{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:20:28Z","timestamp":1790011228934,"version":"4.0.1"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173738"],"award-info":[{"award-number":["82173738"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004775","name":"Gansu Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["23JRRA1667"],"award-info":[{"award-number":["23JRRA1667"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.phymed.2026.157992","type":"journal-article","created":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T23:08:08Z","timestamp":1771801688000},"page":"157992","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Resveratrol dual efficacy in high-altitude hypoxia and NAFLD: inhibits ferroptosis by modulating key proteins, including HIF-1\u03b1, ACSL4, and TfR1"],"prefix":"10.1016","volume":"153","author":[{"given":"Minghui","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfang","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuyixuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianlong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.157992_bib0001","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2025.1600374","article-title":"Dysregulation of metabolites and high-altitude illnesses development under plateau conditions","volume":"16","author":"Bai","year":"2025","journal-title":"Front. Physiol."},{"issue":"4","key":"10.1016\/j.phymed.2026.157992_bib0002","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3350\/cmh.2024.0562","volume":"30","author":"Bae","year":"2024","journal-title":"Clin. Mol. Hepatol."},{"key":"10.1016\/j.phymed.2026.157992_bib0003","first-page":"507","article-title":"Changes of ferroptosis related pathways in hippocampus of mice exposed to high-altitude hypoxia","volume":"76","author":"Chang","year":"2024","journal-title":"Acta Physiol. Sin."},{"issue":"3","key":"10.1016\/j.phymed.2026.157992_bib0004","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41418-022-00941-0","article-title":"The multifaceted role of ferroptosis in liver disease","volume":"29","author":"Chen","year":"2022","journal-title":"Cell Death Differ."},{"issue":"2","key":"10.1016\/j.phymed.2026.157992_bib0005","article-title":"Ferroptosis: the dawn of reversing drug resistance in digestive cancers","volume":"13","author":"Chen","year":"2026","journal-title":"Genes Dis."},{"issue":"3","key":"10.1016\/j.phymed.2026.157992_bib0006","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2337\/db22-0553","article-title":"Isorhapontigenin attenuates cardiac microvascular injury in diabetes via the inhibition of mitochondria-associated ferroptosis through PRDX2-MFN2-ACSL4 pathways","volume":"72","author":"Chen","year":"2023","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.phymed.2026.157992_bib0007","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s41065-025-00453-0","article-title":"RBM15 promotes hypoxia\/reoxygenation-induced ferroptosis in human cardiomyocytes by mediating m6A modification of ACSL4","volume":"162","author":"Cheng","year":"2025","journal-title":"Hereditas"},{"issue":"12","key":"10.1016\/j.phymed.2026.157992_bib0008","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/s41589-019-0408-1","article-title":"The chemical basis of ferroptosis","volume":"15","author":"Conrad","year":"2019","journal-title":"Nat. Chem. Biol."},{"issue":"16","key":"10.1016\/j.phymed.2026.157992_bib0009","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21165611","article-title":"Hypoxia and HIF signaling: one axis with divergent effects","volume":"21","author":"Corrado","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.phymed.2026.157992_bib0010","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1002\/ueg2.70072","article-title":"The rising global burden of MASLD and other metabolic diseases (2000-2021)","volume":"13","author":"Danpanichkul","year":"2025","journal-title":"United Eur. Gastroenterol. J."},{"issue":"1","key":"10.1016\/j.phymed.2026.157992_bib0011","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nchembio.1416","article-title":"The role of iron and reactive oxygen species in cell death","volume":"10","author":"Dixon","year":"2014","journal-title":"Nat. Chem. Biol."},{"issue":"1","key":"10.1016\/j.phymed.2026.157992_bib0012","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00018-025-05958-5","article-title":"Ferroptosis inhibitors: mechanisms of action and therapeutic potential","volume":"82","author":"Duo","year":"2025","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.phymed.2026.157992_bib0013","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jhep.2020.03.039","article-title":"A new definition for metabolic dysfunction-associated fatty liver disease: an international expert consensus statement","volume":"73","author":"Eslam","year":"2020","journal-title":"J. Hepatol."},{"issue":"6","key":"10.1016\/j.phymed.2026.157992_bib0014","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s12072-020-10094-2","article-title":"The Asian Pacific association for the study of the liver clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease","volume":"14","author":"Eslam","year":"2020","journal-title":"Hepatol. Int."