{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T05:20:45Z","timestamp":1774934445801,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","doi-asserted-by":"publisher","award":["GZY-KJS-SD-2024-079"],"award-info":[{"award-number":["GZY-KJS-SD-2024-079"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","doi-asserted-by":"publisher","award":["GZY-KJS\\u20132023-018"],"award-info":[{"award-number":["GZY-KJS\\u20132023-018"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022MH067"],"award-info":[{"award-number":["ZR2022MH067"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M773875"],"award-info":[{"award-number":["2025M773875"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023T160726"],"award-info":[{"award-number":["2023T160726"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M733914"],"award-info":[{"award-number":["2023M733914"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.phymed.2026.157866","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T16:43:36Z","timestamp":1769013816000},"page":"157866","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Tongmai Yishen Formula alleviates post-stroke depression by restoring neuronal homeostasis in the lateral habenula via the ITPKA signaling pathway"],"prefix":"10.1016","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8330-0038","authenticated-orcid":false,"given":"Zhen-Ling","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Yu Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng-Xian","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4483-4110","authenticated-orcid":false,"given":"Huai-Qian","family":"Bo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zong-Yan","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai-Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Ran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng-Ye","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6214-2598","authenticated-orcid":false,"given":"Xiang-Qing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-Dong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1825-0799","authenticated-orcid":false,"given":"Wen-Qiang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.157866_bib0001","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1177\/17474930231166306","article-title":"The evolution of blood-brain barrier permeability changes after stroke and its implications on clinical outcome: a systematic review and meta-analysis","volume":"18","author":"Bernardo-Castro","year":"2023","journal-title":"Int. J. Stroke"},{"key":"10.1016\/j.phymed.2026.157866_bib0002","doi-asserted-by":"crossref","first-page":"19838","DOI":"10.1021\/acs.jafc.4c04394","article-title":"Ginsenoside re prevents depression-like behaviors via inhibition of inflammation, oxidative stress, and activating BDNF\/TrkB\/ERK\/CREB signaling: an in vivo and in vitro study","volume":"72","author":"Chen","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2026.157866_bib0003","doi-asserted-by":"crossref","first-page":"eado7010","DOI":"10.1126\/science.ado7010","article-title":"Brain region-specific action of ketamine as a rapid antidepressant","volume":"385","author":"Chen","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.phymed.2026.157866_bib36","article-title":"MicroRNA-204-5p deficiency within the vmPFC region contributes to neuroinflammation and behavioral disorders via the JAK2\/STAT3 signaling pathway in rats","volume":"12","author":"Chen","year":"2025","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.phymed.2026.157866_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157078","article-title":"Xiaoyaosan improves depression-like behaviours in mice with post-stroke depression by modulating gut microbiota and microbial metabolism and regulating P2\u00d77R\/NLRP3 inflammasome","volume":"145","author":"Chen","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.157866_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpain.2018.07.011","article-title":"Spinal serotonin 1A receptor contributes to the analgesia of acupoint catgut embedding by inhibiting phosphorylation of the N-methyl-d-aspartate receptor GluN1 subunit in complete Freund\u2019s adjuvant-induced inflammatory pain in rats","volume":"20","author":"Cui","year":"2019","journal-title":"J. Pain"},{"key":"10.1016\/j.phymed.2026.157866_bib0006","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41398-025-03621-y","article-title":"The involvement of 5-HT was necessary for EA-mediated improvement of post-stroke depression","volume":"15","author":"Deng","year":"2025","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.phymed.2026.157866_bib0007","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2217\/fnl.13.38","article-title":"In vivo astrocytic Ca2+ signaling in health and brain disorders","volume":"8","author":"Ding","year":"2013","journal-title":"Future Neurol."},{"key":"10.1016\/j.phymed.2026.157866_bib0008","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s11658-023-00423-2","article-title":"Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets","volume":"28","author":"Janaszak-Jasiecka","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.phymed.2026.157866_bib0009","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6673967","article-title":"Tilianin ameliorates cognitive dysfunction and neuronal damage in rats with vascular dementia via p-CaMKII\/ERK\/CREB and ox-CaMKII-dependent MAPK\/NF-\u03bab pathways","author":"Jiang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phymed.2026.157866_bib0010","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.cellsig.2015.10.016","article-title":"Inositol-1,4,5-trisphosphate-3-kinase-a controls morphology of hippocampal dendritic spines","volume":"28","author":"K\u00f6ster","year":"2016","journal-title":"Cell Signal."},{"key":"10.1016\/j.phymed.2026.157866_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2025.115533","article-title":"The neurovascular unit response to cerebral ischemia as a promising area for translational studies - comments on some opened questions","volume":"396","author":"Kowia\u0144ski","year":"2026","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phymed.2026.157866_bib0012","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1126\/science.1240729","article-title":"\u03b2CaMKII in lateral habenula mediates core symptoms of depression","volume":"341","author":"Li","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.phymed.2026.157866_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108541","article-title":"Signaling pathways in brain ischemia: mechanisms and therapeutic implications","volume":"251","author":"Lin","year":"2023","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2026.157866_bib0014","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/s41586-023-06624-1","article-title":"Sustained antidepressant effect of ketamine through NMDAR trapping in the LHb","volume":"622","author":"Ma","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2026.157866_bib0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0171558","article-title":"Evolution of