{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T21:28:24Z","timestamp":1786483704375,"version":"build-2736575974"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012326","name":"International Science and Technology Cooperation Programme","doi-asserted-by":"publisher","award":["2025E01054"],"award-info":[{"award-number":["2025E01054"]}],"id":[{"id":"10.13039\/501100012326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFE0205600"],"award-info":[{"award-number":["2020YFE0205600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.phymed.2026.157949","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:57:28Z","timestamp":1770685048000},"page":"157949","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Neveskin from Ferula samarcandica exerts anti-gastric cancer effects via the Hippo-YAP signaling pathway"],"prefix":"10.1016","volume":"153","author":[{"given":"Mayire","family":"Nueraihemaiti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khamidulla","family":"Kamoldinov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5943-6771","authenticated-orcid":false,"given":"Niu","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4652-6879","authenticated-orcid":false,"given":"Haji Akber","family":"Aisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.phymed.2026.157949_bib0001","article-title":"Nivolumab, Ramucirumab and Paclitaxel combination as second line therapy for advanced stage gastric cancer","volume":"8","author":"Akbas","year":"2024","journal-title":"EJMO"},{"issue":"7","key":"10.1016\/j.phymed.2026.157949_bib0002","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.semcdb.2012.07.002","article-title":"Protein kinases of the Hippo pathway: regulation and substrates","volume":"23","author":"Avruch","year":"2012","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.phymed.2026.157949_bib0003","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/6165192","article-title":"Silibinin induced Human glioblastoma cell apoptosis concomitant with autophagy through simultaneous inhibition of mTOR and YAP","author":"Bai","year":"2018","journal-title":"Biomed. Res. Int."},{"issue":"1","key":"10.1016\/j.phymed.2026.157949_bib0004","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1007\/s11033-025-10573-5","article-title":"Autophagy mediated immune response regulation and drug resistance in cancer","volume":"52","author":"Bandyopadhyay","year":"2025","journal-title":"Mol. Biol. Rep."},{"issue":"9742","key":"10.1016\/j.phymed.2026.157949_bib0005","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0140-6736(10)61121-X","article-title":"Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial","volume":"376","author":"Bang","year":"2010","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.phymed.2026.157949_bib0006","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1093\/neuonc\/noab244","article-title":"Anti-invasive efficacy and survival benefit of the YAP-TEAD inhibitor verteporfin in preclinical glioblastoma models","volume":"24","author":"Barrette","year":"2022","journal-title":"Neuro Oncol."},{"issue":"5","key":"10.1016\/j.phymed.2026.157949_bib0007","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1096\/fj.14-269043","article-title":"Translating dosages from animal models to human clinical trials\u2013revisiting body surface area scaling","volume":"29","author":"Blanchard","year":"2015","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.phymed.2026.157949_bib0008","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2144\/000113382","article-title":"Antibody validation","volume":"48","author":"Bordeaux","year":"2010","journal-title":"Biotechniques"},{"issue":"11","key":"10.1016\/j.phymed.2026.157949_bib0009","doi-asserted-by":"crossref","first-page":"4963","DOI":"10.1038\/s41596-021-00615-0","article-title":"Analysis of clonogenic growth in vitro","volume":"16","author":"Brix","year":"2021","journal-title":"Nat. Protoc."},{"issue":"9","key":"10.1016\/j.phymed.2026.157949_bib0010","doi-asserted-by":"crossref","DOI":"10.1101\/pdb.prot087205","article-title":"Analyzing cell death by nuclear staining with Hoechst 33342","volume":"2016","author":"Crowley","year":"2016","journal-title":"Cold. Spring. Harb. Protoc."},{"key":"10.1016\/j.phymed.2026.157949_bib0011","article-title":"Hematoxylin and eosin staining of tissue and cell sections","author":"Fischer","year":"2008","journal-title":"CSH Protoc 2008(pdb.prot4986"},{"issue":"2","key":"10.1016\/j.phymed.2026.157949_bib0012","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1016\/j.jid.2016.11.020","article-title":"Research techniques made simple: analysis of collective cell migration using the wound healing assay","volume":"137","author":"Grada","year":"2017","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.phymed.2026.157949_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104463","article-title":"Pharmacological properties and derivatives of shikonin-A review in recent years","volume":"149","author":"Guo","year":"2019","journal-title":"Pharmacol. Res."