{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:16:11Z","timestamp":1793232971865,"version":"4.5.0"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.phymed.2026.158013","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T16:18:07Z","timestamp":1772036287000},"page":"158013","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Zinc-doped carbon dots from natural Isatis Indigotica folium and calamine: SOD\/CAT-mimetic activity targets ROS-Ca\u00b2\u207a-NLRP3 axis for psoriatic dermatitis therapy"],"prefix":"10.1016","volume":"153","author":[{"given":"Xinrong","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ertong","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minlong","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1382-7985","authenticated-orcid":false,"given":"Hui","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihua","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.phymed.2026.158013_bib0001","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1080\/21691401.2019.1652631","article-title":"Oxidative stress promotes ventilator-induced lung injury through activating NLRP3 inflammasome and TRPM2 channel","volume":"47","author":"An","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"issue":"19","key":"10.1016\/j.phymed.2026.158013_bib0002","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1001\/jama.2020.4006","article-title":"Pathophysiology, clinical presentation, and treatment of psoriasis: a review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMa"},{"issue":"9997","key":"10.1016\/j.phymed.2026.158013_bib0003","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(14)61909-7","article-title":"Psoriasis","volume":"386","author":"Boehncke","year":"2015","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.phymed.2026.158013_bib0004","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41577-019-0228-2","article-title":"The gasdermins, a protein family executing cell death and inflammation","volume":"20","author":"Broz","year":"2020","journal-title":"Nat. Rev. Immunol."},{"issue":"9","key":"10.1016\/j.phymed.2026.158013_bib0005","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1016\/j.apsb.2021.02.006","article-title":"Gasdermin D in pyroptosis","volume":"11","author":"Burdette","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2026.158013_bib0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molimm.2023.09.004","article-title":"Keratinocyte derived HMGB1 aggravates psoriasis dermatitis via facilitating inflammatory polarization of macrophages and hyperproliferation of keratinocyte","volume":"163","author":"Chen","year":"2023","journal-title":"Mol. Immunol."},{"issue":"7610","key":"10.1016\/j.phymed.2026.158013_bib0007","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature18590","article-title":"Pore-forming activity and structural autoinhibition of the gasdermin family","volume":"535","author":"Ding","year":"2016","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.phymed.2026.158013_bib0008","article-title":"The involvement of oxidative stress in psoriasis","volume":"11","author":"Dobric\u0103","year":"2022","journal-title":"Syst. Rev. Antioxid."},{"key":"10.1016\/j.phymed.2026.158013_bib0009","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-1-60761-411-1_4","article-title":"Identification of ROS using oxidized DCFDA and flow-cytometry","volume":"594","author":"Eruslanov","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.phymed.2026.158013_bib0010","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/978-3-642-54215-2_16","article-title":"TRPM2","volume":"222","author":"Faouzi","year":"2014","journal-title":"Handb. Exp. Pharmacol."},{"issue":"7237","key":"10.1016\/j.phymed.2026.158013_bib0011","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nature07710","article-title":"AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA","volume":"458","author":"Fernandes-Alnemri","year":"2009","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.phymed.2026.158013_bib0012","article-title":"Polysaccharide nanoparticles from Isatis indigotica Fort","volume":"12","author":"Gao","year":"2021","journal-title":"Root Decoction Divers. Cytotox. Antivir. Act. Nanomater."},{"issue":"33","key":"10.1016\/j.phymed.2026.158013_bib0013","doi-asserted-by":"crossref","first-page":"6553","DOI":"10.1039\/D1TB01077H","article-title":"Carbon dots: synthesis, properties and biomedical applications","volume":"9","author":"Ge","year":"2021","journal-title":"J. Mater. Chem. B."},{"issue":"1","key":"10.1016\/j.phymed.2026.158013_bib0014","doi-asserted-by":"crossref","first-page":"6371","DOI":"10.1038\/s41598-023-33652-8","article-title":"Green synthesis of multi-functional carbon dots from medicinal plant leaves for antimicrobial, antioxidant, and bioimaging applications","volume":"13","author":"Gedda","year":"2023","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.phymed.2026.158013_bib0015","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1001\/archderm.141.12.1537","article-title":"Prevalence and treatment of psoriasis in the United Kingdom: a population-based study","volume":"141","author":"Gelfand","year":"2005","journal-title":"Arch. Dermatol."