{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T05:57:20Z","timestamp":1792907840995,"version":"4.5.0"},"reference-count":406,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82575038"],"award-info":[{"award-number":["82575038"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074046"],"award-info":[{"award-number":["82074046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016075","name":"Chinese Association of Integrative Medicine","doi-asserted-by":"publisher","award":["22JBZ015"],"award-info":[{"award-number":["22JBZ015"]}],"id":[{"id":"10.13039\/100016075","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019081","name":"Science and Technology Program of Hunan Province","doi-asserted-by":"publisher","award":["2023RC3166"],"award-info":[{"award-number":["2023RC3166"]}],"id":[{"id":"10.13039\/501100019081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019081","name":"Science and Technology Program of Hunan Province","doi-asserted-by":"publisher","award":["2024RC1060"],"award-info":[{"award-number":["2024RC1060"]}],"id":[{"id":"10.13039\/501100019081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014978","name":"Hunan University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014978","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2025JJ90003"],"award-info":[{"award-number":["2025JJ90003"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ20033"],"award-info":[{"award-number":["2023JJ20033"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.phymed.2025.157738","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:12:22Z","timestamp":1766535142000},"page":"157738","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Natural glycosides as multi-target neuroprotective agents in Alzheimer\u2019s disease: Bridging mechanistic insights and translational potential"],"prefix":"10.1016","volume":"150","author":[{"given":"Mengfen","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangying","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wengjing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaowu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0758-7484","authenticated-orcid":false,"given":"zhenyan","family":"song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.phymed.2025.157738_bib0001","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1016\/j.bmc.2014.02.014","article-title":"Benzophenone C-glucosides and gallotannins from mango tree stem bark with broad-spectrum anti-viral activity","volume":"22","author":"Abdel-Mageed","year":"2014","journal-title":"Bioorg. med. chem."},{"key":"10.1016\/j.phymed.2025.157738_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117996","article-title":"Alzheimer's disease; a review of the pathophysiological basis and therapeutic interventions","volume":"256","author":"Abeysinghe","year":"2020","journal-title":"Life sci."},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0003","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3233\/JAD-215600","article-title":"Pelargonidin and Berry Intake Association with Alzheimer's Disease Neuropathology: a Community-Based Study","volume":"88","author":"Agarwal","year":"2022","journal-title":"J. Alzheimer's dis. : JAD"},{"issue":"12","key":"10.1016\/j.phymed.2025.157738_bib0004","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.3390\/nu11123060","article-title":"Association of Strawberries and Anthocyanidin Intake with Alzheimer's Dementia Risk","volume":"11","author":"Agarwal","year":"2019","journal-title":"Nutrients"},{"issue":"6571","key":"10.1016\/j.phymed.2025.157738_bib0005","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1126\/science.abi6087","article-title":"Signaling inflammation across the gut-brain axis","volume":"374","author":"Agirman","year":"2021","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.phymed.2025.157738_bib0006","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.chom.2018.05.003","article-title":"Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease","volume":"23","author":"Agus","year":"2018","journal-title":"Cell host microbe"},{"issue":"3","key":"10.1016\/j.phymed.2025.157738_bib0007","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jfda.2015.01.007","article-title":"Application of polymeric nanoparticles and micelles in insulin oral delivery","volume":"23","author":"Alai","year":"2015","journal-title":"J. food drug anal."},{"key":"10.1016\/j.phymed.2025.157738_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2019.06.020","article-title":"Flavanone glycosides inhibit \u03b2-site amyloid precursor protein cleaving enzyme 1 and cholinesterase and reduce A\u03b2 aggregation in the amyloidogenic pathway","volume":"309","author":"Ali","year":"2019","journal-title":"Chem.-biol. interact."},{"issue":"7","key":"10.1016\/j.phymed.2025.157738_bib0009","doi-asserted-by":"crossref","first-page":"6076","DOI":"10.1007\/s12035-017-0798-6","article-title":"Natural Dietary Supplementation of Anthocyanins via PI3K\/Akt\/Nrf2\/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer's Disease","volume":"55","author":"Ali","year":"2018","journal-title":"Mol. neurobiol."},{"key":"10.1016\/j.phymed.2025.157738_bib0010","doi-asserted-by":"crossref","DOI":"10.1038\/srep11708","article-title":"Osmotin attenuates amyloid beta-induced memory impairment, tau phosphorylation and neurodegeneration in the mouse hippocampus","volume":"5","author":"Ali","year":"2015","journal-title":"Sci. rep."},{"issue":"6","key":"10.1016\/j.phymed.2025.157738_bib0011","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.biotechadv.2014.07.001","article-title":"Verbascoside\u2013a review of its occurrence, (bio)synthesis and pharmacological significance","volume":"32","author":"Alipieva","year":"2014","journal-title":"Biotechnol. adv."},{"issue":"26","key":"10.1016\/j.phymed.2025.157738_bib0012","doi-asserted-by":"crossref","first-page":"68101","DOI":"10.1007\/s11356-023-27354-x","article-title":"Protective effect of arbutin against cyclophosphamide-induced oxidative stress, inflammation, and hepatotoxicity via Nrf2\/HO-1 pathway in rats","volume":"30","author":"Alruhaimi","year":"2023","journal-title":"Environ. sci. pollut. res. int."},{"issue":"12","key":"10.1016\/j.phymed.2025.157738_bib0013","article-title":"Cytochrome c and cancer cell metabolism: a new perspective","volume":"32","author":"Alshehri","year":"2024","journal-title":"Saudi pharm. j. : SPJ : off. publ. Saudi Pharm. Soc."},{"issue":"8","key":"10.1016\/j.phymed.2025.157738_bib0014","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s43587-021-00098-4","article-title":"Autophagy in healthy aging and disease","volume":"1","author":"Aman","year":"2021","journal-title":"Nat. Aging"},{"issue":"4","key":"10.1016\/j.phymed.2025.157738_bib0015","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/s41574-021-00626-7","article-title":"Mitochondrial and metabolic dysfunction in ageing and age-related diseases","volume":"18","author":"Amorim","year":"2022","journal-title":"Nat. rev. Endocrinol."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.2009.06133.x","article-title":"Neuroprotection by estrogen in the brain: the mitochondrial compartment as presumed therapeutic target","volume":"110","author":"Arnold","year":"2009","journal-title":"J. neurochem."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0017","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s12974-023-02950-3","article-title":"Cyanidin-3-O-glucoside protects the brain and improves cognitive function in APPswe\/PS1\u0394E9 transgenic mice model","volume":"20","author":"Baek","year":"2023","journal-title":"J. neuroinflammation"},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0018","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/s42004-025-01587-y","article-title":"Structure-based discovery of forsythoside A as an effective inhibitor to reduce the neurotoxicity of amyloid \u03b2","volume":"8","author":"Bai","year":"2025","journal-title":"Commun. chem."},{"issue":"7","key":"10.1016\/j.phymed.2025.157738_bib0019","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1093\/ajhp\/62.7.700","article-title":"Rationale for using serotonergic agents to treat irritable bowel syndrome","volume":"62","author":"Baker","year":"2005","journal-title":"Am. j. health-syst. pharm. : AJHP : off. j. Am. Soc. Health-Syst. Pharm."},{"issue":"Pt 6","key":"10.1016\/j.phymed.2025.157738_bib0020","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1093\/brain\/awv024","article-title":"Neuronal amyloid-\u03b2 accumulation within cholinergic basal forebrain in ageing and Alzheimer's disease","volume":"138","author":"Baker-Nigh","year":"2015","journal-title":"Brain : j. neurol."},{"key":"10.1016\/j.phymed.2025.157738_bib0021","article-title":"Advanced Nanotechnological Approaches for Effective Delivery of Rutin: an Updated Review","author":"Bansal","year":"2024","journal-title":"Pharm. nanotechnol."},{"issue":"12","key":"10.1016\/j.phymed.2025.157738_bib0022","first-page":"9","article-title":"Advances in the physiological function of cellular cholesterol and its metabolic abnormalities related diseases","volume":"39","author":"Baoyu","year":"2017","journal-title":"Chin. J. Cell Biol."},{"issue":"10","key":"10.1016\/j.phymed.2025.157738_bib0023","doi-asserted-by":"crossref","DOI":"10.3390\/biom12101514","article-title":"Amygdalin: a Review on Its Characteristics, Antioxidant Potential, Gastrointestinal Microbiota Intervention, Anticancer Therapeutic and Mechanisms, Toxicity, and Encapsulation","volume":"12","author":"Barakat","year":"2022","journal-title":"Biomolecules"},{"issue":"5","key":"10.1016\/j.phymed.2025.157738_bib0024","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3390\/toxins13050344","article-title":"Quo vadis Cardiac Glycoside Research","volume":"13","author":"Bej\u010dek","year":"2021","journal-title":"Toxins"},{"issue":"8","key":"10.1016\/j.phymed.2025.157738_bib0025","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.neuropharm.2011.08.024","article-title":"Nicotinic excitatory postsynaptic potentials in hippocampal CA1 interneurons are predominantly mediated by nicotinic receptors that contain \u03b14 and \u03b22 subunits","volume":"61","author":"Bell","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phymed.2025.157738_bib0026","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.pharmthera.2014.11.016","article-title":"Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases","volume":"148","author":"Beurel","year":"2015","journal-title":"Pharmacol. ther."},{"key":"10.1016\/j.phymed.2025.157738_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2020.117253","article-title":"Role of mitochondrial dysfunction, oxidative stress and autophagy in progression of Alzheimer's disease","volume":"421","author":"Bhatia","year":"2021","journal-title":"J. neurol. sci."},{"key":"10.1016\/j.phymed.2025.157738_bib0028","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3389\/fncel.2013.00153","article-title":"Alzheimer's disease and the microbiome","volume":"7","author":"Bhattacharjee","year":"2013","journal-title":"Front. cell. neurosci."},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0029","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.bbr.2009.12.048","article-title":"The cholinergic system and Parkinson disease","volume":"221","author":"Bohnen","year":"2011","journal-title":"Behav. brain res."},{"issue":"4","key":"10.1016\/j.phymed.2025.157738_bib0030","doi-asserted-by":"crossref","first-page":"387","DOI":"10.2174\/1871527316666170328113309","article-title":"Neuroprotective Effects of Citrus Fruit-Derived Flavonoids, Nobiletin and Tangeretin in Alzheimer's and Parkinson's Disease","volume":"16","author":"Braidy","year":"2017","journal-title":"CNS neurol. disord. drug targets"},{"issue":"10","key":"10.1016\/j.phymed.2025.157738_bib0031","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1038\/s41593-020-0687-6","article-title":"Synergy between amyloid-\u03b2 and tau in Alzheimer's disease","volume":"23","author":"Busche","year":"2020","journal-title":"Nat. neurosci."},{"issue":"6","key":"10.1016\/j.phymed.2025.157738_bib0032","first-page":"1282","article-title":"Advances in the role of microglia and NLRP3 inflammatory vesicles in cognitive dysfunction","volume":"14","author":"Caihong","year":"2023","journal-title":"Concordia Med. J."},{"issue":"4","key":"10.1016\/j.phymed.2025.157738_bib0033","first-page":"902","article-title":"The role of NLRP3 inflammatory vesicles in the prevention and treatment of cognitive dysfunction-related diseases and the research progress of traditional Chinese medicine intervention","volume":"49","author":"Caihong","year":"2024","journal-title":"Chin. J. Tradit. Chin. Med."},{"issue":"23","key":"10.1016\/j.phymed.2025.157738_bib0034","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232314835","article-title":"The Neuroprotective Potentiality of Flavonoids on Alzheimer's Disease","volume":"23","author":"Calderaro","year":"2022","journal-title":"Int. j. mol. sci."},{"key":"10.1016\/j.phymed.2025.157738_bib0035","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.888420","article-title":"Importin-Mediated Pathological Tau Nuclear Translocation Causes Disruption of the Nuclear Lamina, TDP-43 Mislocalization and Cell Death","volume":"15","author":"Candia","year":"2022","journal-title":"Front. mol. neurosci."},{"key":"10.1016\/j.phymed.2025.157738_bib0036","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6840432","article-title":"Traditional Chinese Medicine Huannao Yicong Decoction Extract Decreases Tau Hyperphosphorylation in the Brain of Alzheimer's Disease Model Rats Induced by A\u03b21-42","volume":"2016","author":"Cao","year":"2016","journal-title":"Evid.-based complement. altern. med. : eCAM"},{"key":"10.1016\/j.phymed.2025.157738_bib0037","article-title":"The role of peripheral innate immune cells in Alzheimer's disease progression","volume":"16","author":"Cao","year":"2025","journal-title":"Front. immunol."},{"key":"10.1016\/j.phymed.2025.157738_bib0038","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3389\/fnagi.2019.00311","article-title":"Dysfunctional Mitochondria and Mitophagy as Drivers of Alzheimer's Disease Pathogenesis","volume":"11","author":"Chakravorty","year":"2019","journal-title":"Front. aging neurosci."},{"key":"10.1016\/j.phymed.2025.157738_bib0039","first-page":"4","article-title":"Progress in activation of Nrf2 by reactive oxygen species through MAPKs and PI3K\/AKT pathway","volume":"32","author":"Chen","year":"2016"},{"key":"10.1016\/j.phymed.2025.157738_bib0041","article-title":"The role of the gut-brain axis in diseases","author":"Chen","year":"2025","journal-title":"Physiol. (Bethesda Md,)"},{"issue":"28","key":"10.1016\/j.phymed.2025.157738_bib0042","doi-asserted-by":"crossref","first-page":"7730","DOI":"10.1080\/10408398.2021.1917508","article-title":"Absorption, metabolism and bioavailability of flavonoids: a review","volume":"62","author":"Chen","year":"2022","journal-title":"Crit. rev. food sci. nutr."},{"key":"10.1016\/j.phymed.2025.157738_bib0043","article-title":"New insights into the role of mitochondrial dynamics in oxidative stress-induced diseases","volume":"178","author":"Chen","year":"2024","journal-title":"Biomed. pharmacother. = Biomed. pharmacother."},{"issue":"7","key":"10.1016\/j.phymed.2025.157738_bib0044","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.3390\/nu14071417","article-title":"The Neuroprotection of Verbascoside in Alzheimer's Disease Mediated through Mitigation of Neuroinflammation via Blocking NF-\u03baB-p65 Signaling","volume":"14","author":"Chen","year":"2022","journal-title":"Nutrients"},{"issue":"9","key":"10.1016\/j.phymed.2025.157738_bib0045","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: machinery and regulation","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0046","article-title":"Oxidative stress induces mitochondrial iron overload and ferroptotic cell death","volume":"13","author":"Chen","year":"2023","journal-title":"Sci. rep."},{"key":"10.1016\/j.phymed.2025.157738_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112834","article-title":"Establishment of the concurrent experimental model of osteoporosis combined with Alzheimer's disease in rat and the dual-effects of echinacoside and acteoside from Cistanche tubulosa","volume":"257","author":"Chen","year":"2020","journal-title":"J. ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157738_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153883","article-title":"Ginsenoside Rd: a promising natural neuroprotective agent","volume":"95","author":"Chen","year":"2022","journal-title":"Phytomed.: int. j. phytother. phytopharm."},{"issue":"08","key":"10.1016\/j.phymed.2025.157738_bib0049","first-page":"685","article-title":"Post-translational modification of PPAR\u03b3","volume":"28","author":"Chen","year":"2012","journal-title":"Chin. J. Biochem. Mol. Biol."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0050","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12974-023-02853-3","article-title":"Tau and neuroinflammation in Alzheimer's disease: interplay mechanisms and clinical translation","volume":"20","author":"Chen","year":"2023","journal-title":"J. neuroinflammation"},{"key":"10.1016\/j.phymed.2025.157738_bib0051","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ceb.2016.03.021","article-title":"N-linked glycosylation and homeostasis of the endoplasmic reticulum","volume":"41","author":"Cherepanova","year":"2016","journal-title":"Curr. opin. cell biol."},{"issue":"6","key":"10.1016\/j.phymed.2025.157738_bib0052","doi-asserted-by":"crossref","first-page":"593","DOI":"10.4162\/nrp.2020.14.6.593","article-title":"Paeoniflorin ameliorates A\u03b2-stimulated neuroinflammation via regulation of NF-\u03baB signaling pathway and A\u03b2 degradation in C6 glial cells","volume":"14","author":"Cho","year":"2020","journal-title":"Nutr. res. pract."},{"issue":"7","key":"10.1016\/j.phymed.2025.157738_bib0053","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.biotechadv.2014.07.006","article-title":"A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules","volume":"32","author":"Choonara","year":"2014","journal-title":"Biotechnol. adv."},{"key":"10.1016\/j.phymed.2025.157738_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108373","article-title":"Molecular mechanisms of ferroptosis and their involvement in brain diseases","volume":"244","author":"Costa","year":"2023","journal-title":"Pharmacol. ther."},{"issue":"3\u20134","key":"10.1016\/j.phymed.2025.157738_bib0055","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1159\/000113710","article-title":"Galanin hyperinnervation upregulates choline acetyltransferase expression in cholinergic basal forebrain neurons in Alzheimer's disease","volume":"5","author":"Counts","year":"2008","journal-title":"Neuro-degener. dis."},{"issue":"12","key":"10.1016\/j.phymed.2025.157738_bib0056","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1001\/archneur.64.12.1771","article-title":"Alpha7 nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer disease","volume":"64","author":"Counts","year":"2007","journal-title":"Arch. neurol."},{"key":"10.1016\/j.phymed.2025.157738_bib0057","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.jep.2016.07.024","article-title":"The effect of Liuwei Dihuang decoction on PI3K\/Akt signaling pathway in liver of type 2 diabetes mellitus (T2DM) rats with insulin resistance","volume":"192","author":"Dai","year":"2016","journal-title":"J. ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157738_bib0058","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.cbi.2018.02.017","article-title":"Isoquercetin attenuates oxidative stress and neuronal apoptosis after ischemia\/reperfusion injury via Nrf2-mediated inhibition of the NOX4\/ROS\/NF-\u03baB pathway","volume":"284","author":"Dai","year":"2018","journal-title":"Chem.-biol. interact."},{"issue":"3","key":"10.1016\/j.phymed.2025.157738_bib0059","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1007\/s12035-023-03646-8","article-title":"Oxytosis\/Ferroptosis in Neurodegeneration: the Underlying Role of Master Regulator Glutathione Peroxidase 4 (GPX4)","volume":"61","author":"Dar","year":"2024","journal-title":"Mol. neurobiol."},{"issue":"9","key":"10.1016\/j.phymed.2025.157738_bib0060","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/s41577-021-00524-z","article-title":"The cGAS-STING pathway as a therapeutic target in inflammatory diseases","volume":"21","author":"Decout","year":"2021","journal-title":"Nat. rev., Immunol."},{"key":"10.1016\/j.phymed.2025.157738_bib0061","article-title":"The Janus face of mitophagy in myocardial ischemia\/reperfusion injury and recovery","volume":"173","author":"Deng","year":"2024","journal-title":"Biomed. pharmacother. = Biomed. pharmacother."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0062","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/ana.23594","article-title":"Dietary intakes of berries and flavonoids in relation to cognitive decline","volume":"72","author":"Devore","year":"2012","journal-title":"Ann. neurol."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0063","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2174\/1567201052772843","article-title":"New prospects for glycopeptide based analgesia: glycoside-induced penetration of the blood-brain barrier","volume":"2","author":"Dhanasekaran","year":"2005","journal-title":"Curr. drug deliv."},{"issue":"12","key":"10.1016\/j.phymed.2025.157738_bib0064","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1007\/s40265-021-01569-z","article-title":"Aducanumab: first Approval","volume":"81","author":"Dhillon","year":"2021","journal-title":"Drugs"},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0065","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.nut.2015.08.017","article-title":"Beneficial action of resveratrol: how and why","volume":"32","author":"Diaz-Gerevini","year":"2016","journal-title":"Nutrition"},{"issue":"6","key":"10.1016\/j.phymed.2025.157738_bib0066","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/joim.13543","article-title":"Antibiotics and mental health: the good, the bad and the ugly","volume":"292","author":"Dinan","year":"2022","journal-title":"J. intern. med."},{"key":"10.1016\/j.phymed.2025.157738_bib0067","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.829642","article-title":"Shikonin Attenuates Cochlear Spiral Ganglion Neuron Degeneration by Activating Nrf2-ARE Signaling Pathway","volume":"15","author":"Du","year":"2022","journal-title":"Front. mol. neurosci."},{"issue":"4","key":"10.1016\/j.phymed.2025.157738_bib0068","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.immuni.2024.02.019","article-title":"New frontiers in the cGAS-STING intracellular DNA-sensing pathway","volume":"57","author":"Dvorkin","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.phymed.2025.157738_bib0069","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.psych.48.1.649","article-title":"Central cholinergic systems and cognition","volume":"48","author":"Everitt","year":"1997","journal-title":"Annu. rev. psychol."},{"issue":"20","key":"10.1016\/j.phymed.2025.157738_bib0070","doi-asserted-by":"crossref","first-page":"7993","DOI":"10.1523\/JNEUROSCI.21-20-07993.2001","article-title":"Ultrastructural distribution of the alpha7 nicotinic acetylcholine receptor subunit in rat hippocampus","volume":"21","author":"Fabian-Fine","year":"2001","journal-title":"J. neurosci. : off. j. Soc. Neurosci."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0071","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/15548627.2016.1240855","article-title":"Identification of natural products with neuronal and metabolic benefits through autophagy induction","volume":"13","author":"Fan","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2025.157738_bib0072","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.628988","article-title":"Baicalin Prevents Myocardial Ischemia\/Reperfusion Injury Through Inhibiting ACSL4 Mediated Ferroptosis","volume":"12","author":"Fan","year":"2021","journal-title":"Front. pharmacol."},{"issue":"21","key":"10.1016\/j.phymed.2025.157738_bib0073","doi-asserted-by":"crossref","first-page":"5140","DOI":"10.3390\/molecules25215140","article-title":"Simultaneous Preparation of Abundant Flavonol Triglycosides from Tea Leaves","volume":"25","author":"Fang","year":"2020","journal-title":"Mol. : j. synth. chem. nat. prod. chem."},{"key":"10.1016\/j.phymed.2025.157738_bib0074","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.gerinurse.2023.03.006","article-title":"Probiotic intervention benefits multiple neural behaviors in older adults with mild cognitive impairment","volume":"51","author":"Fei","year":"2023","journal-title":"Geriatr. nurs. (N. Y. N.Y.)"},{"key":"10.1016\/j.phymed.2025.157738_bib0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.125814","article-title":"Inhibition of advance glycation end products formation, gastrointestinal digestion, absorption and toxicity: a comprehensive review","volume":"249","author":"Feng","year":"2023","journal-title":"Int. j. biol. macromol."},{"issue":"8","key":"10.1016\/j.phymed.2025.157738_bib0076","doi-asserted-by":"crossref","first-page":"351","DOI":"10.31083\/ph.2021.1393","article-title":"Stilbene glucoside: recent advances in pharmacology, bioinformatics investigation, toxicity and future opportunities","volume":"76","author":"Feng","year":"2021","journal-title":"Pharmazie"},{"key":"10.1016\/j.phymed.2025.157738_bib0077","article-title":"Ginsenoside Rd: a promising target for ischemia-reperfusion injury therapy (A mini review)","volume":"171","author":"Feng","year":"2024","journal-title":"Biomed. pharmacother. = Biomed. pharmacother."},{"key":"10.1016\/j.phymed.2025.157738_bib0078","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/610813","article-title":"Interrelation of oxidative stress and inflammation in neurodegenerative disease: role of TNF","volume":"2015","author":"Fischer","year":"2015","journal-title":"Oxidative med. cell. longev."},{"issue":"24","key":"10.1016\/j.phymed.2025.157738_bib0079","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1001\/jama.287.24.3261","article-title":"Dietary intake of antioxidants and risk of Alzheimer disease: food for thought","volume":"287","author":"Foley","year":"2002","journal-title":"JAMA"},{"issue":"14","key":"10.1016\/j.phymed.2025.157738_bib0080","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.2174\/1381612822666160127112021","article-title":"Role of Nicotinic and Muscarinic Receptors on Synaptic Plasticity and Neurological Diseases","volume":"22","author":"Fuenzalida","year":"2016","journal-title":"Curr. pharm. des."},{"key":"10.1016\/j.phymed.2025.157738_bib0081","article-title":"Integrated multimodal cell atlas of Alzheimer's disease","author":"Gabitto","year":"2023","journal-title":"Res. sq."},{"issue":"12","key":"10.1016\/j.phymed.2025.157738_bib0082","article-title":"Iron homeostasis and oxidative stress: an intimate relationship. Biochimica et biophysica acta","volume":"1866","author":"Galaris","year":"2019","journal-title":"Mol. cell res."},{"issue":"39","key":"10.1016\/j.phymed.2025.157738_bib0083","doi-asserted-by":"crossref","first-page":"18319","DOI":"10.1039\/D4NR01487A","article-title":"Lipid nanoparticles for enhancing oral bioavailability","volume":"16","author":"Gangavarapu","year":"2024","journal-title":"Nanoscale"},{"key":"10.1016\/j.phymed.2025.157738_bib0084","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175809","article-title":"Tetrahydroxy stilbene glycoside ameliorates neuroinflammation for Alzheimer's disease via cGAS-STING","volume":"953","author":"Gao","year":"2023","journal-title":"Eur. j. pharmacol."},{"issue":"4","key":"10.1016\/j.phymed.2025.157738_bib0085","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s11011-016-9813-2","article-title":"Salidroside suppresses inflammation in a d-galactose-induced rat model of Alzheimer's disease via SIRT1\/NF-\u03baB pathway","volume":"31","author":"Gao","year":"2016","journal-title":"Metab. brain dis."},{"key":"10.1016\/j.phymed.2025.157738_bib0086","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.msec.2016.05.119","article-title":"Solid lipid nanoparticles as attractive drug vehicles: composition, properties and therapeutic strategies","volume":"68","author":"Geszke-Moritz","year":"2016","journal-title":"Mater. sci. eng., C Mater. biol. appl."},{"key":"10.1016\/j.phymed.2025.157738_bib0087","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2020.111122","article-title":"Naringin nano-ethosomal novel sunscreen creams: development and performance evaluation","volume":"193","author":"Gollavilli","year":"2020","journal-title":"Colloids surf., B Biointerfaces"},{"issue":"12","key":"10.1016\/j.phymed.2025.157738_bib0088","first-page":"1721","article-title":"Research advances in the role of MAPK cascade in regulation of cell growth, immunity, inflammation, and cancer","volume":"47","author":"Gong","year":"2022","journal-title":"Zhong nan xue xue bao, Yi xue ban = J. Cent. South Univ., Med. sci."},{"issue":"5","key":"10.1016\/j.phymed.2025.157738_bib0089","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1002\/ptr.8152","article-title":"Curculigoside, a traditional Chinese medicine monomer, ameliorates oxidative stress in Alzheimer's disease mouse model via suppressing ferroptosis","volume":"38","author":"Gong","year":"2024","journal-title":"Phytother. res. : PTR"},{"issue":"10","key":"10.1016\/j.phymed.2025.157738_bib0090","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1038\/s41593-024-01740-1","article-title":"Tau is required for glial lipid droplet formation and resistance to neuronal oxidative stress","volume":"27","author":"Goodman","year":"2024","journal-title":"Nat. neurosci."},{"issue":"15","key":"10.1016\/j.phymed.2025.157738_bib0091","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.3390\/nu15153454","article-title":"Polyphenols and Their Impact on the Prevention of Neurodegenerative Diseases and Development","volume":"15","author":"Grabska-Koby\u0142ecka","year":"2023","journal-title":"Nutrients"},{"issue":"10 Pt 2","key":"10.1016\/j.phymed.2025.157738_bib0092","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1016\/j.neubiorev.2013.09.003","article-title":"The nucleus basalis of Meynert: a new target for deep brain stimulation in dementia","volume":"37","author":"Gratwicke","year":"2013","journal-title":"Neurosci. biobehav. rev."},{"issue":"1\u20133","key":"10.1016\/j.phymed.2025.157738_bib0093","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/BF00447184","article-title":"Basidiomycetes as agents of human infections: a review","volume":"65","author":"Greer","year":"1978","journal-title":"Mycopathologia"},{"key":"10.1016\/j.phymed.2025.157738_bib0094","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bbrc.2021.03.174","article-title":"Lipid membranes induce structural conversion from amyloid oligomers to fibrils","volume":"557","author":"Gu","year":"2021","journal-title":"Biochem. biophys. res. commun."},{"issue":"9","key":"10.1016\/j.phymed.2025.157738_bib0095","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.3390\/molecules24091748","article-title":"Silymarin's Inhibition and Treatment Effects for Alzheimer's Disease","volume":"24","author":"Guo","year":"2019","journal-title":"Mol. : j. synth. chem. nat. prod. chem."},{"issue":"8","key":"10.1016\/j.phymed.2025.157738_bib0096","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24086978","article-title":"The Pathogenesis of Diabetes","volume":"24","author":"Guo","year":"2023","journal-title":"Int. j. mol. sci."},{"issue":"19","key":"10.1016\/j.phymed.2025.157738_bib0097","doi-asserted-by":"crossref","first-page":"6714","DOI":"10.1080\/10408398.2023.2173719","article-title":"Pectin mediates the mechanism of host blood glucose regulation through intestinal flora","volume":"64","author":"Guo","year":"2024","journal-title":"Crit. rev. food sci. nutr."},{"issue":"5","key":"10.1016\/j.phymed.2025.157738_bib0098","doi-asserted-by":"crossref","first-page":"528","DOI":"10.3892\/br.2016.639","article-title":"Cell-penetrating peptides: possible transduction mechanisms and therapeutic applications","volume":"4","author":"Guo","year":"2016","journal-title":"Biomed. rep."