{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:10:20Z","timestamp":1790115020478,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574852"],"award-info":[{"award-number":["82574852"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002418","name":"China Academy of Chinese Medical Sciences Institute of Chinese Materia Medica","doi-asserted-by":"publisher","award":["CI2023C010YL"],"award-info":[{"award-number":["CI2023C010YL"]}],"id":[{"id":"10.13039\/501100002418","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.phymed.2026.158099","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T15:55:59Z","timestamp":1774108559000},"page":"158099","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Mahuang decoction targets fluid retention in heart failure with preserved ejection fraction"],"prefix":"10.1016","volume":"155","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5130-4130","authenticated-orcid":false,"given":"Xiaoyu","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7600-1892","authenticated-orcid":false,"given":"Xiaopeng","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongcheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanchang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4100-4465","authenticated-orcid":false,"given":"Guoju","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luqi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158099_bib0001","first-page":"00040","article-title":"Enhancing sweat rate for in-hospital and home-based decongestive therapy","volume":"9164","author":"Aronson","year":"2025","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.phymed.2026.158099_bib0002","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/23328940.2019.1632145","article-title":"Physiology of sweat gland function: the roles of sweating and sweat composition in human health","volume":"6","author":"Baker","year":"2019","journal-title":"Temperature"},{"key":"10.1016\/j.phymed.2026.158099_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.05.049","article-title":"Obestatin ameliorates water retention in chronic heart failure by downregulating renal aquaporin 2 through GPR39, V2R and PPARG signaling","volume":"231","author":"Bao","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.phymed.2026.158099_bib0004","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s00395-022-00955-2","article-title":"Cardiomyocyte p38 MAPKalpha suppresses a heart-adipose tissue-neutrophil crosstalk in heart failure development","volume":"117","author":"Bottermann","year":"2022","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.phymed.2026.158099_bib0005","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.biocel.2017.11.010","article-title":"Functional analysis of corin protein domains required for PCSK6-mediated activation","volume":"94","author":"Chen","year":"2018","journal-title":"Int J. Biochem. Cell Biol."},{"key":"10.1016\/j.phymed.2026.158099_bib0006","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.3390\/ijms24031889","article-title":"Aquaporin-5 dynamic regulation","volume":"24","author":"D'Agostino","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158099_bib0007","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1056\/NEJMc2313870","article-title":"Corin and left atrial cardiomyopathy, hypertension, arrhythmia, and fibrosis","volume":"390","author":"Dominy","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phymed.2026.158099_bib0008","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41569-024-01067-1","article-title":"Pathophysiological insights into HFpEF from studies of human cardiac tissue","volume":"22","author":"Fayyaz","year":"2025","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.phymed.2026.158099_bib0009","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2024.1421008","article-title":"Exploration of chemical components and metabolite synthesis pathways in eight Ephedra species based on HS-GCMS\u2013 and UPLC-Q-TOF-MS","volume":"15","author":"Guo","year":"2024","journal-title":"Front Plant Sci"},{"key":"10.1016\/j.phymed.2026.158099_bib0010","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11897-019-0424-1","article-title":"Diuretic resistance in heart failure","volume":"16","author":"Gupta","year":"2019","journal-title":"Curr. Heart. Fail. Rep."},{"key":"10.1016\/j.phymed.2026.158099_bib0011","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41572-024-00540-y","article-title":"Heart failure with preserved ejection fraction","volume":"10","author":"Hamo","year":"2024","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.phymed.2026.158099_bib0012","first-page":"145","article-title":"Analysis of clinical effect of Mahuang Shengma decoction in the treatment of chronic pulmonary heart disease and heart failure","volume":"4","author":"Han","year":"2016","journal-title":"Cardiovasc Dis Electron J. Integr Tradit Chin West Med"},{"key":"10.1016\/j.phymed.2026.158099_bib0013","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1002\/ptr.7869","article-title":"Glycyrrhizae radix et rhizoma: the popular occurrence of herbal medicine applied in classical prescriptions","volume":"37","author":"He","year":"2023","journal-title":"Phytother Res"},{"key":"10.1016\/j.phymed.2026.158099_bib0014","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001090","article-title":"The protease corin regulates electrolyte homeostasis in eccrine sweat glands","volume":"19","author":"He","year":"2021","journal-title":"PLoS Biol."},{"key":"10.1016\/j.phymed.2026.158099_bib0015","doi-asserted-by":"crossref","first-page":"e263","DOI":"10.1016\/j.jacc.2021.12.012","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure: a report of the american college of cardiology\/american heart association joint committee on clinical practice guidelines","volume":"79","author":"Heidenreich","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.phymed.2026.158099_bib0016","doi-asserted-by":"crossref","DOI":"10.15420\/cfr.2023.03","article-title":"Epidemiology, clinical characteristics and cause-specific outcomes in heart failure with preserved ejection fraction","volume":"9","author":"Kapelios","year":"2023","journal-title":"Card. Fail. Rev."