{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:47:06Z","timestamp":1793234826667,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003627","name":"Rural Development Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003627","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020610","name":"National Institute of Horticultural and Herbal Science","doi-asserted-by":"publisher","award":["RS-2022-RD010270"],"award-info":[{"award-number":["RS-2022-RD010270"]}],"id":[{"id":"10.13039\/501100020610","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.phymed.2026.158054","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T16:49:12Z","timestamp":1773074952000},"page":"158054","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Cannabisin A and B from hemp seed hulls improve glucose homeostasis by re-engaging insulin, leptin, and AMPK pathways via selective PTP1B inhibition"],"prefix":"10.1016","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2498-6241","authenticated-orcid":false,"given":"Jang Hoon","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2767-2065","authenticated-orcid":false,"given":"Sang Seop","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyong Hwan","family":"Bang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Goo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4438-6506","authenticated-orcid":false,"given":"Sung Yeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4867-7646","authenticated-orcid":false,"given":"Ik Soo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8905-6104","authenticated-orcid":false,"given":"Yung Choon","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158054_bib0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-3746-2_1","article-title":"The extended Family of protein tyrosine phosphatases","volume":"1447","author":"Alonso","year":"2016","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158054_bib0002","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/nar\/27.1.119","article-title":"The HuGeMap Database: interconnection and visualization of human genome maps","volume":"27","author":"Barillot","year":"1999","journal-title":"Nucleic. Acids. Res."},{"issue":"2","key":"10.1016\/j.phymed.2026.158054_bib0003","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3390\/ijms20020298","article-title":"Homeostasis of glucose and lipid in Non-Alcoholic fatty liver disease","volume":"20","author":"Chao","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.phymed.2026.158054_bib0004","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1038\/s41598-024-84487-w","article-title":"Combination of dapagliflozin and pioglitazone lacks superiority against monotherapy in streptozotocin-induced nephropathy","volume":"15","author":"Cinakova","year":"2025","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.phymed.2026.158054_bib0005","doi-asserted-by":"crossref","first-page":"682","DOI":"10.3390\/nu8110682","article-title":"Liver fatty acid composition and inflammation in mice fed with high-carbohydrate diet or high-fat diet","volume":"8","author":"Da Silva-Santi","year":"2016","journal-title":"Nutrients."},{"key":"10.1016\/j.phymed.2026.158054_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112563","article-title":"AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: A pre-clinical and clinical investigation","volume":"146","author":"Entezari","year":"2022","journal-title":"Biomed. PharmacOther"},{"issue":"7","key":"10.1016\/j.phymed.2026.158054_bib0007","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.3390\/nu12071935","article-title":"The seed of industrial hemp (Cannabis sativa L.): nutritional quality and potential functionality for Human health and nutrition","volume":"12","author":"Farinon","year":"2020","journal-title":"Nutrients."},{"issue":"6","key":"10.1016\/j.phymed.2026.158054_bib0008","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.cmet.2014.09.018","article-title":"Metformin: from mechanisms of action to therapies","volume":"20","author":"Foretz","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.phymed.2026.158054_bib0009","doi-asserted-by":"crossref","first-page":"5.47.1","DOI":"10.1002\/0471141755.ph0547s70","article-title":"Streptozotocin-induced diabetic models in mice and rats","volume":"70","author":"Furman","year":"2015","journal-title":"Curr. Protoc. Pharmacol."