{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:22:04Z","timestamp":1781659324560,"version":"3.54.5"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370829"],"award-info":[{"award-number":["82370829"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20814"],"award-info":[{"award-number":["U24A20814"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017599","name":"Science and Technology Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2026ZL0494"],"award-info":[{"award-number":["2026ZL0494"]}],"id":[{"id":"10.13039\/501100017599","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.phymed.2026.157976","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T23:34:44Z","timestamp":1771112084000},"page":"157976","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Lycorine improves inflammatory imbalance in diabetic cardiomyopathy by targeting ILF3"],"prefix":"10.1016","volume":"153","author":[{"given":"Qian","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanyan","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenjie","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingnan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8945-3107","authenticated-orcid":false,"given":"Zheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3026-718X","authenticated-orcid":false,"given":"Nipon","family":"Chattipakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8278-849X","authenticated-orcid":false,"given":"Guang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.157976_bib0001","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.it.2022.07.004","article-title":"NF-kappaB: blending metabolism, immunity, and inflammation","volume":"43","author":"Capece","year":"2022","journal-title":"Trends. Immunol."},{"key":"10.1016\/j.phymed.2026.157976_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107268","article-title":"Nrf2 mediated signaling axis in heart failure: potential pharmacological receptor","volume":"206","author":"Cheng","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2026.157976_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2024.156062","article-title":"Targeting endoplasmic reticulum stress as a potential therapeutic strategy for diabetic cardiomyopathy","volume":"162","author":"Congur","year":"2025","journal-title":"Metabolism"},{"key":"10.1016\/j.phymed.2026.157976_bib0004","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s12933-025-02734-4","article-title":"Dysregulated inflammation, oxidative stress, and protein quality control in diabetic HFpEF: unraveling mechanisms and therapeutic targets","volume":"24","author":"Delalat","year":"2025","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.phymed.2026.157976_bib0005","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S2213-8587(25)00299-2","article-title":"11th edition of the IDF diabetes atlas: global, regional, and national diabetes prevalence estimates for 2024 and projections for 2050","volume":"14","author":"Genitsaridi","year":"2025","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.phymed.2026.157976_bib0006","doi-asserted-by":"crossref","first-page":"780","DOI":"10.2337\/db23-0700","article-title":"Macrophage SHP2 deficiency alleviates diabetic nephropathy via suppression of MAPK\/NF-kappaB-dependent inflammation","volume":"73","author":"Han","year":"2024","journal-title":"Diabetes"},{"key":"10.1016\/j.phymed.2026.157976_bib0007","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1161\/CIRCULATIONAHA.122.059631","article-title":"FGF21-Sirtuin 3 axis confers the protective effects of exercise against diabetic cardiomyopathy by governing mitochondrial integrity","volume":"146","author":"Jin","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.phymed.2026.157976_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104884","article-title":"Lycorine ameliorates bleomycin-induced pulmonary fibrosis via inhibiting NLRP3 inflammasome activation and pyroptosis","volume":"158","author":"Liang","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2026.157976_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102389","article-title":"Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway","volume":"54","author":"Liu","year":"2022","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2026.157976_bib0010","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.freeradbiomed.2024.01.015","article-title":"Cardiovascular benefits of SGLT2 inhibitors and GLP-1 receptor agonists through effects on mitochondrial function and oxidative stress","volume":"213","author":"Luna-Marco","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2026.157976_bib0011","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.freeradbiomed.2024.12.049","article-title":"Lipotoxicity-induced upregulation of FIS1 exacerbates mitochondrial fragmentation and promotes NLRP3-dependent pyroptosis in diabetic cardiomyopathy","volume":"228","author":"Luo","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2026.157976_bib0012","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202202590","article-title":"Schisandrin B attenuates diabetic cardiomyopathy by targeting MyD88 and inhibiting MyD88-dependent inflammation","volume":"9","author":"Luo","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.phymed.2026.157976_bib0013","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.4049\/jimmunol.2001235","article-title":"ILF3 is a negative transcriptional regulator of innate immune responses and myeloid dendritic cell maturation","volume":"206","author":"Nazitto","year":"2021","journal-title":"J. Immunol."