},{"key":"10.1016\/j.phymed.2026.157992_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114538","article-title":"Effect of ferroptosis on chronic cerebral hypoperfusion in vascular dementia","volume":"370","author":"Fu","year":"2023","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.phymed.2026.157992_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117135","article-title":"Chronic hypoxia drives the occurrence of ferroptosis in liver of fat greening (Hexagrammos otakii) by activating HIF-1\u03b1 and promoting iron production","volume":"285","author":"Gao","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.phymed.2026.157992_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2025.189528","article-title":"Targeting ferroptosis with flavonoids for cancer therapy: mechanisms and opportunities","volume":"1881","author":"Gong","year":"2026","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.phymed.2026.157992_bib0018","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1661050","article-title":"Exploring the mechanism of Qingre Yishen Xiaozheng formula in treating diabetic kidney disease via the HIF-1\u03b1\/HO-1 signaling pathway: an integrated network pharmacology and experimental study","volume":"16","author":"Han","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.157992_bib0019","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1230783","article-title":"Integrative evidence construction for resveratrol treatment of nonalcoholic fatty liver disease: preclinical and clinical meta-analyses","volume":"14","author":"He","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"8","key":"10.1016\/j.phymed.2026.157992_bib0020","article-title":"Normalization of oxygen levels induces a metabolic reprogramming in livers exposed to intermittent hypoxia mimicking obstructive sleep apnea","volume":"14","author":"Hern\u00e1ndez-Garc\u00eda","year":"2025","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.phymed.2026.157992_bib0021","doi-asserted-by":"crossref","DOI":"10.1097\/HEP.0000000000001606","article-title":"KLF9 drives intermittent hypoxia-induced NAFLD by suppressing the NR4A1-p38 MAPK hepatic metabolic axis","author":"Hua","year":"2025","journal-title":"Hepatology"},{"key":"10.1016\/j.phymed.2026.157992_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2025.112212","article-title":"Ferroptosis modulation by METTL14 in cancers: from molecular insights to therapeutic strategies","volume":"138","author":"Huang","year":"2026","journal-title":"Cell Signal."},{"key":"10.1016\/j.phymed.2026.157992_bib0023","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jes.2025.04.059","article-title":"Ferroptosis involved in inhaled polystyrene microplastics leaded myocardial fibrosis through HIF-ROS-SLC7A11\/GPX4 pathway","volume":"159","author":"Huang","year":"2026","journal-title":"J. Environ. Sci."},{"issue":"1","key":"10.1016\/j.phymed.2026.157992_bib0024","doi-asserted-by":"crossref","DOI":"10.1080\/21505594.2025.2546680","article-title":"Roles of hypoxia inducible factors in viral infection: are they a potential therapeutic target?","volume":"16","author":"Jia","year":"2025","journal-title":"Virulence"},{"key":"10.1016\/j.phymed.2026.157992_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102963","article-title":"Arbutin alleviates fatty liver by inhibiting ferroptosis via FTO\/SLC7A11 pathway","volume":"68","author":"Jiang","year":"2023","journal-title":"Redox Biol."},{"issue":"11\u201312","key":"10.1016\/j.phymed.2026.157992_bib0026","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1080\/10715762.2023.2169683","article-title":"Transferrin-mediated increase of labile iron pool following simulated ischemia causes lipid peroxidation during the early phase of reperfusion","volume":"56","author":"Lee","year":"2022","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.phymed.2026.157992_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2026.118377","article-title":"Evaluating ferroptosis susceptibility by monitoring lipid peroxidation in endoplasmic reticulum with a tailored fluorescence probe","volume":"297","author":"Li","year":"2026","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.phymed.2026.157992_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.178375","article-title":"Empagliflozin alleviates iron accumulation and ferroptosis to mitigate bleomycin-induced pulmonary fibrosis through TFEB-mediated regulation of ACSL4 and GPX4","volume":"1010","author":"Li","year":"2026","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2026.157992_bib0029","first-page":"705","article-title":"Research progress on the rapid ascent of people with chronic underlying diseases to high altitudes","volume":"53","author":"Lian","year":"2025","journal-title":"Mod. Med. J."},{"key":"10.1016\/j.phymed.2026.157992_bib0030","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/5157417","article-title":"Enriched environment attenuates ferroptosis after cerebral ischemia\/reperfusion injury via the HIF-1\u03b1-ACSL4 pathway","volume":"2023","author":"Liu","year":"2023","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.phymed.2026.157992_bib0031","article-title":"Efficacy of flavonoids in non-alcoholic fatty liver disease: an updated systematic review and meta-analysis","volume":"12","author":"Liu","year":"2025","journal-title":"Front. Nutr."},{"key":"10.1016\/j.phymed.2026.157992_bib0032","first-page":"3925","article-title":"Advances in regulation of hypoxia on adipocyte development and lipid metabolism","volume":"39","author":"Liu","year":"2023","journal-title":"Chin. J. Biotechnol."},{"key":"10.1016\/j.phymed.2026.157992_bib0033","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.freeradbiomed.2025.06.050","article-title":"Chronic intermittent hypoxia exacerbates the progression of NAFLD via SPP1-mediated inflammatory polarization in macrophages","volume":"238","author":"Lu","year":"2025","journal-title":"Free Radic. Biol. Med."