{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:11:44Z","timestamp":1788455504234,"version":"build-2803163510"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018553","name":"Science and Technology Plan Project of Wenzhou Municipality","doi-asserted-by":"publisher","award":["ZN2024008"],"award-info":[{"award-number":["ZN2024008"]}],"id":[{"id":"10.13039\/501100018553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82405062"],"award-info":[{"award-number":["82405062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LTGY23H090011"],"award-info":[{"award-number":["LTGY23H090011"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["202317008"],"award-info":[{"award-number":["202317008"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LQ24H280004"],"award-info":[{"award-number":["LQ24H280004"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.phymed.2026.157863","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T07:43:01Z","timestamp":1768894981000},"page":"157863","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Dendrobium polysaccharides ameliorate alcohol-induced liver injury by inhibiting the pathogenic ER stress-sphingolipid axis"],"prefix":"10.1016","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7252-217X","authenticated-orcid":false,"given":"Jiawei","family":"Ling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2968-6074","authenticated-orcid":false,"given":"Renhu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongchen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3212-568X","authenticated-orcid":false,"given":"Tengfei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.157863_bib0001","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1097\/HEP.0000000000000899","article-title":"Alcohol-associated liver disease-global epidemiology","volume":"80","author":"\u00c5berg","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2026.157863_bib0002","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jhep.2019.10.003","article-title":"The gut-liver axis in liver disease: pathophysiological basis for therapy","volume":"72","author":"Albillos","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2026.157863_bib0003","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jceh.2022.09.001","article-title":"Epidemiology and disease burden of alcohol associated liver disease","volume":"13","author":"Aslam","year":"2023","journal-title":"J. Clin. Exp. Hepatol."},{"key":"10.1016\/j.phymed.2026.157863_bib0004","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/21623945.2021.2021700","article-title":"S1P\/S1PR3 signalling axis protects against obesity-induced metabolic dysfunction","volume":"11","author":"Chakrabarty","year":"2022","journal-title":"Adipocyte"},{"key":"10.1016\/j.phymed.2026.157863_bib0005","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/HEP.0000000000000373","article-title":"Persistent mTORC1 activation due to loss of liver tuberous sclerosis complex 1 promotes liver injury in alcoholic hepatitis","volume":"78","author":"Chao","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2026.157863_bib0006","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev-physiol-031620-093815","article-title":"Ceramides in metabolism: key lipotoxic players","volume":"83","author":"Chaurasia","year":"2021","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.phymed.2026.157863_bib0007","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3390\/diseases12090195","article-title":"Ceramides\u2014Emerging biomarkers of lipotoxicity in obesity, diabetes, cardiovascular diseases, and inflammation","volume":"12","author":"Delcheva","year":"2024","journal-title":"Diseases"},{"key":"10.1016\/j.phymed.2026.157863_bib0008","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24043735","article-title":"Alcohol, inflammation, and microbiota in alcoholic liver disease","volume":"24","author":"Duki\u0107","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.157863_bib0009","doi-asserted-by":"crossref","DOI":"10.3390\/cells14151130","article-title":"Rethinking short-chain fatty acids: A closer look at propionate in inflammation, metabolism, and mucosal homeostasis","volume":"14","author":"Facchin","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2026.157863_bib0010","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.7150\/ijbs.103789","article-title":"Activated AXL ameliorates alcohol-associated steatotic liver ischemia-reperfusion injury by inhibiting ER stress and mitochondria-associated apoptosis","volume":"21","author":"Fang","year":"2025","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.phymed.2026.157863_bib0011","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-981-10-8684-7_3","article-title":"Pathogenesis of NASH: how metabolic complications of overnutrition favour lipotoxicity and pro-inflammatory fatty liver disease","volume":"1061","author":"Farrell","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.phymed.2026.157863_bib0012","doi-asserted-by":"crossref","first-page":"8323","DOI":"10.3748\/wjg.v27.i48.8323","article-title":"Dual therapy with zinc acetate and rifaximin prevents from ethanol-induced liver fibrosis by maintaining intestinal barrier integrity","volume":"27","author":"Fujimoto","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phymed.2026.157863_bib0013","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jhep.2018.10.008","article-title":"Hepatocellular carcinoma in the setting of alcohol-related liver disease","volume":"70","author":"Ganne-Carri\u00e9","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2026.157863_bib0014","article-title":"Inflammation and gut microbiota in the alcoholic liver disease","volume":"1","author":"Gao","year":"2024","journal-title":"Food Med. Homol."