},{"key":"10.1016\/j.phymed.2026.157976_bib0014","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1161\/CIRCRESAHA.125.326154","article-title":"Mitochondrial NNT promotes diastolic dysfunction in cardiometabolic HFpEF","volume":"136","author":"Pepin","year":"2025","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2026.157976_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107515","article-title":"PPARbeta\/delta prevents inflammation and fibrosis during diabetic cardiomyopathy","volume":"210","author":"Rostami","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2026.157976_bib0016","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41467-024-55557-4","article-title":"The transcriptional repressor HEY2 regulates mitochondrial oxidative respiration to maintain cardiac homeostasis","volume":"16","author":"She","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.157976_bib0017","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41569-020-0339-2","article-title":"Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence","volume":"17","author":"Tan","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.phymed.2026.157976_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155464","article-title":"Lycorine inhibits Ang II-induced heart remodeling and inflammation by suppressing the PI3K-AKT\/NF-kappaB pathway","volume":"128","author":"Tuo","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.157976_bib0019","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s12933-021-01378-4","article-title":"Diabetes status-related differences in risk factors and mediators of heart failure in the general population: results from the MORGAM\/BiomarCaRE consortium","volume":"20","author":"Vuori","year":"2021","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.phymed.2026.157976_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154987","article-title":"beta-elemene alleviates hyperglycemia-induced cardiac inflammation and remodeling by inhibiting the JAK\/STAT3-NF-kappaB pathway","volume":"119","author":"Wang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.157976_bib0021","doi-asserted-by":"crossref","first-page":"7249","DOI":"10.1038\/s41467-024-51030-4","article-title":"Macrophage ILF3 promotes abdominal aortic aneurysm by inducing inflammatory imbalance in male mice","volume":"15","author":"Wang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.157976_bib0022","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.freeradbiomed.2023.11.032","article-title":"Upregulation of NF-kappaB by USP24 aggravates ferroptosis in diabetic cardiomyopathy","volume":"210","author":"Wu","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2026.157976_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154266","article-title":"Lycorine and organ protection: review of its potential effects and molecular mechanisms","volume":"104","author":"Xiao","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.157976_bib0024","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1038\/s41467-024-49315-9","article-title":"Smooth muscle NF90 deficiency ameliorates diabetic atherosclerotic calcification in male mice via FBXW7-AGER1-AGEs axis","volume":"15","author":"Xie","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.157976_bib0025","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1161\/CIRCRESAHA.121.319478","article-title":"Targeting CaMKII-delta9 ameliorates cardiac ischemia\/reperfusion injury by inhibiting myocardial inflammation","volume":"130","author":"Yao","year":"2022","journal-title":"Circ. Res."},{"key":"10.1016\/j.phymed.2026.157976_bib0026","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/s12933-025-02777-7","article-title":"Impact of sodium-glucose transport protein-2 (SGLT2) inhibitors on the inflammasome pathway in acute myocardial infarction in type 2 diabetes mellitus: a comprehensive review","volume":"24","author":"Yoo","year":"2025","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.phymed.2026.157976_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105985","article-title":"Lycorine improves peripheral nerve function by promoting schwann cell autophagy via AMPK pathway activation and MMP9 downregulation in diabetic peripheral neuropathy","volume":"175","author":"Yuan","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phymed.2026.157976_bib0028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2023.01.010","article-title":"Lycorine protects against septic myocardial injury by activating AMPK-related pathways","volume":"197","author":"Zhao","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2026.157976_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153578","article-title":"Lycorine, a natural alkaloid, promotes the degradation of alpha-synuclein via PKA-mediated UPS activation in transgenic Parkinson's disease models","volume":"87","author":"Zhu","year":"2021","journal-title":"Phytomedicine"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326002138?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326002138?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:53:57Z","timestamp":1777593237000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326002138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":29,"alternative-id":["S0944711326002138"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.157976","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lycorine improves inflammatory imbalance in diabetic cardiomyopathy by targeting ILF3","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.157976","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157976"}}