cancer","volume":"39","author":"Oh","year":"2021","journal-title":"Cancer Cell"},{"issue":"2","key":"10.1016\/j.phymed.2025.157648_bib0067","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/10408347.2014.881250","article-title":"Surface plasmon resonance (SPR) biosensors in pharmaceutical analysis","volume":"45","author":"Olaru","year":"2015","journal-title":"Crit. Rev. Anal. Chem."},{"issue":"5.5","key":"10.1016\/j.phymed.2025.157648_bib0068","first-page":"619","article-title":"New therapies for ovarian cancer","volume":"17","author":"O'Malley","year":"2019","journal-title":"J. Natl. Compr. Canc. Netw."},{"issue":"45","key":"10.1016\/j.phymed.2025.157648_bib0069","doi-asserted-by":"crossref","first-page":"19320","DOI":"10.1073\/pnas.1012044107","article-title":"Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity","volume":"107","author":"Park","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.phymed.2025.157648_bib0070","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ccell.2020.11.009","article-title":"Immunomodulation by targeted anticancer agents","volume":"39","author":"Petroni","year":"2021","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.phymed.2025.157648_bib0071","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ctrv.2006.09.006","article-title":"Molecular mechanisms of resistance and toxicity associated with platinating agents","volume":"33","author":"Rabik","year":"2007","journal-title":"Cancer Treat. Rev."},{"issue":"12","key":"10.1016\/j.phymed.2025.157648_bib0072","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004586","article-title":"AutoDockFR: advances in protein-ligand docking with explicitly specified binding site flexibility","volume":"11","author":"Ravindranath","year":"2015","journal-title":"PLoS Comput. Biol."},{"issue":"1","key":"10.1016\/j.phymed.2025.157648_bib0073","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1186\/s12967-022-03641-y","article-title":"CDK1 serves as a therapeutic target of adrenocortical carcinoma via regulating epithelial-mesenchymal transition, G2\/M phase transition, and PANoptosis","volume":"20","author":"Ren","year":"2022","journal-title":"J. Transl. Med."},{"issue":"6","key":"10.1016\/j.phymed.2025.157648_bib0074","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1001\/jamaoncol.2023.0197","article-title":"Advances in ovarian cancer care and unmet treatment needs for patients with platinum resistance: a narrative review","volume":"9","author":"Richardson","year":"2023","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.phymed.2025.157648_bib0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115323","article-title":"Cisplatin in cancer treatment","volume":"206","author":"Romani","year":"2022","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2025.157648_bib0076","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41568-020-00308-y","article-title":"The rediscovery of platinum-based cancer therapy","volume":"21","author":"Rottenberg","year":"2021","journal-title":"Nat. Rev. Cancer"},{"issue":"9","key":"10.1016\/j.phymed.2025.157648_bib0077","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.trecan.2017.07.002","article-title":"The unfolded protein response in immunogenic cell death and cancer immunotherapy","volume":"3","author":"Rufo","year":"2017","journal-title":"Trends Cancer"},{"issue":"1","key":"10.1016\/j.phymed.2025.157648_bib0078","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev.biophys.28.1.155","article-title":"Molecular dynamics simulations of biomolecules: long-range electrostatic effects","volume":"28","author":"Sagui","year":"1999","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"issue":"2","key":"10.1016\/j.phymed.2025.157648_bib0079","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/wcms.1121","article-title":"An overview of the Amber biomolecular simulation package","volume":"3","author":"Salomon-Ferrer","year":"2013","journal-title":"Wiley Interdiscip. Rev. Comput. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.157648_bib0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.111079","article-title":"Overview of cisplatin-induced neurotoxicity and ototoxicity, and the protective agents","volume":"136","author":"Santos","year":"2020","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.phymed.2025.157648_bib0081","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"4","key":"10.1016\/j.phymed.2025.157648_bib0082","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/modpathol.3800575","article-title":"Epithelial growth factor receptor status in primary and recurrent ovarian cancer","volume":"19","author":"Stadlmann","year":"2006","journal-title":"Mod. Pathol."},{"issue":"33","key":"10.1016\/j.phymed.2025.157648_bib0083","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1200\/JCO.22.01934","article-title":"Poly(ADP-Ribose) polymerase inhibitors in the management of ovarian cancer: ASCO guideline rapid recommendation update","volume":"40","author":"Tew","year":"2022","journal-title":"J. Clin. Oncol."},{"issue":"12","key":"10.1016\/j.phymed.2025.157648_bib0084","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1158\/2326-6066.CIR-17-0235","article-title":"Cisplatin alters antitumor immunity and synergizes with PD-1\/PD-L1 inhibition in head and neck squamous cell carcinoma","volume":"5","author":"Tran","year":"2017","journal-title":"Cancer Immunol. Res."},{"issue":"2","key":"10.1016\/j.phymed.2025.157648_bib0085","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"issue":"2","key":"10.1016\/j.phymed.2025.157648_bib0086","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ygyno.2018.11.017","article-title":"Pembrolizumab in patients with programmed death ligand 1-positive advanced ovarian cancer: analysis of KEYNOTE-028","volume":"152","author":"Varga","year":"2019","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.phymed.2025.157648_bib0087","doi-asserted-by":"crossref","first-page":"TPS5603","DOI":"10.1200\/JCO.2019.37.15_suppl.TPS5603","article-title":"ENGOT-OV43\/KEYLYNK-001: a phase III, randomized, double-blind, active- and placebo-controlled study of pembrolizumab plus chemotherapy with olaparib maintenance for first-line treatment of BRCA-nonmutated advanced epithelial ovarian cancer","volume":"37","author":"Vergote","year":"2019","journal-title":"J. Clin. Oncol."