},{"issue":"009","key":"10.1016\/j.phymed.2025.157738_bib0099","first-page":"1903","article-title":"Logistic regression analysis of risk factors for Alzheimer's disease","volume":"32","author":"Guoli","year":"2012","journal-title":"Gerontol. China"},{"issue":"8","key":"10.1016\/j.phymed.2025.157738_bib0100","first-page":"7","article-title":"Functional significance of the lysosomal pathway in the process of cellular autophagy","volume":"23","author":"Haijie","year":"2011","journal-title":"Life sci."},{"issue":"3","key":"10.1016\/j.phymed.2025.157738_bib0101","doi-asserted-by":"crossref","first-page":"648","DOI":"10.3390\/molecules24030648","article-title":"Hesperidin as a Neuroprotective Agent: a Review of Animal and Clinical Evidence","volume":"24","author":"Hajialyani","year":"2019","journal-title":"Mol. : j. synth. chem. nat. prod. chem."},{"issue":"7","key":"10.1016\/j.phymed.2025.157738_bib0102","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1093\/brain\/awy132","article-title":"The cholinergic system in the pathophysiology and treatment of Alzheimer's disease","volume":"141","author":"Hampel","year":"2018","journal-title":"Brain : j. neurol."},{"key":"10.1016\/j.phymed.2025.157738_bib0103","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102010","article-title":"Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy","volume":"44","author":"Han","year":"2021","journal-title":"Redox biol."},{"issue":"9","key":"10.1016\/j.phymed.2025.157738_bib0104","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1007\/s00011-023-01790-4","article-title":"Role of NLRP3 inflammasome-mediated neuronal pyroptosis and neuroinflammation in neurodegenerative diseases","volume":"72","author":"Han","year":"2023","journal-title":"Inflamm. res. : off. j. Eur. Histamine Res. Soc. [et al,]"},{"issue":"11","key":"10.1016\/j.phymed.2025.157738_bib0105","first-page":"2020","article-title":"Progress on mechanism of action and neuroprotective effects of notoginsenoside R1","volume":"40","author":"Hanlong","year":"2024","journal-title":"Chin. J. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157738_bib0106","article-title":"Molecular mechanisms by which SIRT1 regulates acetylation modifications of its downstream non-histone molecules affecting apoptosis","author":"Hanzhi","year":"2021","journal-title":"Chin. J. Biochem. Mol. Biol."},{"key":"10.1016\/j.phymed.2025.157738_bib0107","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.molimm.2017.02.013","article-title":"Autophagy and inflammasomes","volume":"86","author":"Harris","year":"2017","journal-title":"Mol. immunol."},{"key":"10.1016\/j.phymed.2025.157738_bib0108","doi-asserted-by":"crossref","first-page":"4165","DOI":"10.2147\/JIR.S422114","article-title":"Non-Coding RNA in Microglia Activation and Neuroinflammation in Alzheimer's Disease","volume":"16","author":"He","year":"2023","journal-title":"J. inflamm. res."},{"key":"10.1016\/j.phymed.2025.157738_bib0109","article-title":"Graveoline attenuates d-GalN\/LPS-induced acute liver injury via inhibition of JAK1\/STAT3 signaling pathway","volume":"177","author":"He","year":"2024","journal-title":"Biomed. pharmacother. = Biomed. pharmacother."},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e13411","article-title":"Astragaloside IV attenuates neuroinflammation and ameliorates cognitive impairment in Alzheimer's disease via inhibiting NF-\u03baB signaling pathway","volume":"9","author":"He","year":"2023","journal-title":"Heliyon"},{"issue":"4","key":"10.1016\/j.phymed.2025.157738_bib0111","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer's disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet, Neurol."},{"issue":"4","key":"10.1016\/j.phymed.2025.157738_bib0112","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1523\/JNEUROSCI.13-04-01551.1993","article-title":"Immunocytochemical localization of a neuronal nicotinic receptor: the beta 2-subunit","volume":"13","author":"Hill","year":"1993","journal-title":"J. neurosci. : off. j. Soc. Neurosci."},{"key":"10.1016\/j.phymed.2025.157738_bib0113","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fneur.2014.00043","article-title":"The gastrointestinal tract microbiome and potential link to Alzheimer's disease","volume":"5","author":"Hill","year":"2014","journal-title":"Front. neurol."},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0114","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3233\/JAD-150566","article-title":"Puerarin Ameliorates d-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain","volume":"51","author":"Hong","year":"2016","journal-title":"J. Alzheimer's dis. : JAD"},{"issue":"3","key":"10.1016\/j.phymed.2025.157738_bib0115","article-title":"Reactive Oxygen Species Signaling and Oxidative Stress: transcriptional Regulation and Evolution","volume":"13","author":"Hong","year":"2024","journal-title":"Antioxid. (Basel Switz.)"},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0116","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3892\/ijmm.2013.1552","article-title":"Long-term administration of ginsenoside Rh1 enhances learning and memory by promoting cell survival in the mouse hippocampus","volume":"33","author":"Hou","year":"2014","journal-title":"Int. j. mol. med."},{"issue":"4","key":"10.1016\/j.phymed.2025.157738_bib0117","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1080\/15548627.2022.2125629","article-title":"The Acid Gate in the Lysosome","volume":"19","author":"Hu","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2025.157738_bib0118","article-title":"Targeted Dephosphorylation of Tau by Phosphorylation Targeting Chimeras (PhosTACs) as a Therapeutic Modality","author":"Hu","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.phymed.2025.157738_bib0119","article-title":"Study on the origin, chemical structure and immune-enhancing activity of natural polysaccharides","volume":"12","author":"Hu","year":"2024","journal-title":"Hans J. Med. Chem."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0120","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/15548627.2022.2064624","article-title":"Acetylation of SCFD1 regulates SNARE complex formation and autophagosome-lysosome fusion","volume":"19","author":"Huang","year":"2023","journal-title":"Autophagy"},{"issue":"5","key":"10.1016\/j.phymed.2025.157738_bib0121","doi-asserted-by":"crossref","DOI":"10.3390\/foods11050769","article-title":"Research Progress and Trends of Phenylethanoid Glycoside Delivery Systems","volume":"11","author":"Huang","year":"2022","journal-title":"Foods"},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0122","first-page":"81","article-title":"The emerging role of ferroptosis in the pathological development and progression of sepsis","volume":"12","author":"Hui-Ting","year":"2025","journal-title":"Mil. Med. Res."},{"issue":"8","key":"10.1016\/j.phymed.2025.157738_bib0123","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1038\/npp.2015.37","article-title":"Anemoside A3 Enhances Cognition through the Regulation of Synaptic Function and Neuroprotection","volume":"40","author":"Ip","year":"2015","journal-title":"Neuropsychopharmacol. : off. publ. Am. Coll. Neuropsychopharmacol."},{"issue":"5","key":"10.1016\/j.phymed.2025.157738_bib0124","first-page":"412","article-title":"Liposomal Formulation to Increase Stability and Prolong Antineuropathic Activity of Verbascoside","volume":"83","author":"Isacchi","year":"2017","journal-title":"Planta med."},{"issue":"4","key":"10.1016\/j.phymed.2025.157738_bib0125","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/j.2042-7158.2011.01264.x","article-title":"Antihyperalgesic activity of verbascoside in two models of neuropathic pain","volume":"63","author":"Isacchi","year":"2011","journal-title":"J. pharm. pharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0126","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/01616412.2016.1251711","article-title":"Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders","volume":"39","author":"Islam","year":"2017","journal-title":"Neurol. res."},{"key":"10.1016\/j.phymed.2025.157738_bib0127","first-page":"4391","article-title":"Nanotechnology-based approaches in anticancer research","volume":"7","author":"Jabir","year":"2012","journal-title":"Int. j. nanomed."},{"key":"10.1016\/j.phymed.2025.157738_bib0128","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.46630","article-title":"Synergy between serum amyloid A and secretory phospholipase A(2)","volume":"8","author":"Jayaraman","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.phymed.2025.157738_bib0129","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.126474","article-title":"New insights into potential nutritional effects of dietary saponins in protecting against the development of obesity","volume":"318","author":"Jeepipalli","year":"2020","journal-title":"Food chem."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0130","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s12974-024-03195-4","article-title":"Secoisolariciresinol diglucoside attenuates neuroinflammation and cognitive impairment in female Alzheimer's disease mice via modulating gut microbiota metabolism and GPER\/CREB\/BDNF pathway","volume":"21","author":"Jia","year":"2024","journal-title":"J. neuroinflammation"},{"key":"10.1016\/j.phymed.2025.157738_bib0131","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1370619","article-title":"Neuroprotective effects of total phenolics from Hemerocallis citrina Baroni leaves through the PI3K\/AKT pathway","volume":"15","author":"Jia","year":"2024","journal-title":"Front. pharmacol."},{"key":"10.1016\/j.phymed.2025.157738_bib0132","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107578","article-title":"Ginsenosides Rg1, Rb1 and rare ginsenosides: promising candidate agents for Parkinson's disease and Alzheimer's disease and network pharmacology analysis","volume":"212","author":"Jiang","year":"2025","journal-title":"Pharmacol. res."},{"issue":"4","key":"10.1016\/j.phymed.2025.157738_bib0133","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. rev., Mol. cell biol."},{"key":"10.1016\/j.phymed.2025.157738_bib0134","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.biopha.2017.09.134","article-title":"Tetrahydroxy stilbene glycoside (TSG) antagonizes A\u03b2-induced hippocampal neuron injury by suppressing mitochondrial dysfunction via Nrf2-dependent HO-1 pathway","volume":"96","author":"Jiao","year":"2017","journal-title":"Biomed. pharmacother. = Biomed. pharmacother."},{"issue":"12","key":"10.1016\/j.phymed.2025.157738_bib0135","first-page":"1281","article-title":"Advances in the study of the interconnection between intestinal flora and brain function","volume":"17","author":"Jiaojiao","year":"2018","journal-title":"Chin. J. Neurol."},{"issue":"6","key":"10.1016\/j.phymed.2025.157738_bib0136","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.12677\/acm.2024.1461901","article-title":"Research Progress of Tryptophan and Its Metabolites in the Microbial-Gut-Brain Axis","volume":"14","author":"Jie","year":"2024","journal-title":"Adv. Clin. Med."},{"issue":"13","key":"10.1016\/j.phymed.2025.157738_bib0137","first-page":"2","article-title":"Serum beta-amyloid level and its relationship with insulin resistance in patients with type 2 diabetes mellitus","volume":"42","author":"Jiejun","year":"2002","journal-title":"Shandong Med."},{"issue":"8017","key":"10.1016\/j.phymed.2025.157738_bib0138","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/s41586-024-07469-y","article-title":"A body-brain circuit that regulates body inflammatory responses","volume":"630","author":"Jin","year":"2024","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0139","first-page":"6","article-title":"Advances in the study of the relationship between cardiovascular disease risk factors and Alzheimer's disease","author":"Jin","year":"2014","journal-title":"Chin. J. Cerebrovasc. Dis.: Electron. Ed."},{"issue":"6","key":"10.1016\/j.phymed.2025.157738_bib0140","first-page":"1772","article-title":"Progress in the study of chemical composition and pharmacological effects of dihuang (Dihuang)","volume":"52","author":"Jinpeng","year":"2021","journal-title":"Chin. herb. med."},{"issue":"6","key":"10.1016\/j.phymed.2025.157738_bib0141","article-title":"Research progress on chemical constituents and pharmacological actions of Rehmannia glutinosa","author":"Jinpeng","year":"2021","journal-title":"Chin. herb. med."},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0142","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ijpharm.2013.03.046","article-title":"Proof of concept studies to confirm the delivery of curcumin loaded solid lipid nanoparticles (C-SLNs) to brain","volume":"448","author":"Kakkar","year":"2013","journal-title":"Int. j. pharm."},{"issue":"4","key":"10.1016\/j.phymed.2025.157738_bib0143","doi-asserted-by":"crossref","first-page":"584","DOI":"10.2174\/1389557511313040010","article-title":"Drug-glycosidation and drug development","volume":"13","author":"Kapoor","year":"2013","journal-title":"Mini rev. med. chem."},{"issue":"19","key":"10.1016\/j.phymed.2025.157738_bib0144","doi-asserted-by":"crossref","first-page":"6474","DOI":"10.3390\/molecules27196474","article-title":"Polydatin: pharmacological Mechanisms, Therapeutic Targets, Biological Activities, and Health Benefits","volume":"27","author":"Karami","year":"2022","journal-title":"Mol. : j. synth. chem. nat. prod. chem."},{"issue":"7","key":"10.1016\/j.phymed.2025.157738_bib0145","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.3390\/molecules27072079","article-title":"Neuroprotective Effects of Green Tea Seed Isolated Saponin Due to the Amelioration of Tauopathy and Alleviation of Neuroinflammation: a Therapeutic Approach to Alzheimer's Disease","volume":"27","author":"Khan","year":"2022","journal-title":"Mol. : j. synth. chem. nat. prod. chem."},{"issue":"10","key":"10.1016\/j.phymed.2025.157738_bib0146","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.3390\/molecules25102334","article-title":"Green Tea Seed Isolated Theasaponin E1 Ameliorates AD Promoting Neurotoxic Pathogenesis by Attenuating A\u03b2 Peptide Levels in SweAPP N2a Cells","volume":"25","author":"Khan","year":"2020","journal-title":"Mol. : j. synth. chem. nat. prod. chem."},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0147","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat. cell biol."},{"issue":"3","key":"10.1016\/j.phymed.2025.157738_bib0148","doi-asserted-by":"crossref","first-page":"481","DOI":"10.24272\/j.issn.2095-8137.2021.479","article-title":"Adult hippocampal neurogenesis and its impairment in Alzheimer's disease","volume":"43","author":"Kim","year":"2022","journal-title":"Zool. res."},{"issue":"3","key":"10.1016\/j.phymed.2025.157738_bib0149","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jgr.2024.03.002","article-title":"Ginsenosides for the treatment of insulin resistance and diabetes: therapeutic perspectives and mechanistic insights","volume":"48","author":"Kim","year":"2024","journal-title":"J. ginseng res."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2020.1797280","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1)","volume":"17","author":"Klionsky","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2025.157738_bib0151","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1463-1326.2010.01267.x","article-title":"Impact of nitric oxide on metabolism in health and age-related disease","volume":"12 Suppl 2","author":"Knott","year":"2010","journal-title":"Diabetes obes. metab."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0152","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1186\/s12974-020-01967-2","article-title":"Forsythoside B attenuates memory impairment and neuroinflammation via inhibition on NF-\u03baB signaling in Alzheimer's disease","volume":"17","author":"Kong","year":"2020","journal-title":"J. neuroinflammation"},{"issue":"11","key":"10.1016\/j.phymed.2025.157738_bib0153","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1073\/pnas.83.11.4044","article-title":"Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease","volume":"83","author":"Kosik","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.phymed.2025.157738_bib0154","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/jnc.15887","article-title":"Recent advances in cholinergic mechanisms as reactions to toxicity, stress, and neuroimmune insults","volume":"168","author":"Kovarik","year":"2024","journal-title":"J. neurochem."