{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:39:24Z","timestamp":1790779164939,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82521104"],"award-info":[{"award-number":["82521104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404909"],"award-info":[{"award-number":["82404909"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","award":["tstp20240848"],"award-info":[{"award-number":["tstp20240848"]}],"id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","award":["NO.tstp20240848"],"award-info":[{"award-number":["NO.tstp20240848"]}],"id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["ZZ17-YQ-046"],"award-info":[{"award-number":["ZZ17-YQ-046"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["ZZ17-ND-10"],"award-info":[{"award-number":["ZZ17-ND-10"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["ZZ16-ND-10"],"award-info":[{"award-number":["ZZ16-ND-10"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["ZZ18-ND-10"],"award-info":[{"award-number":["ZZ18-ND-10"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["ZZ18-ND-10-03"],"award-info":[{"award-number":["ZZ18-ND-10-03"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2023E005TS01"],"award-info":[{"award-number":["CI2023E005TS01"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2023D003"],"award-info":[{"award-number":["CI2023D003"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2023E005TS05"],"award-info":[{"award-number":["CI2023E005TS05"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2023E002"],"award-info":[{"award-number":["CI2023E002"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["ZG2024001-05"],"award-info":[{"award-number":["ZG2024001-05"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.phymed.2026.157904","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T17:08:25Z","timestamp":1769792905000},"page":"157904","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Rosmarinic acid alleviates ischemic stroke by targeting BAG3 to modulate autophagy via the P62-Keap1-Nrf2 pathway"],"prefix":"10.1016","volume":"154","author":[{"given":"Cui","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0575-0105","authenticated-orcid":false,"given":"Jigang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.157904_bib0001","doi-asserted-by":"crossref","DOI":"10.3390\/nu15051107","article-title":"Polyphenols mediate neuroprotection in cerebral ischemic stroke-an update","volume":"15","author":"Abdelsalam","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.phymed.2026.157904_bib0002","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1021\/acs.molpharmaceut.7b00832","article-title":"Isotopically-labeled iodoacetamide-alkyne probes for quantitative cysteine-reactivity profiling","volume":"15","author":"Abo","year":"2018","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.phymed.2026.157904_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107848","article-title":"Targeting autophagy in ischemic stroke: from molecular mechanisms to clinical therapeutics","volume":"225","author":"Ajoolabady","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.phymed.2026.157904_bib0004","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1161\/CIRCRESAHA.123.323371","article-title":"LOX-1 and MMP-9 inhibition attenuates the detrimental effects of delayed rt-PA therapy and improves outcomes after acute ischemic stroke","volume":"134","author":"Arkelius","year":"2024","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2026.157904_bib0005","doi-asserted-by":"crossref","first-page":"24729","DOI":"10.1021\/jacs.4c08840","article-title":"From mechanism-based retaining glycosidase inhibitors to activity-based glycosidase profiling","volume":"146","author":"Artola","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.phymed.2026.157904_bib0006","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.csbj.2024.12.014","article-title":"Structure-based identification of HNF4alpha agonists: rosmarinic acid as a promising candidate for NAFLD treatment","volume":"27","author":"Chen","year":"2025","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.phymed.2026.157904_bib0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2478\/jtim-2023-0138","article-title":"Dual antiplatelet instead of intravenous thrombolysis for minor nondisabling acute ischemic stroke: a perspective from China","volume":"12","author":"Cui","year":"2024","journal-title":"J. Transl. Int. Med."},{"key":"10.1016\/j.phymed.2026.157904_bib0008","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41416-021-01446-2","article-title":"An emerging role for BAG3 in gynaecological malignancies","volume":"125","author":"De Marco","year":"2021","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.phymed.2026.157904_bib0009","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1016\/j.drudis.2022.03.003","article-title":"Drug repurposing for stroke intervention","volume":"27","author":"Ghosh","year":"2022","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.phymed.2026.157904_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113966","article-title":"Astrocytic glycogen mobilization participates in salvianolic acid B-mediated neuroprotection against reperfusion injury after ischemic stroke","volume":"349","author":"Guo","year":"2022","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phymed.2026.157904_bib0011","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jns.2019.03.015","article-title":"The progress of neuronal autophagy in cerebral ischemia stroke: mechanisms, roles and research methods","volume":"400","author":"Hou","year":"2019","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.phymed.2026.157904_bib0012","article-title":"Small-molecule targeting BCAT1-mediated BCAA metabolism inhibits the activation of SHOC2-RAS-ERK to induce apoptosis of Triple-negative breast cancer cells","author":"Huang","year":"2024","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.phymed.2026.157904_bib0013","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1080\/15548627.2019.1580096","article-title":"BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT\/Tau degradation via autophagy in neuronal processes","volume":"15","author":"Ji","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2026.157904_bib0014","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.freeradbiomed.2015.06.014","article-title":"p62 links autophagy and Nrf2 signaling","volume":"88","author":"Jiang","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2026.157904_bib0015","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1161\/STROKEAHA.120.032810","article-title":"Thrombus composition and efficacy of thrombolysis and thrombectomy in acute ischemic stroke","volume":"52","author":"Jolugbo","year":"2021","journal-title":"Stroke"},{"key":"10.1016\/j.phymed.2026.157904_bib0016","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s10020-024-00828-5","article-title":"Polyphyllin I alleviates neuroinflammation after cerebral ischemia-reperfusion injury via facilitating autophagy-mediated M2 microglial polarization","volume":"30","author":"Kang","year":"2024","journal-title":"Mol. Med."