{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:15:22Z","timestamp":1791321322518,"version":"4.3.1"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82350710800"],"award-info":[{"award-number":["82350710800"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515110270"],"award-info":[{"award-number":["2023A1515110270"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2024YFA0919200"],"award-info":[{"award-number":["2024YFA0919200"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001801","name":"University of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["KCXFZ20240903094059020"],"award-info":[{"award-number":["KCXFZ20240903094059020"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.phymed.2026.157961","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T16:49:51Z","timestamp":1770828591000},"page":"157961","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Roburic acid inhibits glucocorticoid-induced osteonecrosis of the femoral head associated osteoclast activity via targeting PTP1B"],"prefix":"10.1016","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3769-0784","authenticated-orcid":false,"given":"Gang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7452-8287","authenticated-orcid":false,"given":"Yuting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6240-9333","authenticated-orcid":false,"given":"Jinbo","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2666-8415","authenticated-orcid":false,"given":"Haiming","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianpeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2021-8309","authenticated-orcid":false,"given":"Jiake","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.157961_bib0001","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3109\/17453674.2013.874927","article-title":"Increased risk of revision in patients with non-traumatic femoral head necrosis","volume":"85","author":"Bergh","year":"2014","journal-title":"Acta Orthop."},{"key":"10.1016\/j.phymed.2026.157961_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2020.102460","article-title":"The pathogenesis, diagnosis and clinical manifestations of steroid-induced osteonecrosis","volume":"110","author":"Chang","year":"2020","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.phymed.2026.157961_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2020.102460","article-title":"The pathogenesis, diagnosis and clinical manifestations of steroid-induced osteonecrosis","volume":"110","author":"Chang","year":"2020","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.phymed.2026.157961_bib0004","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1002\/art.33498","article-title":"Alendronate in the prevention of collapse of the femoral head in nontraumatic osteonecrosis: a two-year multicenter, prospective, randomized, double-blind, placebo-controlled study","volume":"64","author":"Chen","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.phymed.2026.157961_bib0006","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1007\/s10753-017-0636-z","article-title":"Roburic acid suppresses NO and IL-6 production via targeting NF-\u03baB and MAPK pathway in RAW264.7 cells","volume":"40","author":"Chen","year":"2017","journal-title":"Inflammation"},{"key":"10.1016\/j.phymed.2026.157961_bib0005","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.7150\/ijbs.40917","article-title":"Steroid-induced osteonecrosis of the femoral head reveals enhanced reactive oxygen species and hyperactive osteoclasts","volume":"16","author":"Chen","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.phymed.2026.157961_bib0007","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.791","article-title":"Dexamethasone promotes the endoplasmic reticulum stress response of bone marrow mesenchymal stem cells by activating the PERK-Nrf2 signaling pathway","volume":"9","author":"Cheng","year":"2021","journal-title":"Pharmacol. Res. Perspect."},{"key":"10.1016\/j.phymed.2026.157961_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110639","article-title":"Early depletion of M1 macrophages retards the progression of glucocorticoid-associated osteonecrosis of the femoral head","volume":"122","author":"Cheng","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2026.157961_bib0009","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1007\/s00198-011-1804-x","article-title":"Pathophysiology of atypical femoral fractures and osteonecrosis of the jaw","volume":"22","author":"Compston","year":"2011","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.phymed.2026.157961_bib0010","doi-asserted-by":"crossref","first-page":"W357","DOI":"10.1093\/nar\/gkz382","article-title":"SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules","volume":"47","author":"Daina","year":"2019","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.phymed.2026.157961_bib0011","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/jemt.10374","article-title":"Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic activities","volume":"61","author":"Delaiss\u00e9","year":"2003","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.phymed.2026.157961_bib0012","doi-asserted-by":"crossref","DOI":"10.3390\/cells9030695","article-title":"ER Stress Responses: An Emerging Modulator for Innate Immunity","volume":"9","author":"Di