},{"issue":"7","key":"10.1016\/j.phymed.2026.158054_bib0010","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.2337\/db09-1918","article-title":"Leptin deficiency causes insulin resistance induced by uncontrolled diabetes","volume":"59","author":"German","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.phymed.2026.158054_bib0012","article-title":"Type 2 diabetes mellitus - conventional therapies and future perspectives in innovative treatment","volume":"42","author":"Gieroba","year":"2025","journal-title":"Biochem. Biophys. Rep."},{"issue":"1","key":"10.1016\/j.phymed.2026.158054_bib0013","first-page":"1","article-title":"Diversity and variability of bioactive compounds in Cannabis sativa","volume":"6","author":"Gonz\u00e1lez","year":"2024","journal-title":"J. Cannabis. Res."},{"issue":"11","key":"10.1016\/j.phymed.2026.158054_bib0014","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1111\/bcp.13618","article-title":"Cannabis, from plant to pill","volume":"84","author":"Grof","year":"2018","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158054_bib0016","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1501690","article-title":"Global burden of type 2 diabetes mellitus from 1990 to 2021, with projections of prevalence to 2044: a systematic analysis across SDI levels for the global burden of disease study 2021","volume":"15","author":"He","year":"2024","journal-title":"Front. Endocrinol."},{"issue":"5","key":"10.1016\/j.phymed.2026.158054_bib0017","doi-asserted-by":"crossref","first-page":"937","DOI":"10.4093\/dmj.2023.0314","article-title":"Pioglitazone as add-on therapy in patients with type 2 diabetes mellitus inadequately controlled with Dapagliflozin and Metformin: double-blind, randomized, placebo-controlled trial","volume":"48","author":"Heo","year":"2024","journal-title":"Diabetes. Metab. J."},{"issue":"21","key":"10.1016\/j.phymed.2026.158054_bib0018","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1091\/mbc.E15-06-0442","article-title":"PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena","volume":"26","author":"Hughes","year":"2015","journal-title":"Mol. Biol. Cell"},{"issue":"Pt 2","key":"10.1016\/j.phymed.2026.158054_bib0021","article-title":"Inhibitory effects of phenylpropionamides from the hemp seed husk on tyrosinase","volume":"282","author":"Kim","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"9","key":"10.1016\/j.phymed.2026.158054_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e19772","article-title":"Inhibitory activity of lignanamides isolated from hemp seed hulls(Cannabis sativa L.) against soluble epoxide hydrolase","volume":"9","author":"Kim","year":"2023","journal-title":"Heliyon."},{"issue":"9","key":"10.1016\/j.phymed.2026.158054_bib66","doi-asserted-by":"crossref","first-page":"3814","DOI":"10.3390\/molecules28093814","article-title":"Protective effects of hemp (Cannabis sativa) root extracts against insulin-deficient diabetes mellitus in mice","volume":"28","author":"Kim","year":"2023","journal-title":"Molecules"},{"issue":"13","key":"10.1016\/j.phymed.2026.158054_bib0023","doi-asserted-by":"crossref","first-page":"7033","DOI":"10.3390\/ijms25137033","article-title":"Protein tyrosine phosphatase 1B (PTP1B): A comprehensive review of its role in pathogenesis of Human diseases","volume":"25","author":"Ko\u0142odziej-Sobczak","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.phymed.2026.158054_bib67","doi-asserted-by":"crossref","first-page":"rgaf091","DOI":"10.1093\/jpp\/rgaf091","article-title":"Additive cardioprotection by dapagliflozin and pioglitazone co-therapy in streptozotocin-induced diabetic rats","volume":"78","author":"Kralova","year":"2026","journal-title":"J. Pharm. Pharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158054_bib0025","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4093\/dmj.2021.0280","article-title":"Insulin resistance: from mechanisms to therapeutic strategies","volume":"46","author":"Lee","year":"2022","journal-title":"Diabetes. Metab. J."