{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:29:56Z","timestamp":1785529796537,"version":"3.56.0"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004610","name":"Science and Technology Support Program of Jiangsu Province","doi-asserted-by":"publisher","award":["KC23130"],"award-info":[{"award-number":["KC23130"]}],"id":[{"id":"10.13039\/501100004610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20181154"],"award-info":[{"award-number":["BK20181154"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012217","name":"Xuzhou Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012217","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31300222"],"award-info":[{"award-number":["31300222"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.phymed.2025.157668","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T08:08:30Z","timestamp":1764922110000},"page":"157668","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Swietenine attenuates renal tubular injury by activating mitophagy in diabetic nephropathy"],"prefix":"10.1016","volume":"150","author":[{"given":"Feilong","family":"Pei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuicui","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1646-828X","authenticated-orcid":false,"given":"Chunping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.157668_bib0001","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.2215\/CJN.11491116","article-title":"Diabetic kidney disease: challenges, progress, and possibilities","volume":"12","author":"Alicic","year":"2017","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phymed.2025.157668_bib0002","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1073\/pnas.1612322114","article-title":"Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes","volume":"114","author":"Anareu-Fern\u00e1ndez","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U S. A"},{"key":"10.1016\/j.phymed.2025.157668_bib0003","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nrneph.2017.107","article-title":"Mitochondrial energetics in the kidney","volume":"13","author":"Bhargava","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.phymed.2025.157668_bib0004","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.joca.2018.05.018","article-title":"Mitochondria and mitophagy: biosensors for cartilage degradation and osteoarthritis","volume":"26","author":"Blanco","year":"2018","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.phymed.2025.157668_bib0005","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1007\/s00125-024-06156-x","article-title":"ACSF2 and lysine lactylation contribute to renal tubule injury in diabetes","volume":"67","author":"Chen","year":"2024","journal-title":"Diabetologia"},{"key":"10.1016\/j.phymed.2025.157668_bib0006","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.kint.2018.10.038","article-title":"Disulfide-bond A oxidoreductase-like protein protects against ectopic fat deposition and lipid-related kidney damage in diabetic nephropathy","volume":"95","author":"Chen","year":"2019","journal-title":"Kidney Int."},{"key":"10.1016\/j.phymed.2025.157668_bib0007","doi-asserted-by":"crossref","first-page":"12775","DOI":"10.1021\/acs.jafc.3c09634","article-title":"Magnoflorine ameliorates chronic kidney disease in high-fat and high-fructose-fed mice by promoting parkin\/pink1-dependent mitophagy to inhibit NLRP3\/Caspase-1-mediated pyroptosis","volume":"72","author":"Cheng","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2025.157668_bib0008","first-page":"646","article-title":"Swietenine alleviates vascular remodelling by enhancing mitophagy of pulmonary arterial smooth muscle cells in experimental pulmonary hypertension","volume":"39","author":"Chu","year":"2023","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.phymed.2025.157668_bib0009","article-title":"Empagliflozin ameliorates type 2 diabetes mellitus-related diabetic nephropathy via altering the gut microbiota","volume":"1867","author":"Deng","year":"2022","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.phymed.2025.157668_bib0010","series-title":"Nuts and Seeds in Health and Disease Prevention","article-title":"Chapter 24 - Swietenine, Big Leaf Mahogany (Swietenia macrophylla) Seed Extract as a Hypoglycemic Agent","author":"Dewanjee","year":"2011"},{"key":"10.1016\/j.phymed.2025.157668_bib0011","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1021\/acs.jafc.1c07795","article-title":"Chicoric acid attenuated renal tubular injury in HFD-induced chronic kidney disease mice through the promotion of mitophagy via the Nrf2\/PINK\/Parkin pathway","volume":"70","author":"Ding","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2025.157668_bib0012","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1002\/tox.23653","article-title":"Natural swietenine attenuates diabetic nephropathy by regulating the NF-\u03baB\/NLRP3\/Caspase-1 signaling pathways: in vivo and in vitro