},{"issue":"10281","key":"10.1016\/j.phymed.2026.158013_bib0016","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.phymed.2026.158013_bib0017","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/709152","article-title":"Zinc therapy in dermatology: a review","volume":"2014","author":"Gupta","year":"2014","journal-title":"Dermatol. Res. Pract."},{"issue":"3","key":"10.1016\/j.phymed.2026.158013_bib0018","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/jdv.12576","article-title":"Decision for biological treatment in real life is more strongly associated with the Psoriasis Area and Severity Index (PASI) than with the Dermatology Life Quality Index (DLQI)","volume":"29","author":"H\u00e4gg","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"12","key":"10.1016\/j.phymed.2026.158013_bib0019","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","article-title":"Mechanism and regulation of NLRP3 inflammasome activation","volume":"41","author":"He","year":"2016","journal-title":"Trends Biochem. Sci."},{"issue":"6","key":"10.1016\/j.phymed.2026.158013_bib0020","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.it.2014.02.007","article-title":"Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome","volume":"35","author":"Horng","year":"2014","journal-title":"Trends Immunol."},{"issue":"7237","key":"10.1016\/j.phymed.2026.158013_bib0021","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nature07725","article-title":"AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC","volume":"458","author":"Hornung","year":"2009","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.phymed.2026.158013_bib0022","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jaad.2018.04.018","article-title":"Topical Janus kinase inhibitors: a review of applications in dermatology","volume":"79","author":"Hosking","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158013_bib0023","doi-asserted-by":"crossref","DOI":"10.1111\/ejn.16657","article-title":"Fast neuronal calcium signals in brain slices loaded with fluo-4 AM ester","volume":"61","author":"\u0130pek \u00d6","year":"2025","journal-title":"Eur. J. Neurosci."},{"issue":"1","key":"10.1016\/j.phymed.2026.158013_bib0024","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1038\/s41467-020-17749-6","article-title":"Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis","volume":"11","author":"J\u00e4ger","year":"2020","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.phymed.2026.158013_bib0025","first-page":"364","article-title":"Transient receptor potential melastatin 2:an ion channel for oxidative stress sensing","volume":"38","author":"Jing","year":"2016","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"issue":"1","key":"10.1016\/j.phymed.2026.158013_bib0026","doi-asserted-by":"crossref","DOI":"10.3390\/jfb14010027","article-title":"Green carbon dots: synthesis, characterization, properties and biomedical applications","volume":"14","author":"Jing","year":"2023","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.phymed.2026.158013_bib0027","article-title":"Silver-doped zinc ferrite nanoparticles: trigger ROS-dependent apoptosis and inhibit migration in MCF-7 breast cancer cells","volume":"56","author":"Jyothish","year":"2025","journal-title":"Surf. Interfaces"},{"issue":"18","key":"10.1016\/j.phymed.2026.158013_bib0028","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184347","article-title":"Risk factors for the development of psoriasis","volume":"20","author":"Kamiya","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.phymed.2026.158013_bib0029","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1046\/j.1523-1747.2000.00926.x","article-title":"Psoriasis and altered calcium metabolism: downregulated capacitative calcium influx and defective calcium-mediated cell signaling in cultured psoriatic keratinocytes","volume":"114","author":"Karvonen","year":"2000","journal-title":"J. Invest. Dermatol."},{"issue":"7371","key":"10.1016\/j.phymed.2026.158013_bib0030","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature10558","article-title":"Non-canonical inflammasome activation targets caspase-11","volume":"479","author":"Kayagaki","year":"2011","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.phymed.2026.158013_bib0031","doi-asserted-by":"crossref","first-page":"7923","DOI":"10.1038\/s41467-023-43707-z","article-title":"Pyroptosis inhibiting nanobodies block gasdermin D pore formation","volume":"14","author":"Kopp","year":"2023","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.phymed.2026.158013_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.nexres.2025.100791","article-title":"Sustainable synthesis of ZnO\/carbon dots nanocomposites and evaluation of antimicrobial, in vitro antioxidant and anti-inflammatory properties","volume":"2","author":"Krishna","year":"2025","journal-title":"Next Res."