{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:21:16Z","timestamp":1790324476200,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["202261050"],"award-info":[{"award-number":["202261050"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82504874"],"award-info":[{"award-number":["82504874"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173860"],"award-info":[{"award-number":["82173860"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2023MH185"],"award-info":[{"award-number":["ZR2023MH185"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2025MS1301"],"award-info":[{"award-number":["ZR2025MS1301"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018936","name":"Qingdao Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["QDBSH20240102179"],"award-info":[{"award-number":["QDBSH20240102179"]}],"id":[{"id":"10.13039\/100018936","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.phymed.2026.157873","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T16:50:54Z","timestamp":1769187054000},"page":"157873","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Inhibition of influenza a virus infection by natural isoquinoline alkaloid neferine targeting virus nucleoprotein"],"prefix":"10.1016","volume":"152","author":[{"given":"Xiaoyao","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lishan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5296-0512","authenticated-orcid":false,"given":"Hongwei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8804-0629","authenticated-orcid":false,"given":"Cui","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6548-6422","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.phymed.2026.157873_bib0001","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1093\/cid\/ciaa107","article-title":"Baloxavir: A novel antiviral agent in the treatment of influenza","volume":"71","author":"Abraham","year":"2020","journal-title":"Clin. Infect. Dis."},{"issue":"12","key":"10.1016\/j.phymed.2026.157873_bib0002","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1086\/504723","article-title":"Distribution of amantadine-resistant H5N1 avian influenza variants in Asia","volume":"193","author":"Cheung","year":"2006","journal-title":"J. Infect. Dis."},{"issue":"9","key":"10.1016\/j.phymed.2026.157873_bib0003","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1002\/ptr.6687","article-title":"Neferine, an alkaloid from lotus seed embryo targets HeLa and SiHa cervical cancer cells via pro-oxidant anticancer mechanism","volume":"34","author":"Dasari","year":"2020","journal-title":"PhytOther Res."},{"issue":"10","key":"10.1016\/j.phymed.2026.157873_bib0004","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1007\/s12098-020-03214-1","article-title":"Influenza","volume":"87","author":"Dharmapalan","year":"2020","journal-title":"Indian J. Pediatr."},{"issue":"10","key":"10.1016\/j.phymed.2026.157873_bib0005","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00205-22","article-title":"Interactions between influenza a virus nucleoprotein and gene segment untranslated regions facilitate selective modulation of viral gene expression","volume":"96","author":"Diefenbacher","year":"2022","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.phymed.2026.157873_bib0006","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/nrmicro3367","article-title":"At the centre: influenza A virus ribonucleoproteins","volume":"13","author":"Eisfeld","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"issue":"6","key":"10.1016\/j.phymed.2026.157873_bib0007","doi-asserted-by":"crossref","first-page":"471","DOI":"10.2165\/00003088-199937060-00003","article-title":"Clinical pharmacokinetics of the prodrug oseltamivir and its active metabolite Ro 64-0802","volume":"37","author":"He","year":"1999","journal-title":"Clin. Pharmacokinet."},{"issue":"7","key":"10.1016\/j.phymed.2026.157873_bib0008","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/bdd.556","article-title":"Pharmacokinetics and metabolism of neferine in rats after a single oral administration","volume":"28","author":"Huang","year":"2007","journal-title":"Biopharm. Drug Dispos."},{"issue":"8","key":"10.1016\/j.phymed.2026.157873_bib0009","doi-asserted-by":"crossref","first-page":"4638","DOI":"10.1002\/jmv.26990","article-title":"A brief review of influenza virus infection","volume":"93","author":"Javanian","year":"2021","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.phymed.2026.157873_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.106118","article-title":"Exploring the anti-influenza virus activity of novel triptolide derivatives targeting nucleoproteins","volume":"129","author":"Jiang","year":"2022","journal-title":"Bioorg. Chem."},{"issue":"6","key":"10.1016\/j.phymed.2026.157873_bib0011","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/nbt.1638","article-title":"Identification of influenza A nucleoprotein as an antiviral target","volume":"28","author":"Kao","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.phymed.2026.157873_bib0012","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.virol.2014.01.023","article-title":"Large-scale analysis of influenza A virus nucleoprotein sequence conservation reveals potential drug-target sites","volume":"454-455","author":"Kukol","year":"2014","journal-title":"Virology"},{"issue":"18","key":"10.1016\/j.phymed.2026.157873_bib0013","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1021\/acs.jafc.7b00276","article-title":"Anti-influenza a virus activity of dendrobine and its mechanism of action","volume":"65","author":"Li","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2026.157873_bib0014","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1752-0509-7-97","article-title":"A comprehensive map of the influenza a virus replication cycle","volume":"7","author":"Matsuoka","year":"2013","journal-title":"BMC. Syst. Biol."