{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:17:17Z","timestamp":1787879837035,"version":"build-2784847793"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270217"],"award-info":[{"award-number":["82270217"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82573067"],"award-info":[{"award-number":["82573067"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["YJS20230145"],"award-info":[{"award-number":["YJS20230145"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["YJS20250068"],"award-info":[{"award-number":["YJS20250068"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["YJS20240076"],"award-info":[{"award-number":["YJS20240076"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.phymed.2026.158057","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T16:49:23Z","timestamp":1773074963000},"page":"158057","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Liquiritigenin targets transferrin receptor to potentiate ferroptosis sensitivity in colorectal cancer cells"],"prefix":"10.1016","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8577-6354","authenticated-orcid":false,"given":"Rui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunxia","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158057_bib0001","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s10787-023-01152-w","article-title":"Liquiritigenin, isoliquiritigenin rich extract of glycyrrhiza glabra roots attenuates inflammation in macrophages and collagen-induced arthritis in rats","volume":"31","author":"Babu","year":"2023","journal-title":"Inflammopharmacology."},{"key":"10.1016\/j.phymed.2026.158057_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2024.114002","article-title":"Natural product-derived ferroptosis mediators","volume":"219","author":"Chen","year":"2024","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phymed.2026.158057_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.111304","article-title":"AMPD3 promotes doxorubicin-induced cardiomyopathy through HSP90\u03b1-mediated ferroptosis","volume":"27","author":"Cheng","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.phymed.2026.158057_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2024.189241","article-title":"Promises of natural products as clinical applications for cancer","volume":"1880","author":"Deng","year":"2025","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.phymed.2026.158057_bib0005","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41580-024-00703-5","article-title":"The cell biology of ferroptosis","volume":"25","author":"Dixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2026.158057_bib0006","doi-asserted-by":"crossref","first-page":"5321","DOI":"10.1016\/j.apsb.2024.07.018","article-title":"Avenanthramide A potentiates Bim-mediated antineoplastic properties of 5-fluorouracil via targeting KDM4C\/MIR17HG\/GSK-3\u03b2 negative feedback loop in colorectal cancer","volume":"14","author":"Fu","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2026.158057_bib0007","doi-asserted-by":"crossref","first-page":"4808","DOI":"10.1021\/acs.jafc.9b00833","article-title":"Avenanthramide A induces cellular senescence via miR-129-3p\/Pirh2\/p53 signaling pathway to suppress colon cancer growth","volume":"67","author":"Fu","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2026.158057_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116345","article-title":"Sanggenol L induces ferroptosis in non-small cell lung cancer cells via regulating the miR-26a-1-3p\/MDM2\/p53 signaling pathway","volume":"226","author":"Fu","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158057_bib0009","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41580-023-00648-1","article-title":"Mechanisms controlling cellular and systemic iron homeostasis","volume":"25","author":"Galy","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2026.158057_bib0010","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202307899","article-title":"Blocking ubiquitin-specific protease 7 induces ferroptosis in gastric cancer via targeting stearoyl-CoA desaturase","volume":"11","author":"Guan","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.phymed.2026.158057_bib0011","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1142\/S0192415X24500599","article-title":"Liquiritigenin, an active ingredient of liquorice, alleviates acute kidney injury by VKORC1-mediated ferroptosis inhibition","volume":"52","author":"Guo","year":"2024","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.phymed.2026.158057_bib0012","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/s41420-021-00574-1","article-title":"TRIB2 desensitizes ferroptosis via \u03b2TrCP-mediated TFRC ubiquitiantion in liver cancer cells","volume":"7","author":"Guo","year":"2021","journal-title":"Cell Death. Discov."},{"key":"10.1016\/j.phymed.2026.158057_bib0013","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/s41467-025-56344-5","article-title":"Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis","volume":"16","author":"Huang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158057_bib0014","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jare.2024.09.027","article-title":"Salidroside sensitizes triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy","volume":"74","author":"Huang","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.phymed.2026.158057_bib0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1011098","article-title":"NeuroD1-GPX4 signaling leads to ferroptosis resistance in hepatocellular carcinoma","volume":"19","author":"Huang","year":"2023","journal-title":"PLoS. Genet."