},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0155","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s10719-025-10180-3","article-title":"Plant glycosides and glycosidases: classification, sources, and therapeutic insights in current medicine","volume":"42","author":"Kowsalya","year":"2025","journal-title":"Glycoconj. j."},{"key":"10.1016\/j.phymed.2025.157738_bib0156","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.ejmech.2016.07.054","article-title":"Protein aggregation and neurodegenerative diseases: from theory to therapy","volume":"124","author":"Kumar","year":"2016","journal-title":"Eur. j. med. chem."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0157","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1186\/s12876-025-04163-9","article-title":"Cruciferous vegetables intake and risk of colon cancer: a dose-response meta-analysis","volume":"25","author":"Lai","year":"2025","journal-title":"BMC gastroenterol."},{"key":"10.1016\/j.phymed.2025.157738_bib0158","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.brainres.2012.12.040","article-title":"Paeoniflorin attenuates amyloid-beta peptide-induced neurotoxicity by ameliorating oxidative stress and regulating the NGF-mediated signaling in rats","volume":"1498","author":"Lan","year":"2013","journal-title":"Brain res."},{"issue":"19","key":"10.1016\/j.phymed.2025.157738_bib0159","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201800890","article-title":"Bioinstructive Naringin-Loaded Micelles for Guiding Stem Cell Osteodifferentiation","volume":"7","author":"Lavrador","year":"2018","journal-title":"Adv. healthc. mater."},{"issue":"6","key":"10.1016\/j.phymed.2025.157738_bib0160","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41593-022-01084-8","article-title":"Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of A\u03b2 in neurons, yielding senile plaques","volume":"25","author":"Lee","year":"2022","journal-title":"Nat. neurosci."},{"key":"10.1016\/j.phymed.2025.157738_bib0161","doi-asserted-by":"crossref","DOI":"10.1177\/17590914211051908","article-title":"Innate Immunity and Cell Death in Alzheimer's Disease","volume":"13","author":"Lee","year":"2021","journal-title":"ASN neuro"},{"issue":"13","key":"10.1016\/j.phymed.2025.157738_bib0162","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1021\/jf506110y","article-title":"Anti-inflammatory mechanism of ginseng saponin metabolite Rh3 in lipopolysaccharide-stimulated microglia: critical role of 5\u2032-adenosine monophosphate-activated protein kinase signaling pathway","volume":"63","author":"Lee","year":"2015","journal-title":"J. agric. food chem."},{"issue":"23","key":"10.1016\/j.phymed.2025.157738_bib0163","doi-asserted-by":"crossref","first-page":"14172","DOI":"10.18632\/aging.205295","article-title":"Gypenoside IX restores Akt\/GSK-3\u03b2 pathway and alleviates Alzheimer's disease-like neuropathology and cognitive deficits","volume":"15","author":"Lei","year":"2023","journal-title":"Aging"},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0164","first-page":"94","article-title":"An overview of the role of tau protein and beta-amyloid in the pathological process of Alzheimer's disease and the mechanism of autophagy","volume":"7","author":"Lei","year":"2019","journal-title":"Chin. Electron. J. Diagn."},{"issue":"4","key":"10.1016\/j.phymed.2025.157738_bib0165","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1142\/S0192415X23500416","article-title":"Ginsenosides are Promising Medicine for Tumor and Inflammation: a Review","volume":"51","author":"Li","year":"2023","journal-title":"Am. j. Chin. med."},{"key":"10.1016\/j.phymed.2025.157738_bib0166","article-title":"Therapeutic Potential and Molecular Mechanisms of Echinacoside in Neurodegenerative Diseases","volume":"13","author":"Li","year":"2022","journal-title":"Front. pharmacol."},{"issue":"3","key":"10.1016\/j.phymed.2025.157738_bib0167","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1271\/bbb.100606","article-title":"Protective effects of decursin and decursinol angelate against amyloid \u03b2-protein-induced oxidative stress in the PC12 cell line: the role of Nrf2 and antioxidant enzymes","volume":"75","author":"Li","year":"2011","journal-title":"Biosci. biotechnol. biochem."},{"key":"10.1016\/j.phymed.2025.157738_bib0168","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.nbd.2013.01.002","article-title":"Ginsenoside Rd attenuates beta-amyloid-induced tau phosphorylation by altering the functional balance of glycogen synthase kinase 3beta and protein phosphatase 2A","volume":"54","author":"Li","year":"2013","journal-title":"Neurobiol. dis."},{"issue":"4","key":"10.1016\/j.phymed.2025.157738_bib0169","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19041135","article-title":"Neuroprotective Effects of Four Phenylethanoid Glycosides on H\u2082O\u2082-Induced Apoptosis on PC12 Cells via the Nrf2\/ARE Pathway","volume":"19","author":"Li","year":"2018","journal-title":"Int. j. mol. sci."},{"issue":"4","key":"10.1016\/j.phymed.2025.157738_bib0170","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1021\/mp800049w","article-title":"Pharmacokinetics and biodistribution of nanoparticles","volume":"5","author":"Li","year":"2008","journal-title":"Mol. pharm."},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0171","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jgr.2024.12.005","article-title":"A narrative review of Panax notoginseng: unique saponins and their pharmacological activities","volume":"49","author":"Li","year":"2025","journal-title":"J. ginseng res."},{"key":"10.1016\/j.phymed.2025.157738_bib0172","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156052","article-title":"Forsythoside A mitigates osteoarthritis and inhibits chondrocyte senescence by promoting mitophagy and suppressing NLRP3 inflammasome via the Nrf2 pathway","volume":"135","author":"Li","year":"2024","journal-title":"Phytomed. : int. j. phytother. phytopharm."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0173","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1142\/S0192415X23500064","article-title":"Ginsenoside Rd Inhibited Ferroptosis to Alleviate CCl(4)-Induced Acute Liver Injury in Mice via cGAS\/STING Pathway","volume":"51","author":"Li","year":"2023","journal-title":"Am. j. Chin. med."},{"key":"10.1016\/j.phymed.2025.157738_bib0174","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.lfs.2019.02.012","article-title":"Panaxadiol inhibits synaptic dysfunction in Alzheimer's disease and targets the Fyn protein in APP\/PS1 mice and APP-SH-SY5Y cells","volume":"221","author":"Liang","year":"2019","journal-title":"Life sci."},{"issue":"16","key":"10.1016\/j.phymed.2025.157738_bib0175","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28166118","article-title":"Pharmacological Effects of Astragaloside IV: a Review","volume":"28","author":"Liang","year":"2023","journal-title":"Mol. : j. synth. chem. nat. prod. chem."},{"issue":"10","key":"10.1016\/j.phymed.2025.157738_bib0176","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25105222","article-title":"Puerarin-A Promising Flavonoid: biosynthesis, Extraction Methods, Analytical Techniques, and Biological Effects","volume":"25","author":"Liga","year":"2024","journal-title":"Int. j. mol. sci."},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0177","doi-asserted-by":"crossref","first-page":"202","DOI":"10.23736\/S0031-0808.23.04944-3","article-title":"Resveratrol ameliorates AGEs-induced thyroid dysfunction: role of oxidative stress, inflammatory cytokines, and mitochondrial damage","volume":"66","author":"Lin","year":"2024","journal-title":"Panminerva med."},{"key":"10.1016\/j.phymed.2025.157738_bib0178","article-title":"Amelioration of experimental autoimmune encephalomyelitis by Rhodiola rosea, a natural adaptogen","volume":"125","author":"Lin","year":"2020","journal-title":"Biomed. pharmacother. = Biomed. pharmacother."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0179","doi-asserted-by":"crossref","first-page":"e4201","DOI":"10.1371\/journal.pone.0004201","article-title":"Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila","volume":"4","author":"Ling","year":"2009","journal-title":"PloS one"},{"issue":"3","key":"10.1016\/j.phymed.2025.157738_bib0181","first-page":"380","article-title":"The mechanism of the protective effect of short-chain fatty acids on stroke and its relationship with post-stroke cognitive impairment","volume":"25","author":"Liu","year":"2022","journal-title":"Chin. Fam. Med."},{"issue":"4","key":"10.1016\/j.phymed.2025.157738_bib0182","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1007\/s12031-015-0632-4","article-title":"Ginsenoside Rd Improves Learning and Memory Ability in APP Transgenic Mice","volume":"57","author":"Liu","year":"2015","journal-title":"J. mol. neurosci. : MN"},{"key":"10.1016\/j.phymed.2025.157738_bib0183","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2025.1555067","article-title":"Ginsenoside Rb1 attenuates neuroflammation via activating Wnt\/\u03b2-catenin signaling pathway to exert neuroprotective effect on cerebral ischemic-reperfusion injury","volume":"17","author":"Liu","year":"2025","journal-title":"Front. aging neurosci."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0187","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/s12967-023-04137-z","article-title":"Anti-Alzheimers molecular mechanism of icariin: insights from gut microbiota, metabolomics, and network pharmacology","volume":"21","author":"Liu","year":"2023","journal-title":"J. transl. med."},{"issue":"9","key":"10.1016\/j.phymed.2025.157738_bib0188","first-page":"5","article-title":"Advances in extraction and purification methods of glycosides from natural plants","volume":"30","author":"Liu","year":"2013","journal-title":"J. Jilin Inst. Chem. Technol."},{"issue":"8013","key":"10.1016\/j.phymed.2025.157738_bib0190","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/s41586-024-07345-9","article-title":"Complete biosynthesis of QS-21 in engineered yeast","volume":"629","author":"Liu","year":"2024","journal-title":"Nature"},{"issue":"01","key":"10.1016\/j.phymed.2025.157738_bib0191","first-page":"146","article-title":"Anti-oxidative stress effects of the Keap1-Nrf2\/ARE signaling pathway and its regulatory mechanisms","volume":"43","author":"Liufang","year":"2016","journal-title":"Int. J. Pharm. Res."},{"issue":"4","key":"10.1016\/j.phymed.2025.157738_bib0192","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/alz.12429","article-title":"Associations among vascular risk factors, neuroimaging biomarkers, and cognition: preliminary analyses from the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"18","author":"Lockhart","year":"2022","journal-title":"Alzheimer's dement. : j. Alzheimer's Assoc."},{"key":"10.1016\/j.phymed.2025.157738_bib0193","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104795","article-title":"Nose to brain drug delivery - A promising strategy for active components from herbal medicine for treating cerebral ischemia reperfusion","volume":"159","author":"Long","year":"2020","journal-title":"Pharmacol. res."},{"issue":"12","key":"10.1016\/j.phymed.2025.157738_bib0194","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.addr.2012.01.012","article-title":"Targeting polymer therapeutics to bone","volume":"64","author":"Low","year":"2012","journal-title":"Adv. drug deliv. rev."},{"issue":"5","key":"10.1016\/j.phymed.2025.157738_bib0195","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/ptr.5797","article-title":"Exploring the Effect of Ginsenoside Rh1 in a Sleep Deprivation-Induced Mouse Memory Impairment Model","volume":"31","author":"Lu","year":"2017","journal-title":"Phytother. res. : PTR"},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0196","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1001\/archneur.60.2.203","article-title":"Antioxidant vitamin intake and risk of Alzheimer disease","volume":"60","author":"Luchsinger","year":"2003","journal-title":"Arch. neurol."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0197","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.intimp.2014.06.018","article-title":"Notoginsenoside R1 attenuates amyloid-\u03b2-induced damage in neurons by inhibiting reactive oxygen species and modulating MAPK activation","volume":"22","author":"Ma","year":"2014","journal-title":"Int. immunopharmacol."},{"key":"10.1016\/j.phymed.2025.157738_bib0198","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.671206","article-title":"Cornel Iridoid Glycoside Protects Against STAT1-Dependent Synapse and Memory Deficits by Increasing N-Methyl-d-aspartate Receptor Expression in a Tau Transgenic Mice","volume":"13","author":"Ma","year":"2021","journal-title":"Front. aging neurosci."},{"issue":"6","key":"10.1016\/j.phymed.2025.157738_bib0199","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s11596-020-2284-z","article-title":"Cornel Iridoid Glycoside Suppresses Hyperactivity Phenotype in rTg4510 Mice through Reducing Tau Pathology and Improving Synaptic Dysfunction","volume":"40","author":"Ma","year":"2020","journal-title":"Curr. med. sci."},{"issue":"10","key":"10.1016\/j.phymed.2025.157738_bib0200","doi-asserted-by":"crossref","first-page":"8795","DOI":"10.3390\/ijms24108795","article-title":"Isoquercitrin Attenuates Steatohepatitis by Inhibition of the Activated NLRP3 Inflammasome through HSP90","volume":"24","author":"Ma","year":"2023","journal-title":"Int. j. mol. sci."},{"issue":"11","key":"10.1016\/j.phymed.2025.157738_bib0201","doi-asserted-by":"crossref","first-page":"8028","DOI":"10.1002\/alz.14298","article-title":"Microglial responses partially mediate the effect of A\u03b2 on cognition in Alzheimer's disease","volume":"20","author":"Madsen","year":"2024","journal-title":"Alzheimer's dement. : j. Alzheimer's Assoc."},{"key":"10.1016\/j.phymed.2025.157738_bib0202","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115257","article-title":"Flavonoids bridging the gut and the brain: intestinal metabolic fate, and direct or indirect effects of natural supporters against neuroinflammation and neurodegeneration","volume":"205","author":"Magni","year":"2022","journal-title":"Biochem. pharmacol."},{"key":"10.1016\/j.phymed.2025.157738_bib0203","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115011","article-title":"Potential role of mitochondria-associated endoplasmic reticulum membrane proteins in diseases","volume":"199","author":"Mao","year":"2022","journal-title":"Biochem. pharmacol."},{"key":"10.1016\/j.phymed.2025.157738_bib0204","first-page":"236","article-title":"Quercetin-3-O-\u03b2-d-glucuronide attenuates osteoarthritis by inhibiting cartilage extracellular matrix degradation and inflammation","volume":"45","author":"Mao","year":"2024","journal-title":"J. orthop. transl."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0205","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s41380-022-01631-6","article-title":"Mitophagy in Alzheimer's disease: molecular defects and therapeutic approaches","volume":"28","author":"Mary","year":"2023","journal-title":"Mol. psychiatry"},{"issue":"16","key":"10.1016\/j.phymed.2025.157738_bib0206","doi-asserted-by":"crossref","first-page":"4539","DOI":"10.1021\/jf026206w","article-title":"Anthocyanin glycosides from berry fruit are absorbed and excreted unmetabolized by both humans and rats","volume":"51","author":"McGhie","year":"2003","journal-title":"J. agric. food chem."},{"key":"10.1016\/j.phymed.2025.157738_bib0207","doi-asserted-by":"crossref","DOI":"10.3389\/fnsyn.2023.1129036","article-title":"Alzheimer's disease as a synaptopathy: evidence for dysfunction of synapses during disease progression","volume":"15","author":"Meftah","year":"2023","journal-title":"Front. synaptic neurosci."},{"key":"10.1016\/j.phymed.2025.157738_bib0208","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/2464163","article-title":"Multiple Roles of Paeoniflorin in Alzheimer's Disease","volume":"2022","author":"Meng","year":"2022","journal-title":"Evid.