{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:12Z","timestamp":1786978092113,"version":"build-2736575974"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.phymed.2026.157839","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T07:40:27Z","timestamp":1768549227000},"page":"157839","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Isodeoxyelephantopin mitigates DSS-induced ulcerative colitis by suppressing IL-1\u03b2-driven inflammation via the TXNIP\/NLRP3 axis"],"prefix":"10.1016","volume":"153","author":[{"given":"Li-Yuan","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2411-0112","authenticated-orcid":false,"given":"Heng-Zhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2423-3119","authenticated-orcid":false,"given":"Man-Mei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He-Yun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7932-626X","authenticated-orcid":false,"given":"Chui-Wen","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.phymed.2026.157839_bib0001","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1136\/gut.2009.197822","article-title":"Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome","volume":"59","author":"Bauer","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.phymed.2026.157839_bib0002","first-page":"141","article-title":"Carthamin yellow alleviates dextran sodium sulfate-induced ulcerative colitis by repairing the intestinal barrier and activating the Nrf2\/GPX4 axis","author":"Bian","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"7","key":"10.1016\/j.phymed.2026.157839_bib0003","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1002\/jcp.24903","article-title":"Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy","volume":"230","author":"Chang","year":"2015","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.phymed.2026.157839_bib0004","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s11658-023-00462-9","article-title":"The NLRP3 inflammasome: contributions to inflammation-related diseases","volume":"28","author":"Chen","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"10","key":"10.1016\/j.phymed.2026.157839_bib0005","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1111\/apt.12712","article-title":"Review article: integrating budesonide-MMX into treatment algorithms for mild-to-moderate ulcerative colitis","volume":"39","author":"Danese","year":"2014","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"9","key":"10.1016\/j.phymed.2026.157839_bib0006","first-page":"2031","article-title":"Are there any differences in the efficacy and safety of different formulations of oral 5-ASA used for induction and maintenance of remission in ulcerative colitis? Evidence from Cochrane Reviews","volume":"19","author":"Feagan","year":"2013","journal-title":"Inflamm. Bowel Dis."},{"issue":"5","key":"10.1016\/j.phymed.2026.157839_bib0007","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1053\/j.gastro.2020.01.006","article-title":"AGA Clinical Practice guidelines on the management of moderate to severe ulcerative colitis","volume":"158","author":"Feuerstein","year":"2020","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.phymed.2026.157839_bib0008","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202401901","article-title":"Development of novel piperine-loaded mesoporous silica nanoparticles: enhanced drug delivery and comprehensive In vivo safety analysis","volume":"22","author":"Francis","year":"2025","journal-title":"Chem Biodivers"},{"key":"10.1016\/j.phymed.2026.157839_bib0009","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.molimm.2018.09.004","article-title":"Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1\u03b2 production","volume":"104","author":"Gong","year":"2018","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.phymed.2026.157839_bib0010","doi-asserted-by":"crossref","first-page":"106528","DOI":"10.1016\/j.intimp.2020.106528","article-title":"Isodeoxyelephantopin, a sesquiterpene lactone from Elephantopus caber Linn., inhibits pro-inflammatory mediators' production through both NF-\u03bab and AP-1 pathways in LPS-activated macrophages","volume":"84","author":"Han","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"19","key":"10.1016\/j.phymed.2026.157839_bib0011","doi-asserted-by":"crossref","first-page":"5910","DOI":"10.1158\/1078-0432.CCR-06-0916","article-title":"Isodeoxyelephantopin, a novel sesquiterpene lactone, potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis through suppression of nuclear factor-\u03bab (NF-\u03baB) activation and NF-\u03bab-regulated gene expression","volume":"12","author":"Ichikawa","year":"2006","journal-title":"Clin. Cancer Res."},{"issue":"12","key":"10.1016\/j.phymed.2026.157839_bib0012","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nrgastro.2015.150","article-title":"The global burden of IBD: from 2015 to 2025","volume":"12","author":"Kaplan","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"13","key":"10.1016\/j.phymed.2026.157839_bib0013","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133328","article-title":"The NLRP3 inflammasome: an overview of mechanisms of activation and regulation","volume":"20","author":"Kelley","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.phymed.2026.157839_bib0014","doi-asserted-by":"crossref","first-page":"253","DOI":"10.9734\/jpri\/2024\/v36i117617","article-title":"Evaluation of potential EGFR inhibitors for non-small cell lung cancer: a structure-based virtual screening and molecular dynamics study","volume":"36","author":"Krishnasamy","year":"2024","journal-title":"J. Pharm. Res. Int."