{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:55:54Z","timestamp":1787237754158,"version":"build-2736575974"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","doi-asserted-by":"publisher","award":["451\\u201303\\u2013136\/2025\\u201303\/200122"],"award-info":[{"award-number":["451\\u201303\\u2013136\/2025\\u201303\/200122"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004564","name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","doi-asserted-by":"publisher","award":["451\\u201303\\u2013136\/2025\\u201303\/200378"],"award-info":[{"award-number":["451\\u201303\\u2013136\/2025\\u201303\/200378"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.phymed.2025.157728","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:08:36Z","timestamp":1766189316000},"page":"157728","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Hesperetin\u2019s antigenotoxicity: the impact on EMS-made lesions within Drosophila melanogaster somatic cells\u2019 DNA, disclosed through molecular modeling"],"prefix":"10.1016","volume":"150","author":[{"given":"Sanja Lj.","family":"Mati\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5218-8293","authenticated-orcid":false,"given":"Nevena","family":"Toma\u0161evi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6718-8800","authenticated-orcid":false,"given":"Mijat","family":"Bo\u017eovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0199-7730","authenticated-orcid":false,"given":"Roberta","family":"Astolfi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2056-9247","authenticated-orcid":false,"given":"Lidia","family":"Giuliani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rino","family":"Ragno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6556-8778","authenticated-orcid":false,"given":"Milan","family":"Mladenovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"73","key":"10.1016\/j.phymed.2025.157728_bib0001","doi-asserted-by":"crossref","first-page":"69421","DOI":"10.1039\/C6RA16640G","article-title":"Inhibition of chikungunya virus replication by hesperetin and naringenin","volume":"6","author":"Ahmadi","year":"2016","journal-title":"RSC. Adv."},{"issue":"15","key":"10.1016\/j.phymed.2025.157728_bib0002","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1002\/jcc.23905","article-title":"DOCK 6: impact of new features and current docking performance","volume":"36","author":"Allen","year":"2015","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.phymed.2025.157728_bib0003","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.ijbiomac.2016.07.057","article-title":"New spiro-acridines: DNA interaction, antiproliferative activity and inhibition of human DNA topoisomerases","volume":"92","author":"Almeida","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.phymed.2025.157728_bib0004","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12859-019-2642-7","article-title":"Statistical assessment and visualization of synergies for large-scale sparse drug combination datasets","volume":"20","author":"Amzallag","year":"2019","journal-title":"BMC. Bioinformatics."},{"issue":"20","key":"10.1016\/j.phymed.2025.157728_bib0005","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1021\/bi7000664","article-title":"Bioflavonoids as poisons of human topoisomerase II alpha and II beta","volume":"46","author":"Bandele","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.phymed.2025.157728_bib0006","unstructured":"Bodin, J.E., Boahene, N.Y., Hofer, T., Bj\u00f8rge M\u00fcller, M.H., Parr, C.L., Dalen, K.T., Holth, T.F., Vogelsang, C., Aakre, I., Stenr\u00f8d, M., 2024. Risk assessment of hesperidin \u2013 \u201cother substances\u201d, in: Norwegian Scientific Committee for, F., Environment (Eds.). VKM Bulletin 2024:26, Oslo, Norway."},{"issue":"2","key":"10.1016\/j.phymed.2025.157728_bib0007","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/em.20604","article-title":"Proposal of an in vivo comet assay using haemocytes of Drosophila melanogaster","volume":"52","author":"Carmona","year":"2011","journal-title":"Environ. Mol. Mutagen."},{"issue":"9","key":"10.1016\/j.phymed.2025.157728_bib0008","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.nut.2006.05.004","article-title":"Effects of hesperetin on vessel structure formation in mouse embryonic stem (mES) cells","volume":"22","author":"Choi","year":"2006","journal-title":"Nutrition"},{"issue":"19","key":"10.1016\/j.phymed.2025.157728_bib0009","doi-asserted-by":"crossref","first-page":"10629","DOI":"10.1073\/pnas.1832879100","article-title":"Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187","volume":"100","author":"Classen","year":"2003","journal-title":"Proc. Natl. Acad. Sci. u S. a"},{"issue":"3","key":"10.1016\/j.phymed.2025.157728_bib0010","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1385\/MB:26:3:249","article-title":"The comet assay for DNA damage and repair: principles, applications, and limitations","volume":"26","author":"Collins","year":"2004","journal-title":"Mol. Biotechnol."