{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:41:20Z","timestamp":1793112080024,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005145","name":"Basic Research Program of Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005145","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82205025"],"award-info":[{"award-number":["82205025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374355"],"award-info":[{"award-number":["82374355"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20251967"],"award-info":[{"award-number":["BK20251967"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.phymed.2026.158080","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T16:10:58Z","timestamp":1773504658000},"page":"158080","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Hyperoside stabilizes ACAT1 to promote fatty acid oxidation and attenuate kidney fibrosis via the L-carnitine\u2013SIRT3 axis"],"prefix":"10.1016","volume":"155","author":[{"given":"Chuchu","family":"Shan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamas","family":"Szili-Torok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GuanYun","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2329-8191","authenticated-orcid":false,"given":"Tomoaki","family":"Morioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinobu","family":"Ochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangyi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liji","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiqiao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7795-3795","authenticated-orcid":false,"given":"Weilong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.phymed.2026.158080_bib0001","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1002\/humu.23831","article-title":"Mutation update on ACAT1 variants associated with mitochondrial acetoacetyl-CoA thiolase (T2) deficiency","volume":"40","author":"Abdelkreem","year":"2019","journal-title":"Hum. Mutat."},{"issue":"7","key":"10.1016\/j.phymed.2026.158080_bib0002","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.2215\/CJN.14180920","article-title":"Management of heart failure patient with CKD","volume":"16","author":"Banerjee","year":"2021","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158080_bib0003","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41581-021-00490-8","article-title":"Mineralocorticoid receptor antagonists in diabetic kidney disease - mechanistic and therapeutic effects","volume":"18","author":"Barrera-Chimal","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"issue":"3","key":"10.1016\/j.phymed.2026.158080_bib0004","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1681\/ASN.2019020213","article-title":"Iron deficiency in chronic kidney disease: updates on pathophysiology","volume":"31","author":"Batchelor","year":"2020","journal-title":"Diagnosis, Treat.. J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158080_bib0005","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-00070-7","article-title":"Total flavone of Abelmoschus Manihot improves colitis by promoting the growth of Akkermansia in mice","volume":"11","author":"Bu","year":"2021","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.phymed.2026.158080_bib0006","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1080\/15376516.2020.1777493","article-title":"Downregulation of Acat1 by miR-21 may participate in liver fibrosis upon chronic DDT exposure","volume":"30","author":"Chanyshev","year":"2020","journal-title":"Toxicol. Mech. Methods"},{"issue":"10","key":"10.1016\/j.phymed.2026.158080_bib0007","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1093\/ndt\/gfp258","article-title":"Peroxisome proliferator-activated receptor alpha plays a crucial role in l-carnitine anti-apoptosis effect in renal tubular cells","volume":"24","author":"Chen","year":"2009","journal-title":"Nephrol. Dial. TransPlant"},{"issue":"2","key":"10.1016\/j.phymed.2026.158080_bib0008","doi-asserted-by":"crossref","first-page":"531","DOI":"10.7150\/thno.80289","article-title":"SIRT3 mediates the effects of PCSK9 inhibitors on inflammation, autophagy, and oxidative stress in endothelial cells","volume":"13","author":"D'Onofrio","year":"2023","journal-title":"Theranostics."},{"issue":"5","key":"10.1016\/j.phymed.2026.158080_bib0009","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/nrneph.2014.31","article-title":"Novel targets of antifibrotic and anti-inflammatory treatment in CKD","volume":"10","author":"Decleves","year":"2014","journal-title":"Nat. Rev. Nephrol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158080_bib0010","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/15548627.2023.2252265","article-title":"Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy through SIRT3-mediated TFAM deacetylation","volume":"20","author":"Deng","year":"2024","journal-title":"Autophagy."},{"issue":"1","key":"10.1016\/j.phymed.2026.158080_bib0011","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1053\/j.ajkd.2018.02.354","article-title":"CKD and ESRD in US Hispanics","volume":"73","author":"Desai","year":"2019","journal-title":"Am. J. Kidney Dis."},{"issue":"6","key":"10.1016\/j.phymed.2026.158080_bib0012","doi-asserted-by":"crossref","DOI":"10.3390\/nu17061010","article-title":"l-carnitine and acetyl-l-carnitine induce metabolism alteration and mitophagy-related cell death in colorectal cancer cells","volume":"17","author":"Donisi","year":"2025","journal-title":"Nutrients."},{"key":"10.1016\/j.phymed.2026.158080_bib0013","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.intimp.2017.06.004","article-title":"Hyperoside inhibits lipopolysaccharide-induced inflammatory responses in microglial cells via p38 and NFkappaB pathways","volume":"50","author":"Fan","year":"2017","journal-title":"Int. Immunopharmacol."