{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:29:11Z","timestamp":1788571751587,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018571","name":"Specific Research Project of Guangxi for Research Bases and Talents","doi-asserted-by":"publisher","award":["AD23026236"],"award-info":[{"award-number":["AD23026236"]}],"id":[{"id":"10.13039\/501100018571","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2023GXNSFAA026220"],"award-info":[{"award-number":["2023GXNSFAA026220"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.phymed.2025.157716","type":"journal-article","created":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T23:03:24Z","timestamp":1765753404000},"page":"157716","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Sophoricoside ameliorates LPS\/D-GalN-induced acute liver failure by inhibiting ferroptosis via activation of the Nrf2\/GPX4 signaling pathway"],"prefix":"10.1016","volume":"150","author":[{"given":"Shaowei","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houkang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiying","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingli","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kefeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riming","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2025.157716_bib0001","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41418-022-00941-0","article-title":"The multifaceted role of ferroptosis in liver disease","volume":"29","author":"Chen","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.phymed.2025.157716_bib0002","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: machinery and regulation","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2025.157716_bib0003","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3892\/ijmm.2023.5281","article-title":"Sophoricoside attenuates autoimmune\u2011mediated liver injury through the regulation of oxidative stress and the NF\u2011\u03baB signaling pathway","volume":"52","author":"Chen","year":"2023","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.phymed.2025.157716_bib0004","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2020.02.025","article-title":"Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease","volume":"152","author":"Chen","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2025.157716_bib0005","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/s41556-019-0305-6","article-title":"ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway","volume":"21","author":"Chu","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.phymed.2025.157716_bib0006","doi-asserted-by":"crossref","first-page":"8082","DOI":"10.3748\/wjg.v20.i25.8082","article-title":"Oxidative stress as a crucial factor in liver diseases","volume":"20","author":"Cicho\u017c-Lach","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phymed.2025.157716_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101107","article-title":"NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis","volume":"23","author":"Dodson","year":"2019","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2025.157716_bib0008","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1146\/annurev-pharmtox-010818-021856","article-title":"Modulating NRF2 in disease: timing is everything","volume":"59","author":"Dodson","year":"2019","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.phymed.2025.157716_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2022.07.006","article-title":"Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis","volume":"34","author":"Gao","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2025.157716_bib0010","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1153528","article-title":"Etiology of viral induced acute liver failure and defensins as potential therapeutic agents in ALF treatment","volume":"14","author":"Hrynkiewicz","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2025.157716_bib0011","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3390\/biom10020320","article-title":"Regulation of Nrf2 by mitochondrial reactive oxygen species in physiology and pathology","volume":"10","author":"Kasai","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.phymed.2025.157716_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111029","article-title":"Sophoricoside from Sophora japonica ameliorates allergic asthma by preventing mast cell activation and CD4(+) T cell differentiation in ovalbumin-induced mice","volume":"133","author":"Kim","year":"2021","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2025.157716_bib0013","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.586578","article-title":"Oxidative damage and antioxidant defense in ferroptosis","volume":"8","author":"Kuang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.phymed.2025.157716_bib0014","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13578-024-01234-4","article-title":"Med1 inhibits ferroptosis and alleviates liver injury in acute liver failure via Nrf2 activation","volume":"14","author":"Lei","year":"2024","journal-title":"Cell Biosci."},{"key":"10.1016\/j.phymed.2025.157716_bib0015","doi-asserted-by":"crossref","first-page":"7038","DOI":"10.1111\/febs.16059","article-title":"Signaling pathways and defense mechanisms of ferroptosis","volume":"289","author":"Liu","year":"2022","journal-title":"FEBS J."