study","volume":"37","author":"Duan","year":"2022","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.phymed.2025.157668_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119981","article-title":"Swietenine improved the progression of diabetic nephropathy through inhibiting ferroptosis via activating Akt\/GSK-3\u03b2\/Nrf2 signaling pathway","volume":"349","author":"Duan","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157668_bib0014","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1002\/tox.23636","article-title":"Swietenine and swietenolide from Swietenia macrophylla king improve insulin secretion and attenuate apoptosis in H(2) O(2) induced INS-1 cells","volume":"37","author":"Duan","year":"2022","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.phymed.2025.157668_bib0015","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1002\/tox.23764","article-title":"Swietenine inhibited oxidative stress through AKT\/Nrf2\/HO-1 signal pathways and the liver-protective effect in T2DM mice: in vivo and in vitro study","volume":"38","author":"Duan","year":"2023","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.phymed.2025.157668_bib0016","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.13668","article-title":"Limonoids isolated from fruits of Swietenia macrophylla king enhance glucose consumption in insulin-resistant HepG2 cells via activating PPAR\u03b3","volume":"45","author":"Duan","year":"2021","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.phymed.2025.157668_bib0017","doi-asserted-by":"crossref","DOI":"10.3389\/fcdhc.2025.1537336","article-title":"Impact of vitamin D and vitamin D receptor activator in diabetic nephropathy","volume":"6","author":"Emini Sadiku","year":"2025","journal-title":"Front. Clin. Diabetes. Healthc."},{"key":"10.1016\/j.phymed.2025.157668_bib0018","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.tem.2016.05.002","article-title":"Mitochondria-power players in kidney function?","volume":"27","author":"Forbes","year":"2016","journal-title":"Trends. Endocrinol. Metab."},{"key":"10.1016\/j.phymed.2025.157668_bib0019","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nrneph.2018.9","article-title":"Mitochondrial dysfunction in diabetic kidney disease","volume":"14","author":"Forbes","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.phymed.2025.157668_bib0020","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.tem.2016.07.002","article-title":"Diabetic nephropathy: perspective on novel molecular mechanisms","volume":"27","author":"Gnudi","year":"2016","journal-title":"Trends. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.phymed.2025.157668_bib0021","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.171961","article-title":"Tubular CPT1A deletion minimally affects aging and chronic kidney injury","volume":"9","author":"Hammoud","year":"2024","journal-title":"JCI. Insight."},{"key":"10.1016\/j.phymed.2025.157668_bib0022","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.lfs.2012.09.003","article-title":"Preventive effects of rutin on the development of experimental diabetic nephropathy in rats","volume":"91","author":"Hao","year":"2012","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2025.157668_bib0023","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1194\/jlr.P040501","article-title":"Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy","volume":"55","author":"Herman-Edelstein","year":"2014","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.phymed.2025.157668_bib0024","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.2147\/DDDT.S360346","article-title":"Astragaloside IV alleviates renal tubular epithelial-mesenchymal transition via CX3CL1-RAF\/MEK\/ERK signaling pathway in diabetic kidney disease","volume":"16","author":"Hu","year":"2022","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.phymed.2025.157668_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.132584","article-title":"Regulatory effects of Astragalus membranaceus polysaccharides on lipid metabolism disorders induced by a high-fat diet in spotted sea bass (Lateolabrax maculatus)","volume":"271","author":"Huang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2025.157668_bib0026","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1016\/j.jdiacomp.2017.08.009","article-title":"Tissue expression of tubular injury markers is associated with renal function decline in diabetic nephropathy","volume":"31","author":"Hwang","year":"2017","journal-title":"J. Diabetes Complications"},{"key":"10.1016\/j.phymed.2025.157668_bib0027","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/sj.ki.5001629","article-title":"Albumin-bound fatty acids induce mitochondrial oxidant stress and impair antioxidant responses in proximal tubular cells","volume":"70","author":"Ishola","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.phymed.2025.157668_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154552","article-title":"Asiatic acid attenuates tubular injury in diabetic kidney disease by regulating mitochondrial dynamics via the Nrf-2 