},{"issue":"4","key":"10.1016\/j.phymed.2026.158013_bib0033","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.wem.2023.08.019","article-title":"An outbreak of paederus dermatitis in a suburban hospital in Southwest China: a report of 134 cases and review of literature","volume":"34","author":"Li","year":"2023","journal-title":"Wilderness Environ. Med."},{"issue":"3","key":"10.1016\/j.phymed.2026.158013_bib0034","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/bjd\/ljae179","article-title":"Gasdermin E-mediated keratinocyte pyroptosis participates in the pathogenesis of psoriasis by promoting skin inflammation","volume":"191","author":"Li","year":"2024","journal-title":"Br. J. Dermatol."},{"issue":"9","key":"10.1016\/j.phymed.2026.158013_bib0035","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/s41419-023-06094-3","article-title":"Gasdermin D-mediated keratinocyte pyroptosis as a key step in psoriasis pathogenesis","volume":"14","author":"Lian","year":"2023","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.phymed.2026.158013_bib0036","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jpha.2019.09.005","article-title":"Erucic acid from Isatis indigotica Fort. Suppresses influenza A virus replication and inflammation in vitro and in vivo through modulation of NF-\u03bab and p38 MAPK pathway","volume":"10","author":"Liang","year":"2020","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.phymed.2026.158013_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2021.111666","article-title":"Zn-doped MnO(2) nanocoating with enhanced catalase-mimetic activity and cytocompatibility protects pre-osteoblasts against H(2)O(2)-induced oxidative stress","volume":"202","author":"Liu","year":"2021","journal-title":"Colloids Surf. B. Biointerfaces."},{"issue":"7610","key":"10.1016\/j.phymed.2026.158013_bib0038","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nature18629","article-title":"Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores","volume":"535","author":"Liu","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2026.158013_bib0039","article-title":"Role of ROS-induced NLRP3 inflammasome activation in the formation of calcium oxalate nephrolithiasis","volume":"13","author":"Liu","year":"2022","journal-title":"Front Immunol."},{"issue":"3","key":"10.1016\/j.phymed.2026.158013_bib0040","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41419-024-06545-5","article-title":"Gasdermin E promotes translocation of p65 and c-jun into nucleus in keratinocytes for progression of psoriatic skin inflammation","volume":"15","author":"Long","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2026.158013_bib0041","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1652244","article-title":"Corilagin restrains NLRP3 inflammasome activation and pyroptosis through the ROS\/TXNIP\/NLRP3 pathway to prevent inflammation","volume":"2022","author":"Luo","year":"2022","journal-title":"Oxid. Med. Cell Longev."},{"issue":"6","key":"10.1016\/j.phymed.2026.158013_bib0042","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/s41419-021-03792-8","article-title":"TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca(2+)\/CaMKII\/Nrf2 signaling pathway","volume":"12","author":"Lv","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2026.158013_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101755","article-title":"TRPM2 channel-mediated cell death: an important mechanism linking oxidative stress-inducing pathological factors to associated pathological conditions","volume":"37","author":"Malko","year":"2020","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.phymed.2026.158013_bib0044","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/path.4133","article-title":"Macrophage plasticity and polarization in tissue repair and remodelling","volume":"229","author":"Mantovani","year":"2013","journal-title":"J. Pathol."},{"issue":"5","key":"10.1016\/j.phymed.2026.158013_bib0045","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.jaad.2008.02.039","article-title":"Guidelines of care for the management of psoriasis and psoriatic arthritis: section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics","volume":"58","author":"Menter","year":"2008","journal-title":"J. Am. Acad. Dermatol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158013_bib0046","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jaad.2009.08.026","article-title":"Guidelines of care for the management of psoriasis and psoriatic arthritis: section 5. guidelines of care for the treatment of psoriasis with phototherapy and photochemotherapy","volume":"62","author":"Menter","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.phymed.2026.158013_bib0047","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.714897","article-title":"Mitochondrial reactive oxygen species are essential for the development of psoriatic inflammation","volume":"12","author":"Mizuguchi","year":"2021","journal-title":"Front