},{"key":"10.1016\/j.phymed.2026.158057_bib0016","first-page":"131","article-title":"TFRC promotes epithelial ovarian cancer cell proliferation and metastasis via up-regulation of AXIN2 expression","volume":"10","author":"Huang","year":"2020","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.phymed.2026.158057_bib0017","doi-asserted-by":"crossref","first-page":"w739","DOI":"10.1093\/nar\/gkac382","article-title":"SynergyFinder 3.0: an interactive analysis and consensus interpretation of multi-drug synergies across multiple samples","volume":"50","author":"Ianevski","year":"2022","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.phymed.2026.158057_bib0018","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/cac2.12519","article-title":"Cellular metabolism: a key player in cancer ferroptosis","volume":"44","author":"Jiang","year":"2024","journal-title":"Cancer Commun."},{"issue":"4","key":"10.1016\/j.phymed.2026.158057_bib0019","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2026.158057_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154601","article-title":"Andrographolide promoted ferroptosis to repress the development of non-small cell lung cancer through activation of the mitochondrial dysfunction","volume":"109","author":"Jiaqi","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158057_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156804","article-title":"The cardiac glycoside periplocymarin sensitizes gastric cancer to ferroptosis via the ATP1A1-src-YAP\/TAZ-TFRC axis","volume":"142","author":"Ke","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158057_bib0022","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1038\/s41467-022-29905-1","article-title":"A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers","volume":"13","author":"Koppula","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158057_bib0023","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","article-title":"Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy","volume":"12","author":"Koppula","year":"2021","journal-title":"Protein Cell"},{"key":"10.1016\/j.phymed.2026.158057_bib0024","doi-asserted-by":"crossref","first-page":"5595","DOI":"10.1021\/acs.jcim.0c00613","article-title":"Alchemical binding free energy calculations in AMBER20: advances and best practices for drug discovery","volume":"60","author":"Lee","year":"2020","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.phymed.2026.158057_bib0025","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41419-025-07581-5","article-title":"Pharmacological targeting of the mitochondrial phosphatase PTPMT1 sensitizes hepatocellular carcinoma to ferroptosis","volume":"16","author":"Li","year":"2025","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.phymed.2026.158057_bib0026","article-title":"Targeting digestive system cancers with isoliquiritigenin: a comprehensive review of antitumor mechanisms","volume":"16","author":"Li","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158057_bib0027","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10549-021-06487-y","article-title":"The estrogen receptor beta agonist liquiritigenin enhances the inhibitory effects of the cholesterol biosynthesis inhibitor RO 48-8071 on hormone-dependent breast-cancer growth","volume":"192","author":"Liang","year":"2022","journal-title":"Breast. Cancer Res. Treat."},{"key":"10.1016\/j.phymed.2026.158057_bib0028","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1016\/j.ccell.2024.10.010","article-title":"Itaconate transporter SLC13A3 impairs tumor immunity via endowing ferroptosis resistance","volume":"42","author":"Lin","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.phymed.2026.158057_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2025.106398","article-title":"Potential of glycyrrhiza in the prevention of colitis-associated colon cancer","volume":"181","author":"Liu","year":"2025","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phymed.2026.158057_bib0030","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s13046-025-03531-3","article-title":"Bufalin inhibits hepatocellular carcinoma progression by blocking EGFR-mediated RAS-RAF-MEK-ERK pathway activation","volume":"44","author":"Liu","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.phymed.2026.158057_bib0031","doi-asserted-by":"crossref","first-page":"9470","DOI":"10.1039\/D2FO00945E","article-title":"Prdx6-induced inhibition of ferroptosis in epithelial cells contributes to liquiritin-exerted alleviation of colitis","volume":"13","author":"Liu","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.phymed.2026.158057_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103867","article-title":"Artesunate induces ferroptosis in gastric cancer by targeting the TFRC-HSPA9 axis for iron homeostasis regulation","volume":"87","author":"Liu","year":"2025","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2026.158057_bib0033","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s12906-021-03425-9","article-title":"Revealing the potential mechanism of Astragalus membranaceus improving prognosis of hepatocellular carcinoma by combining transcriptomics and network pharmacology","volume":"21","author":"Liu","year":"2021","journal-title":"BMC. Complement. Med. Ther."