},{"issue":"4","key":"10.1016\/j.phymed.2026.157949_bib0014","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.7150\/ijbs.80324","article-title":"Polyphyllin B suppresses gastric tumor growth by modulating iron metabolism and inducing ferroptosis","volume":"19","author":"Hu","year":"2023","journal-title":"Int. J. Biol. Sci."},{"issue":"3","key":"10.1016\/j.phymed.2026.157949_bib0015","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.21873\/anticanres.11410","article-title":"Antimetastatic efficacy of the combination of caffeine and valproic acid on an orthotopic Human osteosarcoma cell line model in nude mice","volume":"37","author":"Igarashi","year":"2017","journal-title":"Anticancer Res."},{"key":"10.1016\/j.phymed.2026.157949_bib0016","doi-asserted-by":"crossref","DOI":"10.3791\/51046-v","article-title":"In vitro cell migration and invasion assays","author":"Justus","year":"2014","journal-title":"J. Vis. Exp88"},{"key":"10.1016\/j.phymed.2026.157949_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2021.112705","article-title":"Sesquiterpene coumarins from Ferula samarkandica Korovin and their bioactivity","volume":"187","author":"Kamoldinov","year":"2021","journal-title":"Phytochemistry"},{"issue":"1","key":"10.1016\/j.phymed.2026.157949_bib0018","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1158\/0008-5472.CAN-12-2464","article-title":"Chloroquine in cancer therapy: a double-edged sword of autophagy","volume":"73","author":"Kimura","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.phymed.2026.157949_bib0019","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.2147\/CMAR.S167846","article-title":"Low-dose eribulin mesylate exerts antitumor effects in gastric cancer by inhibiting fibrosis via the suppression of epithelial-mesenchymal transition and acts synergistically with 5-fluorouracil","volume":"10","author":"Kurata","year":"2018","journal-title":"Cancer Manage Res."},{"issue":"1","key":"10.1016\/j.phymed.2026.157949_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2019.12.006","article-title":"Treatment-induced tumor dormancy through yap-mediated transcriptional reprogramming of the apoptotic pathway","volume":"37","author":"Kurppa","year":"2020","journal-title":"Cancer Cell"},{"issue":"6","key":"10.1016\/j.phymed.2026.157949_bib0021","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.molcel.2008.11.019","article-title":"PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop","volume":"32","author":"Lapi","year":"2008","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.phymed.2026.157949_bib0022","doi-asserted-by":"crossref","first-page":"4962","DOI":"10.1038\/s41467-018-07338-z","article-title":"Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap","volume":"9","author":"Lee","year":"2018","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.phymed.2026.157949_bib0023","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1136\/gut.2003.021105","article-title":"Effect of peroxisome proliferator activated receptor gamma ligands on growth and gene expression profiles of gastric cancer cells","volume":"53","author":"Leung","year":"2004","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.phymed.2026.157949_bib0024","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.molcel.2007.12.022","article-title":"Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage","volume":"29","author":"Levy","year":"2008","journal-title":"Mol. Cell"},{"issue":"9","key":"10.1016\/j.phymed.2026.157949_bib0025","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1093\/bioinformatics\/btac122","article-title":"SEPA: signaling entropy-based algorithm to evaluate personalized pathway activation for survival analysis on pan-cancer data","volume":"38","author":"Li","year":"2022","journal-title":"Bioinformatics."},{"issue":"12","key":"10.1016\/j.phymed.2026.157949_bib0026","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1101\/gad.192856.112","article-title":"Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP","volume":"26","author":"Liu-Chittenden","year":"2012","journal-title":"Genes Dev."},{"issue":"1","key":"10.1016\/j.phymed.2026.157949_bib0027","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13062-024-00518-6","article-title":"Disulfidptosis signature predicts immune microenvironment and prognosis of gastric cancer","volume":"19","author":"Liu","year":"2024","journal-title":"Biol. Direct."},{"issue":"1","key":"10.1016\/j.phymed.2026.157949_bib0028","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1038\/s41597-025-05798-9","article-title":"Whole genome sequencing and annotations of Trametes sanguinea","volume":"12","author":"Lodi","year":"2025","journal-title":"ZHSJ. Sci Data"},{"key":"10.1016\/j.phymed.2026.157949_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156161","article-title":"Cepharanthine sensitizes gastric cancer cells to chemotherapy by targeting TRIB3-FOXO3-FOXM1 axis to inhibit autophagy","volume":"135","author":"Lu","year":"2024","journal-title":"Phytomedicine"},{"issue":"9","key":"10.1016\/j.phymed.2026.157949_bib0030","doi-asserted-by":"crossref","first-page":"429","DOI":"10.4103\/1947-2714.100998","article-title":"Western blot: technique, theory, and trouble shooting","volume":"4","author":"Mahmood","year":"2012","journal-title":"N. Am. J. Med. Sci."