Immunol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158013_bib0048","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"issue":"11","key":"10.1016\/j.phymed.2026.158013_bib0049","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1007\/s11064-007-9386-x","article-title":"New molecular mechanisms on the activation of TRPM2 channels by oxidative stress and ADP-ribose","volume":"32","author":"Naziro\u011flu","year":"2007","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.phymed.2026.158013_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2025.111426","article-title":"Knockout of TRPM2 protects against cyclophosphamide-induced premature ovarian failure via inhibiting AMPK\/p53 signaling pathway","volume":"409","author":"Nie","year":"2025","journal-title":"Chem. Biol. Interact."},{"issue":"2","key":"10.1016\/j.phymed.2026.158013_bib0051","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/jid.2012.339","article-title":"Global epidemiology of psoriasis: a systematic review of incidence and prevalence","volume":"133","author":"Parisi","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.phymed.2026.158013_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2023.341874","article-title":"Functionalized heteroatom-doped carbon dots for biomedical applications: a review","volume":"1284","author":"Redondo-Fernandez","year":"2023","journal-title":"Anal. Chim. Acta"},{"issue":"10273","key":"10.1016\/j.phymed.2026.158013_bib0053","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0140-6736(21)00125-2","article-title":"Bimekizumab versus ustekinumab for the treatment of moderate to severe plaque psoriasis (BE VIVID): efficacy and safety from a 52-week, multicentre, double-blind, active comparator and placebo controlled phase 3 trial","volume":"397","author":"Reich","year":"2021","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.phymed.2026.158013_bib0054","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s13659-023-00415-x","article-title":"A recent update on development, synthesis methods, properties and application of natural products derived carbon dots","volume":"13","author":"Sahana","year":"2023","journal-title":"Nat. Prod. Bioprospect."},{"issue":"2","key":"10.1016\/j.phymed.2026.158013_bib0055","doi-asserted-by":"crossref","DOI":"10.1002\/biof.70013","article-title":"The role of NRF2 transcription factor in inflammatory skin diseases","volume":"51","author":"Salman","year":"2025","journal-title":"Biofactors"},{"issue":"46","key":"10.1016\/j.phymed.2026.158013_bib0056","doi-asserted-by":"crossref","first-page":"E10888","DOI":"10.1073\/pnas.1809548115","article-title":"Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection","volume":"115","author":"Sarhan","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"1","key":"10.1016\/j.phymed.2026.158013_bib0057","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1684\/ejd.2010.0815","article-title":"Concordance of the psoriasis area and severity index (PASI) and patient-reported outcomes in psoriasis treatment","volume":"20","author":"Sch\u00e4fer","year":"2010","journal-title":"Eur. J. Dermatol."},{"issue":"7521","key":"10.1016\/j.phymed.2026.158013_bib0058","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature13683","article-title":"Inflammatory caspases are innate immune receptors for intracellular LPS","volume":"514","author":"Shi","year":"2014","journal-title":"Nature"},{"issue":"17","key":"10.1016\/j.phymed.2026.158013_bib0059","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241713528","article-title":"Inhibition of NLRP3 inflammasome activation by 3H-1,2-dithiole-3-thione: a potential therapeutic approach for psoriasis treatment","volume":"24","author":"Shih","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158013_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.156542","article-title":"Tungsten-rosmarinic acid nanoenzyme with SOD mimetic activity for the treatment of psoriasis by eliminating ROS and relieving inflammation","volume":"499","author":"Su","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.phymed.2026.158013_bib0061","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102159","article-title":"The role of NADPH oxidases in infectious and inflammatory diseases","volume":"48","author":"Taylor","year":"2021","journal-title":"Redox Biol."},{"issue":"12","key":"10.1016\/j.phymed.2026.158013_bib0062","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1136\/adc.2006.105114","article-title":"Does the use of calamine or antihistamine provide symptomatic relief from pruritus in children with varicella zoster infection?","volume":"91","author":"Tebruegge","year":"2006","journal-title":"Arch. Dis. Child."},{"issue":"12","key":"10.1016\/j.phymed.2026.158013_bib0063","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1111\/bph.13532","article-title":"Therapeutic potential of NADPH oxidase 1\/4 inhibitors","volume":"174","author":"Teixeira","year":"2017","journal-title":"Br. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.phymed.2026.158013_bib0064","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1093\/rheumatology\/keaa526","article-title":"Treatment of psoriatic arthritis with biologic and targeted synthetic DMARDs: british Society for Rheumatology guideline scope","volume":"60","author":"Tillett","year":"2021","journal-title":"Rheumatology"},{"issue":"20","key":"10.1016\/j.phymed.2026.158013_bib0065","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21207488","article-title":"New treatment addressing the pathogenesis of psoriasis","volume":"21","author":"Tokuyama","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158013_bib0066","article-title":"Optimizing banana preservation with bandgap-dependent curcumin-modified Cu-doped-ZnO nanoparticles in chitosan edible coatings","volume":"61","author":"Wahyuni","year":"2025","journal-title":"Surf. Interfaces"},{"key":"10.1016\/j.phymed.2026.158013_bib0067","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.coi.2020.01.005","article-title":"TRPM2, linking oxidative stress and Ca(2+) permeation to NLRP3 inflammasome activation","volume":"62","author":"Wang","year":"2020","journal-title":"Curr. Opin. Immunol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158013_bib0068","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12872-023-03040-1","article-title":"Uric acid promotes myocardial infarction injury via activating pyrin domain-containing 3 inflammasome and reactive oxygen species\/transient receptor potential melastatin 2\/Ca(2+)pathway","volume":"23","author":"Wu","year":"2023","journal-title":"BMC Cardiovasc. Disord."},{"issue":"1","key":"10.1016\/j.phymed.2026.158013_bib0069","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s12906-019-2513-9","article-title":"Chinese herbal bath therapy for the treatment of uremic pruritus: meta-analysis of randomized controlled trials","volume":"19","author":"Xue","year":"2019","journal-title":"BMC Complement Altern. Med."},{"issue":"11","key":"10.1016\/j.phymed.2026.158013_bib0070","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24112157","article-title":"Datura Metel L. Ameliorates imiquimod-induced psoriasis-like dermatitis and inhibits inflammatory cytokines production through TLR7\/8-MyD88-NF-\u03bab-NLRP3 inflammasome pathway","volume":"24","author":"Yang","year":"2019","journal-title":"Molecules"},{"issue":"7","key":"10.1016\/j.phymed.2026.158013_bib0071","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1089\/acm.2008.0322","article-title":"Effect of extracts from indigowood root (Isatis indigotica Fort.) on immune responses in radiation-induced mucositis","volume":"15","author":"You","year":"2009","journal-title":"J. Altern. Complement Med."},{"issue":"1","key":"10.1016\/j.phymed.2026.158013_bib0072","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12951-021-00847-y","article-title":"Green phellodendri chinensis Cortex-based carbon dots for ameliorating imiquimod-induced psoriasis-like inflammation in mice","volume":"19","author":"Zhang","year":"2021","journal-title":"J. Nanobiotechnol."},{"issue":"7","key":"10.1016\/j.phymed.2026.158013_bib0073","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/s41419-022-05045-8","article-title":"SerpinB7 deficiency contributes to development of psoriasis via calcium-mediated keratinocyte differentiation dysfunction","volume":"13","author":"Zheng","year":"2022","journal-title":"Cell Death Dis."},{"issue":"22","key":"10.1016\/j.phymed.2026.158013_bib0074","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28227527","article-title":"Tiliroside attenuates NLRP3 inflammasome activation in macrophages and protects against acute lung injury in mice","volume":"28","author":"Zhong","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.phymed.2026.158013_bib0075","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1038\/ncomms2608","article-title":"TRPM2 links oxidative stress to NLRP3 inflammasome activation","volume":"4","author":"Zhong","year":"2013","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.phymed.2026.158013_bib0076","doi-asserted-by":"crossref","first-page":"e1205","DOI":"10.1002\/iid3.1205","article-title":"HMGB1 regulates Th17 cell differentiation and function in patients with psoriasis","volume":"12","author":"Zhu","year":"2024","journal-title":"Immun. Inflamm. Dis."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326002503?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326002503?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:52:17Z","timestamp":1777593137000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326002503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":76,"alternative-id":["S0944711326002503"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158013","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zinc-doped carbon dots from natural Isatis Indigotica folium and calamine: SOD\/CAT-mimetic activity targets ROS-Ca\u00b2\u207a-NLRP3 axis for psoriatic dermatitis therapy","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"158013"}}