},{"key":"10.1016\/j.phymed.2026.158057_bib0034","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3390\/ph17010043","article-title":"Isoliquiritigenin inhibits the growth of colorectal cancer cells through the ESR2\/PI3K\/AKT Signalling Pathway","volume":"17","author":"Luo","year":"2023","journal-title":"Pharmaceuticals"},{"issue":"10","key":"10.1016\/j.phymed.2026.158057_bib0035","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/nchem.2778","article-title":"Salinomycin kills cancer stem cells by sequestering iron in lysosomes","volume":"9","author":"Mai","year":"2017","journal-title":"Nat. Chem."},{"key":"10.1016\/j.phymed.2026.158057_bib0036","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/s41556-024-01425-8","article-title":"Exploiting ferroptosis vulnerabilities in cancer","volume":"26","author":"Nakamura","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.phymed.2026.158057_bib0037","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/s41467-019-08902-x","article-title":"ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield","volume":"10","author":"Ou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158057_bib0038","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.chembiol.2025.09.003","article-title":"Inter- and intra-tumoral ALDH1 heterogeneity in breast cancer identifies therapeutic opportunities for ALDH1A-specific inhibitors","volume":"32","author":"Pequerul","year":"2025","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.phymed.2026.158057_bib0039","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-13324-5","article-title":"Sulfasalazine induces ferroptosis in osteosarcomas by regulating Nrf2\/SLC7A11\/GPX4 signaling axis","volume":"15","author":"Qin","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2026.158057_bib0040","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.3390\/cancers17142328","article-title":"Harnessing liquiritigenin: a flavonoid-based approach for the prevention and treatment of cancer","volume":"17","author":"Sajeev","year":"2025","journal-title":"Cancers"},{"key":"10.1016\/j.phymed.2026.158057_bib0041","first-page":"536","article-title":"Activation of estrogen receptor beta signaling reduces stemness of glioma stem cells","volume":"39","author":"Sareddy","year":"2021","journal-title":"Stem. Cells 1981"},{"key":"10.1016\/j.phymed.2026.158057_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111285","article-title":"5-Fluorouracil (5-FU) resistance and the new strategy to enhance the sensitivity against cancer: implication of DNA repair inhibition","volume":"137","author":"Sethy","year":"2021","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.phymed.2026.158057_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2024.111148","article-title":"E3 ubiquitin ligase CHIP interacts with transferrin receptor 1 for degradation and promotes cell proliferation through inhibiting ferroptosis in hepatocellular carcinoma","volume":"118","author":"Shao","year":"2024","journal-title":"Cell Signal."},{"key":"10.1016\/j.phymed.2026.158057_bib0044","doi-asserted-by":"crossref","first-page":"11324","DOI":"10.1021\/acs.jmedchem.3c00815","article-title":"Liquiritigenin confers liver protection by enhancing NRF2 signaling through both canonical and non-canonical signaling pathways","volume":"66","author":"Shi","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.phymed.2026.158057_bib0045","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.phymed.2026.158057_bib0046","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s10565-024-09844-x","article-title":"METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke","volume":"40","author":"Su","year":"2024","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.phymed.2026.158057_bib0047","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/s41467-023-36630-w","article-title":"Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism","volume":"14","author":"Upadhyayula","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158057_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2024.110184","article-title":"Liquiritigenin inhibits the migration, invasion, and EMT of prostate cancer through activating ER stress","volume":"761","author":"Wang","year":"2024","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.phymed.2026.158057_bib0049","doi-asserted-by":"crossref","DOI":"10.1172\/JCI166647","article-title":"RB1-deficient prostate tumor growth and metastasis are vulnerable to ferroptosis induction via the E2F\/ACSL4 axis","volume":"133","author":"Wang","year":"2023","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2026.158057_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.109212","article-title":"Discovery of liquiritigenin derivatives as PKM2 allosteric inhibitors via targeting the polyarginine pocket","volume":"167","author":"Wang","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.phymed.2026.158057_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2022.100916","article-title":"Overcoming cancer chemotherapy resistance by the induction of