-based complement. altern. med. : eCAM"},{"issue":"8","key":"10.1016\/j.phymed.2025.157738_bib0210","doi-asserted-by":"crossref","first-page":"5814","DOI":"10.62347\/LTGZ9375","article-title":"Osteogenic action of the natural plant material icariin and its potential use in biomedical tissue engineering","volume":"17","author":"Mi","year":"2025","journal-title":"Am. j. transl. res."},{"issue":"23","key":"10.1016\/j.phymed.2025.157738_bib0211","doi-asserted-by":"crossref","first-page":"5755","DOI":"10.3390\/molecules25235755","article-title":"Nucleotide Sugars in Chemistry and Biology","volume":"25","author":"Mikkola","year":"2020","journal-title":"Mol. : j. synth. chem. nat. prod. chem."},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0212","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1017\/S0007114521000222","article-title":"Dietary strawberry improves cognition in a randomised, double-blind, placebo-controlled trial in older adults","volume":"126","author":"Miller","year":"2021","journal-title":"Br. j. nutr."},{"issue":"9","key":"10.1016\/j.phymed.2025.157738_bib0213","doi-asserted-by":"crossref","DOI":"10.1002\/alz.70672","article-title":"Retinal biomarkers in cognitive impairment and dementia: structural, functional, and molecular insights","volume":"21","author":"Min","year":"2025","journal-title":"Alzheimer's dement. : j. Alzheimer's Assoc."},{"issue":"9","key":"10.1016\/j.phymed.2025.157738_bib0214","first-page":"10","article-title":"Molecular mechanism of autophagy regulation of oxidative stress in animals","volume":"32","author":"Ming","year":"2020","journal-title":"J. Anim. Nutr."},{"key":"10.1016\/j.phymed.2025.157738_bib0215","article-title":"Probing the mechanism of action of Ginkgo biloba extract for atherosclerosis based on network pharmacology and molecular docking","author":"Ming","year":"2022","journal-title":"Henan Med. Res."},{"issue":"11","key":"10.1016\/j.phymed.2025.157738_bib0216","article-title":"Quercetin as a Therapeutic Product: evaluation of Its Pharmacological Action and Clinical Applications-A Review","volume":"16","author":"Mirza","year":"2023","journal-title":"Pharm. (Basel Switz.)"},{"issue":"4","key":"10.1016\/j.phymed.2025.157738_bib0217","doi-asserted-by":"crossref","first-page":"342","DOI":"10.4103\/joco.joco_85_24","article-title":"Overcoming Resistance: a Comprehensive Review and Treatment Approach for Acyclovir-Resistant Herpes Simplex Keratitis","volume":"36","author":"Mirzaei","year":"2024","journal-title":"J. curr. ophthalmol."},{"key":"10.1016\/j.phymed.2025.157738_bib0218","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2020.108614","article-title":"Sequence and structure-based peptides as potent amyloid inhibitors: a review","volume":"695","author":"Mitra","year":"2020","journal-title":"Arch. biochem. biophys."},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0219","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jgr.2017.01.008","article-title":"Molecular signaling of ginsenosides Rb1, Rg1, and Rg3 and their mode of actions","volume":"42","author":"Mohanan","year":"2018","journal-title":"J. ginseng res."},{"issue":"24","key":"10.1016\/j.phymed.2025.157738_bib0220","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1001\/jama.287.24.3230","article-title":"Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study","volume":"287","author":"Morris","year":"2002","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.phymed.2025.157738_bib0221","first-page":"647","article-title":"In Vitro Enzymatic and Kinetic Studies, and In Silico Drug-Receptor Interactions, and Drug-Like Profiling of the 5-Styrylbenzamide Derivatives as Potential Cholinesterase and \u03b2-Secretase Inhibitors with Antioxidant Properties","volume":"10","author":"Mphahlele","year":"2021","journal-title":"Antioxid. (Basel Switz.)"},{"issue":"7","key":"10.1016\/j.phymed.2025.157738_bib0222","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006338","article-title":"Neurotoxicity of amyloid \u03b2-protein: synaptic and network dysfunction","volume":"2","author":"Mucke","year":"2012","journal-title":"Cold Spring Harb. perspect. med."},{"issue":"11","key":"10.1016\/j.phymed.2025.157738_bib0223","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1586\/14737175.8.11.1703","article-title":"Cholinergic system during the progression of Alzheimer's disease: therapeutic implications","volume":"8","author":"Mufson","year":"2008","journal-title":"Expert rev. neurother."},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0224","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1124\/mi.4.2.8","article-title":"Serotonin transporter: gene, genetic disorders, and pharmacogenetics","volume":"4","author":"Murphy","year":"2004","journal-title":"Mol. interv."},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0225","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0306-4522(01)00460-2","article-title":"Intracellular accumulation of beta-amyloid(1-42) in neurons is facilitated by the alpha 7 nicotinic acetylcholine receptor in Alzheimer's disease","volume":"110","author":"Nagele","year":"2002","journal-title":"Neuroscience"},{"issue":"Pt B","key":"10.1016\/j.phymed.2025.157738_bib0226","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.cbi.2016.04.009","article-title":"AChE and the amyloid precursor protein (APP) - Cross-talk in Alzheimer's disease","volume":"259","author":"Nalivaeva","year":"2016","journal-title":"Chem.-biol. interact."},{"issue":"10","key":"10.1016\/j.phymed.2025.157738_bib0227","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/s41556-024-01513-9","article-title":"The role of PINK1-Parkin in mitochondrial quality control","volume":"26","author":"Narendra","year":"2024","journal-title":"Nat. cell biol."},{"issue":"17","key":"10.1016\/j.phymed.2025.157738_bib0228","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1055\/a-1019-9819","article-title":"Natural Compounds with Anti-BACE1 Activity as Promising Therapeutic Drugs for Treating Alzheimer's Disease","volume":"85","author":"Naushad","year":"2019","journal-title":"Planta med."},{"issue":"8","key":"10.1016\/j.phymed.2025.157738_bib0229","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s12032-025-02894-z","article-title":"Bioactive compounds in Raphanus sativus: mechanisms of apoptosis, anti-angiogenesis, cell cycle arrest and beyond in cancer prevention and treatment","volume":"42","author":"Naveed","year":"2025","journal-title":"Med. oncol. (Northwood Lond. Engl.)"},{"issue":"3","key":"10.1016\/j.phymed.2025.157738_bib0230","first-page":"e169","article-title":"Identifying health conditions associated with Alzheimer's disease up to 15 years before diagnosis: an agnostic study of French and British health records. The Lancet","volume":"4","author":"Nedelec","year":"2022","journal-title":"Digit. health"},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0231","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1038\/s41467-021-23755-z","article-title":"KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease","volume":"12","author":"Neitzel","year":"2021","journal-title":"Nat. commun."},{"issue":"7","key":"10.1016\/j.phymed.2025.157738_bib0232","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s11011-020-00591-6","article-title":"Recent advances in tau-directed immunotherapy against Alzheimer's disease: an overview of pre-clinical and clinical development","volume":"35","author":"Ng","year":"2020","journal-title":"Metab. brain dis."},{"key":"10.1016\/j.phymed.2025.157738_bib0233","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/6473506","article-title":"Ginsenoside Rg1 Ameliorates Behavioral Abnormalities and Modulates the Hippocampal Proteomic Change in Triple Transgenic Mice of Alzheimer's Disease","volume":"2017","author":"Nie","year":"2017","journal-title":"Oxidative med. cell. longev."},{"issue":"11","key":"10.1016\/j.phymed.2025.157738_bib0234","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0188173","article-title":"Effects of a mixed berry beverage on cognitive functions and cardiometabolic risk markers; A randomized cross-over study in healthy older adults","volume":"12","author":"Nilsson","year":"2017","journal-title":"PloS one"},{"issue":"3","key":"10.1016\/j.phymed.2025.157738_bib0235","first-page":"7","article-title":"Advances in biomarkers for repetitive transcranial magnetic stimulation intervention in central nervous system disorders","volume":"41","author":"Ning","year":"2021","journal-title":"J. Hunan Univ. Tradit. Chin. Med."},{"key":"10.1016\/j.phymed.2025.157738_bib0236","article-title":"The Nrf2-HO-1 system and inflammaging","volume":"15","author":"O'Rourke","year":"2024","journal-title":"Front. immunol."},{"issue":"12","key":"10.1016\/j.phymed.2025.157738_bib0237","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1007\/s11064-014-1454-4","article-title":"Apoptosis in Alzheimer's disease: an understanding of the physiology, pathology and therapeutic avenues","volume":"39","author":"Obulesu","year":"2014","journal-title":"Neurochem. res."},{"issue":"23","key":"10.1016\/j.phymed.2025.157738_bib0238","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232314784","article-title":"Enzymatically Modified Isoquercitrin: production, Metabolism, Bioavailability, Toxicity, Pharmacology, and Related Molecular Mechanisms","volume":"23","author":"Owczarek-Januszkiewicz","year":"2022","journal-title":"Int. j. mol. sci."},{"issue":"12","key":"10.1016\/j.phymed.2025.157738_bib0239","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201911170","article-title":"Cerebrospinal fluid and plasma biomarker trajectories with increasing amyloid deposition in Alzheimer's disease","volume":"11","author":"Palmqvist","year":"2019","journal-title":"EMBO mol. med."},{"issue":"6","key":"10.1016\/j.phymed.2025.157738_bib0240","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1056\/NEJMoa2023184","article-title":"Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results","volume":"384","author":"Pan","year":"2021","journal-title":"N. Engl. j. med."},{"issue":"10","key":"10.1016\/j.phymed.2025.157738_bib0241","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.2174\/1871530323666230315145332","article-title":"Current Perspectives on Nanoparticle-based Targeted Drug Delivery Approaches in Breast Cancer Treatment","volume":"23","author":"Pandey","year":"2023","journal-title":"Endocr. metab. immune disord. drug targets"},{"key":"10.1016\/j.phymed.2025.157738_bib0242","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1016\/j.biopha.2018.11.075","article-title":"Resveratrol: from enhanced biosynthesis and bioavailability to multitargeting chronic diseases","volume":"109","author":"Pannu","year":"2019","journal-title":"Biomed. pharmacother. = Biomed. pharmacother."},{"issue":"6","key":"10.1016\/j.phymed.2025.157738_bib0243","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1007\/s40520-019-01341-0","article-title":"Familial Alzheimer's disease presenilin-2 mutants affect Ca(2+) homeostasis and brain network excitability","volume":"33","author":"Pendin","year":"2021","journal-title":"Aging clin. exp. res."},{"key":"10.1016\/j.phymed.2025.157738_bib0244","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.coph.2021.11.009","article-title":"Paeoniflorin is a promising natural monomer for neurodegenerative diseases via modulation of Ca2+ and ROS homeostasis","volume":"62","author":"Peng","year":"2022","journal-title":"Curr. opin. pharmacol."},{"key":"10.1016\/j.phymed.2025.157738_bib0245","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.intimp.2017.09.022","article-title":"Hepatoprotective effect of quercetin against LPS\/d-GalN induced acute liver injury in mice by inhibiting the IKK\/NF-\u03baB and MAPK signal pathways","volume":"52","author":"Peng","year":"2017","journal-title":"Int. immunopharmacol."},{"key":"10.1016\/j.phymed.2025.157738_bib0246","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.brainres.2017.06.023","article-title":"The fate of the brain cholinergic neurons in neurodegenerative diseases","volume":"1670","author":"Pepeu","year":"2017","journal-title":"Brain res."},{"issue":"3","key":"10.1016\/j.phymed.2025.157738_bib0247","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s003600050131","article-title":"The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach","volume":"168","author":"Perez-Campo","year":"1998","journal-title":"J. comp. physiol., B Biochem. syst. environ. physiol."},{"key":"10.1016\/j.phymed.2025.157738_bib0248","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3389\/fnagi.2016.00083","article-title":"A Rat Model of Alzheimer's Disease Based on Abeta42 and Pro-oxidative Substances Exhibits Cognitive Deficit and Alterations in Glutamatergic and Cholinergic Neurotransmitter Systems","volume":"8","author":"Petrasek","year":"2016","journal-title":"Front. aging neurosci."},{"issue":"21","key":"10.1016\/j.phymed.2025.157738_bib0249","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1016\/j.cell.2022.09.023","article-title":"The JAK-STAT pathway at 30: much learned, much more to do","volume":"185","author":"Philips","year":"2022","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.phymed.2025.157738_bib0250","article-title":"Mitochondrial Dysfunction, Oxidative Stress, and Neuroinflammation: intertwined Roads to Neurodegeneration","volume":"9","author":"Picca","year":"2020","journal-title":"Antioxid. (Basel Switz.)"},{"issue":"4","key":"10.1016\/j.phymed.2025.157738_bib0251","doi-asserted-by":"crossref","first-page":"R170","DOI":"10.1016\/j.cub.2018.01.004","article-title":"Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance","volume":"28","author":"Pickles","year":"2018","journal-title":"Curr. biol. : CB"},{"issue":"9","key":"10.1016\/j.phymed.2025.157738_bib0252","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26094209","article-title":"Peripheral Inflammation and Insulin Resistance: their Impact on Blood-Brain Barrier Integrity and Glia Activation in Alzheimer's Disease","volume":"26","author":"Ponce-Lopez","year":"2025","journal-title":"Int. j. mol. sci."},{"key":"10.1016\/j.phymed.2025.157738_bib0253","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.959285","article-title":"Hypertension as a risk factor for atherosclerosis: cardiovascular risk assessment","volume":"9","author":"Poznyak","year":"2022","journal-title":"Front. cardiovasc. med."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0254","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4143\/crt.2014.46.1.2","article-title":"Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice","volume":"46","author":"Prasad","year":"2014","journal-title":"Cancer res. treat."},{"key":"10.1016\/j.phymed.2025.157738_bib0255","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/413808","article-title":"Amyloidosis in Alzheimer's Disease: the Toxicity of Amyloid Beta (A \u03b2), Mechanisms of Its Accumulation and Implications of Medicinal Plants for Therapy","volume":"2013","author":"Prasansuklab","year":"2013","journal-title":"Evid.-based complement. altern. med. : eCAM"},{"issue":"53","key":"10.1016\/j.phymed.2025.157738_bib0256","doi-asserted-by":"crossref","first-page":"14537","DOI":"10.1523\/JNEUROSCI.2692-08.2008","article-title":"Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus","volume":"28","author":"Puzzo","year":"2008","journal-title":"J. neurosci. : off. j. Soc. Neurosci."},{"issue":"5","key":"10.1016\/j.phymed.2025.157738_bib0257","first-page":"438","article-title":"Advancements in the Pharmacological Activity and Mechanisms of Action of Verbascoside","volume":"13","author":"Qi","year":"2024","journal-title":"Pharm. Inf."},{"issue":"03","key":"10.1016\/j.phymed.2025.157738_bib0258","first-page":"104","article-title":"Progress in the study of chemical constituents of gibberellic acid and its pharmacological effects","volume":"27","author":"Qian","year":"2025","journal-title":"J. Liaoning Univ. Tradit. Chin. Med."},{"issue":"11","key":"10.1016\/j.phymed.2025.157738_bib0259","first-page":"136","article-title":"Biocatalysis of phenolic glycoside natural products in Escherichia coli using glycosyltransferase UGT73B6","volume":"33","author":"Qinglin","year":"2017","journal-title":"Biotechnol. Bull."