Conza","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2026.157961_bib0013","first-page":"105","article-title":"Risk for infections during treatment with denosumab for osteoporosis: a systematic review and meta-analysis","author":"Diker-Cohen","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.phymed.2026.157961_bib0014","doi-asserted-by":"crossref","first-page":"5094","DOI":"10.1038\/s41467-024-49159-3","article-title":"Mitochondria from osteolineage cells regulate myeloid cell-mediated bone resorption","volume":"15","author":"Ding","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.157961_bib0015","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3109\/10409238.2013.819830","article-title":"PTP1B: a simple enzyme for a complex world","volume":"48","author":"Feldhammer","year":"2013","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.phymed.2026.157961_bib0016","doi-asserted-by":"crossref","first-page":"543","DOI":"10.7150\/ijbs.35256","article-title":"Inhibition of PERK signaling prevents against glucocorticoid-induced endotheliocyte apoptosis and osteonecrosis of the femoral head","volume":"16","author":"Gao","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.phymed.2026.157961_bib0017","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/jcb.10503","article-title":"Phosphatidylinositol 3-kinase coordinately activates the MEK\/ERK and AKT\/NFkappaB pathways to maintain osteoclast survival","volume":"89","author":"Gingery","year":"2003","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.phymed.2026.157961_bib0018","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1007\/s00264-018-3879-x","article-title":"Subchondral fracture begins from the bone resorption area in osteonecrosis of the femoral head: a micro-computerised tomography study","volume":"42","author":"Hamada","year":"2018","journal-title":"Int. Orthop."},{"key":"10.1016\/j.phymed.2026.157961_bib0019","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1007\/s00264-015-3079-x","article-title":"A prospective cohort study of the clinical presentation of non-traumatic osteonecrosis of the femoral head: spine and knee symptoms as clinical presentation of hip osteonecrosis","volume":"40","author":"Hauzeur","year":"2016","journal-title":"Int. Orthop."},{"key":"10.1016\/j.phymed.2026.157961_bib0020","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1080\/21691401.2020.1774596","article-title":"Osteoclastic activity was associated with the development of steroid-induced osteonecrosis of femoral head","volume":"48","author":"He","year":"2020","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.phymed.2026.157961_bib0021","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.773758","article-title":"The therapeutic effect of Huo Xue Tong Luo capsules in association research circulation osseous (ARCO) Stage II osteonecrosis of the femoral head: a clinical study with an average follow-up period of 7.95 years","volume":"12","author":"He","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.157961_bib0022","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/716538","article-title":"Efficacy of alendronate for preventing collapse of femoral head in adult patients with nontraumatic osteonecrosis","volume":"2014","author":"Hong","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.phymed.2026.157961_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2020.104476","article-title":"Seven new chemical constituents from the roots of Gentiana macrophylla pall","volume":"141","author":"Hou","year":"2020","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phymed.2026.157961_bib0024","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jot.2020.03.014","article-title":"Chinese herbal Huo-Gu formula for the treatment of steroid-associated osteonecrosis of femoral head: A 14-year follow-up of convalescent SARS patients","volume":"23","author":"Huang","year":"2020","journal-title":"J. Orthop. Translat."},{"key":"10.1016\/j.phymed.2026.157961_bib0025","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10822-016-9900-9","article-title":"1001 Ways to run AutoDock Vina for virtual screening","volume":"30","author":"Jaghoori","year":"2016","journal-title":"J. Comput. Aided. Mol. Des."},{"key":"10.1016\/j.phymed.2026.157961_bib0026","doi-asserted-by":"crossref","first-page":"5592","DOI":"10.1210\/en.2006-0459","article-title":"Glucocorticoids act directly on osteoclasts to increase their life span and reduce bone density","volume":"147","author":"Jia","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.phymed.2026.157961_bib0027","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41392-023-01499-0","article-title":"Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms","volume":"8","author":"Jia","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2026.157961_bib0028","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/jbmr.4478","article-title":"Myeloid-specific PTP1B deficiency attenuates inflammation-induced and ovariectomy-induced bone loss in mice by inhibiting osteoclastogenesis","volume":"37","author":"Kim","year":"2022","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.phymed.2026.157961_bib0029","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ejim.2024.01.006","article-title":"Osteonecrosis risk after steroids-related treatment of COVID-19 is not negligible: A cross sectional study","volume":"123","author":"Koutalos","year":"2024","journal-title":"Eur. J. Intern. Med."