},{"key":"10.1016\/j.phymed.2026.157839_bib0015","doi-asserted-by":"crossref","first-page":"S101","DOI":"10.1136\/gutjnl-2019-318484","article-title":"British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults","volume":"68","author":"Lamb","year":"2019","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.phymed.2026.157839_bib0016","first-page":"1131144","article-title":"Isodeoxyelephantopin ameliorates LPS-induced acute peritonitis by inhibiting NLRP3 inflammasome in vitro and in vivo","volume":"143","author":"Li","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2026.157839_bib0017","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jcmgh.2022.03.003","article-title":"Interleukin 1\u03b2 blockade reduces intestinal inflammation in a murine model of Tumor necrosis factor-independent ulcerative colitis","volume":"14","author":"Liso","year":"2022","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"issue":"6","key":"10.1016\/j.phymed.2026.157839_bib0018","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.3390\/molecules22061013","article-title":"Deoxyelephantopin and Isodeoxyelephantopin as potential anticancer agents with effects on multiple signaling pathways","volume":"22","author":"Mehmood","year":"2017","journal-title":"Molecules"},{"issue":"7","key":"10.1016\/j.phymed.2026.157839_bib0019","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27072086","article-title":"Deoxyelephantopin and its isomer Isodeoxyelephantopin: anti-cancer natural products with multiple modes of action","volume":"27","author":"Mehmood","year":"2022","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.phymed.2026.157839_bib0020","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1053\/j.gastro.2006.09.039","article-title":"Infliximab for induction and maintenance therapy for ulcerative colitis","volume":"131","author":"Moss","year":"2006","journal-title":"Gastroenterology"},{"issue":"12","key":"10.1016\/j.phymed.2026.157839_bib0021","article-title":"Anti-inflammatory and antioxidant activity of ocimum tenuiflorum- and stevia rebaudiana-mediated silver nanoparticles: an In vitro study","volume":"15","author":"Pandiyan","year":"2023","journal-title":"Cureus J. Med. Sci."},{"issue":"10","key":"10.1016\/j.phymed.2026.157839_bib0022","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.3390\/cells12101427","article-title":"Optimizing THP-1 macrophage culture for an immune-responsive Human intestinal model","volume":"12","author":"Phuangbubpha","year":"2023","journal-title":"Cells"},{"issue":"288","key":"10.1016\/j.phymed.2026.157839_bib0023","article-title":"NLRP3-inflammasome activating DAMPs stimulate an inflammatory response in glia in the absence of priming which contributes to brain inflammation after injury","volume":"3","author":"Savage","year":"2012","journal-title":"Front. Immunol."},{"issue":"10080","key":"10.1016\/j.phymed.2026.157839_bib0024","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative colitis","volume":"389","author":"Ungaro","year":"2017","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.phymed.2026.157839_bib0025","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1039\/C9FO00572B","article-title":"Green tea polyphenols prevent lipopolysaccharide-induced inflammatory liver injury in mice by inhibiting NLRP3 inflammasome activation","volume":"10","author":"Wang","year":"2019","journal-title":"Food Funct."},{"issue":"8","key":"10.1016\/j.phymed.2026.157839_bib0026","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.4049\/jimmunol.1701495","article-title":"Curcumin suppresses IL-1\u03b2 secretion and prevents inflammation through inhibition of the NLRP3 inflammasome","volume":"200","author":"Yin","year":"2018","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.phymed.2026.157839_bib0027","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ni.1831","article-title":"Thioredoxin-interacting protein links oxidative stress to inflammasome activation","volume":"11","author":"Zhou","year":"2010","journal-title":"Nat. Immunol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326000796?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326000796?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T04:05:08Z","timestamp":1774929908000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326000796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":27,"alternative-id":["S0944711326000796"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.157839","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isodeoxyelephantopin mitigates DSS-induced ulcerative colitis by suppressing IL-1\u03b2-driven inflammation via the TXNIP\/NLRP3 axis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.157839","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157839"}}