},{"issue":"4","key":"10.1016\/j.phymed.2025.157728_bib0012","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3123\/jemsge.34.171","article-title":"Exposure to ethylating agents: where do the thresholds for mutagenic\/clastogenic effects arise?","volume":"34","author":"Gocke","year":"2012","journal-title":"Genes Environ."},{"issue":"22","key":"10.1016\/j.phymed.2025.157728_bib0013","doi-asserted-by":"crossref","first-page":"5911","DOI":"10.1016\/j.bmc.2018.10.038","article-title":"Synthesis, DNA and protein interactions and human topoisomerase inhibition of novel Spiroacridine derivatives","volume":"26","author":"Gouveia","year":"2018","journal-title":"Bioorg. Med. Chem."},{"issue":"9","key":"10.1016\/j.phymed.2025.157728_bib0014","article-title":"Potential protective effect of hesperidin (Vitamin P) against glyphosate-induced spermatogenesis damage in male rats: biochemical and histopathological findings on reproductive parameters","volume":"14","author":"G\u00fcng\u00f6r","year":"2024","journal-title":"Life (Basel)"},{"issue":"2\u20133","key":"10.1016\/j.phymed.2025.157728_bib0015","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0378-4274(96)03847-7","article-title":"The contribution of cytotoxicity to DNA-effects in the single cell gel test (comet assay)","volume":"90","author":"Hartmann","year":"1997","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.phymed.2025.157728_bib0016","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s41936-025-00464-3","article-title":"Effectiveness of hesperidin and rutin on cisplatin-induced testicular dysfunction in rats","volume":"86","author":"Heibashy","year":"2025","journal-title":"J. Basic Appl. Zool."},{"issue":"7","key":"10.1016\/j.phymed.2025.157728_bib0017","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.nucmedbio.2009.06.002","article-title":"Protective effects of hesperidin against genotoxicity induced by (99m)Tc-MIBI in human cultured lymphocyte cells","volume":"36","author":"Hosseinimehr","year":"2009","journal-title":"Nucl. Med. Biol."},{"issue":"3","key":"10.1016\/j.phymed.2025.157728_bib0018","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/mutage\/gep001","article-title":"Radioprotective effects of hesperidin against genotoxicity induced by gamma-irradiation in human lymphocytes","volume":"24","author":"Hosseinimehr","year":"2009","journal-title":"Mutagenesis."},{"issue":"2","key":"10.1016\/j.phymed.2025.157728_bib0019","doi-asserted-by":"crossref","DOI":"10.3390\/nu9020102","article-title":"Evidence of some natural products with antigenotoxic effects. Part 1: fruits and polysaccharides","volume":"9","author":"Izquierdo-Vega","year":"2017","journal-title":"Nutrients."},{"issue":"1\u20132","key":"10.1016\/j.phymed.2025.157728_bib0020","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.mrgentox.2009.03.005","article-title":"Investigation of the radioprotective efficacy of hesperidin against gamma-radiation induced cellular damage in cultured human peripheral blood lymphocytes","volume":"676","author":"Kalpana","year":"2009","journal-title":"Mutat. Res."},{"issue":"1","key":"10.1016\/j.phymed.2025.157728_bib0021","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s10068-016-0114-7","article-title":"Radioprotective effect of hesperetin against \u03b3-irradiation-induced DNA damage and immune dysfunction in murine splenocytes","volume":"25","author":"Kang","year":"2016","journal-title":"Food Sci. Biotechnol."},{"issue":"8","key":"10.1016\/j.phymed.2025.157728_bib0022","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1021\/ci300604z","article-title":"Lessons learned in empirical scoring with smina from the CSAR 2011 benchmarking exercise","volume":"53","author":"Koes","year":"2013","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.phymed.2025.157728_bib0023","doi-asserted-by":"crossref","unstructured":"Korb, O., St\u00fctzle, T., Exner, T.E., 2006. PLANTS: application of ant colony optimization to structure-based drug design, ANTS Workshop.","DOI":"10.1007\/11839088_22"},{"issue":"51","key":"10.1016\/j.phymed.2025.157728_bib0024","doi-asserted-by":"crossref","first-page":"21011","DOI":"10.1074\/jbc.M117.810580","article-title":"Resveratrol: a novel type of topoisomerase II inhibitor","volume":"292","author":"Lee","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2025.157728_bib0025","article-title":"A unified approach to interpreting model predictions","author":"Lundberg","year":"2017","journal-title":"Neural Inf. Process. Syst."},{"issue":"9","key":"10.1016\/j.phymed.2025.157728_bib0026","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/0309-1651(85)90096-7","article-title":"beta-carotene reduces sister chromatid exchanges induced by chemical carcinogens in mouse mammary cells in organ culture","volume":"9","author":"Manoharan","year":"1985","journal-title":"Cell Biol. Int. Rep."},{"issue":"633142","key":"10.1016\/j.phymed.2025.157728_bib0027","article-title":"Discovery of new catalytic topoisomerase II inhibitors for anticancer therapeutics","volume":"10","author":"Matias-Barrios","year":"2020","journal-title":"Front. Oncol."