{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:38:08Z","timestamp":1788388688481,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["211142095031"],"award-info":[{"award-number":["211142095031"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004609","name":"Foundation of Henan Educational Committee","doi-asserted-by":"publisher","award":["23B0018"],"award-info":[{"award-number":["23B0018"]}],"id":[{"id":"10.13039\/501100004609","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204489"],"award-info":[{"award-number":["82204489"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016510","name":"Center for Autonomous Systems and Technologies","doi-asserted-by":"publisher","award":["2023QNRC001"],"award-info":[{"award-number":["2023QNRC001"]}],"id":[{"id":"10.13039\/100016510","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.phymed.2026.157972","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T07:32:04Z","timestamp":1771054324000},"page":"157972","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Bruceine D ameliorates cholestatic liver injury by selectively modulating bile acid synthesis and activating FXR\u2013SHP signaling"],"prefix":"10.1016","volume":"153","author":[{"given":"Chuankui","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.phymed.2026.157972_bib0001","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.jhep.2023.07.034","article-title":"FXR agonists in NASH treatment","volume":"79","author":"Adorini","year":"2023","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.phymed.2026.157972_bib0002","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.bbadis.2017.06.025","article-title":"Bile acids, FGF15\/19 and liver regeneration: from mechanisms to clinical applications","volume":"1864","author":"Alvarez-Sola","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis. Dis."},{"issue":"20","key":"10.1016\/j.phymed.2026.157972_bib0003","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3390\/ijms252011213","article-title":"Activation of Nrf2 and FXR via natural compounds in liver inflammatory disease","volume":"25","author":"Belka","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.phymed.2026.157972_bib0004","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1172\/jci.insight.174164","article-title":"Intestinal FGF15 regulates bile acid and cholesterol metabolism but not glucose and energy balance","volume":"9","author":"Bozadjieva-Kramer","year":"2024","journal-title":"JCI Insight"},{"key":"10.1016\/j.phymed.2026.157972_bib0005","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.pharmthera.2022.108238","article-title":"Bile acid metabolism and signaling, the microbiota, and metabolic disease","volume":"237","author":"Cai","year":"2022","journal-title":"Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.phymed.2026.157972_bib0006","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.jhep.2023.08.016","article-title":"A+T rich interaction domain protein 3a (Arid3a) impairs Mertk-mediated efferocytosis in cholestasis","volume":"79","author":"Chen","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phymed.2026.157972_bib0007","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.canlet.2017.06.014","article-title":"Bruceine D inhibits hepatocellular carcinoma growth by targeting \u03b2-catenin\/jagged1 pathways","volume":"403","author":"Cheng","year":"2017","journal-title":"Cancer Lett."},{"issue":"6","key":"10.1016\/j.phymed.2026.157972_bib0008","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.jhep.2021.01.028","article-title":"STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway","volume":"74","author":"Conde de la Rosa","year":"2021","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.phymed.2026.157972_bib0009","doi-asserted-by":"crossref","first-page":"s4","DOI":"10.5604\/01.3001.0010.5493","volume":"16","author":"Di Ciaula","year":"2017","journal-title":"Bile Acid Physiol. Ann Hepatol."},{"key":"10.1016\/j.phymed.2026.157972_bib0010","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.phymed.2025.157130","article-title":"Capsaicin ameliorates cholestasis through modulation of the FXR-SHP and FXR-FGF15 gut-liver axis in mice","volume":"146","author":"Du","year":"2025","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.phymed.2026.157972_bib0011","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41419-020-2317-3","article-title":"Bruceine D induces lung cancer cell apoptosis and autophagy via the ROS\/MAPK signaling pathway in vitro and in vivo","volume":"11","author":"Fan","year":"2020","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.phymed.2026.157972_bib0012","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jhep.2024.09.032","article-title":"Bile acid metabolism and signalling in liver disease","volume":"82","author":"Fuchs","year":"2025","journal-title":"J. Hepatol."