},{"key":"10.1016\/j.phymed.2026.157961_bib0030","doi-asserted-by":"crossref","first-page":"6706","DOI":"10.1073\/pnas.85.18.6706","article-title":"cDNA cloning and expression of murine macrophage colony-stimulating factor from L929 cells","volume":"85","author":"Ladner","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.phymed.2026.157961_bib0031","first-page":"2155","article-title":"The use of alendronate to prevent early collapse of the femoral head in patients with nontraumatic osteonecrosis. A randomized clinical study","volume":"87","author":"Lai","year":"2005","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.phymed.2026.157961_bib0032","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.2106\/JBJS.N.01157","article-title":"Does zoledronate prevent femoral head collapse from osteonecrosis? A prospective, randomized, open-label, multicenter study","volume":"97","author":"Lee","year":"2015","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.phymed.2026.157961_bib0033","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jot.2017.11.001","article-title":"Herbal Fufang Xian Ling Gu Bao prevents corticosteroid-induced osteonecrosis of the femoral head-A first multicentre, randomised, double-blind, placebo-controlled clinical trial","volume":"12","author":"Li","year":"2018","journal-title":"J. Orthop. Translat."},{"key":"10.1016\/j.phymed.2026.157961_bib0035","first-page":"1003","article-title":"[Clinical observation of Yishen Huoxue decoction(YSHXD) for the treatment of non-traumatic osteonecrosis of femoral head at early and middle stage]","volume":"32","author":"Liu","year":"2019","journal-title":"Zhongguo Gu Shang."},{"key":"10.1016\/j.phymed.2026.157961_bib0036","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.jalz.2019.06.3918","article-title":"Multiple BACE1 inhibitors abnormally increase the BACE1 protein level in neurons by prolonging its half-life","volume":"15","author":"Liu","year":"2019","journal-title":"Alzheimers. Dement."},{"key":"10.1016\/j.phymed.2026.157961_bib0037","doi-asserted-by":"crossref","first-page":"4648","DOI":"10.7150\/thno.35414","article-title":"Loureirin B suppresses RANKL-induced osteoclastogenesis and ovariectomized osteoporosis via attenuating NFATc1 and ROS activities","volume":"9","author":"Liu","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2026.157961_bib0034","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/os.13584","article-title":"Denosumab can prevent collapse in patients with early-stage steroid-induced osteonecrosis of the femoral head by inhibiting osteoclasts and autophagy","volume":"15","author":"Liu","year":"2023","journal-title":"Orthop. Surg."},{"key":"10.1016\/j.phymed.2026.157961_bib0038","doi-asserted-by":"crossref","first-page":"7290","DOI":"10.1038\/s41598-024-57898-y","article-title":"A novel proteomic signature of osteoclast differentiation unveils the deubiquitinase UCHL1 as a necessary osteoclastogenic driver","volume":"14","author":"Materozzi","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2026.157961_bib0039","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/s41598-024-83376-6","article-title":"The pathomechanism of bone marrow edema in the femoral head necrosis with pericollapse stage","volume":"15","author":"Mo","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2026.157961_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157472","article-title":"Bisabolangelone targets CSF1R to impede osteoclastogenesis and attenuate estrogen-deficiency bone loss","volume":"148","author":"Mo","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.157961_bib0041","doi-asserted-by":"crossref","first-page":"4140","DOI":"10.1038\/s41598-024-54685-7","article-title":"The efficacy of Denosumab in the treatment of femoral head osteonecrosis: a retrospective comparative study","volume":"14","author":"Moon","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2026.157961_bib0042","doi-asserted-by":"crossref","first-page":"27096","DOI":"10.1039\/D5RA01244A","article-title":"A comparative chemical composition and main component content of various parts of Gentiana macrophylla Pall. by UPLC-Q-orbitrap MS and HPLC","volume":"15","author":"Mu","year":"2025","journal-title":"RSC Adv."},{"key":"10.1016\/j.phymed.2026.157961_bib0043","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/00003086-198606000-00037","article-title":"Results of conservative management of osteonecrosis of the femoral head. A retrospective review","author":"Musso","year":"1986","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.phymed.2026.157961_bib0044","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1006\/bbrc.1998.9788","article-title":"RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis","volume":"253","author":"Nakagawa","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phymed.2026.157961_bib0045","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-12196-8","article-title":"Excessive activation of TLR4\/NF-\u03baB interactively suppresses the canonical Wnt\/\u03b2-catenin pathway and induces SANFH in SD rats","volume":"7","author":"Pei","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2026.157961_bib0046","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1210\/endrev\/bnad016","article-title":"Treating the side effects of exogenous glucocorticoids; Can we separate the good from the bad?","volume":"44","author":"Pofi","year":"2023","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.phymed.2026.157961_bib0047","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/0300060514554724","article-title":"Biomarkers and pharmaceutical strategies in steroid-induced osteonecrosis of the femoral head: a literature review","volume":"43","author":"Qi","year":"2015","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.phymed.2026.157961_bib0048","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1080\/15548627.2015.1091141","article-title":"ER stress: Autophagy induction, inhibition and selection","volume":"11","author":"Rashid","year":"2015","journal-title":"Autophagy."