pathway","volume":"109","author":"Ji","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157668_bib0029","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1211\/jpp.58.8.0010","article-title":"The influence of rutin on the extracellular matrix in streptozotocin-induced diabetic rat kidney","volume":"58","author":"Kamalakkannan","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157668_bib0030","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nm.3762","article-title":"Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development","volume":"21","author":"Kang","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.phymed.2025.157668_bib0031","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41581-019-0135-6","article-title":"Epigenetics and epigenomics in diabetic kidney disease and metabolic memory","volume":"15","author":"Kato","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.phymed.2025.157668_bib0032","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1042\/CS20160671","article-title":"The 'Goldilocks zone' of fatty acid metabolism; to ensure that the relationship with cardiac function is just right","volume":"131","author":"Kerr","year":"2017","journal-title":"Clin. Sci."},{"issue":"1","key":"10.1016\/j.phymed.2025.157668_bib0033","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1007\/s11033-024-09579-2","article-title":"Scopoletin alleviates high glucose-induced toxicity in human renal proximal tubular cells via inhibition of oxidative damage, epithelial-mesenchymal transition, and fibrogenesis","volume":"51","author":"Kundu","year":"2024","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.phymed.2025.157668_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111965","article-title":"Panax notoginseng saponins reduces the cisplatin-induced acute renal injury by increasing HIF-1\u03b1\/BNIP3 to inhibit mitochondrial apoptosis pathway","volume":"142","author":"Li","year":"2021","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2025.157668_bib0035","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13975","article-title":"l-carnitine alleviates cardiac microvascular dysfunction in diabetic cardiomyopathy by enhancing PINK1-Parkin-dependent mitophagy through the CPT1a-PHB2-PARL pathways","volume":"238","author":"Li","year":"2023","journal-title":"Acta Physiol."},{"key":"10.1016\/j.phymed.2025.157668_bib0036","doi-asserted-by":"crossref","first-page":"m997","DOI":"10.1136\/bmj.m997","article-title":"Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association: national cross sectional study","volume":"369","author":"Li","year":"2020","journal-title":"BMJ-BRIT Med. J."},{"key":"10.1016\/j.phymed.2025.157668_bib0037","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.7150\/thno.71722","article-title":"Twist1 downregulation of PGC-1\u03b1 decreases fatty acid oxidation in tubular epithelial cells, leading to kidney fibrosis","volume":"12","author":"Liu","year":"2022","journal-title":"Theranostics."},{"key":"10.1016\/j.phymed.2025.157668_bib0038","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1080\/0886022X.2022.2072743","article-title":"Role of abnormal energy metabolism in the progression of chronic kidney disease and drug intervention","volume":"44","author":"Liu","year":"2022","journal-title":"Ren. Fail."},{"key":"10.1016\/j.phymed.2025.157668_bib0039","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nrneph.2013.146","article-title":"Nephrology in china","volume":"9","author":"Liu","year":"2013","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.phymed.2025.157668_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111238","article-title":"Telomerase reverse transcriptase protects against diabetic kidney disease by promoting AMPK\/PGC-1a-regulated mitochondrial energy homeostasis","volume":"403","author":"Ma","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.phymed.2025.157668_bib0041","doi-asserted-by":"crossref","first-page":"5011","DOI":"10.1172\/JCI135536","article-title":"p53\/microRNA-214\/ULK1 axis impairs renal tubular autophagy in diabetic kidney disease","volume":"130","author":"Ma","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2025.157668_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.phyplu.2020.100018","article-title":"Studies on the mechanism of anti-inflammatory action of swietenine, a tetranortriterpenoid isolated from Swietenia macrophylla seeds","volume":"1","author":"Mak","year":"2021","journal-title":"Phytomed. Plus"},{"key":"10.1016\/j.phymed.2025.157668_bib0043","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.2147\/DMSO.S494644","article-title":"The mitochondrial metabolism gene ECH1 was identified as a novel biomarker for diabetic nephropathy: using bioinformatics analysis and experimental confirmation","volume":"18","author":"Miao","year":"2025","journal-title":"Diabetes. Metab. Syndr. Obes."