},{"issue":"23","key":"10.1016\/j.phymed.2026.158054_bib0026","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222312693","article-title":"A novel PTP1B inhibitor-phosphate of polymannuronic acid ameliorates insulin resistance by regulating IRS-1\/Akt signaling","volume":"22","author":"Li","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.phymed.2026.158054_bib0027","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/s41392-022-01073-0","article-title":"Trends in insulin resistance: insights into mechanisms and therapeutic strategy","volume":"7","author":"Li","year":"2022","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"6","key":"10.1016\/j.phymed.2026.158054_bib0028","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1111\/dom.15526","article-title":"A multicentre, double-blind, placebo-controlled, randomized, parallel comparison, phase 3 trial to evaluate the efficacy and safety of pioglitazone add-on therapy in type 2 diabetic patients treated with metformin and dapagliflozin","volume":"26","author":"Lim","year":"2024","journal-title":"Diabetes. Obes. Metab."},{"issue":"1","key":"10.1016\/j.phymed.2026.158054_bib0029","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12986-021-00569-w","article-title":"STAT3 phosphorylation in central leptin resistance","volume":"18","author":"Liu","year":"2021","journal-title":"Nutr. Metab."},{"issue":"13","key":"10.1016\/j.phymed.2026.158054_bib0030","doi-asserted-by":"crossref","first-page":"7027","DOI":"10.3390\/ijms23137027","article-title":"Human protein tyrosine phosphatase 1B (PTP1B): from structure to clinical inhibitor perspectives","volume":"23","author":"Liu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.phymed.2026.158054_bib0032","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41392-024-01951-9","article-title":"Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy","volume":"9","author":"Lu","year":"2024","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"6","key":"10.1016\/j.phymed.2026.158054_bib0033","doi-asserted-by":"crossref","first-page":"393","DOI":"10.4103\/ijp.ijp_860_22","article-title":"Translational research: bridging the gap between preclinical and clinical research","volume":"54","author":"Mahalmani","year":"2022","journal-title":"Indian J. Pharmacol."},{"issue":"8","key":"10.1016\/j.phymed.2026.158054_bib0034","doi-asserted-by":"crossref","first-page":"878","DOI":"10.3390\/jpm14080878","article-title":"A review of stage 0 biomarkers in type 1 diabetes: the holy grail of early detection and prevention?","volume":"14","author":"M\u0103nescu","year":"2024","journal-title":"J. Pers. Med."},{"issue":"13","key":"10.1016\/j.phymed.2026.158054_bib0035","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.008865","article-title":"Increased protein tyrosine phosphatase 1B (PTP1B) activity and cardiac insulin resistance precede mitochondrial and contractile dysfunction in pressure-overloaded hearts","volume":"7","author":"Nguyen","year":"2018","journal-title":"J. Am. Heart. Assoc."},{"key":"10.1016\/j.phymed.2026.158054_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113709","article-title":"Protein tyrosine phosphatase 1B (PTP1B) as a potential therapeutic target for neurological disorders","volume":"155","author":"Olloquequi","year":"2022","journal-title":"Biomed. PharmacOther"},{"issue":"3","key":"10.1016\/j.phymed.2026.158054_bib0037","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1007\/s00125-012-2782-z","article-title":"Endoplasmic reticulum stress upregulates protein tyrosine phosphatase 1B and impairs glucose uptake in cultured myotubes","volume":"56","author":"Panzhinskiy","year":"2013","journal-title":"Diabetologia"},{"key":"10.1016\/j.phymed.2026.158054_bib0038","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.941918","article-title":"Editorial: first regulatory approval for allogeneic pancreatic islet beta cell infusion for adult patients with type 1 diabetes mellitus","volume":"29","author":"Parums","year":"2023","journal-title":"Med. Sci. Monit."},{"issue":"42","key":"10.1016\/j.phymed.2026.158054_bib0039","doi-asserted-by":"crossref","first-page":"14379","DOI":"10.1074\/jbc.REV120.008387","article-title":"Sodium-glucose cotransporter-2 inhibitors: understanding the mechanisms for therapeutic promise and persisting risks","volume":"295","author":"Perry","year":"2020","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.phymed.2026.158054_bib0040","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1152\/physrev.00063.2017","article-title":"Mechanisms of Insulin action and Insulin resistance","volume":"98","author":"Petersen","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phymed.2026.158054_bib0041","article-title":"The cannabidiol and marijuana research expansion act: promotion of scientific knowledge to prevent a national health crisis","volume":"14","author":"Purcell","year":"2022","journal-title":"Lancet Reg. Health Am."