},{"issue":"47","key":"10.1016\/j.phymed.2025.157728_bib0028","doi-asserted-by":"crossref","first-page":"39337","DOI":"10.1074\/jbc.M503320200","article-title":"Human topoisomerase IIalpha rapidly relaxes positively supercoiled DNA: implications for enzyme action ahead of replication forks","volume":"280","author":"McClendon","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phymed.2025.157728_bib0029","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fgene.2019.00051","article-title":"Drosophila melanogaster: a model organism to study cancer","volume":"10","author":"Mirzoyan","year":"2019","journal-title":"Front. Genet."},{"issue":"4","key":"10.1016\/j.phymed.2025.157728_bib0030","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1021\/acs.jcim.6b00608","article-title":"Understanding the molecular determinant of reversible Human monoamine oxidase B inhibitors containing 2H-chromen-2-one core: structure-based and ligand-based derived three-dimensional quantitative structure-activity relationships predictive models","volume":"57","author":"Mladenovi\u0107","year":"2017","journal-title":"J. Chem. Inf. Model."},{"issue":"1","key":"10.1016\/j.phymed.2025.157728_bib0031","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.bcp.2015.08.106","article-title":"Newly discovered chroman-2,4-diones neutralize the in vivo DNA damage induced by alkylation through the inhibition of topoisomerase II\u03b1: a story behind the molecular modeling approach","volume":"98","author":"Mladenovi\u0107","year":"2015","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2025.157728_bib0032","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1177\/10915818221134022","article-title":"Mutagenic, acute, and subchronic toxicity studies of the hesperetin-7-glucoside-\u03b2-cyclodextrin inclusion complex","volume":"42","author":"Moriwaki","year":"2023","journal-title":"Int. J. Toxicol."},{"issue":"16","key":"10.1016\/j.phymed.2025.157728_bib0033","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"issue":"2","key":"10.1016\/j.phymed.2025.157728_bib0034","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/mutage\/geh007","article-title":"Evaluation of in vivo genotoxicity of cypermethrin in Drosophila melanogaster using the alkaline Comet assay","volume":"19","author":"Mukhopadhyay","year":"2004","journal-title":"Mutagenesis"},{"issue":"13","key":"10.1016\/j.phymed.2025.157728_bib0035","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2013a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"issue":"5","key":"10.1016\/j.phymed.2025.157728_bib0036","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.chembiol.2010.04.012","article-title":"DNA topoisomerases and their poisoning by anticancer and antibacterial drugs","volume":"17","author":"Pommier","year":"2010","journal-title":"Chem. Biol."},{"issue":"6","key":"10.1016\/j.phymed.2025.157728_bib0037","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/s41580-022-00452-3","article-title":"Human topoisomerases and their roles in genome stability and organization","volume":"23","author":"Pommier","year":"2022","journal-title":"Nature Rev. Molecular Cell Biol."},{"issue":"15","key":"10.1016\/j.phymed.2025.157728_bib0038","doi-asserted-by":"crossref","first-page":"8219","DOI":"10.1073\/pnas.111006998","article-title":"Topological challenges to DNA replication: conformations at the fork","volume":"98","author":"Postow","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.phymed.2025.157728_bib0039","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1038\/s41598-020-59553-8","article-title":"Essential oils against bacterial isolates from cystic fibrosis patients by means of antimicrobial and unsupervised machine learning approaches","volume":"10","author":"Ragno","year":"2020","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.phymed.2025.157728_bib0040","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1517\/13543776.17.9.1061","article-title":"Alkylating agents and cancer therapy","volume":"17","author":"Ralhan","year":"2007","journal-title":"Expert. Opin. Ther. Pat."},{"issue":"4","key":"10.1016\/j.phymed.2025.157728_bib0041","doi-asserted-by":"crossref","first-page":"4009","DOI":"10.1007\/s00210-024-03531-8","article-title":"Hesperidin as a bioactive compound in citrus fruits reduces N-ethyl-N-nitrosourea-induced mortality and toxicity in mice: as a model for chronic lymphocytic leukemia","volume":"398","author":"Salimi","year":"2025","journal-title":"Naunyn. Schmiedebergs. Arch. Pharmacol."},{"issue":"14","key":"10.1016\/j.phymed.2025.157728_bib0042","doi-asserted-by":"crossref","first-page":"7182","DOI":"10.1093\/nar\/gkz586","article-title":"Closing the DNA replication cycle: from simple circular molecules to supercoiled and knotted DNA catenanes","volume":"47","author":"Schvartzman","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.phymed.2025.157728_bib0043","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0165-1110(84)90007-1","article-title":"A review of the genetic effects of ethyl methanesulfonate","volume":"134","author":"Sega","year":"1984","journal-title":"Mutation Res.\/Rev. Genetic Toxicol."