},{"issue":"5","key":"10.1016\/j.phymed.2025.157668_bib0044","doi-asserted-by":"crossref","DOI":"10.1172\/JCI140695","article-title":"Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis","volume":"131","author":"Miguel","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2025.157668_bib0045","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.kint.2022.04.021","article-title":"Rho-associated, coiled-coil-containing protein kinase 1 regulates development of diabetic kidney disease via modulation of fatty acid metabolism","volume":"102","author":"Nagai","year":"2022","journal-title":"Kidney Int."},{"key":"10.1016\/j.phymed.2025.157668_bib0046","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/ki.2012.475","article-title":"Selective estrogen receptor modulation attenuates proteinuria-induced renal tubular damage by modulating mitochondrial oxidative status","volume":"83","author":"Nishi","year":"2013","journal-title":"Kidney Int."},{"key":"10.1016\/j.phymed.2025.157668_bib0047","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2023.2292753","article-title":"CD36 deletion ameliorates diabetic kidney disease by restoring fatty acid oxidation and improving mitochondrial function","volume":"45","author":"Niu","year":"2023","journal-title":"Ren. Fail."},{"key":"10.1016\/j.phymed.2025.157668_bib0048","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3892\/mmr.2025.13500","article-title":"Obacunone inhibits ferroptosis through regulation of Nrf2 homeostasis to treat diabetic nephropathy","volume":"31","author":"Ou","year":"2025","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.phymed.2025.157668_bib0049","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1016\/S0140-6736(14)62459-4","article-title":"Comparative efficacy and safety of blood pressure-lowering agents in adults with diabetes and kidney disease: a network meta-analysis","volume":"385","author":"Palmer","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2025.157668_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155861","article-title":"Hong Guo Ginseng Guo (HGGG) protects against kidney injury in diabetic nephropathy by inhibiting NLRP3 inflammasome and regulating intestinal flora","volume":"132","author":"Pan","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157668_bib0051","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.2337\/dc14-2330","article-title":"Kidney injury molecule-1 and the loss of kidney function in diabetic nephropathy: a likely causal link in patients with type 1 diabetes","volume":"38","author":"Panduru","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1016\/j.phymed.2025.157668_bib0052","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/19390211.2018.1483462","article-title":"Hedychium coronarium rhizomes: promising antidiabetic and natural inhibitor of \u03b1-amylase and \u03b1-glucosidase","volume":"17","author":"Panigrahy","year":"2020","journal-title":"J. Diet. Suppl."},{"issue":"11","key":"10.1016\/j.phymed.2025.157668_bib0053","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.3390\/nu16111669","article-title":"Antidiabetic effect of passiflora ligularis leaves in high fat-diet\/streptozotocin-induced diabetic mice","volume":"16","author":"Rey","year":"2024","journal-title":"Nutrients."},{"key":"10.1016\/j.phymed.2025.157668_bib0054","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.freeradbiomed.2023.03.022","article-title":"Astragaloside IV attenuates podocyte apoptosis through ameliorating mitochondrial dysfunction by up-regulated Nrf2-ARE\/TFAM signaling in diabetic kidney disease","volume":"203","author":"Shen","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2025.157668_bib0055","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.freeradbiomed.2023.02.003","article-title":"Inhibition of ACSF2 protects against renal ischemia\/reperfusion injury via mediating mitophagy in proximal tubular cells","volume":"198","author":"Shi","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2025.157668_bib0056","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111576","article-title":"Swietenine potentiates the antihyperglycemic and antioxidant activity of Metformin in Streptozotocin induced diabetic rats","volume":"139","author":"Shiming","year":"2021","journal-title":"Biomed. PharmacOther"},{"issue":"2","key":"10.1016\/j.phymed.2025.157668_bib0057","doi-asserted-by":"crossref","first-page":"806","DOI":"10.3390\/ijms26020806","article-title":"Autophagy and mitophagy in diabetic kidney disease-a literature review","volume":"26","author":"Stanigut","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.157668_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e03536","article-title":"The recent use of Swietenia mahagoni (L.) Jacq. as antidiabetes type 2 phytomedicine: a systematic review","volume":"6","author":"Sukardiman","year":"2020","journal-title":"Heliyon."