},{"issue":"7","key":"10.1016\/j.phymed.2026.157992_bib0034","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0025-6196(24)00530-5","article-title":"Nonalcoholic steatohepatitis: Mayo clinic experiences with a hitherto unnamed disease","volume":"55","author":"Ludwig","year":"1980","journal-title":"Mayo Clin. Proc."},{"issue":"1","key":"10.1016\/j.phymed.2026.157992_bib0035","doi-asserted-by":"crossref","first-page":"E92","DOI":"10.1152\/ajpendo.00287.2023","article-title":"Hepatocyte HIF-2\u03b1 aggravates NAFLD by inducing ferroptosis through increasing extracellular iron","volume":"328","author":"Luo","year":"2025","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.phymed.2026.157992_bib0036","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1007\/s12265-025-10671-6","article-title":"Hypoxia aggravates myocardial ischemia\/reperfusion injury through the promotion of ferroptosis via ACSL4 lactylation","volume":"18","author":"Lv","year":"2025","journal-title":"J. Cardiovasc. Transl. Res."},{"issue":"1","key":"10.1016\/j.phymed.2026.157992_bib0037","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-12357-0","article-title":"In silico and in vitro investigations reveal pan-PPAR agonist activity and anti-NAFLD efficacy of polydatin by modulating hepatic lipid-energy metabolism","volume":"15","author":"Mandal","year":"2025","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.phymed.2026.157992_bib0038","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/s42003-020-01367-5","article-title":"Fatty-acid-induced FABP5\/HIF-1 reprograms lipid metabolism and enhances the proliferation of liver cancer cells","volume":"3","author":"Seo","year":"2020","journal-title":"Commun. Biol."},{"key":"10.1016\/j.phymed.2026.157992_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116780","article-title":"Study on the mechanism of Shuganzhi tablet against nonalcoholic fatty liver disease and lipid regulation effects of its main substances in vitro","volume":"316","author":"Tang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.157992_bib0040","first-page":"636","article-title":"A study on the acute mountain sickness and mental health of the medical personnel rushing to plateau during public health emergencies","volume":"59","author":"Tian","year":"2023","journal-title":"Chin. J. Med."},{"issue":"9","key":"10.1016\/j.phymed.2026.157992_bib0041","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1016\/j.apsb.2022.02.003","article-title":"Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease","volume":"12","author":"Tong","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2026.157992_bib0042","article-title":"Association between obstructive sleep apnoea and liver fibrosis in patients with suspected nonalcoholic fatty liver disease","author":"Trzepizur","year":"2025","journal-title":"Sleep"},{"key":"10.1016\/j.phymed.2026.157992_bib0043","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: the role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.phymed.2026.157992_bib0044","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2446391","article-title":"Gut microbiota-derived 4-hydroxyphenylacetic acid from resveratrol supplementation prevents obesity through SIRT1 signaling activation","volume":"17","author":"Wang","year":"2025","journal-title":"Gut Microbes"},{"issue":"2","key":"10.1016\/j.phymed.2026.157992_bib0045","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.apsb.2021.10.005","article-title":"Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK\/NRF2 pathways","volume":"12","author":"Wang","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2026.157992_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.108054","article-title":"Proteolysis targeting chimera degraders target pseudokinases to treat metabolic dysfunction-associated steatohepatitis and fibrosis: mechanisms and therapeutic insights","volume":"222","author":"Wang","year":"2025","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.phymed.2026.157992_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcmgh.2025.101633","article-title":"Glycogen synthase kinase 3 \u03b2 hepatocyte deletion attenuates ferroptosis and metabolic dysfunction-associated steatohepatitis in mice","volume":"20","author":"Warasnhe","year":"2026","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.phymed.2026.157992_bib0048","first-page":"10","article-title":"Network pharmacology-based investigation of the mechanism of Liupao tea polyphenol extract in preventing MAFLD via the hepatic EGFR-AKT pathway","author":"Wei","year":"2026","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.phymed.2026.157992_bib0049","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2025.2500099","article-title":"Advances in the acting mechanism and treatment of gut microbiota in metabolic dysfunction-associated steatotic liver disease","volume":"17","author":"Wu","year":"2025","journal-title":"Gut Microbes"},{"issue":"1","key":"10.1016\/j.phymed.2026.157992_bib0050","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1186\/s13098-025-01932-0","article-title":"Global burden of chronic liver disease due to NAFLD from 2012 to 2021: a trend, decomposition, and health inequality analysis","volume":"17","author":"Wu","year":"2025","journal-title":"Diabetol. Metab. Syndr."