},{"issue":"7","key":"10.1016\/j.phymed.2026.158080_bib0014","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11071356","article-title":"Tubular mitochondrial dysfunction, oxidative stress, and progression of chronic kidney disease","volume":"11","author":"Fontecha-Barriuso","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2026.158080_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101671","article-title":"HIF-1alpha-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia\/reperfusion injury","volume":"36","author":"Fu","year":"2020","journal-title":"Redox. Biol."},{"issue":"12","key":"10.1016\/j.phymed.2026.158080_bib0016","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1093\/ndt\/gfad118","article-title":"Hypertension in chronic kidney disease-treatment standard 2023","volume":"38","author":"Georgianos","year":"2023","journal-title":"Nephrol. Dial. TransPlant"},{"issue":"11","key":"10.1016\/j.phymed.2026.158080_bib0017","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1038\/s41388-020-1156-0","article-title":"Stabilization of FASN by ACAT1-mediated GNPAT acetylation promotes lipid metabolism and hepatocarcinogenesis","volume":"39","author":"Gu","year":"2020","journal-title":"Oncogene"},{"key":"10.1016\/j.phymed.2026.158080_bib0018","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev-physiol-021115-105045","article-title":"The biochemistry and physiology of mitochondrial fatty acid beta-oxidation and its genetic disorders","volume":"78","author":"Houten","year":"2016","journal-title":"Annu. Rev. Physiol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158080_bib0019","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41392-023-01379-7","article-title":"Kidney fibrosis: from mechanisms to therapeutic medicines","volume":"8","author":"Huang","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"8","key":"10.1016\/j.phymed.2026.158080_bib0020","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11081437","article-title":"Hyperoside as a potential natural product targeting oxidative stress in liver diseases","volume":"11","author":"Jang","year":"2022","journal-title":"Antioxidants"},{"issue":"7","key":"10.1016\/j.phymed.2026.158080_bib0021","doi-asserted-by":"crossref","DOI":"10.1172\/JCI181517","article-title":"ACAT1 regulates tertiary lymphoid structures and correlates with immunotherapy response in non-small cell lung cancer","volume":"135","author":"Jiao","year":"2025","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phymed.2026.158080_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101426","article-title":"Mitochondrial quality control in pulmonary fibrosis","volume":"33","author":"Larson-Casey","year":"2020","journal-title":"Redox. Biol."},{"issue":"38","key":"10.1016\/j.phymed.2026.158080_bib0023","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2505752122","article-title":"Tubular ACSM3 deficiency impairs medium-chain fatty acid metabolism and aggravates kidney fibrosis","volume":"122","author":"Li","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.phymed.2026.158080_bib0024","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13975","article-title":"l-carnitine alleviates cardiac microvascular dysfunction in diabetic cardiomyopathy by enhancing PINK1-parkin-dependent mitophagy through the CPT1a-PHB2-PARL pathways","volume":"238","author":"Li","year":"2023","journal-title":"Acta Physiol."},{"issue":"43","key":"10.1016\/j.phymed.2026.158080_bib0025","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202404753","article-title":"Mitochondrial dysfunction-evoked DHODH acetylation is involved in renal cell ferroptosis during cisplatin-induced acute kidney injury","volume":"11","author":"Liang","year":"2024","journal-title":"Adv. Sci."},{"issue":"4","key":"10.1016\/j.phymed.2026.158080_bib0026","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.7150\/ijbs.80775","article-title":"Mitophagy alleviates cisplatin-induced renal tubular epithelial cell ferroptosis through ROS\/HO-1\/GPX4 axis","volume":"19","author":"Lin","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.phymed.2026.158080_bib0027","article-title":"Hyperoside suppresses renal inflammation by regulating macrophage polarization in mice with type 2","volume":"12","author":"Liu","year":"2021","journal-title":"Diabetes Mellitus. Front. Immunol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158080_bib0028","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41581-020-00363-6","article-title":"Sustainable Development Goals relevant to kidney health: an update on progress","volume":"17","author":"Luyckx","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"issue":"5","key":"10.1016\/j.phymed.2026.158080_bib0029","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/biof.1673","article-title":"Mitochondrial dysfunction and endoplasmic reticulum stress in the promotion of fibrosis in obstructive nephropathy induced by unilateral ureteral obstruction","volume":"46","author":"Martinez-Klimova","year":"2020","journal-title":"Biofactors"},{"issue":"2","key":"10.1016\/j.phymed.2026.158080_bib0030","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.metabol.2003.11.005","article-title":"Inflammation and pathogenesis of diabetic nephropathy","volume":"53","author":"Mora","year":"2004","journal-title":"Metabolism."},{"key":"10.1016\/j.phymed.2026.158080_bib0031","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.addr.2017.12.019","article-title":"Targeting renal fibrosis: mechanisms and drug delivery systems","volume":"129","author":"Nastase","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.phymed.2026.158080_bib0032","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2215\/CJN.09340817","article-title":"Hyperkalemia across the continuum of kidney function","volume":"13","author":"Palmer","year":"2018","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158080_bib0033","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41392-024-01816-1","article-title":"2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis","volume":"9","author":"Peng","year":"2024","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"7","key":"10.1016\/j.phymed.2026.158080_bib0034","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS. Biol."