},{"key":"10.1016\/j.phymed.2026.157904_bib0017","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/s41419-021-04227-0","article-title":"Sitagliptin activates the p62-Keap1-Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute lung injury","volume":"12","author":"Kong","year":"2021","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.phymed.2026.157904_bib0018","doi-asserted-by":"crossref","first-page":"355","DOI":"10.2478\/jtim-2023-0099","article-title":"Autophagy-dependent ferroptosis in infectious disease","volume":"11","author":"Li","year":"2023","journal-title":"J. Transl. Int. Med."},{"key":"10.1016\/j.phymed.2026.157904_bib0019","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1002\/glia.24232","article-title":"EphA4 regulates white matter remyelination after ischemic stroke through Ephexin-1\/RhoA\/ROCK signaling pathway","volume":"70","author":"Liu","year":"2022","journal-title":"Glia"},{"key":"10.1016\/j.phymed.2026.157904_bib0020","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/s41419-023-06154-8","article-title":"Autophagy: regulator of cell death","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.phymed.2026.157904_bib0021","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1177\/0271678X18810617","article-title":"Molecular switching from ubiquitin-proteasome to autophagy pathways in mice stroke model","volume":"40","author":"Liu","year":"2020","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.phymed.2026.157904_bib0022","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1161\/STROKEAHA.123.041783","article-title":"BAG3 overexpression attenuates ischemic stroke injury by activating autophagy and inhibiting apoptosis","volume":"54","author":"Liu","year":"2023","journal-title":"Stroke"},{"key":"10.1016\/j.phymed.2026.157904_bib0023","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s41420-024-02067-3","article-title":"Curcumol ameliorates neuroinflammation after cerebral ischemia-reperfusion injury via affecting microglial polarization and Treg\/Th17 balance through Nrf2\/HO-1 and NF-kappaB signaling","volume":"10","author":"Liu","year":"2024","journal-title":"Cell Death. Discov."},{"key":"10.1016\/j.phymed.2026.157904_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118196","article-title":"Rosmarinic acid alleviates toosendanin-induced liver injury through restoration of autophagic flux and lysosomal function by activating JAK2\/STAT3\/CTSC pathway","volume":"330","author":"Luo","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.157904_bib0025","article-title":"Rosmarinic acid ameliorates pulmonary ischemia\/reperfusion injury by activating the PI3K\/Akt signaling pathway","volume":"13","author":"Luo","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.157904_bib0026","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.4103\/1673-5374.274331","article-title":"Autophagy and inflammation in ischemic stroke","volume":"15","author":"Mo","year":"2020","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.phymed.2026.157904_bib0027","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/ame2.12166","article-title":"Preclinical animal studies in ischemic stroke: challenges and some solutions","volume":"4","author":"Narayan","year":"2021","journal-title":"Animal. Model. Exp. Med."},{"key":"10.1016\/j.phymed.2026.157904_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117058","article-title":"Elucidating the chemical interaction effects of herb pair Danshen-Chuanxiong and its anti-ischemic stroke activities evaluation","volume":"318","author":"Pang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.157904_bib0029","article-title":"Epigallocatechin gallate improves neuronal damage in animal model of ischemic stroke and glutamate-exposed neurons via modulation of hippocalcin expression","volume":"19","author":"Park","year":"2024","journal-title":"PLoS. One"},{"key":"10.1016\/j.phymed.2026.157904_bib0030","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/s41392-022-01129-1","article-title":"Correction to: signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions","volume":"7","author":"Qin","year":"2022","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2026.157904_bib0031","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1080\/13880209.2021.1878236","article-title":"Cardioprotective effect of rosmarinic acid against myocardial ischaemia\/reperfusion injury via suppression of the NF-kappaB inflammatory signalling pathway and ROS production in mice","volume":"59","author":"Quan","year":"2021","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.phymed.2026.157904_bib0032","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jneumeth.2005.02.013","article-title":"A simplified procedure for the quantitative measurement of neurological deficits after forebrain ischemia in mice","volume":"147","author":"Rodriguez","year":"2005","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.phymed.2026.157904_bib0033","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1212\/WNL.0000000000012781","article-title":"Global Epidemiology of Stroke and Access to Acute Ischemic Stroke Interventions","volume":"97","author":"Saini","year":"2021","journal-title":"Neurology."