{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:31:42Z","timestamp":1776213102637,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82141207"],"award-info":[{"award-number":["82141207"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012172","name":"Double First Class University Plan","doi-asserted-by":"publisher","award":["CPU2022PZQ05"],"award-info":[{"award-number":["CPU2022PZQ05"]}],"id":[{"id":"10.13039\/501100012172","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.phymed.2026.157795","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T16:12:24Z","timestamp":1767802344000},"page":"157795","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Complementary roles and synergy of the Ephedra-Glycyrrhiza herb pair across murine models of respiratory symptoms and poly(I:C)-induced pneumonia"],"prefix":"10.1016","volume":"151","author":[{"given":"Fan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Mei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinrong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6023-4499","authenticated-orcid":false,"given":"Xiaoyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boyang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.157795_bib0001","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0140-6736(21)00630-9","article-title":"Community-acquired pneumonia","volume":"398","author":"Aliberti","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2026.157795_bib0002","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/sj.bjp.0706145","article-title":"Unresponsiveness of mu-opioid receptor knockout mice to lipopolysaccharide-induced fever","volume":"144","author":"Benamar","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phymed.2026.157795_bib0003","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.cell.2020.06.034","article-title":"The global phosphorylation landscape of SARS-CoV-2 infection","volume":"182","author":"Bouhaddou","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2026.157795_bib0004","first-page":"1","article-title":"Dictionary of immune responses to cytokines at single-cell resolution","author":"Cui","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2026.157795_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114177","article-title":"Reverse tracing anti-thrombotic active ingredients from dried Rehmannia Radix based on multidimensional spectrum-effect relationship analysis of steaming and drying for nine cycles","volume":"276","author":"Gong","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.157795_bib0006","doi-asserted-by":"crossref","first-page":"W739","DOI":"10.1093\/nar\/gkac382","article-title":"SynergyFinder 3.0: an interactive analysis and consensus interpretation of multi-drug synergies across multiple samples","volume":"50","author":"Ianevski","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.phymed.2026.157795_bib0007","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/s42256-019-0122-4","article-title":"Prediction of drug combination effects with a minimal set of experiments","volume":"1","author":"Ianevski","year":"2019","journal-title":"Nat. Mach. Intell."},{"key":"10.1016\/j.phymed.2026.157795_bib0008","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s11655-021-2880-1","article-title":"Medication rule analysis of the diagnosis and treatment programs of Chinese medicine for the prevention and treatment of COVID-19 in China","volume":"28","author":"Ji","year":"2022","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.phymed.2026.157795_bib0009","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.157795_bib0010","doi-asserted-by":"crossref","DOI":"10.1080\/14756366.2023.2242704","article-title":"Inhibition by components of glycyrrhiza uralensis of 3CLpro and HCoV-OC43 proliferation","volume":"38","author":"Kim","year":"2023","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.phymed.2026.157795_bib0011","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.phymed.2026.157795_bib0012","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.bmc.2017.11.046","article-title":"Antitussive and expectorant activities of licorice and its major compounds","volume":"26","author":"Kuang","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.phymed.2026.157795_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116456","article-title":"Anti-inflammatory effect and pharmacokinetics of dehydroandrographolide, an active component of Andrographis paniculata, on Poly(I:c)-induced acute lung injury","volume":"174","author":"Liu","year":"2024","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2026.157795_bib0014","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cytogfr.2011.10.001","article-title":"Understanding the mechanism of IL-1\u03b2 secretion","volume":"22","author":"Lopez-Castejon","year":"2011","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.phymed.2026.157795_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112687","article-title":"Compound-based Chinese medicine formula: from discovery to compatibility mechanism","volume":"254","author":"Luan","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.157795_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114303","article-title":"Active components in Ephedra sinica stapf disrupt the interaction between ACE2 and SARS-CoV-2 RBD: potent COVID-19 therapeutic agents","volume":"278","author":"Mei","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.157795_bib0017","series-title":"Pharmacopoeia of the People\u2019s Republic of China 2020","year":"2020"},{"key":"10.1016\/j.phymed.2026.157795_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104299","article-title":"Interleukin-1 and the NLRP3 inflammasome in COVID-19: pathogenetic and therapeutic implications","volume":"85","author":"Potere","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.phymed.2026.157795_bib0019","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41392-021-00475-w","article-title":"Evaluation of the immunomodulatory effects of anti-COVID-19 TCM formulae by multiple virus-related pathways","volume":"6","author":"Qiao","year":"2021","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2026.157795_bib0020","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nmeth.4150","article-title":"Single-cell mRNA quantification and differential analysis with Census","volume":"14","author":"Qiu","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.phymed.2026.157795_bib0021","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1465-9921-10-43","article-title":"Long-term activation of TLR3 by poly(I:C) induces inflammation and impairs lung function in mice","volume":"10","author":"Stowell","year":"2009","journal-title":"Respir. Res."},{"key":"10.1016\/j.phymed.2026.157795_bib0022","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.phymed.2026.157795_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108863","article-title":"Metabolic programs define dysfunctional immune responses in severe COVID-19 patients","volume":"34","author":"Thompson","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.phymed.2026.157795_bib0024","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1080\/21505594.2022.2040188","article-title":"AP-1 signaling pathway promotes pro-IL-1\u03b2 transcription to facilitate NLRP3 inflammasome activation upon influenza a virus infection","volume":"13","author":"Wan","year":"2022","journal-title":"Virulence"},{"key":"10.1016\/j.phymed.2026.157795_bib0025","doi-asserted-by":"crossref","DOI":"10.1002\/jssc.202400090","article-title":"A ternary correlation multi-symptom network strategy based on in vivo chemical profile identification and metabolomics to explore the molecular basis of Ephedra herb against viral pneumonia","volume":"47","author":"Wang","year":"2024","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.phymed.2026.157795_bib0026","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1142\/S0192415X2150049X","article-title":"How Chinese herbal medicine prevents epidemics: from ancient pestilences to COVID-19 pandemic","volume":"49","author":"Wu","year":"2021","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.phymed.2026.157795_bib0027","doi-asserted-by":"crossref","first-page":"e2171","DOI":"10.1002\/rmv.2171","article-title":"The unique features of SARS-CoV-2 transmission: comparison with SARS-CoV, MERS-CoV and 2009 H1N1 pandemic influenza virus","volume":"31","author":"Wu","year":"2021","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.phymed.2026.157795_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.108507","article-title":"A single-cell atlas of the peripheral immune response in patients with influenza a virus infection","volume":"26","author":"Zhang","year":"2023","journal-title":"iScience"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326000322?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326000322?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T23:05:18Z","timestamp":1769036718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326000322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":28,"alternative-id":["S0944711326000322"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.157795","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complementary roles and synergy of the Ephedra-Glycyrrhiza herb pair across murine models of respiratory symptoms and poly(I:C)-induced pneumonia","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.157795","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"157795"}}