},{"issue":"2","key":"10.1016\/j.phymed.2026.157972_bib0013","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jhep.2023.10.035","article-title":"Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis","volume":"80","author":"Ghallab","year":"2024","journal-title":"J. Hepatol."},{"issue":"10","key":"10.1016\/j.phymed.2026.157972_bib0014","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s40265-021-01545-7","article-title":"Cholestatic liver disease: current treatment strategies and new therapeutic agents","volume":"81","author":"Hasegawa","year":"2021","journal-title":"Drugs"},{"issue":"9","key":"10.1016\/j.phymed.2026.157972_bib0015","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1136\/gutjnl-2017-315259","article-title":"The British Society of Gastroenterology\/UK-PBC primary biliary cholangitis treatment and management guidelines","volume":"67","author":"Hirschfield","year":"2018","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.phymed.2026.157972_bib0016","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/HEP.0000000000000395","article-title":"Seladelpar efficacy and safety at 3 months in patients with primary biliary cholangitis: ENHANCE, a phase 3, randomized, placebo-controlled study","volume":"78","author":"Hirschfield","year":"2023","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.phymed.2026.157972_bib0017","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1016\/j.apsb.2021.05.009","article-title":"Bruceine D inhibits HIF-1\u03b1-mediated glucose metabolism in hepatocellular carcinoma by blocking ICAT\/\u03b2-catenin interaction","volume":"11","author":"Huang","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"6","key":"10.1016\/j.phymed.2026.157972_bib0018","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1002\/hep.32437","article-title":"Cholestatic liver diseases of genetic etiology: advances and controversies","volume":"75","author":"Ibrahim","year":"2022","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.phymed.2026.157972_bib0019","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s11427-023-2353-0","article-title":"Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis","volume":"67","author":"Jia","year":"2024","journal-title":"Sci. China Life Sci."},{"issue":"5","key":"10.1016\/j.phymed.2026.157972_bib0020","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s13238-020-00804-9","article-title":"Targeting the alternative bile acid synthetic pathway for metabolic diseases","volume":"12","author":"Jia","year":"2021","journal-title":"Protein Cell"},{"issue":"2","key":"10.1016\/j.phymed.2026.157972_bib0021","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrgastro.2017.119","article-title":"Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis","volume":"15","author":"Jia","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.phymed.2026.157972_bib0022","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/ajg.2016.517","article-title":"ACG clinical guideline: evaluation of abnormal liver chemistries","volume":"112","author":"Kwo","year":"2017","journal-title":"Am. J. Gastroenterol."},{"issue":"8","key":"10.1016\/j.phymed.2026.157972_bib0023","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1016\/j.cgh.2023.02.005","article-title":"New treatment paradigms in primary biliary cholangitis","volume":"21","author":"Levy","year":"2023","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"5","key":"10.1016\/j.phymed.2026.157972_bib0024","first-page":"849","article-title":"Bruceine D inhibits cell proliferation through downregulating LINC01667\/MicroRNA-138-5p\/Cyclin E1 axis in gastric cancer","volume":"11","author":"Li","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.phymed.2026.157972_bib0025","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.chom.2023.12.015","article-title":"A gut microbiota-bile acid axis promotes intestinal homeostasis upon aspirin-mediated damage","volume":"32","author":"Li","year":"2024","journal-title":"Cell Host. Microbe"},{"issue":"17","key":"10.1016\/j.phymed.2026.157972_bib0026","first-page":"79","article-title":"Bruceine D inhibits CAF-promoted angiogenesis of breast cancer via suppressing IL-6-mediated activation of the STAT3\/Notch1\/VEGFR2 axis","volume":"1003","author":"Ma","year":"2025","journal-title":"Eur. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.phymed.2026.157972_bib0027","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.chom.2024.06.008","article-title":"Dietary fiber alleviates alcoholic liver injury via Bacteroides acidifaciens and subsequent ammonia detoxification","volume":"32","author":"Shen","year":"2024","journal-title":"Cell Host. Microbe"},{"issue":"1","key":"10.1016\/j.phymed.2026.157972_bib0028","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/imt2.272","article-title":"Cross-tissue multi-omics analyses reveal the gut microbiota's absence impacts organ morphology, immune homeostasis, bile acid and lipid metabolism","volume":"4","author":"Shen","year":"2025","journal-title":"Imeta."},{"issue":"1","key":"10.1016\/j.phymed.2026.157972_bib0029","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.cmet.2024.09.008","article-title":"Hepatic FXR-FGF4 is required for bile acid homeostasis via an FGFR4-LRH-1 signal node under cholestatic stress","volume":"37","author":"Song","year":"2025","journal-title":"Cell Metab."},{"issue":"38","key":"10.1016\/j.phymed.2026.157972_bib0030","doi-asserted-by":"crossref","first-page":"12014","DOI":"10.1021\/acs.jafc.2c04817","article-title":"Nuciferine protects against high-fat diet-induced hepatic steatosis via modulation of gut microbiota and bile acid metabolism in rats","volume":"70","author":"Sun","year":"2022","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.phymed.2026.157972_bib0031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40265-023-01979-1","article-title":"New therapies on the horizon for primary biliary cholangitis","volume":"84","author":"Tanaka","year":"2024","journal-title":"Drugs"},{"key":"10.1016\/j.phymed.2026.157972_bib0032","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jare.2023.05.012","article-title":"Targeting Trop2 by Bruceine D suppresses breast cancer metastasis by blocking Trop2\/\u03b2-catenin positive feedback loop","volume":"58","author":"Tang","year":"2024","journal-title":"J. Adv. Res."},{"issue":"1","key":"10.1016\/j.phymed.2026.157972_bib0033","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1136\/gutjnl-2021-324305","article-title":"Novel therapeutic targets for cholestatic and fatty liver disease","volume":"71","author":"Trauner","year":"2022","journal-title":"Gut"},{"issue":"6730","key":"10.1016\/j.phymed.2026.157972_bib0034","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1126\/science.adl4100","article-title":"Bile acid synthesis impedes tumor-specific T cell responses during liver cancer","volume":"387","author":"Varanasi","year":"2025","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.phymed.2026.157972_bib0035","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1002\/hep.31484","article-title":"Functional role of the secretin\/secretin receptor signaling during cholestatic liver injury","volume":"72","author":"Wu","year":"2020","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.phymed.2026.157972_bib0036","first-page":"2406","article-title":"Clostridium scindens protects against vancomycin-induced cholestasis and liver fibrosis by activating intestinal FXR-FGF15\/19 signaling","volume":"12","author":"Xiao","year":"2025","journal-title":"Adv. Sci. (Weinh)"},{"issue":"1","key":"10.1016\/j.phymed.2026.157972_bib0037","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/s40168-023-01709-5","article-title":"Gut microbiota-bile acid crosstalk regulates murine lipid metabolism via the intestinal FXR-FGF19 axis in diet-induced humanized dyslipidemia","volume":"11","author":"Xu","year":"2023","journal-title":"Microbiome"},{"issue":"1","key":"10.1016\/j.phymed.2026.157972_bib0038","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s13578-023-01035-1","article-title":"Bile acid-mediated signaling in cholestatic liver diseases","volume":"13","author":"Zeng","year":"2023","journal-title":"Cell Biosci."},{"issue":"1","key":"10.1016\/j.phymed.2026.157972_bib0039","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13046-022-02270-z","article-title":"Brucein D augments the chemosensitivity of gemcitabine in pancreatic cancer via inhibiting the Nrf2 pathway","volume":"41","author":"Zhang","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326002096?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326002096?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:52:40Z","timestamp":1777593160000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326002096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":39,"alternative-id":["S0944711326002096"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.157972","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bruceine D ameliorates cholestatic liver injury by selectively modulating bile acid synthesis and activating FXR\u2013SHP signaling","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.157972","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157972"}}