},{"key":"10.1016\/j.phymed.2026.157961_bib0052","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s11914-022-00771-6","article-title":"Denosumab discontinuation","volume":"21","author":"S\u00f8lling","year":"2023","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.phymed.2026.157961_bib0049","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1007\/s00264-023-05761-6","article-title":"The outcomes of total hip replacement in osteonecrosis versus osteoarthritis: a systematic review and meta-analysis","volume":"47","author":"Salman","year":"2023","journal-title":"Int. Orthop."},{"key":"10.1016\/j.phymed.2026.157961_bib0050","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1016\/j.arth.2020.10.039","article-title":"Osteoarthritis and osteonecrosis in total hip arthroplasty: 90-Day postoperative costs and outcomes","volume":"36","author":"Sax","year":"2021","journal-title":"J. Arthroplasty."},{"key":"10.1016\/j.phymed.2026.157961_bib0051","unstructured":"Schr\u00f6dinger, L. & Delano, W. 2020. The PyMOL molecular graphics system, version 2.0 Schr\u00f6dinger, LLC (2017). http:\/\/www.pymol.org\/pymol."},{"key":"10.1016\/j.phymed.2026.157961_bib0053","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1016\/j.febslet.2009.06.047","article-title":"Regulatory mechanism of NFATc1 in RANKL-induced osteoclast activation","volume":"583","author":"Song","year":"2009","journal-title":"FEBS Lett."},{"key":"10.1016\/j.phymed.2026.157961_bib0054","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.0105-2896.2005.00327.x","article-title":"Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system","volume":"208","author":"Tanaka","year":"2005","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.phymed.2026.157961_bib0055","doi-asserted-by":"crossref","first-page":"733","DOI":"10.7150\/thno.17450","article-title":"Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated endoplasmic reticulum stress in rat osteonecrosis of the femoral head via the Akt\/Bad\/Bcl-2 signal pathway","volume":"7","author":"Tao","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.phymed.2026.157961_bib0059","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00198-015-3225-8","article-title":"Abnormal subchondral bone microstructure following steroid administration is involved in the early pathogenesis of steroid-induced osteonecrosis","volume":"27","author":"Wang","year":"2016","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.phymed.2026.157961_bib0056","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.gene.2018.05.091","article-title":"The pathogenesis of steroid-induced osteonecrosis of the femoral head: a systematic review of the literature","volume":"671","author":"Wang","year":"2018","journal-title":"Gene"},{"key":"10.1016\/j.phymed.2026.157961_bib0061","article-title":"Using network pharmacology and molecular docking to explore the mechanism of Shan Ci Gu (Cremastra appendiculata) against non-small cell lung cancer","volume":"9","author":"Wang","year":"2021","journal-title":"Front. Chem."},{"key":"10.1016\/j.phymed.2026.157961_bib0057","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1002\/jcp.30642","article-title":"Roburic acid attenuates osteoclastogenesis and bone resorption by targeting RANKL-induced intracellular signaling pathways","volume":"237","author":"Wang","year":"2022","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.phymed.2026.157961_bib0060","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1080\/14756366.2021.2018684","article-title":"Inhibitory effect of roburic acid in combination with docetaxel on human prostate cancer cells","volume":"37","author":"Wang","year":"2022","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.phymed.2026.157961_bib0058","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jot.2024.01.009","article-title":"Cycloastragenol prevents bone loss via inhibiting osteoclast activity in glucocorticoid-induced osteonecrosis of the femoral head: an in vivo study","volume":"45","author":"Wang","year":"2024","journal-title":"J. Orthop. Translat."},{"key":"10.1016\/j.phymed.2026.157961_bib0062","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jot.2018.11.002","article-title":"Huo Xue Tong Luo capsule, a vasoactive herbal formula prevents progression of asymptomatic osteonecrosis of femoral head: a prospective study","volume":"18","author":"Wei","year":"2019","journal-title":"J. Orthop. Translat."