},{"key":"10.1016\/j.phymed.2025.157728_bib0044","series-title":"Notes On the N-Person Game — II: The Value of an N-Person Game","author":"Shapley","year":"1951"},{"issue":"2","key":"10.1016\/j.phymed.2025.157728_bib0045","first-page":"57","article-title":"Hesperidin, a citrus bioflavonoid, ameliorates genotoxicity-induced by diazinon in human blood lymphocytes","volume":"65","author":"Shokrzadeh","year":"2015","journal-title":"Drug Res. (Stuttg)"},{"issue":"4","key":"10.1016\/j.phymed.2025.157728_bib0046","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/mutage\/gei032","article-title":"Validation of drosophila melanogaster as an in vivo model for genotoxicity assessment using modified alkaline Comet assay","volume":"20","author":"Siddique","year":"2005","journal-title":"Mutagenesis."},{"issue":"1","key":"10.1016\/j.phymed.2025.157728_bib0047","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/pro.3290","article-title":"Clustal Omega for making accurate alignments of many protein sequences","volume":"27","author":"Sievers","year":"2018","journal-title":"Protein Sci."},{"issue":"1","key":"10.1016\/j.phymed.2025.157728_bib0048","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A simple technique for quantitation of low levels of DNA damage in individual cells","volume":"175","author":"Singh","year":"1988","journal-title":"Exp. Cell Res."},{"issue":"1","key":"10.1016\/j.phymed.2025.157728_bib0049","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19010223","article-title":"Dietary resveratrol does not affect life span, body composition, stress response, and longevity-related gene expression in drosophila melanogaster","volume":"19","author":"Staats","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.phymed.2025.157728_bib0050","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.fct.2010.12.005","article-title":"Hesperetin protects testicular toxicity of doxorubicin in rat: role of NF\u03baB, p38 and caspase-3","volume":"49","author":"Trivedi","year":"2011","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.phymed.2025.157728_bib0051","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.phymed.2025.157728_bib0052","article-title":"Antigenotoxic effects of Resveratrol in somatic cells of Drosophila melanogaster","volume":"23","author":"Turna","year":"2014","journal-title":"Fresenius Environ. Bull."},{"issue":"Web Server issue","key":"10.1016\/j.phymed.2025.157728_bib0053","doi-asserted-by":"crossref","first-page":"W235","DOI":"10.1093\/nar\/gkp287","article-title":"3D-DART: a DNA structure modelling server","volume":"37","author":"van Dijk","year":"2009","journal-title":"Nucleic. Acids. Res."},{"issue":"1","key":"10.1016\/j.phymed.2025.157728_bib0054","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1038\/s41467-021-23136-6","article-title":"Structural basis for allosteric regulation of Human topoisomerase ii\u03b1","volume":"12","author":"Vanden Broeck","year":"2021","journal-title":"Nat. Commun."},{"issue":"D1","key":"10.1016\/j.phymed.2025.157728_bib0055","doi-asserted-by":"crossref","first-page":"D439","DOI":"10.1093\/nar\/gkab1061","article-title":"AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models","volume":"50","author":"Varadi","year":"2021","journal-title":"Nucleic. Acids. Res."},{"issue":"18","key":"10.1016\/j.phymed.2025.157728_bib0056","doi-asserted-by":"crossref","first-page":"10861","DOI":"10.1093\/nar\/gkx742","article-title":"Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry","volume":"45","author":"Wang","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.phymed.2025.157728_bib0057","doi-asserted-by":"crossref","first-page":"6907","DOI":"10.1038\/s41467-022-34577-y","article-title":"Replication collisions induced by de-repressed S-phase transcription are connected with malignant transformation of adult stem cells","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.phymed.2025.157728_bib0058","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1177\/1087057114521867","article-title":"A new Bliss independence model to analyze drug combination data","volume":"19","author":"Zhao","year":"2014","journal-title":"SLAS Discovery"},{"issue":"3","key":"10.1016\/j.phymed.2025.157728_bib0059","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27030879","article-title":"Antioxidant and antitumor activities of newly synthesized hesperetin derivatives","volume":"27","author":"Zhong","year":"2022","journal-title":"Molecules."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325013625?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325013625?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T18:37:06Z","timestamp":1773945426000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325013625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":58,"alternative-id":["S0944711325013625"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157728","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hesperetin\u2019s antigenotoxicity: the impact on EMS-made lesions within Drosophila melanogaster somatic cells\u2019 DNA, disclosed through molecular modeling","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157728","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"157728"}}