},{"issue":"9","key":"10.1016\/j.phymed.2026.157992_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.burns.2024.07.002","article-title":"Resveratrol promotes diabetic wound healing by inhibiting ferroptosis in vascular endothelial cells","volume":"50","author":"Xiao","year":"2024","journal-title":"Burns"},{"key":"10.1016\/j.phymed.2026.157992_bib0052","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.2147\/JIR.S307081","article-title":"Role of ferroptosis in lung diseases","volume":"14","author":"Xu","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.phymed.2026.157992_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120938","article-title":"Sesamin promotes the survival of skin flaps in rats by inhibiting ferroptosis through the Nrf2\/SLC7A11\/GPX4 signaling pathway","volume":"357","author":"Yang","year":"2026","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2026.157992_bib0054","article-title":"Hepatic hypoxia-inducible factor 1\u03b1 mediates ferroptosis via transferrin receptor 1 in acute liver injury","volume":"15","author":"Yang","year":"2026","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.phymed.2026.157992_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120950","article-title":"Based on network pharmacology and experiments to investigate the inhibitory effect of Licoricesaponin G2 on lung cancer tumor growth","volume":"357","author":"Yang","year":"2026","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2026.157992_bib0056","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-08450-z","article-title":"Resveratrol attenuates hepatic oxidative stress and preserves gut mucosal integrity in high-fat diet-fed rats by modulating antioxidant and anti-inflammatory pathways","volume":"15","author":"Yasmin","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2026.157992_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120743","article-title":"An integrated approach of experiment validation and single-cell RNA sequencing reveal dual-pathway inhibition of NLRP3\/ferroptosis by flavonoids of Sanyeqing fibrous root in acute lung injury","volume":"356","author":"Zhan","year":"2026","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.157992_bib0058","first-page":"900","article-title":"The changes in epidemiology and treatment outcomes after the academic renaming from NAFLD to MAFLD\/MASLD","volume":"30","author":"Zhang","year":"2025","journal-title":"Chin. Hepatol."},{"issue":"3","key":"10.1016\/j.phymed.2026.157992_bib0059","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s11427-020-1795-4","article-title":"Biochemistry of mammalian ferritins in the regulation of cellular iron homeostasis and oxidative responses","volume":"64","author":"Zhang","year":"2021","journal-title":"Sci. China Life Sci."},{"issue":"1","key":"10.1016\/j.phymed.2026.157992_bib0060","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1186\/s12964-025-02471-x","article-title":"Hypoxia-mediated regulation of mRNA metabolism: from transcription to stability","volume":"23","author":"Zhang","year":"2025","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.phymed.2026.157992_bib0061","first-page":"1388","article-title":"Research progress on oxygen inhalation therapy for occupational high altitude disease","volume":"19","author":"Zhang","year":"2024","journal-title":"Chin. J. Emerg. Resusc. Disaster Med."},{"key":"10.1016\/j.phymed.2026.157992_bib0062","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2026.218243","article-title":"The Zeb1\/system X(c)(-) axis safeguards iron-loaded cancer-associated fibroblasts against ferroptosis and promotes immunosuppression in prostate cancer","volume":"639","author":"Zhang","year":"2026","journal-title":"Cancer Lett."},{"issue":"8","key":"10.1016\/j.phymed.2026.157992_bib0063","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1039\/D4FO04787G","article-title":"Effects of polyphenols on non-alcoholic fatty liver disease: a case study of resveratrol","volume":"16","author":"Zhao","year":"2025","journal-title":"Food Funct."},{"issue":"11","key":"10.1016\/j.phymed.2026.157992_bib0064","doi-asserted-by":"crossref","DOI":"10.1111\/cns.70648","article-title":"Groundbreaking insights into SIRT1\/NRF2-mediated ferroptosis inhibition by resveratrol in Parkinson's disease models","volume":"31","author":"Zheng","year":"2025","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.phymed.2026.157992_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108852","article-title":"Isoliquiritin apioside relieves intestinal ischemia\/reperfusion-induced acute lung injury by blocking Hif-1\u03b1-mediated ferroptosis","volume":"108","author":"Zhongyin","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2026.157992_bib0066","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.apsb.2024.10.010","article-title":"Akkermansia muciniphila-derived acetate activates the hepatic AMPK\/SIRT1\/PGC-1\u03b1 axis to alleviate ferroptosis in metabolic-associated fatty liver disease","volume":"15","author":"Zhuge","year":"2025","journal-title":"Acta Pharm. Sin. B"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326002291?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326002291?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:52:34Z","timestamp":1777593154000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326002291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":66,"alternative-id":["S0944711326002291"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.157992","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resveratrol dual efficacy in high-altitude hypoxia and NAFLD: inhibits ferroptosis by modulating key proteins, including HIF-1\u03b1, ACSL4, and TfR1","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.157992","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"157992"}}