},{"issue":"6141","key":"10.1016\/j.phymed.2026.157949_bib0031","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.1233606","article-title":"Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay","volume":"341","author":"Martinez Molina","year":"2013","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.phymed.2026.157949_bib0032","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.molcel.2007.08.008","article-title":"RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein","volume":"27","author":"Matallanas","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.phymed.2026.157949_bib0033","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4137\/BMI.S2185","article-title":"Immunohistochemistry as an important tool in biomarkers detection and clinical practice","volume":"5","author":"Matos","year":"2010","journal-title":"Biomark. Insights."},{"issue":"15","key":"10.1016\/j.phymed.2026.157949_bib0034","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25153342","article-title":"Current perspectives of the applications of polyphenols and flavonoids in cancer therapy","volume":"25","author":"Montan\u00e9","year":"2020","journal-title":"Molecules."},{"issue":"1","key":"10.1016\/j.phymed.2026.157949_bib0035","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev-pathmechdis-051222-115023","article-title":"Apoptosis in cancer biology and therapy","volume":"20","author":"Moyer","year":"2025","journal-title":"Annu Rev. Pathol."},{"issue":"8","key":"10.1016\/j.phymed.2026.157949_bib0036","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1002\/jso.24771","article-title":"Feasibility and safety of hyperthermic intraperitoneal chemotherapy using 5-fluorouracil combined with cisplatin and mitomycin C in patients undergoing gastrectomy for advanced gastric cancer","volume":"116","author":"Murata","year":"2017","journal-title":"J. Surg. Oncol."},{"issue":"3","key":"10.1016\/j.phymed.2026.157949_bib0037","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/ptr.3311","article-title":"Biologically active sesquiterpene coumarins from Ferula species","volume":"25","author":"Nazari","year":"2011","journal-title":"PhytOther Res."},{"issue":"3","key":"10.1016\/j.phymed.2026.157949_bib0038","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/toxres\/tfad024","article-title":"Celastrol inhibits gastric cancer cell proliferation, migration, and invasion via the FOXA1\/CLDN4 axis","volume":"12","author":"Peng","year":"2023","journal-title":"Toxicol. Res. (Camb)"},{"key":"10.1016\/j.phymed.2026.157949_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217285","article-title":"Autophagy and cancer therapy","volume":"605","author":"Pimentel","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.phymed.2026.157949_bib0040","doi-asserted-by":"crossref","first-page":"135","DOI":"10.14744\/ejmo.2024.61923","article-title":"Effect of Losartan on cell proliferation and reactive oxygen species scavenging in gastric cancer cell lines","author":"Raei","year":"2024","journal-title":"Eurasian Journal of Medical Advances"},{"key":"10.1016\/j.phymed.2026.157949_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109726","article-title":"Salidroside induces apoptosis and protective autophagy in human gastric cancer AGS cells through the PI3K\/akt\/mTOR pathway","volume":"122","author":"Rong","year":"2020","journal-title":"Biomed. PharmacOther"},{"issue":"2","key":"10.1016\/j.phymed.2026.157949_bib0042","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s12253-010-9332-0","article-title":"Upregulation of Twist in gastric carcinoma associated with tumor invasion and poor prognosis","volume":"17","author":"Ru","year":"2011","journal-title":"Pathol. Oncol. Res."},{"issue":"13","key":"10.1016\/j.phymed.2026.157949_bib0043","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.2174\/1389557520666200505125618","article-title":"Pharmacological and therapeutic aspects of plants from the genus Ferula: a comprehensive review","volume":"20","author":"Sabzehzari","year":"2020","journal-title":"Mini. Rev. Med. Chem."},{"issue":"8","key":"10.1016\/j.phymed.2026.157949_bib0044","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1002\/stem.2406","article-title":"Concise review: stem cells and epithelial-mesenchymal transition in cancer: biological implications and therapeutic targets","volume":"34","author":"Sato","year":"2016","journal-title":"Stem Cells"},{"issue":"5","key":"10.1016\/j.phymed.2026.157949_bib0045","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines8050126","article-title":"Assessment of the antitumor potential of Umbelliprenin, a naturally occurring sesquiterpene coumarin","volume":"8","author":"Shahzadi","year":"2020","journal-title":"Biomedicines."