blood-brain-barrier permeability after acute ischemic stroke","volume":"12","author":"Merali","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.phymed.2026.157866_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154989","article-title":"Saffron carotenoids reversed the UCMS-induced depression and anxiety in rats: behavioral and biochemical parameters, and hippocampal BDNF\/ERK\/CREB and NR2B signaling markers","volume":"119","author":"Mohammadi","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.157866_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.119275","article-title":"Buyang Huanwu decoction prevents hemorrhagic transformation after delayed t-PA infusion via inhibiting NLRP3 inflammasome\/pyroptosis associated with microglial PGC-1\u03b1","volume":"340","author":"Pan","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.157866_bib0018","first-page":"1","article-title":"The effect of sertraline on networks of mood and anxiety symptoms: secondary analysis of the PANDA randomized controlled trial","author":"Piazza","year":"2025","journal-title":"Nat. Mental Health"},{"key":"10.1016\/j.phymed.2026.157866_bib0019","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.bbrc.2013.08.053","article-title":"Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase a","volume":"439","author":"Schr\u00f6der","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phymed.2026.157866_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113125","article-title":"Glutamate excitotoxicity: potential therapeutic target for ischemic stroke","volume":"151","author":"Shen","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2026.157866_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102780","article-title":"Unravelling the brain resilience following stroke: from injury to rewiring of the brain through pathway activation, drug targets, and therapeutic interventions","volume":"109","author":"Singh","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.phymed.2026.157866_bib0022","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.apsb.2019.01.010","article-title":"Inhibition of FOXO3a\/BIM signaling pathway contributes to the protective effect of salvianolic acid a against cerebral ischemia\/reperfusion injury","volume":"9","author":"Song","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2026.157866_bib0023","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1111\/ejn.16093","article-title":"A new perspective on hippocampal synaptic plasticity and post-stroke depression","volume":"58","author":"Sun","year":"2023","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.phymed.2026.157866_bib0024","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/s41467-017-01192-1","article-title":"Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms","volume":"8","author":"Tchenio","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.157866_bib0025","first-page":"1063","article-title":"G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+\/CaM kinase)","volume":"6","author":"Tombes","year":"1995","journal-title":"Cell Growth Differ."},{"key":"10.1016\/j.phymed.2026.157866_bib0026","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1039\/C9FO02475A","article-title":"Study on the therapeutic material basis and effect of acanthopanax senticosus (rupr. et maxim.) harms leaves in the treatment of ischemic stroke by PK-PD analysis based on online microdialysis-LC-MS\/MS method","volume":"11","author":"Wang","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2026.157866_bib0027","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.586226","article-title":"Characterization of the blood brain barrier disruption in the photothrombotic stroke model","volume":"11","author":"Weber","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.phymed.2026.157866_bib0028","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.cellsig.2011.11.010","article-title":"Inositol-1,4,5-trisphosphate 3-kinase a regulates dendritic morphology and shapes synaptic Ca2+ transients","volume":"24","author":"Windhorst","year":"2012","journal-title":"Cell Signal."},{"key":"10.1016\/j.phymed.2026.157866_bib0029","article-title":"An efficient brain delivery system co-loaded with multiple components of salvia miltiorrhiza for synergistic treatment of ischemic stroke","volume":"34","author":"Xia","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.phymed.2026.157866_bib0035","first-page":"997","article-title":"Effect of Gardenia Jasminoides-acanthopanax Senticosus containing serum on hippocampal neurogenesis in rats","volume":"38","author":"Xu","year":"2018","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"key":"10.1016\/j.phymed.2026.157866_bib0030","doi-asserted-by":"crossref","first-page":"298","DOI":"10.4103\/pm.pm_273_18","article-title":"Effect of gardenia\/acanthopanax-medicated serum on high level corticosterone-induced pheochromocytoma cell apoptosis and calcium ion concentration","volume":"15","author":"Xu","year":"2019","journal-title":"Phcog. Mag."},{"key":"10.1016\/j.phymed.2026.157866_bib0032","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.conb.2017.10.024","article-title":"Lateral habenula in the pathophysiology of depression","volume":"48","author":"Yang","year":"2018","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.phymed.2026.157866_bib0031","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41398-021-01667-2","article-title":"ProBDNF expression induces apoptosis and inhibits synaptic regeneration by regulating the RhoA-JNK pathway in an in vitro post-stroke depression model","volume":"11","author":"Yang","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.phymed.2026.157866_bib0033","article-title":"Prevalence of depression and cognitive impairment and their inter-relationship and association with quality of life among older stroke survivors: the findings of a national survey in China","author":"Zheng","year":"2025","journal-title":"Stroke Vasc. Neurol."},{"key":"10.1016\/j.phymed.2026.157866_bib0034","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.981190","article-title":"N-methyl D-aspartate receptor subtype 2B\/Ca2+\/calmodulin-dependent protein kinase II signaling in the lateral habenula regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia","volume":"16","author":"Zhuang","year":"2022","journal-title":"Front. Cell Neurosci."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326001054?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326001054?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:47:12Z","timestamp":1774928832000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326001054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":36,"alternative-id":["S0944711326001054"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.157866","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tongmai Yishen Formula alleviates post-stroke depression by restoring neuronal homeostasis in the lateral habenula via the ITPKA signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.157866","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"157866"}}