},{"issue":"4","key":"10.1016\/j.phymed.2026.158054_bib0042","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3390\/ph18040446","article-title":"Unlocking the antidiabetic potential of CBD: In vivo preclinical studies","volume":"18","author":"Rafailovska","year":"2025","journal-title":"Pharmaceuticals"},{"issue":"23","key":"10.1016\/j.phymed.2026.158054_bib0043","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1056\/NEJMoa2308743","article-title":"Teplizumab and \u03b2-cell function in newly diagnosed type 1 diabetes","volume":"389","author":"Ramos","year":"2023","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.phymed.2026.158054_bib0044","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3390\/biom15030408","article-title":"Weight reduction with GLP-1 agonists and paths for discontinuation while maintaining Weight loss","volume":"15","author":"Reiss","year":"2025","journal-title":"Biomolecules."},{"issue":"7","key":"10.1016\/j.phymed.2026.158054_bib0045","doi-asserted-by":"crossref","first-page":"944","DOI":"10.3390\/pharmaceutics16070944","article-title":"Advancements in insulin pumps: A comprehensive exploration of insulin pump systems, technologies, and future directions","volume":"16","author":"Rimon","year":"2024","journal-title":"Pharmaceutics."},{"issue":"1","key":"10.1016\/j.phymed.2026.158054_bib0046","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00592-014-0630-y","article-title":"Levels of adiponectin and leptin at onset of type 1 diabetes have changed over time in children and adolescents","volume":"52","author":"Safai","year":"2015","journal-title":"Acta Diabetol."},{"issue":"9","key":"10.1016\/j.phymed.2026.158054_bib0047","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s00894-019-4172-7","article-title":"In silico investigations on the binding efficacy and allosteric mechanism of six different natural product compounds towards PTP1B inhibition through docking and molecular dynamics simulations","volume":"25","author":"SarathKumar","year":"2019","journal-title":"J. Mol. Model."},{"issue":"2","key":"10.1016\/j.phymed.2026.158054_bib0048","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.ando.2022.12.423","article-title":"Dual GIP\/GLP-1 receptor agonists: new advances for treating type-2 diabetes","volume":"84","author":"Scheen","year":"2023","journal-title":"Ann. Endocrinol."},{"issue":"11","key":"10.1016\/j.phymed.2026.158054_bib0049","doi-asserted-by":"crossref","first-page":"5812","DOI":"10.3390\/ijms22115812","article-title":"Role of receptor protein tyrosine phosphatases (RPTPs) in insulin signaling and secretion","volume":"22","author":"Sevillano","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.phymed.2026.158054_bib0050","doi-asserted-by":"crossref","first-page":"C1640","DOI":"10.1152\/ajpcell.1998.275.6.C1640","article-title":"Activation of the JAK-STAT pathway by reactive oxygen species","volume":"275","author":"Simon","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.phymed.2026.158054_bib0051","first-page":"105","article-title":"Nutraceutical potential, phytochemistry of hemp seed (Cannabis sativa), and its applications in functional foods","volume":"94","author":"Singh","year":"2024","journal-title":"J. Funct. Foods."},{"issue":"4","key":"10.1016\/j.phymed.2026.158054_bib0052","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.cmet.2014.08.005","article-title":"Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes","volume":"20","author":"Soccio","year":"2014","journal-title":"Cell Metab."},{"issue":"11","key":"10.1016\/j.phymed.2026.158054_bib0053","doi-asserted-by":"crossref","first-page":"5749","DOI":"10.3390\/ijms25115749","article-title":"The use of compounds derived from cannabis sativa in the treatment of epilepsy, painful conditions, and neuropsychiatric and neurodegenerative disorders","volume":"25","author":"Stasi\u0142owicz-Krzemie\u0144","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158054_bib0054","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2024.1445739","article-title":"Protein tyrosine phosphatase 1B in metabolic and cardiovascular diseases: from mechanisms to therapeutics","volume":"11","author":"Sun","year":"2024","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.phymed.2026.158054_bib0055","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/926857","article-title":"The genetics of PTPN1 and obesity: insights from mouse models of tissue-specific PTP1B deficiency","volume":"2012","author":"Tsou","year":"2012","journal-title":"J. Obes."