},{"key":"10.1016\/j.phymed.2025.157738_bib0260","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.freeradbiomed.2021.12.263","article-title":"Polygala saponins inhibit NLRP3 inflammasome-mediated neuroinflammation via SHP-2-Mediated mitophagy","volume":"179","author":"Qiu","year":"2022","journal-title":"Free radic. biol. med."},{"key":"10.1016\/j.phymed.2025.157738_bib0262","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jneuroim.2019.01.014","article-title":"Effect of cornel iridoid glycoside on microglia activation through suppression of the JAK\/STAT signalling pathway","volume":"330","author":"Qu","year":"2019","journal-title":"J. neuroimmunol."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0263","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s12974-023-02866-y","article-title":"Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration","volume":"20","author":"Quick","year":"2023","journal-title":"J. neuroinflammation"},{"issue":"12","key":"10.1016\/j.phymed.2025.157738_bib0264","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s11910-017-0802-6","article-title":"Microbiota-Brain-Gut Axis and Neurodegenerative Diseases","volume":"17","author":"Quigley","year":"2017","journal-title":"Curr. neurol. neurosci. rep."},{"key":"10.1016\/j.phymed.2025.157738_bib0265","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.colsurfb.2015.11.050","article-title":"Improved oral delivery of resveratrol from N-trimethyl chitosan-g-palmitic acid surface-modified solid lipid nanoparticles","volume":"139","author":"Ramalingam","year":"2016","journal-title":"Colloids surf., B Biointerfaces"},{"issue":"4","key":"10.1016\/j.phymed.2025.157738_bib0266","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1142\/S0192415X25500405","article-title":"Astragaloside IV: a Promising Drug to Prevent the Transition from Colitis to Colorectal Cancer","volume":"53","author":"Ran","year":"2025","journal-title":"Am. j. Chin. med."},{"issue":"4","key":"10.1016\/j.phymed.2025.157738_bib0267","first-page":"2975","article-title":"Panax ginseng components and the pathogenesis of Alzheimer's disease (Review)","volume":"19","author":"Razgonova","year":"2019","journal-title":"Mol. med. rep."},{"issue":"5","key":"10.1016\/j.phymed.2025.157738_bib0268","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3390\/cells8050488","article-title":"Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer's Disease","volume":"8","author":"Reddy","year":"2019","journal-title":"Cells"},{"issue":"8","key":"10.1016\/j.phymed.2025.157738_bib0269","article-title":"Interactions between reactive oxygen species and autophagy: special issue: death mechanisms in cellular homeostasis. Biochimica et biophysica acta","volume":"1868","author":"Redza-Dutordoir","year":"2021","journal-title":"Mol. cell res."},{"issue":"9","key":"10.1016\/j.phymed.2025.157738_bib0270","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.0393-24.2024","article-title":"Amyloid-\u03b2-Driven Synaptic Deficits Are Mediated by Synaptic Removal of GluA3-Containing AMPA Receptors","volume":"45","author":"Reinders","year":"2025","journal-title":"J. neurosci. : off. j. Soc. Neurosci."},{"issue":"37","key":"10.1016\/j.phymed.2025.157738_bib0271","doi-asserted-by":"crossref","first-page":"13783","DOI":"10.1021\/acs.jafc.3c02550","article-title":"Ginsenoside Rh4 Alleviates Amyloid \u03b2 Plaque and Tau Hyperphosphorylation by Regulating Neuroinflammation and the Glycogen Synthase Kinase 3\u03b2 Signaling Pathway","volume":"71","author":"Ren","year":"2023","journal-title":"J. agric. food chem."},{"issue":"8","key":"10.1016\/j.phymed.2025.157738_bib0272","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.4103\/1673-5374.332127","article-title":"Amyloid-beta peptide and tau protein crosstalk in Alzheimer's disease","volume":"17","author":"Roda","year":"2022","journal-title":"Neural regen. res."},{"issue":"14","key":"10.1016\/j.phymed.2025.157738_bib0273","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1039\/D0OB00470G","article-title":"S-Glycosides: synthesis of S-linked arabinoxylan oligosaccharides","volume":"18","author":"Roman\u00f2","year":"2020","journal-title":"Org. biomol. chem."},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0274","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3390\/cells10020204","article-title":"Calcium Signaling and Mitochondrial Function in Presenilin 2 Knock-Out Mice: looking for Any Loss-of-Function Phenotype Related to Alzheimer's Disease","volume":"10","author":"Rossi","year":"2021","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.phymed.2025.157738_bib0275","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/cen3.12475","article-title":"Neuroinflammation in mouse models of Alzheimer's disease","volume":"9","author":"Saito","year":"2018","journal-title":"Clin. exp. neuroimmunol."},{"issue":"3","key":"10.1016\/j.phymed.2025.157738_bib0276","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.pneurobio.2009.01.001","article-title":"Inflammation in Alzheimer's disease: amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors","volume":"87","author":"Salminen","year":"2009","journal-title":"Prog. neurobiol."},{"key":"10.1016\/j.phymed.2025.157738_bib0277","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156007","article-title":"Recent advances in nano and micro formulations of Ginsenoside to enhance their therapeutic efficacy","volume":"134","author":"Sana","year":"2024","journal-title":"Phytomed. : int. j. phytother. phytopharm."},{"issue":"7","key":"10.1016\/j.phymed.2025.157738_bib0278","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.2217\/nnm.12.78","article-title":"From nano- to macro-scale: nanotechnology approaches for spatially controlled delivery of bioactive factors for bone and cartilage engineering","volume":"7","author":"Santo","year":"2012","journal-title":"Nanomed. (Lond. Engl.)"},{"issue":"4","key":"10.1016\/j.phymed.2025.157738_bib0279","doi-asserted-by":"crossref","DOI":"10.3390\/cells10040721","article-title":"GSK-3 and Tau: a Key Duet in Alzheimer's Disease","volume":"10","author":"Sayas","year":"2021","journal-title":"Cells"},{"issue":"10284","key":"10.1016\/j.phymed.2025.157738_bib0280","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer's disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.phymed.2025.157738_bib0281","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1007\/s00702-006-0579-2","article-title":"The significance of the cholinergic system in the brain during aging and in Alzheimer's disease","volume":"113","author":"Schliebs","year":"2006","journal-title":"J. neural transm. (Vienna Austria : 1996)"},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0282","doi-asserted-by":"crossref","DOI":"10.1016\/j.phyplu.2022.100220","article-title":"Focus on the high therapeutic potentials of quercetin and its derivatives","volume":"2","author":"Septembre-Malaterre","year":"2022","journal-title":"Phytomed. plus : int. j. phytother. phytopharm."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0283","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S1474-4422(20)30412-9","article-title":"APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches","volume":"20","author":"Serrano-Pozo","year":"2021","journal-title":"Lancet, Neurol."},{"issue":"4","key":"10.1016\/j.phymed.2025.157738_bib0284","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1002\/ptr.7754","article-title":"Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: therapeutic and biotechnological prospects","volume":"37","author":"Shahcheraghi","year":"2023","journal-title":"Phytother. res. : PTR"},{"key":"10.1016\/j.phymed.2025.157738_bib0285","doi-asserted-by":"crossref","first-page":"6477","DOI":"10.2147\/IJN.S139602","article-title":"Ginsenoside Rg1 nanoparticle penetrating the blood-brain barrier to improve the cerebral function of diabetic rats complicated with cerebral infarction","volume":"12","author":"Shen","year":"2017","journal-title":"Int. j. nanomed."},{"issue":"11","key":"10.1016\/j.phymed.2025.157738_bib0286","first-page":"3781","article-title":"[Microbe-gut-brain axis and neurological disorders: a review]","volume":"37","author":"Shen","year":"2021","journal-title":"Sheng wu gong cheng xue bao = Chin. j. biotechnol."},{"key":"10.1016\/j.phymed.2025.157738_bib0287","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/7464872","article-title":"Icariin Attenuates Synaptic and Cognitive Deficits in an A\u03b2(1-42)-Induced Rat Model of Alzheimer's Disease","volume":"2017","author":"Sheng","year":"2017","journal-title":"BioMed res. int."},{"key":"10.1016\/j.phymed.2025.157738_bib0288","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.952332","article-title":"Pharmacological effects of natural medicine ginsenosides against Alzheimer's disease","volume":"13","author":"Shi","year":"2022","journal-title":"Front. pharmacol."},{"key":"10.1016\/j.phymed.2025.157738_bib0289","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fnmol.2015.00077","article-title":"NF-kappaB Signaling Pathways in Neurological Inflammation: a Mini Review","volume":"8","author":"Shih","year":"2015","journal-title":"Front. mol. neurosci."},{"issue":"3","key":"10.1016\/j.phymed.2025.157738_bib0290","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrm3757","article-title":"Making new contacts: the mTOR network in metabolism and signalling crosstalk","volume":"15","author":"Shimobayashi","year":"2014","journal-title":"Nat. rev., Mol. cell biol."},{"issue":"11","key":"10.1016\/j.phymed.2025.157738_bib0291","doi-asserted-by":"crossref","first-page":"5222","DOI":"10.1002\/ptr.70097","article-title":"Pharmacological Diversity of Flavonoids and Their Clinical Application Prospects in Neurological Disorders","volume":"39","author":"Shuai","year":"2025","journal-title":"Phytother. res. : PTR"},{"issue":"8","key":"10.1016\/j.phymed.2025.157738_bib0292","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1016\/j.drudis.2021.04.011","article-title":"Nanotechnological approaches for targeting amyloid-\u03b2 aggregation with potential for neurodegenerative disease therapy and diagnosis","volume":"26","author":"Shukla","year":"2021","journal-title":"Drug discov. today"},{"key":"10.1016\/j.phymed.2025.157738_bib0293","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1258516","article-title":"Unlocking the power of nanomedicine: the future of nutraceuticals in oncology treatment","volume":"10","author":"Singla","year":"2023","journal-title":"Front. nutr."},{"issue":"17","key":"10.1016\/j.phymed.2025.157738_bib0294","doi-asserted-by":"crossref","first-page":"9207","DOI":"10.3390\/ijms22179207","article-title":"Tau Protein Interaction Partners and Their Roles in Alzheimer's Disease and Other Tauopathies","volume":"22","author":"Sinsky","year":"2021","journal-title":"Int. j. mol. sci."},{"key":"10.1016\/j.phymed.2025.157738_bib0295","article-title":"Salidroside attenuates acute lung injury via inhibition of inflammatory cytokine production","volume":"142","author":"Song","year":"2021","journal-title":"Biomed. pharmacother. = Biomed. pharmacother."},{"key":"10.1016\/j.phymed.2025.157738_bib0296","article-title":"Novel advances in inhibiting advanced glycation end product formation using natural compounds","volume":"140","author":"Song","year":"2021","journal-title":"Biomed. pharmacother. = Biomed. pharmacother."},{"key":"10.1016\/j.phymed.2025.157738_bib0297","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ejmech.2017.09.001","article-title":"Anti-inflammatory effects of flavonoids in neurodegenerative disorders","volume":"153","author":"Spagnuolo","year":"2018","journal-title":"Eur. j. med. chem."},{"issue":"21","key":"10.1016\/j.phymed.2025.157738_bib0298","doi-asserted-by":"crossref","first-page":"4564","DOI":"10.3390\/nu14214564","article-title":"Diet in the Prevention of Alzheimer's Disease: current Knowledge and Future Research Requirements","volume":"14","author":"Stefaniak","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2025.157738_bib0299","article-title":"Senescence in Aging and Alzheimer's Disease","author":"Sun","year":"2025","journal-title":"Aging dis."},{"key":"10.1016\/j.phymed.2025.157738_bib0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.135540","article-title":"Anthocyanins distribution, transcriptional regulation, epigenetic and post-translational modification in fruits","volume":"411","author":"Sun","year":"2023","journal-title":"Food chem."},{"issue":"8","key":"10.1016\/j.phymed.2025.157738_bib0301","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1136\/gut.2005.077503","article-title":"A controlled crossover study of the selective serotonin reuptake inhibitor citalopram in irritable bowel syndrome","volume":"55","author":"Tack","year":"2006","journal-title":"Gut"},{"issue":"39","key":"10.1016\/j.phymed.2025.157738_bib0302","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000022224","article-title":"Efficacy and safety of total glucosides of paeony for rheumatoid arthritis: a protocol for systematic review and meta-analysis","volume":"99","author":"Tang","year":"2020","journal-title":"Medicine"},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0303","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2174\/18756190MTA3tMjgey","article-title":"Protective Effects of Polydatin Against Dementia-Related Disorders","volume":"19","author":"Tang","year":"2021","journal-title":"Curr. neuropharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0304","doi-asserted-by":"crossref","first-page":"8540","DOI":"10.1080\/21655979.2021.1987082","article-title":"Tripterygium glycoside ameliorates neuroinflammation in a mouse model of A\u03b225-35-induced Alzheimer's disease by inhibiting the phosphorylation of I\u03baB\u03b1 and p38","volume":"12","author":"Tang","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.phymed.2025.157738_bib0305","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fnsyn.2013.00002","article-title":"Cholinergic modulation of hippocampal network function","volume":"5","author":"Teles-Grilo Ruivo","year":"2013","journal-title":"Front. synaptic neurosci."},{"issue":"5","key":"10.1016\/j.phymed.2025.157738_bib0306","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s00401-011-0871-6","article-title":"Stages of granulovacuolar degeneration: their relation to Alzheimer's disease and chronic stress response","volume":"122","author":"Thal","year":"2011","journal-title":"Acta neuropathol."},{"key":"10.1016\/j.phymed.2025.157738_bib0307","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.brainresbull.2022.10.006","article-title":"The central role of tau in Alzheimer's disease: from neurofibrillary tangle maturation to the induction of cell death","volume":"190","author":"Thal","year":"2022","journal-title":"Brain res. bull."},{"issue":"19","key":"10.1016\/j.phymed.2025.157738_bib0308","doi-asserted-by":"crossref","first-page":"22629","DOI":"10.18632\/aging.203597","article-title":"Green tea catechins EGCG and ECG enhance the fitness and lifespan of Caenorhabditis elegans by complex I inhibition","volume":"13","author":"Tian","year":"2021","journal-title":"Aging"},{"key":"10.1016\/j.phymed.2025.157738_bib0309","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-3-030-74046-7_10","article-title":"NGF and the Amyloid Precursor Protein in Alzheimer's Disease: from Molecular Players to Neuronal Circuits","volume":"1331","author":"Triaca","year":"2021","journal-title":"Adv. exp. med. biol."},{"issue":"20","key":"10.1016\/j.phymed.2025.157738_bib0310","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1016\/j.febslet.2011.09.005","article-title":"Complex formation of rutin and quercetin with copper alters the mode of inhibition of ribonuclease A","volume":"585","author":"Tripathy","year":"2011","journal-title":"FEBS lett."},{"issue":"6","key":"10.1016\/j.phymed.2025.157738_bib0311","article-title":"Emerging Trends in Green Extraction Techniques, Chemical Modifications, and Drug Delivery Systems for Resveratrol","volume":"14","author":"Trombino","year":"2025","journal-title":"Antioxid. (Basel Switz.)"