},{"key":"10.1016\/j.phymed.2026.157863_bib0015","doi-asserted-by":"crossref","DOI":"10.3390\/foods13233733","article-title":"Green radish polysaccharide prevents alcoholic liver injury by interfering with intestinal bacteria and short-chain fatty acids in mice","volume":"13","author":"Geng","year":"2024","journal-title":"Foods"},{"key":"10.1016\/j.phymed.2026.157863_bib0016","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/4806541","article-title":"The role of sphingosine-1-phosphate and ceramide-1-phosphate in inflammation and cancer","volume":"2017","author":"Hait","year":"2017","journal-title":"Mediat. Inflamm"},{"key":"10.1016\/j.phymed.2026.157863_bib0017","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jpha.2023.08.003","article-title":"Gut microbiome-based thiamine metabolism contributes to the protective effect of one acidic polysaccharide from Selaginella uncinata (Desv.) Spring against inflammatory bowel disease","volume":"14","author":"Hui","year":"2024","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.phymed.2026.157863_bib0018","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202405060","article-title":"Ceramide mediates cell-to-cell ER stress transmission by modulating membrane fluidity","volume":"224","author":"Huo","year":"2025","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.phymed.2026.157863_bib0019","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.cmet.2025.01.016","article-title":"Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism","volume":"37","author":"Jiang","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2026.157863_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpha.2023.08.019","article-title":"Lipid metabolism analysis in esophageal cancer and associated drug discovery","volume":"14","author":"Jiao","year":"2024","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.phymed.2026.157863_bib0021","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1194\/jlr.M063412","article-title":"Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1\u03b1-dependent manner","volume":"57","author":"Kakazu","year":"2016","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.phymed.2026.157863_bib0022","doi-asserted-by":"crossref","first-page":"371","DOI":"10.56557\/upjoz\/2024\/v45i184456","article-title":"In vivo molecular functional aging and gradual senescence with hTERT gene as antiaging interventions in Danio rerio","volume":"45","author":"Kalyanaraman","year":"2024","journal-title":"UTTAR PRADESH J. OF ZOOL."},{"key":"10.1016\/j.phymed.2026.157863_bib0023","first-page":"1","article-title":"Hepatic triglyceride accumulation via endoplasmic reticulum stress-induced SREBP-1 activation is regulated by ceramide synthases","volume":"51","author":"Kim","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.phymed.2026.157863_bib0024","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.1111\/ijfs.16608","article-title":"A flavour perspective of Tiepishihu (Dendrobium officinale) - an emerging food ingredient from popular traditional Chinese medicinal plants: a review","volume":"58","author":"Kirkwood","year":"2023","journal-title":"Int. J. Food Sci. Technol."},{"key":"10.1016\/j.phymed.2026.157863_bib0025","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/hep4.1825","article-title":"Lipidomics and redox Lipidomics indicate early stage alcohol-induced liver damage","volume":"6","author":"Koelmel","year":"2022","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.phymed.2026.157863_bib0026","doi-asserted-by":"crossref","DOI":"10.9734\/jpri\/2024\/v36i117617","article-title":"Evaluation of potential EGFR inhibitors for non-small cell lung cancer: A structure-based virtual screening and molecular dynamics study","author":"Krishnasamy","year":"2024","journal-title":"J. Pharm. Res. Int."},{"key":"10.1016\/j.phymed.2026.157863_bib0027","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/s41580-024-00742-y","article-title":"Regulation of cellular and systemic sphingolipid homeostasis","volume":"25","author":"Kuo","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2026.157863_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116382","article-title":"Traditional uses, chemical compositions and pharmacological activities of dendrobium: A review","volume":"310","author":"Li","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.157863_bib0029","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ajpath.2019.09.023","article-title":"Role of mechanistic target of rapamycin and autophagy in alcohol-induced adipose atrophy and liver injury","volume":"190","author":"Li","year":"2020","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.phymed.2026.157863_bib0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911195","article-title":"The extracts of dendrobium alleviate dry eye disease