},{"issue":"4","key":"10.1016\/j.phymed.2026.158054_bib0056","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1002\/hep.25798","article-title":"Retinoids ameliorate insulin resistance in a leptin-dependent manner in mice","volume":"56","author":"Tsuchiya","year":"2012","journal-title":"Hepatology"},{"issue":"22","key":"10.1016\/j.phymed.2026.158054_bib0057","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.3390\/cells13221827","article-title":"Ex vivo tools and models in MASLD research","volume":"13","author":"Velliou","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.phymed.2026.158054_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176116","article-title":"Oleanolic acid derivative alleviates cardiac fibrosis through inhibiting PTP1B activity and regulating AMPK\/TGF-\u03b2\/smads pathway","volume":"960","author":"Wang","year":"2023","journal-title":"Eur. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.phymed.2026.158054_bib0059","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1007\/s00125-019-04971-1","article-title":"Adenine nucleotide-mediated regulation of hepatic PTP1B activity in mouse models of type 2 diabetes","volume":"62","author":"Yang","year":"2019","journal-title":"Diabetologia"},{"issue":"3","key":"10.1016\/j.phymed.2026.158054_bib0060","doi-asserted-by":"crossref","first-page":"405","DOI":"10.25122\/jml-2021-0417","article-title":"Evaluation of metformin performance on alloxan-induced diabetic rabbits","volume":"15","author":"Yasin","year":"2022","journal-title":"J. Med. Life"},{"key":"10.1016\/j.phymed.2026.158054_bib0061","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s12933-016-0408-3","article-title":"Metformin improves the angiogenic functions of endothelial progenitor cells via activating AMPK\/eNOS pathway in diabetic mice","volume":"15","author":"Yu","year":"2016","journal-title":"Cardiovasc. Diabetol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158054_bib0062","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s40104-025-01200-1","article-title":"High fat diet (HFD) induced hepatic lipogenic metabolism and lipotoxicity via Parkin-dependent mitophagy and Err\u03b1 signal of Pelteobagrus fulvidraco","volume":"16","author":"Yu","year":"2025","journal-title":"J. Anim. Sci. Biotechnol."},{"issue":"2","key":"10.1016\/j.phymed.2026.158054_bib0063","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/jat\/bkae001","article-title":"Pharmacokinetics and pharmacodynamics of five distinct commercially available hemp-derived topical cannabidiol products","volume":"48","author":"Zamarripa","year":"2024","journal-title":"J. Anal. Toxicol."},{"issue":"5","key":"10.1016\/j.phymed.2026.158054_bib0064","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1021\/acsptsci.4c00054","article-title":"Site-specifically modified peptide inhibitors of protein tyrosine phosphatase 1B and T-cell protein tyrosine phosphatase with enhanced stability and improved In vivo long-acting activity","volume":"7","author":"Zhang","year":"2024","journal-title":"ACS. Pharmacol. Transl. Sci."},{"issue":"11","key":"10.1016\/j.phymed.2026.158054_bib0065","doi-asserted-by":"crossref","first-page":"15988","DOI":"10.1021\/acsomega.8b02250","article-title":"Hemp (Cannabis sativa L.) seed phenylpropionamides composition and effects on memory dysfunction and biomarkers of neuroinflammation induced by lipopolysaccharide in mice","volume":"3","author":"Zhou","year":"2018","journal-title":"ACS. Omega"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326002904?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326002904?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T06:50:27Z","timestamp":1776149427000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326002904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":61,"alternative-id":["S0944711326002904"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158054","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cannabisin A and B from hemp seed hulls improve glucose homeostasis by re-engaging insulin, leptin, and AMPK pathways via selective PTP1B inhibition","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158054"}}