},{"key":"10.1016\/j.phymed.2026.157904_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156060","article-title":"Rosmarinic acid attenuates glioblastoma cells and spheroids' growth and EMT\/stem-like state by PTEN\/PI3K\/AKT downregulation and ERK-induced apoptosis","volume":"135","author":"Sengelen","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.157904_bib0035","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/j.neuron.2023.05.006","article-title":"An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology","volume":"111","author":"Sheehan","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.phymed.2026.157904_bib0036","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/jcb.30111","article-title":"The role of Bag3 in cell signaling","volume":"123","author":"Sherman","year":"2022","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.phymed.2026.157904_bib0037","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1007\/s10571-023-01382-0","article-title":"The pathological mechanism of neuronal autophagy-lysosome dysfunction after ischemic stroke","volume":"43","author":"Shi","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.phymed.2026.157904_bib0038","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/s41418-021-00913-w","article-title":"SPOP mutations promote p62\/SQSTM1-dependent autophagy and Nrf2 activation in prostate cancer","volume":"29","author":"Shi","year":"2022","journal-title":"Cell Death. Differ."},{"key":"10.1016\/j.phymed.2026.157904_bib0039","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-25784-0","article-title":"Nrf2 and Parkin-Hsc70 regulate the expression and protein stability of p62\/SQSTM1 under hypoxia","volume":"12","author":"Siswanto","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2026.157904_bib0040","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s00401-024-02810-1","article-title":"Neuronal BAG3 attenuates tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits induced by traumatic brain injury via the regulation of autophagy-lysosome pathway","volume":"148","author":"Sweeney","year":"2024","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.phymed.2026.157904_bib0041","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S1474-4422(22)00519-1","article-title":"Thrombolysis for acute ischaemic stroke: current status and future perspectives","volume":"22","author":"Tsivgoulis","year":"2023","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.phymed.2026.157904_bib0042","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/s10020-024-00995-5","article-title":"Triolein alleviates ischemic stroke brain injury by regulating autophagy and inflammation through the AKT\/mTOR signaling pathway","volume":"30","author":"Wang","year":"2024","journal-title":"Mol. Med."},{"key":"10.1016\/j.phymed.2026.157904_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2021.147336","article-title":"Rosmarinic acid protects rats against post-stroke depression after transient focal cerebral ischemic injury through enhancing antioxidant response","volume":"1757","author":"Wang","year":"2021","journal-title":"Brain Res."},{"key":"10.1016\/j.phymed.2026.157904_bib0044","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2478\/jtim-2022-0057","article-title":"Impact of the Alberta Stroke Program CT Score subregions on long-term functional outcomes in acute ischemic stroke: results from two multicenter studies in China","volume":"12","author":"Wang","year":"2024","journal-title":"J. Transl. Int. Med."},{"key":"10.1016\/j.phymed.2026.157904_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102842","article-title":"Bidirectional regulation of neuronal autophagy in ischemic stroke: Mechanisms and therapeutic potential","volume":"111","author":"Wu","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.phymed.2026.157904_bib0046","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6687386","article-title":"Neuroprotective phytochemicals in experimental ischemic stroke: mechanisms and potential clinical applications","volume":"2021","author":"Xu","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.phymed.2026.157904_bib0047","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.21037\/atm-22-5159","article-title":"BAG3 promotes autophagy and suppresses NLRP3 inflammasome activation in Parkinson's disease","volume":"10","author":"Ying","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.phymed.2026.157904_bib0048","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.chembiol.2022.06.011","article-title":"Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis","volume":"29","author":"Zhang","year":"2022","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.phymed.2026.157904_bib0049","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jconrel.2024.03.050","article-title":"Remodeling brain pathological microenvironment to lessen cerebral ischemia injury by multifunctional injectable hydrogels","volume":"369","author":"Zhang","year":"2024","journal-title":"J. Control Release"},{"key":"10.1016\/j.phymed.2026.157904_bib0050","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1080\/15548627.2020.1840796","article-title":"Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons","volume":"17","author":"Zhang","year":"2021","journal-title":"Autophagy."},{"key":"10.1016\/j.phymed.2026.157904_bib0051","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/978-981-15-4272-5_7","article-title":"Autophagy and Ischemic Stroke","volume":"1207","author":"Zhang","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.phymed.2026.157904_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113574","article-title":"Activin A improves the neurological outcome after ischemic stroke in mice by promoting oligodendroglial ACVR1B-mediated white matter remyelination","volume":"337","author":"Zheng","year":"2021","journal-title":"Exp. Neurol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326001431?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326001431?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:19:10Z","timestamp":1778559550000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326001431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":52,"alternative-id":["S0944711326001431"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.157904","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rosmarinic acid alleviates ischemic stroke by targeting BAG3 to modulate autophagy via the P62-Keap1-Nrf2 pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.157904","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157904"}}