in rat model by regulating aquaporin expression and MAPKs\/NF-\u03bab signalling","volume":"23","author":"Ling","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.157863_bib0031","article-title":"Characterization of polysaccharides isolated from Dendrobium loddigesii Rolfe and study of its hepatoprotective activity in vivo","author":"Ling","year":"2025","journal-title":"Food Sci. Hum. Wellness"},{"key":"10.1016\/j.phymed.2026.157863_bib0032","article-title":"Alcohol-related liver disease: basic mechanisms and clinical perspectives","volume":"22","author":"Liu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.157863_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.140087","article-title":"Comparative study on the anti-alcoholic liver disease efficiency of the ethanol- and water-soluble polysaccharides from Baijiu vinasses","volume":"299","author":"Liu","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.157863_bib0034","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/479348","article-title":"Insulin resistance, ceramide accumulation, and endoplasmic reticulum stress in human chronic alcohol-related liver disease","volume":"2012","author":"Longato","year":"2012","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.phymed.2026.157863_bib0035","doi-asserted-by":"crossref","DOI":"10.1172\/JCI176345","article-title":"Alcohol-associated liver disease","volume":"134","author":"Mackowiak","year":"2024","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2026.157863_bib0036","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232416226","article-title":"Fatty liver disease-alcoholic and non-alcoholic: similar but different","volume":"23","author":"Malnick","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.157863_bib0037","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s12072-016-9752-3","article-title":"New approaches for fibrosis regression in alcoholic cirrhosis","volume":"10","author":"Mehal","year":"2016","journal-title":"Hepatol. Int."},{"key":"10.1016\/j.phymed.2026.157863_bib0038","doi-asserted-by":"crossref","first-page":"4814","DOI":"10.3748\/wjg.v25.i33.4814","article-title":"Intestinal permeability in the pathogenesis of liver damage: from non-alcoholic fatty liver disease to liver transplantation","volume":"25","author":"Nicoletti","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.phymed.2026.157863_bib0039","article-title":"Artemisia argyi polysaccharide alleviates intestinal inflammation and intestinal flora dysbiosis in lipopolysaccharide-treated mice","volume":"1","author":"Ning","year":"2024","journal-title":"Food Med. Homol."},{"key":"10.1016\/j.phymed.2026.157863_bib0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22136921","article-title":"Intestinal permeability is a mechanical rheostat in the pathogenesis of liver cirrhosis","volume":"22","author":"Nishimura","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.157863_bib0041","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1016\/j.jceh.2022.05.004","article-title":"Pathogenesis of alcohol-associated liver disease","volume":"12","author":"Osna","year":"2022","journal-title":"J. Clin. Exp. Hepatol."},{"key":"10.1016\/j.phymed.2026.157863_bib0042","doi-asserted-by":"crossref","first-page":"e792","DOI":"10.1002\/mco2.792","article-title":"Metabolomics-driven approaches for identifying therapeutic targets in drug discovery","volume":"5","author":"Pan","year":"2024","journal-title":"MedComm"},{"key":"10.1016\/j.phymed.2026.157863_bib0043","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14786419.2025.2513583","article-title":"Unlocking nature's secrets: a review on the pharmacokinetics of plant-based medicines and herbal remedies","author":"Parthasarathy","year":"2025","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.phymed.2026.157863_bib0044","doi-asserted-by":"crossref","first-page":"tfaf095","DOI":"10.1093\/toxres\/tfaf095","article-title":"Zebrafish in the spotlight: expanding frontiers in toxicology and drug discovery","volume":"14","author":"Parthasarathy","year":"2025","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.phymed.2026.157863_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.prostaglandins.2020.106436","article-title":"Sphingosine 1-phosphate signaling in ischemia and reperfusion injury","volume":"149","author":"Raza","year":"2020","journal-title":"Prostaglandins. Other Lipid Mediat."},{"key":"10.1016\/j.phymed.2026.157863_bib0046","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000535524","article-title":"Mechanisms and therapeutic strategies for MAFLD targeting TLR4 signaling pathways","volume":"16","author":"Ren","year":"2024","journal-title":"J. Innate Immun."},{"key":"10.1016\/j.phymed.2026.157863_bib0047","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41572-018-0014-7","article-title":"Alcoholic liver disease","volume":"4","author":"Seitz","year":"2018","journal-title":"Nat. Rev. Dis. Primers."},{"key":"10.1016\/j.phymed.2026.157863_bib0048","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.chom.2024.06.008","article-title":"Dietary fiber alleviates alcoholic liver injury via Bacteroides acidifaciens and subsequent ammonia detoxification","volume":"32","author":"Shen","year":"2024","journal-title":"Cell Host. Microbe"},{"key":"10.1016\/j.phymed.2026.157863_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.139408","article-title":"Polysaccharides in fruits: biological activities, structures, and structure-activity relationships and influencing factors-A review","volume":"451","author":"Shi","year":"2024","journal-title":"Food Chem."