},{"issue":"10","key":"10.1016\/j.phymed.2026.157873_bib0015","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.3201\/eid2510.190607","article-title":"Susceptibility of influenza A, B, C, and D viruses to baloxavir1","volume":"25","author":"Mishin","year":"2019","journal-title":"Emerg. Infect. Dis."},{"issue":"4","key":"10.1016\/j.phymed.2026.157873_bib0016","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s10753-019-01143-6","article-title":"Neferine inhibits expression of inflammatory mediators and matrix degrading enzymes in il-1\u03b2-treated rat chondrocytes via suppressing MAPK and nf-\u03bab signaling pathways","volume":"43","author":"Ni","year":"2020","journal-title":"Inflammation"},{"issue":"12","key":"10.1016\/j.phymed.2026.157873_bib0017","doi-asserted-by":"crossref","first-page":"6304","DOI":"10.1007\/s12035-021-02554-z","article-title":"Neferine protects against brain damage in permanent cerebral ischemic rat associated with autophagy suppression and AMPK\/mTOR Regulation","volume":"58","author":"Sengking","year":"2021","journal-title":"Mol. Neurobiol."},{"issue":"40","key":"10.1016\/j.phymed.2026.157873_bib0018","doi-asserted-by":"crossref","first-page":"16515","DOI":"10.1073\/pnas.1113107108","article-title":"E339...R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors","volume":"108","author":"Shen","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.phymed.2026.157873_bib0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/cid\/cis351","article-title":"Emergency use authorization for intravenous peramivir: evaluation of safety in the treatment of hospitalized patients infected with 2009 H1N1 influenza A virus","volume":"55","author":"Sorbello","year":"2012","journal-title":"Clin. Infect. Dis."},{"issue":"6428","key":"10.1016\/j.phymed.2026.157873_bib0020","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/363418a0","article-title":"Rational design of potent sialidase-based inhibitors of influenza virus replication","volume":"363","author":"von Itzstein","year":"1993","journal-title":"Nature"},{"issue":"16","key":"10.1016\/j.phymed.2026.157873_bib0021","doi-asserted-by":"crossref","first-page":"7850","DOI":"10.1128\/JVI.00735-09","article-title":"Nuclear factor 90 negatively regulates influenza virus replication by interacting with viral nucleoprotein","volume":"83","author":"Wang","year":"2009","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.phymed.2026.157873_bib0022","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1021\/acsinfecdis.7b00120","article-title":"Broad Spectrum Inhibitor of influenza A and B viruses targeting the viral nucleoprotein","volume":"4","author":"White","year":"2018","journal-title":"ACS. Infect. Dis."},{"issue":"1","key":"10.1016\/j.phymed.2026.157873_bib0023","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41467-018-02886-w","article-title":"Nucleotide resolution mapping of influenza A virus nucleoprotein-RNA interactions reveals RNA features required for replication","volume":"9","author":"Williams","year":"2018","journal-title":"Nat. Commun."},{"issue":"15","key":"10.1016\/j.phymed.2026.157873_bib0024","doi-asserted-by":"crossref","first-page":"8237","DOI":"10.3390\/ijms22158237","article-title":"Effect of neferine on DNCB-induced atopic dermatitis in HaCaT cells and BALB\/c mice","volume":"22","author":"Yang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"7122","key":"10.1016\/j.phymed.2026.157873_bib0025","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/nature05379","article-title":"The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA","volume":"444","author":"Ye","year":"2006","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.phymed.2026.157873_bib0026","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22429","article-title":"Nootropic effect of neferine on aluminium chloride-induced Alzheimer's disease in experimental models","volume":"34","author":"Yin","year":"2020","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"2","key":"10.1016\/j.phymed.2026.157873_bib0027","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.28499","article-title":"Inhibition of influenza A virus replication by a marine derived quinolone alkaloid targeting virus nucleoprotein","volume":"95","author":"Zhang","year":"2023","journal-title":"J. Med. Virol."},{"issue":"2","key":"10.1016\/j.phymed.2026.157873_bib0028","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jchromb.2007.07.043","article-title":"Improved RP-HPLC method to determine neferine in dog plasma and its application to pharmacokinetics","volume":"857","author":"Zhao","year":"2007","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326001121?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326001121?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T21:12:49Z","timestamp":1770671569000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326001121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":28,"alternative-id":["S0944711326001121"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.157873","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of influenza a virus infection by natural isoquinoline alkaloid neferine targeting virus nucleoprotein","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.157873","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157873"}}