},{"key":"10.1016\/j.phymed.2025.157668_bib0059","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF Diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.phymed.2025.157668_bib0060","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41581-020-0309-2","article-title":"Autophagy in kidney homeostasis and disease","volume":"16","author":"Tang","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.phymed.2025.157668_bib0061","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.kint.2022.05.012","article-title":"Molecular mechanisms and therapeutic targets for diabetic kidney disease","volume":"102","author":"Tuttle","year":"2022","journal-title":"Kidney Int."},{"key":"10.1016\/j.phymed.2025.157668_bib0062","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104831","article-title":"Astragaloside IV acts through multi-scale mechanisms to effectively reduce diabetic nephropathy","volume":"157","author":"Wang","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2025.157668_bib0063","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.2337\/db21-0050","article-title":"The attenuation of diabetic nephropathy by annexin A1 via regulation of lipid metabolism through the AMPK\/PPAR\u03b1\/CPT1b pathway","volume":"70","author":"Wu","year":"2021","journal-title":"Diabetes"},{"key":"10.1016\/j.phymed.2025.157668_bib0064","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.redox.2016.12.022","article-title":"The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2\/PINK1","volume":"11","author":"Xiao","year":"2017","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2025.157668_bib0065","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1159\/000529460","article-title":"IL-37 ameliorates renal fibrosis by restoring CPT1A-mediated fatty acid oxidation in diabetic kidney disease","volume":"9","author":"Xiong","year":"2023","journal-title":"Kidney Dis."},{"key":"10.1016\/j.phymed.2025.157668_bib0066","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1080\/15548627.2019.1628520","article-title":"PHB2 (prohibitin 2) promotes PINK1-PRKN\/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis","volume":"16","author":"Yan","year":"2020","journal-title":"Autophagy."},{"key":"10.1016\/j.phymed.2025.157668_bib0067","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2024.2371988","article-title":"Chlorogenic acid alleviates renal fibrosis by reducing lipid accumulation in diabetic kidney disease through suppressing the Notch1 and Stat3 signaling pathway","volume":"46","author":"Yang","year":"2024","journal-title":"Ren. Fail."},{"key":"10.1016\/j.phymed.2025.157668_bib0068","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2022.155195","article-title":"Mitochondrial dysfunction in diabetic tubulopathy","volume":"131","author":"Yao","year":"2022","journal-title":"Metabolism."},{"key":"10.1016\/j.phymed.2025.157668_bib0069","first-page":"18","article-title":"A Molecular Approach to Mitophagy and Mitochondrial Dynamics","volume":"41","author":"Yoo","year":"2018","journal-title":"Mol. Cells"},{"key":"10.1016\/j.phymed.2025.157668_bib0070","doi-asserted-by":"crossref","first-page":"e516","DOI":"10.1002\/mco2.516","article-title":"Inflammation in diabetes complications: molecular mechanisms and therapeutic interventions","volume":"5","author":"Zhao","year":"2024","journal-title":"MedComm. (2020)"},{"key":"10.1016\/j.phymed.2025.157668_bib0071","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.trsl.2024.09.005","article-title":"Dihydrolipoamide S-acetyltransferase activation alleviates diabetic kidney disease via AMPK-autophagy axis and mitochondrial protection","volume":"274","author":"Zhou","year":"2024","journal-title":"Transl. Res."},{"key":"10.1016\/j.phymed.2025.157668_bib0072","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2025.114463","article-title":"Endoplasmic reticulum stress and unfolded protein response in renal lipid metabolism","volume":"446","author":"Zhou","year":"2025","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.phymed.2025.157668_bib0073","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.7150\/ijbs.82417","article-title":"Limonin, a natural ERK2 agonist, protects against ischemic acute kidney injury","volume":"19","author":"Zhou","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.phymed.2025.157668_bib0074","doi-asserted-by":"crossref","first-page":"693","DOI":"10.2147\/JIR.S440374","article-title":"Comprehensive Analysis of Fatty Acid Metabolism in Diabetic Nephropathy from the Perspective of Immune Landscapes, Diagnosis and Precise Therapy","volume":"17","author":"Zhu","year":"2024","journal-title":"J. Inflamm. Res."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325013030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325013030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:28:34Z","timestamp":1768397314000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325013030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":74,"alternative-id":["S0944711325013030"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157668","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Swietenine attenuates renal tubular injury by activating mitophagy in diabetic nephropathy","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157668","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157668"}}