},{"key":"10.1016\/j.phymed.2026.157863_bib0050","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1055\/s-0036-1593882","article-title":"Bidirectional communication between liver and gut during alcoholic Liver disease","volume":"36","author":"St\u00e4rkel","year":"2016","journal-title":"Semin. Liver. Dis."},{"key":"10.1016\/j.phymed.2026.157863_bib0051","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.freeradbiomed.2019.05.029","article-title":"Lipidomic biomarkers and mechanisms of lipotoxicity in non-alcoholic fatty liver disease","volume":"144","author":"Svegliati-Baroni","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2026.157863_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.127553","article-title":"Mechanisms and structure-activity relationships of polysaccharides in the intervention of Alzheimer's disease: A review","volume":"254","author":"Tang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.157863_bib0053","article-title":"Lacticaseibacillus paracasei 36 mitigates alcoholic-associated liver disease through modulation of microbiota and AMPK signaling","volume":"17","author":"Wang","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.157863_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113851","article-title":"Traditional uses, chemical constituents, pharmacological activities, and toxicological effects of Dendrobium leaves: A review","volume":"270","author":"Wang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.157863_bib0055","doi-asserted-by":"crossref","DOI":"10.4028\/b-XDTcg5","article-title":"ER-phagy activation by AMFR attenuates cardiac fibrosis post-myocardial infarction via mTORC1 pathway","author":"Wang","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.phymed.2026.157863_bib0056","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2021.109959","article-title":"Sphingosine 1-phosphate metabolism and insulin signaling","volume":"82","author":"Wigger","year":"2021","journal-title":"Cell Signal."},{"key":"10.1016\/j.phymed.2026.157863_bib0057","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev-pathmechdis-031521-030435","article-title":"Recent advances in understanding of pathogenesis of alcohol-associated liver disease","volume":"18","author":"Wu","year":"2023","journal-title":"Annu Rev. Pathol."},{"key":"10.1016\/j.phymed.2026.157863_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2024.101101","article-title":"Natural product virtual-interact-phenotypic target characterization: A novel approach demonstrated with Salvia miltiorrhiza extract","volume":"15","author":"Xu","year":"2025","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.phymed.2026.157863_bib0059","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/s41392-022-01119-3","article-title":"Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver\/steatohepatitis (NAFL\/NASH)","volume":"7","author":"Xu","year":"2022","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2026.157863_bib0060","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.ijbiomac.2019.03.213","article-title":"Chemically modified polysaccharides: synthesis, characterization, structure activity relationships of action","volume":"132","author":"Xu","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phymed.2026.157863_bib0061","article-title":"A bibliometric analysis of lipid peroxidation in alcoholic liver disease from 2001 to 2024","volume":"1","author":"Yao","year":"2024","journal-title":"Food Med. Homol."},{"key":"10.1016\/j.phymed.2026.157863_bib0062","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jhep.2018.10.037","article-title":"Effect of ethanol on lipid metabolism","volume":"70","author":"You","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2026.157863_bib0063","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115157","article-title":"Ceramide de novo synthesis in non-alcoholic fatty liver disease: pathogenic mechanisms and therapeutic perspectives","volume":"202","author":"Yu","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2026.157863_bib0064","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27217233","article-title":"Recent research progress on natural stilbenes in dendrobium species","volume":"27","author":"Zhai","year":"2022","journal-title":"Molecules"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326001030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326001030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T10:52:04Z","timestamp":1774003924000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326001030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":64,"alternative-id":["S0944711326001030"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.157863","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dendrobium polysaccharides ameliorate alcohol-induced liver injury by inhibiting the pathogenic ER stress-sphingolipid axis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.157863","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157863"}}