},{"key":"10.1016\/j.phymed.2026.158099_bib0017","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.673497","article-title":"Distribution of cardiac and renal corin and proprotein convertase subtilisin\/kexin-6 in the experimental model of cardio-renal syndrome of various severities","volume":"12","author":"Khoury","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.phymed.2026.158099_bib0018","doi-asserted-by":"crossref","first-page":"7457","DOI":"10.1007\/s11033-021-06763-6","article-title":"The role of AQP3 and AQP4 channels in cisplatin-induced cardiovascular edema and the protective effect of melatonin","volume":"48","author":"Koral","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.phymed.2026.158099_bib0019","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1093\/eurheartj\/ehy301","article-title":"Heart failure with preserved ejection fraction: from mechanisms to therapies","volume":"39","author":"Lam","year":"2018","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.phymed.2026.158099_bib0020","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/978-981-19-7415-1_19","article-title":"Aquaporins in edema","volume":"1398","author":"Li","year":"2023","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.phymed.2026.158099_bib0021","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.biopha.2017.10.090","article-title":"Corin protects H2O2-induced apoptosis through PI3K\/AKT and NF-kappaB pathway in cardiomyocytes","volume":"97","author":"Li","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phymed.2026.158099_bib0022","first-page":"194","article-title":"Discussion on the application and thinking of sweating method in chronic heart failure based on \"sweat is the fluid of the heart\"","volume":"43","author":"Liang","year":"2025","journal-title":"Chin Arch Tradit. Chin. Med."},{"key":"10.1016\/j.phymed.2026.158099_bib0023","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.599180","article-title":"Mahuang decoction antagonizes acute liver failure via modulating tricarboxylic acid cycle and amino acids metabolism","volume":"12","author":"Liao","year":"2021","journal-title":"Front Pharmacol."},{"key":"10.1016\/j.phymed.2026.158099_bib0024","doi-asserted-by":"crossref","first-page":"W159","DOI":"10.1093\/nar\/gkac394","article-title":"CB-Dock2: improved protein-ligand blind docking by integrating cavity detection, docking and homologous template fitting","volume":"50","author":"Liu","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.phymed.2026.158099_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113745","article-title":"Herb pair of Ephedrae Herba-Armeniacae Semen Amarum alleviates airway injury in asthmatic rats","volume":"269","author":"Ma","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158099_bib0026","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/ehf2.14309","article-title":"Differences in red blood cell mass profiles impact intravascular volume and outcome risk in chronic heart failure","volume":"10","author":"Miller","year":"2023","journal-title":"ESC Heart. Fail."},{"key":"10.1016\/j.phymed.2026.158099_bib0027","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/4602612","article-title":"The herbal formula granule prescription Mahuang decoction ameliorated chronic kidney disease which was associated with restoration of dysbiosis of intestinal microbiota in rats","volume":"2021","author":"Ming","year":"2021","journal-title":"Evid. Based Complement Altern Med."},{"key":"10.1016\/j.phymed.2026.158099_bib0028","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"key":"10.1016\/j.phymed.2026.158099_bib0029","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41586-019-1100-z","article-title":"Nitrosative stress drives heart failure with preserved ejection fraction","volume":"568","author":"Schiattarella","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2026.158099_bib0030","doi-asserted-by":"crossref","first-page":"36082","DOI":"10.1021\/acsomega.5c03687","article-title":"Inhibition of cardiac p38 highlights the role of the phosphoproteome in heart failure progression","volume":"10","author":"Sedighi","year":"2025","journal-title":"ACS Omega"},{"key":"10.1016\/j.phymed.2026.158099_bib0031","doi-asserted-by":"crossref","DOI":"10.1002\/jms.5069","article-title":"Rapid identification of various chemical components in Cinnamomi ramulus by UPLC-Q-Orbitrap-MS","volume":"59","author":"Shu","year":"2024","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.phymed.2026.158099_bib0032","article-title":"Armeniacae semen amarum: a review on its botany, phytochemistry, pharmacology, clinical application, toxicology and pharmacokinetics","volume":"15","author":"Tang","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158099_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118110","article-title":"Kidney-tonifying blood-activating decoction delays ventricular remodeling in rats with chronic heart failure by regulating gut microbiota and metabolites and p38 mitogen-activated protein kinase\/p65 nuclear factor kappa-B\/aquaporin-4 signaling pathway","volume":"330","author":"Xu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158099_bib0034","first-page":"258","article-title":"Analysis of the prescription and medication rules for treating heart failure in the Treatise on Febrile Diseases and Miscellaneous Diseases","volume":"30","author":"Xu","year":"2024","journal-title":"J. Basic Chin. Med."},{"key":"10.1016\/j.phymed.2026.158099_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115538","article-title":"Mahuang Xixin Fuzi decoction ameliorates apoptosis via the mitochondrial-mediated signaling pathway in MCM cells","volume":"297","author":"Yang","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phymed.2026.158099_bib0036","doi-asserted-by":"crossref","first-page":"717","DOI":"10.3390\/biology11050717","article-title":"Corin: a key mediator in sodium homeostasis, vascular remodeling, and heart failure","volume":"11","author":"Zhang","year":"2022","journal-title":"Biol"},{"key":"10.1016\/j.phymed.2026.158099_bib0037","first-page":"35","article-title":"Effect of modified Xiaoqinglong decoction on chronic heart failure and its influence on neuroendocrine and cytokines","volume":"13","author":"Zhao","year":"2023","journal-title":"Prev. Treat. Cardiovasc. Dis."},{"key":"10.1016\/j.phymed.2026.158099_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116153","article-title":"Ephedrae herba: a comprehensive review of its traditional uses, phytochemistry, pharmacology, and toxicology","volume":"307","author":"Zheng","year":"2023","journal-title":"J. Ethnopharmacol."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132600334X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S094471132600334X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:57:03Z","timestamp":1790114223000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S094471132600334X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":38,"alternative-id":["S094471132600334X"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158099","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mahuang decoction targets fluid retention in heart failure with preserved ejection fraction","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158099","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"158099"}}