},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0312","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3233\/JAD-220218","article-title":"Astrocyte Dysregulation and Calcium Ion Imbalance May Link the Development of Osteoporosis and Alzheimer's Disease","volume":"88","author":"Tsai","year":"2022","journal-title":"J. Alzheimer's dis. : JAD"},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0313","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.biocel.2004.07.009","article-title":"The role of inflammation in Alzheimer's disease","volume":"37","author":"Tuppo","year":"2005","journal-title":"int. j. biochem. cell biol."},{"issue":"7","key":"10.1016\/j.phymed.2025.157738_bib0314","doi-asserted-by":"crossref","first-page":"6518","DOI":"10.3390\/ijms24076518","article-title":"Inflammatory Processes in Alzheimer's Disease-Pathomechanism, Diagnosis and Treatment: a Review","volume":"24","author":"Twarowski","year":"2023","journal-title":"Int. j. mol. sci."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0315","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41582-022-00749-z","article-title":"Synaptic degeneration in Alzheimer disease","volume":"19","author":"Tzioras","year":"2023","journal-title":"Nat. rev., Neurol."},{"key":"10.1016\/j.phymed.2025.157738_bib0316","article-title":"Alzheimer's disease prevention by flavonols and their analogs","author":"Uhl","year":"2025","journal-title":"j. prev. Alzheimer's dis."},{"issue":"6","key":"10.1016\/j.phymed.2025.157738_bib0317","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/j.celrep.2014.08.006","article-title":"AMPK modulates tissue and organismal aging in a non-cell-autonomous manner","volume":"8","author":"Ulgherait","year":"2014","journal-title":"Cell rep."},{"issue":"7","key":"10.1016\/j.phymed.2025.157738_bib0318","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/jnr.22640","article-title":"Intraneuronal amyloid \u03b2 oligomers cause cell death via endoplasmic reticulum stress, endosomal\/lysosomal leakage, and mitochondrial dysfunction in vivo","volume":"89","author":"Umeda","year":"2011","journal-title":"J. neurosci. res."},{"key":"10.1016\/j.phymed.2025.157738_bib0319","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.fct.2014.03.018","article-title":"Isoquercitrin: pharmacology, toxicology, and metabolism","volume":"68","author":"Valentov\u00e1","year":"2014","journal-title":"Food chem. toxicol. : int. j. publ. Br. Ind. Biol. Res. Assoc."},{"issue":"5440","key":"10.1016\/j.phymed.2025.157738_bib0320","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1126\/science.286.5440.735","article-title":"Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE","volume":"286","author":"Vassar","year":"1999","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.phymed.2025.157738_bib0321","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s00204-023-03476-6","article-title":"ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis","volume":"97","author":"Wang","year":"2023","journal-title":"Arch. toxicol."},{"issue":"5","key":"10.1016\/j.phymed.2025.157738_bib0322","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.7150\/ijbs.69714","article-title":"Forsythoside A Mitigates Alzheimer's-like Pathology by Inhibiting Ferroptosis-mediated Neuroinflammation via Nrf2\/GPX4 Axis Activation","volume":"18","author":"Wang","year":"2022","journal-title":"Int. j. biol. sci."},{"key":"10.1016\/j.phymed.2025.157738_bib0323","article-title":"A Review of Pharmacology, Toxicity and Pharmacokinetics of 2,3,5,4\u2032-Tetrahydroxystilbene-2-O-\u03b2-d-Glucoside","volume":"12","author":"Wang","year":"2021","journal-title":"Front. pharmacol."},{"issue":"6","key":"10.1016\/j.phymed.2025.157738_bib0324","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1007\/s10571-023-01343-7","article-title":"Ferroptosis and Neurodegenerative Diseases: insights into the Regulatory Roles of SLC7A11","volume":"43","author":"Wang","year":"2023","journal-title":"Cell. mol. neurobiol."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0325","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s12017-022-08717-y","article-title":"Phenylethanoid Glycosides of Cistanche Improve Learning and Memory Disorders in APP\/PS1 Mice by Regulating Glial Cell Activation and Inhibiting TLR4\/NF-\u03baB Signaling Pathway","volume":"25","author":"Wang","year":"2023","journal-title":"Neuromolecular med."},{"issue":"11","key":"10.1016\/j.phymed.2025.157738_bib0326","article-title":"Pharmacological Activity, Pharmacokinetics, and Clinical Research Progress of Puerarin","volume":"11","author":"Wang","year":"2022","journal-title":"Antioxid. (Basel Switz.)"},{"key":"10.1016\/j.phymed.2025.157738_bib0327","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.695479","article-title":"Relationship Between Amyloid-\u03b2 Deposition and Blood-Brain Barrier Dysfunction in Alzheimer's Disease","volume":"15","author":"Wang","year":"2021","journal-title":"Front. cell. neurosci."},{"key":"10.1016\/j.phymed.2025.157738_bib0328","article-title":"Iron Dyshomeostasis and Ferroptosis: a New Alzheimer's Disease Hypothesis","volume":"14","author":"Wang","year":"2022","journal-title":"Front. aging neurosci."},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0329","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.yexcr.2017.05.030","article-title":"Puerarin inhibits amyloid \u03b2-induced NLRP3 inflammasome activation in retinal pigment epithelial cells via suppressing ROS-dependent oxidative and endoplasmic reticulum stresses","volume":"357","author":"Wang","year":"2017","journal-title":"Exp. cell res."},{"key":"10.1016\/j.phymed.2025.157738_bib0330","article-title":"Arbutin Ameliorates Murine Colitis by Inhibiting JAK2 Signaling Pathway","volume":"12","author":"Wang","year":"2021","journal-title":"Front. pharmacol."},{"issue":"9","key":"10.1016\/j.phymed.2025.157738_bib0331","doi-asserted-by":"crossref","first-page":"8328","DOI":"10.3390\/ijms24098328","article-title":"Puerarin Prevents Cadmium-Induced Neuronal Injury by Alleviating Autophagic Dysfunction in Rat Cerebral Cortical Neurons","volume":"24","author":"Wang","year":"2023","journal-title":"Int. j. mol. sci."},{"key":"10.1016\/j.phymed.2025.157738_bib0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106951","article-title":"Echinacoside: a promising active natural products and pharmacological agents","volume":"197","author":"Wang","year":"2023","journal-title":"Pharmacol. res."},{"issue":"21","key":"10.1016\/j.phymed.2025.157738_bib0336","doi-asserted-by":"crossref","first-page":"4118","DOI":"10.1093\/hmg\/ddx299","article-title":"Inhibition of mitochondrial fragmentation protects against Alzheimer's disease in rodent model","volume":"26","author":"Wang","year":"2017","journal-title":"Hum. mol. genet."},{"key":"10.1016\/j.phymed.2025.157738_bib0338","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109186","article-title":"Astragaloside IV regulates the ferroptosis signaling pathway via the Nrf2\/SLC7A11\/GPX4 axis to inhibit PM2.5-mediated lung injury in mice","volume":"112","author":"Wang","year":"2022","journal-title":"Int. immunopharmacol."},{"key":"10.1016\/j.phymed.2025.157738_bib0339","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156882","article-title":"Ginsenoside Rg1 alleviates cognitive impairment in vascular dementia by modulating Adcy1\/Kdr-mediated cholinergic synapse and PI3K-AKT pathway","volume":"143","author":"Wang","year":"2025","journal-title":"Phytomed. : int. j. phytother. phytopharm."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0340","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.neurobiolaging.2014.07.035","article-title":"Cross talk between PI3K-AKT-GSK-3\u03b2 and PP2A pathways determines tau hyperphosphorylation","volume":"36","author":"Wang","year":"2015","journal-title":"Neurobiol. aging"},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0341","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41593-024-01829-7","article-title":"In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds","volume":"28","author":"Watamura","year":"2025","journal-title":"Nat. neurosci."},{"key":"10.1016\/j.phymed.2025.157738_bib0342","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116265","article-title":"Phytochemistry and pharmacology of Armeniacae semen Amarum: a review","volume":"308","author":"Wei","year":"2023","journal-title":"J. ethnopharmacol."},{"key":"10.1016\/j.phymed.2025.157738_bib0343","doi-asserted-by":"crossref","first-page":"F1000","DOI":"10.12688\/f1000research.14506.1","article-title":"Current understanding of Alzheimer's disease diagnosis and treatment","volume":"7","author":"Weller","year":"2018","journal-title":"F1000Research"},{"key":"10.1016\/j.phymed.2025.157738_bib0344","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102667","article-title":"Oxidative stress and mitochondrial impairment: key drivers in neurodegenerative disorders","volume":"104","author":"Wen","year":"2025","journal-title":"Ageing res. rev."},{"issue":"10","key":"10.1016\/j.phymed.2025.157738_bib0345","article-title":"Pro-apoptotic complexes of BAX and BAK on the outer mitochondrial membrane. Biochimica et biophysica acta","volume":"1869","author":"Wolf","year":"2022","journal-title":"Mol. cell res."},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0346","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3390\/ijms20020381","article-title":"Review of Current Strategies for Delivering Alzheimer's Disease Drugs across the Blood-Brain Barrier","volume":"20","author":"Wong","year":"2019","journal-title":"Int. j. mol. sci."},{"issue":"11","key":"10.1016\/j.phymed.2025.157738_bib0347","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1073\/pnas.83.11.4040","article-title":"Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)","volume":"83","author":"Wood","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.phymed.2025.157738_bib0348","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s13238-020-00814-7","article-title":"The role of the gut microbiome and its metabolites in metabolic diseases","volume":"12","author":"Wu","year":"2021","journal-title":"Protein cell"},{"key":"10.1016\/j.phymed.2025.157738_bib0349","article-title":"New insights into the role and mechanisms of ginsenoside Rg1 in the management of Alzheimer's disease","volume":"152","author":"Wu","year":"2022","journal-title":"Biomed. pharmacother. = Biomed. pharmacother."},{"key":"10.1016\/j.phymed.2025.157738_bib0350","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3697067","article-title":"Lycopene Improves Bone Quality and Regulates AGE\/RAGE\/NF-\u043aB Signaling Pathway in High-Fat Diet-Induced Obese Mice","volume":"2022","author":"Xia","year":"2022","journal-title":"Oxidative med. cell. longev."},{"key":"10.1016\/j.phymed.2025.157738_bib0351","article-title":"Protective effect and mechanisms of puerarin in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis of animal studies","volume":"222","author":"Xiang-Yun","year":"2025","journal-title":"Pharmacol. res."},{"key":"10.1016\/j.phymed.2025.157738_bib0352","article-title":"The pharmacokinetic property and pharmacological activity of acteoside: a review","volume":"153","author":"Xiao","year":"2022","journal-title":"Biomed. pharmacother. = Biomed. pharmacother."},{"issue":"10","key":"10.1016\/j.phymed.2025.157738_bib0353","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/j.chembiol.2024.09.003","article-title":"A tau dephosphorylation-targeting chimeraselectively recruits protein phosphatase-1 to ameliorate Alzheimer's disease and tauopathies","volume":"31","author":"Xiao","year":"2024","journal-title":"Cell chem. biol."},{"key":"10.1016\/j.phymed.2025.157738_bib0354","article-title":"Cistanche deserticola extract and its active components, echinacoside, ameliorate sarcopenia by activating the IGF-1\/PI3K-AKT pathway to modulate ferroptosis","volume":"148","author":"Xiaomin","year":"2025","journal-title":"Phytomed. : int. j. phytother. phytopharm."},{"key":"10.1016\/j.phymed.2025.157738_bib0355","article-title":"Overview of cGAS-STING signaling pathway activation mechanisms and cellular function studies","volume":"14","author":"Xiaoyan","year":"2024","journal-title":"Hans J. Biomed."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0356","article-title":"The Efficacy and Pharmacological Mechanism of Zn(7)MT3 to Protect against Alzheimer's Disease","volume":"7","author":"Xu","year":"2017","journal-title":"Sci. rep."},{"issue":"8","key":"10.1016\/j.phymed.2025.157738_bib0357","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.cmet.2023.06.004","article-title":"Tryptophan metabolism in health and disease","volume":"35","author":"Xue","year":"2023","journal-title":"Cell metab."},{"issue":"06","key":"10.1016\/j.phymed.2025.157738_bib0358","first-page":"69","article-title":"Progress in the study of chemical composition and biological activity of cyclic enol ether terpene glycosides from Cornus officinalis (Cornus officinalis)","volume":"42","author":"Yadi","year":"2024","journal-title":"Chin. J. Tradit. Chin. Med."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0359","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/2008-2231-22-24","article-title":"Silymarin effect on amyloid-\u03b2 plaque accumulation and gene expression of APP in an Alzheimer's disease rat model","volume":"22","author":"Yaghmaei","year":"2014","journal-title":"Daru : j. Fac. Pharm. Tehran Univ. Med. Sci."},{"issue":"6","key":"10.1016\/j.phymed.2025.157738_bib0360","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41576-022-00562-w","article-title":"Autophagy genes in biology and disease","volume":"24","author":"Yamamoto","year":"2023","journal-title":"Nat. rev., Genet."},{"issue":"5","key":"10.1016\/j.phymed.2025.157738_bib0361","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1159\/000484192","article-title":"Protective Effect of Phillyrin on Lethal LPS-Induced Neutrophil Inflammation in Zebrafish","volume":"43","author":"Yang","year":"2017","journal-title":"CELL. PHYSIOL. AND BIOCHEM."},{"issue":"8","key":"10.1016\/j.phymed.2025.157738_bib0364","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.2174\/1570159X19666210915122820","article-title":"7,8-Dihydroxyflavone and Neuropsychiatric Disorders: a Translational Perspective from the Mechanism to Drug Development","volume":"20","author":"Yang","year":"2022","journal-title":"Curr. neuropharmacol."},{"issue":"5","key":"10.1016\/j.phymed.2025.157738_bib0365","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/s41401-022-01022-1","article-title":"Ginsenoside Rg1 in neurological diseases: from bench to bedside","volume":"44","author":"Yang","year":"2023","journal-title":"Acta pharmacol. Sin."},{"issue":"9","key":"10.1016\/j.phymed.2025.157738_bib0366","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1038\/s41401-020-00558-4","article-title":"Ginsenoside Rg1 exerts neuroprotective effects in 3-nitropronpionic acid-induced mouse model of Huntington's disease via suppressing MAPKs and NF-\u03baB pathways in the striatum","volume":"42","author":"Yang","year":"2021","journal-title":"Acta pharmacol. Sin."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0367","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12906-024-04403-7","article-title":"Panax notoginseng saponins prevent dementia and oxidative stress in brains of SAMP8 mice by enhancing mitophagy","volume":"24","author":"Yang","year":"2024","journal-title":"BMC complement. med. ther."},{"issue":"5","key":"10.1016\/j.phymed.2025.157738_bib0369","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1536\/ihj.21-585","article-title":"Forsythiaside Protected H9c2 Cardiomyocytes from H(2)O(2)-Induced Oxidative Stress and Apoptosis via Activating Nrf2\/HO-1 Signaling Pathway","volume":"63","author":"Yang","year":"2022","journal-title":"Int. heart j."},{"issue":"01","key":"10.1016\/j.phymed.2025.157738_bib0370","first-page":"55","article-title":"Progress in the study of nucleoside antiviral drugs","volume":"31","author":"Yanying","year":"2021","journal-title":"Chin. J. Med. Chem."