},{"key":"10.1016\/j.phymed.2025.157716_bib0016","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of nrf2 in oxidative stress and toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.phymed.2025.157716_bib0017","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0140-6736(24)00693-7","article-title":"Acute liver failure","volume":"404","author":"Maiwall","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2025.157716_bib0018","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.2147\/DDDT.S380324","article-title":"Protective effects of p-CA against acute liver damage induced by LPS\/D-GalN in Wistar albino rats","volume":"16","author":"Mehdi","year":"2022","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.phymed.2025.157716_bib0019","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3390\/ijms24010449","article-title":"Lipid peroxidation and iron metabolism: two corner stones in the homeostasis control of ferroptosis","volume":"24","author":"Rochette","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2025.157716_bib0020","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1097\/HEP.0000000000000458","article-title":"Future directions in acute liver failure","volume":"78","author":"Stravitz","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2025.157716_bib0021","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41392-023-01606-1","article-title":"Targeting ferroptosis opens new avenues for the development of novel therapeutics","volume":"8","author":"Sun","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2025.157716_bib0022","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.phymed.2025.157716_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108159","article-title":"Isoliquiritigenin alleviates LPS\/D-GalN-induced acute liver failure by activating the PGC-1\u03b1\/ Nrf2 pathway to reduce oxidative stress and inflammatory response","volume":"100","author":"Wang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2025.157716_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102262","article-title":"ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury","volume":"51","author":"Wang","year":"2022","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2025.157716_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155846","article-title":"Sophoricoside ameliorates methicillin-resistant Staphylococcus aureus-induced acute lung injury by inhibiting Bach1\/Akt pathway","volume":"132","author":"Wu","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2025.157716_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102349","article-title":"Ethyl carbamate triggers ferroptosis in liver through inhibiting GSH synthesis and suppressing Nrf2 activation","volume":"53","author":"Xu","year":"2022","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2025.157716_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114633","article-title":"Polysaccharides from Dicliptera chinensis (L.) Juss. Attenuates drug-induced liver injury by phosphorylating AMPK and thus facilitating the entry of FOXO3 into the cell nucleus","volume":"155","author":"Yang","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2025.157716_bib0028","doi-asserted-by":"crossref","first-page":"248","DOI":"10.5114\/aoms.2020.93638","article-title":"Sophoricoside attenuates neuronal injury and altered cognitive function by regulating the LTR-4\/NF-\u03baB\/PI3K signalling pathway in anaesthetic-exposed neonatal rats","volume":"20","author":"Yang","year":"2024","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.phymed.2025.157716_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2024.03.001","article-title":"Mechanisms and therapeutic targets of ferroptosis: Implications for nanomedicine design","volume":"14","author":"Zhang","year":"2024","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.phymed.2025.157716_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116512","article-title":"GPX4, ferroptosis, and diseases","volume":"174","author":"Zhang","year":"2024","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2025.157716_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115420","article-title":"Piceatannol alleviates oxidative stress and ferroptosis in alcohol-induced liver injury by activation of Nrf2\/GPX4 signaling","volume":"165","author":"Zhang","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2025.157716_bib0032","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1002\/ptr.6747","article-title":"Sophoricoside is a selective LXR\u03b2 antagonist with potent therapeutic effects on hepatic steatosis of mice","volume":"34","author":"Zhang","year":"2020","journal-title":"PhytOther Res."},{"key":"10.1016\/j.phymed.2025.157716_bib0033","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.freeradbiomed.2023.11.038","article-title":"STING modulates iron metabolism to promote liver injury and inflammation in acute immune hepatitis","volume":"210","author":"Zhao","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2025.157716_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115376","article-title":"KLF6 enhances ferroptosis in S-AKI through the NCOA4\/ACSL4\/LPCAT3 axis","volume":"164","author":"Zhou","year":"2025","journal-title":"Int. Immunopharmacol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325013509?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325013509?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T21:01:10Z","timestamp":1768942870000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325013509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":34,"alternative-id":["S0944711325013509"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157716","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sophoricoside ameliorates LPS\/D-GalN-induced acute liver failure by inhibiting ferroptosis via activation of the Nrf2\/GPX4 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157716","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157716"}}