},{"issue":"7","key":"10.1016\/j.phymed.2026.158080_bib0035","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1080\/15548627.2015.1052208","article-title":"SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin","volume":"11","author":"Pi","year":"2015","journal-title":"Autophagy."},{"key":"10.1016\/j.phymed.2026.158080_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2021.101117","article-title":"PARPs in lipid metabolism and related diseases","volume":"84","author":"Szanto","year":"2021","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.phymed.2026.158080_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154390","article-title":"Gambogenic acid alleviates kidney fibrosis via epigenetic inhibition of EZH2 to regulate Smad7-dependent mechanism","volume":"106","author":"Tao","year":"2022","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.phymed.2026.158080_bib0038","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.kint.2024.12.020","article-title":"Repurposing mitochondria-targeted therapeutics for kidney diseases","volume":"107","author":"Thompson","year":"2025","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.phymed.2026.158080_bib0039","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/s41401-023-01156-w","article-title":"Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis","volume":"45","author":"Wang","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"issue":"37","key":"10.1016\/j.phymed.2026.158080_bib0040","doi-asserted-by":"crossref","first-page":"48993","DOI":"10.1021\/acsami.4c07604","article-title":"Rapamycin and hyperoside-Co-loaded macrophage delivery system enhanced Pulmonary fibrosis therapy by autophagy upregulation and epithelial-to-mesenchymal transition inhibition","volume":"16","author":"Wang","year":"2024","journal-title":"ACS. Appl. Mater. Interfaces."},{"key":"10.1016\/j.phymed.2026.158080_bib0041","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jare.2021.06.001","article-title":"Hyperoside attenuates non-alcoholic fatty liver disease in rats via cholesterol metabolism and bile acid metabolism","volume":"34","author":"Wang","year":"2021","journal-title":"J. Adv. Res."},{"issue":"1","key":"10.1016\/j.phymed.2026.158080_bib0042","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s10020-023-00730-6","article-title":"Resveratrol reduces ROS-induced ferroptosis by activating SIRT3 and compensating the GSH\/GPX4 pathway","volume":"29","author":"Wang","year":"2023","journal-title":"Mol. Med."},{"issue":"4","key":"10.1016\/j.phymed.2026.158080_bib0043","doi-asserted-by":"crossref","first-page":"eadq9301","DOI":"10.1126\/sciadv.adq9301","article-title":"Mitochondrial fatty acid oxidation regulates monocytic type I interferon signaling via histone acetylation","volume":"11","author":"Wu","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.phymed.2026.158080_bib0044","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.redox.2016.12.022","article-title":"The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2\/PINK1","volume":"11","author":"Xiao","year":"2017","journal-title":"Redox. Biol."},{"issue":"114187","key":"10.1016\/j.phymed.2026.158080_bib0045","article-title":"The role and mechanism of hyperoside against myocardial infarction in mice by regulating autophagy via NLRP1 inflammation pathway","volume":"276","author":"Yang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158080_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2022.155195","article-title":"Mitochondrial dysfunction in diabetic tubulopathy","volume":"131","author":"Yao","year":"2022","journal-title":"Metabolism."},{"issue":"176178","key":"10.1016\/j.phymed.2026.158080_bib0047","article-title":"Hyperoside attenuates carbon tetrachloride-induced hepatic fibrosis via the poly(ADP-ribose)polymerase-1-high mobility group protein 1 pathway","volume":"960","author":"Zeng","year":"2023","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158080_bib0048","first-page":"324","article-title":"Total flavone of Abelmoschus manihot ameliorates Crohn's disease by regulating the NF\u2011kappaB and MAPK signaling pathways","volume":"44","author":"Zhang","year":"2019","journal-title":"Int. J. Mol. Med."},{"issue":"12","key":"10.1016\/j.phymed.2026.158080_bib0049","doi-asserted-by":"crossref","first-page":"5871","DOI":"10.1002\/ptr.7993","article-title":"Hyperoside mediates protection from diabetes kidney disease by regulating ROS-ERK signaling pathway and pyroptosis","volume":"37","author":"Zhang","year":"2023","journal-title":"PhytOther Res."},{"key":"10.1016\/j.phymed.2026.158080_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102707","article-title":"The deubiquitinase USP11 ameliorates intervertebral disc degeneration by regulating oxidative stress-induced ferroptosis via deubiquitinating and stabilizing Sirt3","volume":"62","author":"Zhu","year":"2023","journal-title":"Redox. Biol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158080_bib0051","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.molcel.2019.10.015","article-title":"Dynamic regulation of ME1 phosphorylation and acetylation affects lipid metabolism and colorectal tumorigenesis","volume":"77","author":"Zhu","year":"2020","journal-title":"Mol. Cell"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326003156?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326003156?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:04:24Z","timestamp":1790114664000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326003156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":51,"alternative-id":["S0944711326003156"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158080","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyperoside stabilizes ACAT1 to promote fatty acid oxidation and attenuate kidney fibrosis via the L-carnitine\u2013SIRT3 axis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158080","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158080"}}