},{"issue":"8","key":"10.1016\/j.phymed.2025.157738_bib0371","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1007\/s00213-022-06133-5","article-title":"Astragalin attenuates depression-like behaviors and memory deficits and promotes M2 microglia polarization by regulating IL-4R\/JAK1\/STAT6 signaling pathway in a murine model of perimenopausal depression","volume":"239","author":"Yao","year":"2022","journal-title":"Psychopharmacology"},{"issue":"6","key":"10.1016\/j.phymed.2025.157738_bib0372","doi-asserted-by":"crossref","first-page":"9081","DOI":"10.3892\/mmr.2017.7702","article-title":"Puerarin inhibits \u03b2\u2011amyloid peptide 1\u201142\u2011induced tau hyperphosphorylation via the Wnt\/\u03b2\u2011catenin signaling pathway","volume":"16","author":"Yao","year":"2017","journal-title":"Mol. med. rep."},{"issue":"04","key":"10.1016\/j.phymed.2025.157738_bib0373","first-page":"439","article-title":"Selective autophagy junction protein p62 and Keap1-Nrf2 signaling pathway in neurodegenerative diseases","volume":"47","author":"Yaran","year":"2020","journal-title":"Int. J. Neurol. Neurosurg."},{"issue":"19","key":"10.1016\/j.phymed.2025.157738_bib0374","first-page":"3800","article-title":"Promotional effects of brain-derived neurotrophic factor on peripheral nerve repair and regeneration","volume":"11","author":"Yazhen","year":"2007","journal-title":"China Tissue Eng. Res. Clin. Rehabil."},{"key":"10.1016\/j.phymed.2025.157738_bib0375","article-title":"Mechanistic insights into the antidepressant potential of plant-derived flavonoids: a preclinical review","author":"Yingjun","year":"2025","journal-title":"Prog. neuro-psychopharmacol. biol. psychiatry"},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0376","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1046\/j.1471-4159.2003.01652.x","article-title":"Interaction between flavonoids and the blood-brain barrier: in vitro studies","volume":"85","author":"Youdim","year":"2003","journal-title":"J. neurochem."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0377","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-73075-7","article-title":"Quercetin as a therapeutic agent activate the Nrf2\/Keap1 pathway to alleviate lung ischemia-reperfusion injury","volume":"14","author":"Yousefi Zardak","year":"2024","journal-title":"Sci. rep."},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0380","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/15548627.2017.1378838","article-title":"Autophagy pathway: cellular and molecular mechanisms","volume":"14","author":"Yu","year":"2018","journal-title":"Autophagy"},{"issue":"4","key":"10.1016\/j.phymed.2025.157738_bib0381","first-page":"12","article-title":"Advances in research related to the role of abnormal cholinergic neuron function in Alzheimer's disease in the basal forebrain","volume":"7","author":"Yu","year":"2017","journal-title":"J. Neuropharmacol."},{"key":"10.1016\/j.phymed.2025.157738_bib0382","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1072007","article-title":"Therapeutic potential of paeoniflorin in atherosclerosis: a cellular action and mechanism-based perspective","volume":"13","author":"Yu","year":"2022","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.phymed.2025.157738_bib0383","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1002\/ptr.8121","article-title":"Hesperetin promotes diabetic wound healing by inhibiting ferroptosis through the activation of SIRT3","volume":"38","author":"Yu","year":"2024","journal-title":"Phytother. Res. : PTR"},{"key":"10.1016\/j.phymed.2025.157738_bib0384","article-title":"Unlocking ginsenosides' therapeutic power with polymer-based delivery systems: current applications and future perspectives","volume":"16","author":"Yu","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"17","key":"10.1016\/j.phymed.2025.157738_bib0385","first-page":"216","article-title":"Research Progress on the Hydrolysis of Glycosides in Plants and Their Pharmacological Effects","author":"Yuan","year":"2021","journal-title":"Mod. Agric. Technol."},{"issue":"05","key":"10.1016\/j.phymed.2025.157738_bib0386","first-page":"721","article-title":"Advances in the conversion of glycosidic natural products by commercial glycosidases","volume":"36","author":"Yue","year":"2020","journal-title":"J. Nanjing Univ. Chin. Med."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0387","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s11658-022-00355-3","article-title":"Quercetin as a JAK-STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases","volume":"27","author":"Zalpoor","year":"2022","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.phymed.2025.157738_bib0388","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.lfs.2019.03.055","article-title":"Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease","volume":"224","author":"Zaplatic","year":"2019","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.phymed.2025.157738_bib0389","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1177\/0091270009344334","article-title":"Pharmacokinetics and safety of ginsenoside Rd following a single or multiple intravenous dose in healthy Chinese volunteers","volume":"50","author":"Zeng","year":"2010","journal-title":"J. Clin. Pharmacol."},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0390","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0005-2736(95)00058-B","article-title":"Comparison of phosphatidylcholines containing one or two docosahexaenoic acyl chains on properties of phospholipid monolayers and bilayers","volume":"1236","author":"Zerouga","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phymed.2025.157738_bib0391","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2025.1604539","article-title":"The role of gut microbiota dysbiosis in drug-induced brain injury: mechanisms and therapeutic implications","volume":"13","author":"Zhai","year":"2025","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.phymed.2025.157738_bib0394","article-title":"Effects of hemosiderin capsules on repair and regeneration of autologous neural stem cells in rat infarcted brain tissue","author":"Zhang","year":"2014","journal-title":"J. Chin. Med."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0395","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41392-024-01911-3","article-title":"Recent advances in Alzheimer's disease: mechanisms, clinical trials and new drug development strategies","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2025.157738_bib0396","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3641960","article-title":"Biological Effects of Tetrahydroxystilbene Glucoside: an Active Component of a Rhizome Extracted from Polygonum multiflorum","volume":"2018","author":"Zhang","year":"2018","journal-title":"Oxidative med. Cell. Longev."},{"key":"10.1016\/j.phymed.2025.157738_bib0398","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jep.2016.05.025","article-title":"Traditional Chinese medicine formulas for the treatment of osteoporosis: implication for antiosteoporotic drug discovery","volume":"189","author":"Zhang","year":"2016","journal-title":"J. Ethnopharmacol."},{"issue":"12","key":"10.1016\/j.phymed.2025.157738_bib0399","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.4103\/1673-5374.373680","article-title":"The role of natural flavonoids on neuroinflammation as a therapeutic target for Alzheimer's disease: a narrative review","volume":"18","author":"Zhang","year":"2023","journal-title":"Neural Regen. Res."},{"issue":"13","key":"10.1016\/j.phymed.2025.157738_bib0400","article-title":"Therapeutic Candidates for Alzheimer's Disease: saponins","volume":"24","author":"Zhang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.phymed.2025.157738_bib0401","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1017\/S000711451700109X","article-title":"Citrus consumption and incident dementia in elderly Japanese: the Ohsaki Cohort 2006 Study","volume":"117","author":"Zhang","year":"2017","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.phymed.2025.157738_bib0402","article-title":"Mechanisms of ferroptosis regulating oxidative stress and energy metabolism in myocardial ischemia-reperfusion injury and a novel perspective of natural plant active ingredients for its treatment","volume":"165","author":"Zhang","year":"2023","journal-title":"Biomed. Pharmacother. = biomed. Pharmacother."},{"issue":"12","key":"10.1016\/j.phymed.2025.157738_bib0403","doi-asserted-by":"crossref","first-page":"16088","DOI":"10.18632\/aging.203136","article-title":"High glucose exacerbates neuroinflammation and apoptosis at the intermediate stage after post-traumatic brain injury","volume":"13","author":"Zhang","year":"2021","journal-title":"Aging"},{"issue":"11","key":"10.1016\/j.phymed.2025.157738_bib0404","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.4103\/1673-5374.335829","article-title":"The relationship between amyloid-beta and brain capillary endothelial cells in Alzheimer's disease","volume":"17","author":"Zhang","year":"2022","journal-title":"Neural regen. Res."},{"key":"10.1016\/j.phymed.2025.157738_bib0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2022.108030","article-title":"Advances in plant-derived C-glycosides: phytochemistry, bioactivities, and biotechnological production","volume":"60","author":"Zhang","year":"2022","journal-title":"Biotechnol. Adv."},{"issue":"9","key":"10.1016\/j.phymed.2025.157738_bib0406","doi-asserted-by":"crossref","first-page":"11822","DOI":"10.1007\/s12035-025-05017-x","article-title":"A Ginsenoside Composition Ameliorated A\u03b2 and Tau Aggregation via Autophagy Lysosome Pathway","volume":"62","author":"Zhao","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"8","key":"10.1016\/j.phymed.2025.157738_bib0407","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1007\/s12010-015-1704-1","article-title":"Coupling of Spinosad Fermentation and Separation Process via Two-Step Macroporous Resin Adsorption Method","volume":"176","author":"Zhao","year":"2015","journal-title":"Appl. Biochem. Biotechnol."},{"issue":"7","key":"10.1016\/j.phymed.2025.157738_bib0408","first-page":"3","article-title":"Advances in the study of Alzheimer's disease due to traumatic craniocerebral injury","volume":"13","author":"Zhao","year":"2018","journal-title":"Nerve Inj. Funct. Reconstr."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0409","doi-asserted-by":"crossref","first-page":"2","DOI":"10.31083\/j.jin2201002","article-title":"A Review of the Pathogenesis and Chinese Medicine Intervention of Alzheimer's Disease","volume":"22","author":"Zhao","year":"2022","journal-title":"J. Integr. Neurosci."},{"key":"10.1016\/j.phymed.2025.157738_bib0410","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1405546","article-title":"SIRT1 exerts protective effects by inhibiting endoplasmic reticulum stress and NF-\u03baB signaling pathways","volume":"12","author":"Zhao","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"issue":"12","key":"10.1016\/j.phymed.2025.157738_bib0411","doi-asserted-by":"crossref","first-page":"6450","DOI":"10.1039\/D2FO00899H","article-title":"Therapeutic effects of ginseng and ginsenosides on colorectal cancer","volume":"13","author":"Zhao","year":"2022","journal-title":"Food Funct."},{"issue":"11","key":"10.1016\/j.phymed.2025.157738_bib0412","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/s41580-021-00392-4","article-title":"Machinery, regulation and pathophysiological implications of autophagosome maturation","volume":"22","author":"Zhao","year":"2021","journal-title":"Nat. Rev., Mol. Cell biol."},{"issue":"09","key":"10.1016\/j.phymed.2025.157738_bib0413","first-page":"450","article-title":"Advances in the study of the role of Tau proteins in Alzheimer's disease","volume":"14","author":"Zhaoyun","year":"2019","journal-title":"Nerve Inj. Funct. Reconstr."},{"issue":"38","key":"10.1016\/j.phymed.2025.157738_bib0414","doi-asserted-by":"crossref","first-page":"11967","DOI":"10.1021\/acs.jafc.2c03851","article-title":"Cornel Iridoid Glycoside Alleviates Microglia-Mediated Inflammatory Response via the NLRP3\/Calpain Pathway","volume":"70","author":"Zheng","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2025.157738_bib0415","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154890","article-title":"Molecular mechanisms and therapeutic potential of icariin in the treatment of Alzheimer's disease","volume":"116","author":"Zheng","year":"2023","journal-title":"Phytomed. : Int. J. Phytother. Phytopharm."},{"issue":"2","key":"10.1016\/j.phymed.2025.157738_bib0416","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/procel\/pwae026","article-title":"Alzheimer's disease: insights into pathology, molecular mechanisms, and therapy","volume":"16","author":"Zheng","year":"2025","journal-title":"Protein Cell"},{"key":"10.1016\/j.phymed.2025.157738_bib0417","article-title":"Mechanistic insights into the antitumor effects of astragaloside IV and astragalus polysaccharide in digestive system cancers","volume":"16","author":"Zhenhua","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2025.157738_bib0418","unstructured":"Zhiwei, L. Research on the Synthesis Methods of Glycoside Derivatives, 2011."},{"issue":"06","key":"10.1016\/j.phymed.2025.157738_bib0419","first-page":"1630","article-title":"Advances in mitochondrial oxidative stress and targeted delivery systems in Alzheimer's disease","volume":"57","author":"Zhou","year":"2022","journal-title":"J. Pharm."},{"key":"10.1016\/j.phymed.2025.157738_bib0420","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2023.105691","article-title":"Neuroprotective neolignan glycosides from the pseudobulbs of Bletilla striata","volume":"171","author":"Zhou","year":"2023","journal-title":"Fitoterapia"},{"issue":"10","key":"10.1016\/j.phymed.2025.157738_bib0421","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.2174\/1389201021999201110204735","article-title":"Panax notoginseng Saponins Attenuate Neuroinflammation through TXNIP-Mediated NLRP3 Inflammasome Activation in Aging Rats","volume":"22","author":"Zhou","year":"2021","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.phymed.2025.157738_bib0422","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.140262","article-title":"The bioavailability, absorption, metabolism, and regulation of glucolipid metabolism disorders by quercetin and its important glycosides: a review","volume":"458","author":"Zhu","year":"2024","journal-title":"Food Chem."},{"issue":"1","key":"10.1016\/j.phymed.2025.157738_bib0423","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s12017-024-08815-z","article-title":"The Interplay Between Accumulation of Amyloid-Beta and Tau Proteins, PANoptosis, and Inflammation in Alzheimer's Disease","volume":"27","author":"Zhuang","year":"2024","journal-title":"Neuromolecular Med."},{"issue":"5","key":"10.1016\/j.phymed.2025.157738_bib0424","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.immuni.2023.04.011","article-title":"Cytokines as emerging regulators of central nervous system synapses","volume":"56","author":"Zipp","year":"2023","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.phymed.2025.157738_bib0425","first-page":"2284","article-title":"Advances in natural products ameliorate Alzheimer's disease by modulating neuroinflammation","volume":"54","author":"Zongwu","year":"2023","journal-title":"Chin. Herb. Med."},{"issue":"04","key":"10.1016\/j.phymed.2025.157738_bib0426","first-page":"1","article-title":"Research Progress on the Content, Stability, and Extraction Techniques of Glucosinolates in Cruciferous Vegetables","volume":"38","author":"Zunyi","year":"2025","journal-title":"Chin. Melons Veg."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325013728?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711325013728?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:51:48Z","timestamp":1778561508000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711325013728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":406,"alternative-id":["S0944711325013728"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157738","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Natural glycosides as multi-target neuroprotective agents in Alzheimer\u2019s disease: Bridging mechanistic insights and translational potential","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2025.157738","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157738"}}