ferroptosis","volume":"66","author":"Wang","year":"2023","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.phymed.2026.158057_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217992","article-title":"Synergistic targeting of FASN and HMGCS1 by cerulenin enhances tumor cell ferroptosis sensitivity through rewiring lipid metabolism and blocking GPX4 biosynthesis","volume":"633","author":"Xia","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.phymed.2026.158057_bib0053","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202500019","article-title":"MTCH2 deficiency promotes E2F4\/TFRC-mediated ferroptosis and sensitizes colorectal cancer liver metastasis to sorafenib","volume":"12","author":"Xing","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.phymed.2026.158057_bib0054","doi-asserted-by":"crossref","DOI":"10.7189\/jogh.13.04096","article-title":"National and subnational incidence, mortality and associated factors of colorectal cancer in China: a systematic analysis and modelling study","volume":"13","author":"Xu","year":"2023","journal-title":"J. Glob. Health"},{"key":"10.1016\/j.phymed.2026.158057_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2025.111578","article-title":"Liquiritigenin regulates MAPK (p38\/JNK) signaling through inhibition of IRAK4, attenuates inflammatory response, fibrosis and kidney dysfunction in a high-salt diet induced chronic kidney disease","volume":"418","author":"Yan","year":"2025","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.phymed.2026.158057_bib0056","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1021\/acs.jafc.1c07952","article-title":"Cucurbitacin E triggers cellular senescence in colon cancer cells via regulating the miR-371b-5p\/TFAP4 signaling pathway","volume":"70","author":"Yang","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2026.158057_bib0057","doi-asserted-by":"crossref","first-page":"14148","DOI":"10.1021\/acs.jafc.0c05551","article-title":"Cucurbitacin E chemosensitizes colorectal cancer cells via mitigating TFAP4\/wnt\/\u03b2-catenin signaling","volume":"68","author":"Yang","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2026.158057_bib0058","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1111\/cas.70015","article-title":"Transferrin receptor promotes endometrial cancer proliferation by activating the iron-dependent PI3K\/AKT\/mTOR signaling pathway","volume":"116","author":"Yang","year":"2025","journal-title":"Cancer Sci."},{"key":"10.1016\/j.phymed.2026.158057_bib0059","first-page":"1","article-title":"Isoliquiritigenin alleviates myocardial ischemia-reperfusion injury by regulating the Nrf2\/HO-1\/SLC7a11\/GPX4 axis in mice. Free radic","volume":"221","author":"Yao","year":"2024","journal-title":"Biol. Med."},{"key":"10.1016\/j.phymed.2026.158057_bib0060","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41392-025-02296-7","article-title":"Acevaltrate as a novel ferroptosis inducer with dual targets of PCBP1\/2 and GPX4 in colorectal cancer","volume":"10","author":"Yu","year":"2025","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2026.158057_bib0061","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.3724\/abbs.2023120","article-title":"Molecular mechanisms of ferroptosis and its antitumor applications in natural products","volume":"55","author":"Yu","year":"2023","journal-title":"Acta Biochim. Bioph. Sin."},{"key":"10.1016\/j.phymed.2026.158057_bib0062","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.7150\/jca.116357","article-title":"Isoliquiritigenin inhibits colorectal cancer progression by targeting the FGFR4\/FASN mediated lipid metabolism pathway","volume":"16","author":"Zhai","year":"2025","journal-title":"J. Cancer"},{"key":"10.1016\/j.phymed.2026.158057_bib0063","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155746","article-title":"Paris saponin VII inhibits triple-negative breast cancer by targeting the MEK\/ERK\/STMN1 signaling axis","volume":"130","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phymed.2026.158057_bib0064","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/s43018-023-00715-8","article-title":"Targeted activation of ferroptosis in colorectal cancer via LGR4 targeting overcomes acquired drug resistance","volume":"5","author":"Zheng","year":"2024","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.phymed.2026.158057_bib0065","first-page":"5902","article-title":"Natural flavonoids and ferroptosis: potential therapeutic opportunities for human diseases","volume":"71","author":"Zhou","year":"2023","journal-title":"J. Agric. Food Chem."}],"updated-by":[{"DOI":"10.1016\/j.phymed.2026.158416","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000}},{"DOI":"10.1016\/j.phymed.2026.158416","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000}}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132600293X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132600293X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:38:53Z","timestamp":1786480733000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471132600293X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":65,"alternative-id":["S094471132600293X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158057","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liquiritigenin targets transferrin receptor to potentiate ferroptosis sensitivity in colorectal cancer cells","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158057"}}