},{"key":"10.1016\/j.phymed.2026.157961_bib0063","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.1210\/en.2017-00662","article-title":"The pathophysiological sequence of glucocorticoid-induced osteonecrosis of the femoral head in male mice","volume":"158","author":"Weinstein","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.phymed.2026.157961_bib0064","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1186\/s13018-023-04435-8","article-title":"Systematic analysis of hip-preserving treatment for early osteonecrosis of the femoral head from the perspective of bibliometrics (2010-2023)","volume":"18","author":"Wu","year":"2023","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.phymed.2026.157961_bib0065","article-title":"Identification and validation of endoplasmic reticulum stress-related genes in patients with steroid-induced osteonecrosis of the femoral head","volume":"14","author":"Wu","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2026.157961_bib0067","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1359\/jbmr.2000.15.11.2178","article-title":"Cloning, sequencing, and functional characterization of the rat homologue of receptor activator of NF-kappaB ligand","volume":"15","author":"Xu","year":"2000","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.phymed.2026.157961_bib0066","article-title":"Roburic acid targets TNF to inhibit the NF-\u03baB signaling pathway and suppress human colorectal cancer cell growth","volume":"13","author":"Xu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.phymed.2026.157961_bib0068","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s10822-016-9915-2","article-title":"TargetNet: a web service for predicting potential drug-target interaction profiling via multi-target SAR models","volume":"30","author":"Yao","year":"2016","journal-title":"J. Comput. Aided. Mol. Des."},{"key":"10.1016\/j.phymed.2026.157961_bib0069","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.tibs.2010.03.004","article-title":"PTP1B: a double agent in metabolism and oncogenesis","volume":"35","author":"Yip","year":"2010","journal-title":"Trends. Biochem. Sci."},{"key":"10.1016\/j.phymed.2026.157961_bib0070","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jep.2004.06.025","article-title":"Inhibitory effects of the Gentiana macrophylla (Gentianaceae) extract on rheumatoid arthritis of rats","volume":"95","author":"Yu","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.157961_bib0071","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00198-015-3317-5","article-title":"The use of bisphosphonate in the treatment of osteonecrosis of the femoral head: a meta-analysis of randomized control trials","volume":"27","author":"Yuan","year":"2016","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.phymed.2026.157961_bib0072","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/s13018-024-04711-1","article-title":"Exosomes derived from M2 macrophages prevent steroid-induced osteonecrosis of the femoral head by modulating inflammation, promoting bone formation and inhibiting bone resorption","volume":"19","author":"Yuan","year":"2024","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.phymed.2026.157961_bib0075","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.drudis.2007.03.011","article-title":"PTP1B as a drug target: recent developments in PTP1B inhibitor discovery","volume":"12","author":"Zhang","year":"2007","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.phymed.2026.157961_bib0074","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.4103\/0366-6999.244111","article-title":"Pericollapse stage of osteonecrosis of the femoral head: a last chance for joint preservation","volume":"131","author":"Zhang","year":"2018","journal-title":"Chin. Med. J. (Engl)"},{"key":"10.1016\/j.phymed.2026.157961_bib0073","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s13018-025-05541-5","article-title":"Association of serum and local GRP78 and CHOP expressions with disease progression in patients with non-traumatic osteonecrosis of femoral head","volume":"20","author":"Zhang","year":"2025","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.phymed.2026.157961_bib0076","doi-asserted-by":"crossref","first-page":"e8834","DOI":"10.1097\/MD.0000000000008834","article-title":"Clinical analysis of 23 cases of steroid-associated osteonecrosis of the femoral head with normal initial magnetic resonance imaging presentation","volume":"96","author":"Zhao","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.phymed.2026.157961_bib0077","article-title":"Dopamine D1 receptor contributes to glucocorticoid-associated osteonecrosis of femoral head protection through the ATF3\/CHOP axis to inhibit osteoblastic apoptosis","volume":"12","author":"Zheng","year":"2025","journal-title":"Adv. Sci. (Weinh)"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326001984?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326001984?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T16:09:41Z","timestamp":1778515781000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326001984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":77,"alternative-id":["S0944711326001984"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.157961","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Roburic acid inhibits glucocorticoid-induced osteonecrosis of the femoral head associated osteoclast activity via targeting PTP1B","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.157961","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157961"}}