},{"issue":"10142","key":"10.1016\/j.phymed.2026.157949_bib0046","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0140-6736(18)31257-1","article-title":"Pembrolizumab versus paclitaxel for previously treated, advanced gastric or gastro-oesophageal junction cancer (KEYNOTE-061): a randomised, open-label, controlled, phase 3 trial","volume":"392","author":"Shitara","year":"2018","journal-title":"Lancet"},{"issue":"10251","key":"10.1016\/j.phymed.2026.157949_bib0047","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0140-6736(20)31288-5","article-title":"Gastric cancer","volume":"396","author":"Smyth","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2026.157949_bib0048","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-0716-3441-7_1","article-title":"Computer-aided drug discovery and design: recent advances and future prospects","volume":"2714","author":"Talevi","year":"2024","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"10.1016\/j.phymed.2026.157949_bib0049","doi-asserted-by":"crossref","first-page":"5755","DOI":"10.1038\/s41467-019-13591-7","article-title":"LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function","volume":"10","author":"Tang","year":"2019","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.phymed.2026.157949_bib0050","first-page":"600","article-title":"Administration of substances to laboratory animals: routes of administration and factors to consider","volume":"50","author":"Turner","year":"2011","journal-title":"J. Am. Assoc. Lab. Anim. Sci."},{"key":"10.1016\/j.phymed.2026.157949_bib0051","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/978-1-61779-080-5_20","article-title":"Cell sensitivity assays: the MTT assay","volume":"731","author":"van Meerloo","year":"2011","journal-title":"Methods Mol. Biol."},{"issue":"8","key":"10.1016\/j.phymed.2026.157949_bib0052","article-title":"Chemotherapy for advanced gastric cancer","volume":"8","author":"Wagner","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"issue":"10","key":"10.1016\/j.phymed.2026.157949_bib0053","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/s41419-020-03069-6","article-title":"Emerging role of the Hippo pathway in autophagy","volume":"11","author":"Wang","year":"2020","journal-title":"Cell Death. Dis."},{"issue":"1","key":"10.1016\/j.phymed.2026.157949_bib0054","article-title":"Sesquiterpenes and sesquiterpene derivatives from Ferula: their chemical structures","volume":"13","author":"Wang","year":"2023","journal-title":"Biosynthetic Pathways, and Biological Properties. Antioxidants (Basel)"},{"issue":"6","key":"10.1016\/j.phymed.2026.157949_bib0055","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/s41419-019-1664-4","article-title":"Activation of Aurora A kinase increases YAP stability via blockage of autophagy","volume":"10","author":"Wang","year":"2019","journal-title":"Cell Death. Dis."},{"issue":"1","key":"10.1016\/j.phymed.2026.157949_bib0056","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1007\/s12672-025-02503-5","article-title":"Lysionotin promoted apoptosis of hepatocellular carcinoma cells via inducing autophagy","volume":"16","author":"Wang","year":"2025","journal-title":"Discov. Oncol."},{"issue":"8","key":"10.1016\/j.phymed.2026.157949_bib0057","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s11655-011-0878-9","article-title":"Anticancer effects of 5-fluorouracil combined with warming and relieving cold phlegm formula on human breast cancer","volume":"18","author":"Wang","year":"2012","journal-title":"Chin. J. Integr. Med."},{"issue":"18","key":"10.1016\/j.phymed.2026.157949_bib0058","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1091\/mbc.e14-04-0916","article-title":"How Taxol\/paclitaxel kills cancer cells","volume":"25","author":"Weaver","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.phymed.2026.157949_bib0059","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2022.106344","article-title":"CircSETD3 mediates acquired resistance to gefitinib in non-small lung cancer cells by FXR1\/ECT2 pathway","volume":"154","author":"Wen","year":"2023","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.phymed.2026.157949_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156975","article-title":"Protective effects of pollenin B in asthma: pPAR-\u03b3-mediated regulation of inflammatory pathways and arachidonic acid metabolism","volume":"145","author":"Wu","year":"2025","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.phymed.2026.157949_bib0061","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/s12951-024-02521-5","article-title":"A humanized trivalent Nectin-4-targeting nanobody drug conjugate displays potent antitumor activity in gastric cancer","volume":"22","author":"Wu","year":"2024","journal-title":"J. Nanobiotechnology."