},{"issue":"22","key":"10.1016\/j.phymed.2025.157648_bib0088","first-page":"U403","article-title":"Antechamber: an accessory software package for molecular mechanical calculations","volume":"122","author":"Wang","year":"2001","journal-title":"J. Am. Chem. Soc."},{"issue":"9","key":"10.1016\/j.phymed.2025.157648_bib0089","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/jcc.20035","article-title":"Development and testing of a general amber force field","volume":"25","author":"Wang","year":"2004","journal-title":"J. Comput. Chem."},{"issue":"7799","key":"10.1016\/j.phymed.2025.157648_bib0090","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41586-020-2079-1","article-title":"A bioorthogonal system reveals antitumour immune function of pyroptosis","volume":"579","author":"Wang","year":"2020","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.phymed.2025.157648_bib0091","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/2211-5463.13035","article-title":"Sorafenib and CuB exert synergistic antitumor effects against hepatocellular carcinoma cells via inhibition of STAT3 phosphorylation","volume":"11","author":"Wang","year":"2021","journal-title":"FEBS Open Bio"},{"issue":"1","key":"10.1016\/j.phymed.2025.157648_bib0092","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41577-019-0210-z","article-title":"Dendritic cells in cancer immunology and immunotherapy","volume":"20","author":"Wculek","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phymed.2025.157648_bib0093","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157017","article-title":"Cucurbitacin B stimulates PD-1 immunotherapy response in malignant breast cancer by covalent targeting MTCH2","volume":"145","author":"Xu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157648_bib0094","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114529","article-title":"CBL0137 activates ROS\/BAX signaling to promote caspase-3\/GSDME-dependent pyroptosis in ovarian cancer cells","volume":"161","author":"Yang","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.phymed.2025.157648_bib0095","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s12672-023-00758-4","article-title":"A target map of clinical combination therapies in oncology: an analysis of clinicaltrials.Gov","volume":"14","author":"Yang","year":"2023","journal-title":"Discov. Oncol."},{"issue":"6","key":"10.1016\/j.phymed.2025.157648_bib0096","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3892\/or.2023.8552","article-title":"Paclitaxel induces pyroptosis by inhibiting the volume-sensitive chloride channel leucine-rich repeat-containing 8a in ovarian cancer cells","volume":"49","author":"Yang","year":"2023","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.phymed.2025.157648_bib0098","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154669","article-title":"Label-free-based quantitative proteomic analysis of the inhibition of cisplatin-resistant ovarian cancer cell proliferation by cucurbitacin B","volume":"111","author":"Yin","year":"2023","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.phymed.2025.157648_bib0099","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41392-021-00507-5","article-title":"Pyroptosis: mechanisms and diseases","volume":"6","author":"Yu","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2025.157648_bib0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105748","article-title":"Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4\/NLRP3\/GSDMD-dependent pyroptosis","volume":"170","author":"Yuan","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2025.157648_bib0101","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116695","article-title":"Gambogic acid induces GSDME dependent pyroptotic signaling pathway via ROS\/P53\/mitochondria\/caspase-3 in ovarian cancer cells","volume":"232","author":"Zhang","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157648_bib0102","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155828","article-title":"Immunogenic cell death inducers for cancer therapy: an emerging focus on natural products","volume":"132","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157648_bib108","doi-asserted-by":"crossref","first-page":"114536","DOI":"10.1016\/j.bcp.2021.114536","article-title":"FGFR3 phosphorylates EGFR to promote cisplatin-resistance in ovarian cancer","volume":"190","author":"Zhao","year":"2021","journal-title":"Biochem. Pharmacol."},{"issue":"15","key":"10.1016\/j.phymed.2025.157648_bib0104","doi-asserted-by":"crossref","first-page":"6036","DOI":"10.7150\/thno.99407","article-title":"p-STAT3-elevated E3 ubiquitin ligase DTX4 confers the stability of HBV cccDNA by ubiquitinating APOBEC3B in liver","volume":"14","author":"Zhao","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2025.157648_bib0105","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jconrel.2021.02.032","article-title":"Oxygen and oxaliplatin-loaded nanoparticles combined with photo-sonodynamic inducing enhanced immunogenic cell death in syngeneic mouse models of ovarian cancer","volume":"332","author":"Zheng","year":"2021","journal-title":"J. Control Release"},{"issue":"6","key":"10.1016\/j.phymed.2025.157648_bib0106","first-page":"341","article-title":"Newly identified function of caspase-6 in ZBP1-mediated innate immune responses, NLRP3 inflammasome activation, PANoptosis, and host defense","volume":"2","author":"Zheng","year":"2020","journal-title":"J. Cell. Immunol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325012826?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325012826?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T14:20:36Z","timestamp":1768400436000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325012826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":101,"alternative-id":["S0944711325012826"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157648","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cucurbitacin I induces immunogenic cell death and synergistically potentiates cisplatin efficacy in epithelial ovarian cancer","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157648","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"157648"}}