},{"issue":"4","key":"10.1016\/j.phymed.2026.157949_bib0062","doi-asserted-by":"crossref","DOI":"10.1177\/15593258231203585","article-title":"Curcumin's dose-dependent attenuation of gastric cancer cell progression via the PI3K pathway blockade","volume":"21","author":"Xi","year":"2023","journal-title":"Dose Response"},{"issue":"14","key":"10.1016\/j.phymed.2026.157949_bib0063","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27144523","article-title":"Anticancer effects and mechanisms of berberine from medicinal herbs: an update review","volume":"27","author":"Xiong","year":"2022","journal-title":"Molecules."},{"issue":"8","key":"10.1016\/j.phymed.2026.157949_bib0064","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22818","article-title":"Inhibiting the JNK\/ERK signaling pathway with geraniol for attenuating the proliferation of human gastric adenocarcinoma AGS cells","volume":"35","author":"Yang","year":"2021","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"6","key":"10.1016\/j.phymed.2026.157949_bib0065","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41580-020-0237-9","article-title":"Guidelines and definitions for research on epithelial-mesenchymal transition","volume":"21","author":"Yang","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2026.157949_bib0066","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119555","article-title":"The potential of natural herbal plants in the treatment and prevention of non-small cell lung cancer: an encounter between ferroptosis and mitophagy","volume":"346","author":"Yang","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.157949_bib0067","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2025.149546","article-title":"Targeting programmed cell death pathways in gastric cancer: a focus on pyroptosis, apoptosis, necroptosis and PANoptosis","volume":"960","author":"Yao","year":"2025","journal-title":"Gene"},{"issue":"11","key":"10.1016\/j.phymed.2026.157949_bib0068","doi-asserted-by":"crossref","first-page":"6955","DOI":"10.62347\/MJOA5699","article-title":"Predictive and prognostic value of combined detection of sTim-3, PG and PD-L1 in immune checkpoint inhibitor therapy for advanced gastric cancer","volume":"16","author":"Zhang","year":"2024","journal-title":"Am. J. Transl. Res."},{"issue":"1","key":"10.1016\/j.phymed.2026.157949_bib0069","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41420-024-01943-2","article-title":"USP12 facilitates gastric cancer progression via stabilizing YAP","volume":"10","author":"Zhang","year":"2024","journal-title":"Cell Death. Discov."},{"key":"10.1016\/j.phymed.2026.157949_bib0070","article-title":"The role of SIRT1 in the development of gastrointestinal tumors","volume":"13","author":"Zhang","year":"2025","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.phymed.2026.157949_bib0071","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.103016","article-title":"M2 macrophage exosome-derived lncRNA AK083884 protects mice from CVB3-induced viral myocarditis through regulating PKM2\/HIF-1\u03b1 axis mediated metabolic reprogramming of macrophages","volume":"69","author":"Zhang","year":"2024","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2026.157949_bib0072","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156879","article-title":"Curzerene suppresses epithelial-mesenchymal transition in gastric precancerous lesion cells through targeted regulation of YAP via the long non-coding RNA AFAP1-AS1","volume":"143","author":"Zhou","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.157949_bib0073","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2023.171045","article-title":"Substance P promote macrophage M2 polarization to attenuate secondary lymphedema by regulating NF-kB\/NLRP3 signaling pathway","volume":"168","author":"Zhou","year":"2023","journal-title":"Peptides."},{"key":"10.1016\/j.phymed.2026.157949_bib0074","doi-asserted-by":"crossref","first-page":"7035","DOI":"10.12659\/MSM.910650","article-title":"Curcumin induces autophagy via inhibition of yes-associated protein (YAP) in Human colon cancer cells","volume":"24","author":"Zhu","year":"2018","journal-title":"Med. Sci. Monit."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132600187X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132600187X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:39:03Z","timestamp":1786480743000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471132600187X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":74,"alternative-id":["S094471132600187X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.157949","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neveskin from Ferula samarcandica exerts anti-gastric cancer effects via the Hippo-YAP signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.157949","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157949"}}