{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:11:41Z","timestamp":1792181501933,"version":"4.4.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171467"],"award-info":[{"award-number":["82171467"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371477"],"award-info":[{"award-number":["82371477"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ30864"],"award-info":[{"award-number":["2023JJ30864"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ7635"],"award-info":[{"award-number":["2024JJ7635"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ30936"],"award-info":[{"award-number":["2023JJ30936"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2025JJ50621"],"award-info":[{"award-number":["2025JJ50621"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.phymed.2026.158104","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:21:15Z","timestamp":1774398075000},"page":"158104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Chrysophanol exerts neuroprotection against cerebral ischemia- reperfusion injury by regulating I\u03baB\u03b1-stabilized MLKL via ZNF460-TRAF6 axis"],"prefix":"10.1016","volume":"155","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7059-9221","authenticated-orcid":false,"given":"Congyi","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaofeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianfang","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yundan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158104_bib0001","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/978-1-0716-2063-2_16","article-title":"Generation of monoubiquitin and K63-linked polyubiquitin chains for protein interaction studies","volume":"2444","author":"Anoh","year":"2022","journal-title":"Methods Mol. Biol."},{"issue":"4","key":"10.1016\/j.phymed.2026.158104_bib0002","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1136\/jnnp-2019-322424","article-title":"Ischaemic stroke in young adults: a global perspective","volume":"91","author":"Boot","year":"2020","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"1","key":"10.1016\/j.phymed.2026.158104_bib0003","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ncb2883","article-title":"Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis","volume":"16","author":"Cai","year":"2014","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158104_bib0004","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/gene.1078","article-title":"A CamKIIalpha iCre BAC allows brain-specific gene inactivation","volume":"31","author":"Casanova","year":"2001","journal-title":"Genesis"},{"issue":"4","key":"10.1016\/j.phymed.2026.158104_bib0005","doi-asserted-by":"crossref","first-page":"807","DOI":"10.14336\/AD.2018.0728","article-title":"Necrostatin-1 prevents necroptosis in brains after ischemic stroke via inhibition of RIPK1-mediated RIPK3\/MLKL signaling","volume":"10","author":"Deng","year":"2019","journal-title":"Aging Dis."},{"issue":"3","key":"10.1016\/j.phymed.2026.158104_bib0006","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/jnc.14075","article-title":"Tumor necrosis factor receptor-associated factor 6 participates in early brain injury after subarachnoid hemorrhage in rats through inhibiting autophagy and promoting oxidative stress","volume":"142","author":"Dou","year":"2017","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.phymed.2026.158104_bib0007","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41467-024-54715-y","article-title":"Stereo-seq of the prefrontal cortex in aging and Alzheimer's disease","volume":"16","author":"Gong","year":"2025","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.phymed.2026.158104_bib0008","doi-asserted-by":"crossref","first-page":"3198","DOI":"10.7150\/jca.55079","article-title":"Overexpression of ZNF460 predicts worse survival and promotes metastasis through JAK2\/STAT3 signaling pathway in patient with colon cancer","volume":"12","author":"Hao","year":"2021","journal-title":"J. Cancer"},{"issue":"42","key":"10.1016\/j.phymed.2026.158104_bib0009","doi-asserted-by":"crossref","first-page":"15072","DOI":"10.1073\/pnas.1408987111","article-title":"Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death","volume":"111","author":"Hildebrand","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.phymed.2026.158104_bib0010","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/s41418-020-00606-w","article-title":"TRIM22 activates NF-\u03bab signaling in glioblastoma by accelerating the degradation of i\u03bab\u03b1","volume":"28","author":"Ji","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.phymed.2026.158104_bib0011","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11267","article-title":"The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling","volume":"7","author":"Ji","year":"2016","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.phymed.2026.158104_bib0012","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1161\/STROKEAHA.120.032810","article-title":"Thrombus composition and efficacy of thrombolysis and thrombectomy in acute ischemic stroke","volume":"52","author":"Jolugbo","year":"2021","journal-title":"Stroke"},{"issue":"36","key":"10.1016\/j.phymed.2026.158104_bib0013","doi-asserted-by":"crossref","first-page":"24871","DOI":"10.1074\/jbc.M802749200","article-title":"The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL","volume":"283","author":"Lamothe","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.phymed.2026.158104_bib0014","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1038\/s41418-023-01161-w","article-title":"IKK-mediated TRAF6 and RIPK1 interaction stifles cell death complex assembly leading to the suppression of TNF-\u03b1-induced cell death","volume":"30","author":"Lee","year":"2023","journal-title":"Cell Death Differ."},{"issue":"46","key":"10.1016\/j.phymed.2026.158104_bib0015","doi-asserted-by":"crossref","first-page":"13476","DOI":"10.1021\/bi035390r","article-title":"An NF-kappaB-specific inhibitor, IkappaBalpha, binds to and inhibits cyclin-dependent kinase 4","volume":"42","author":"Li","year":"2003","journal-title":"Biochemistry"},{"issue":"12","key":"10.1016\/j.phymed.2026.158104_bib0016","doi-asserted-by":"crossref","DOI":"10.1111\/cns.70144","article-title":"Mef2c exacerbates neuron necroptosis via modulating alternative splicing of Cflar in ischemic stroke with hyperlipidemia","volume":"30","author":"Li","year":"2024","journal-title":"CNS Neurosci. Ther."},{"issue":"50","key":"10.1016\/j.phymed.2026.158104_bib0017","doi-asserted-by":"crossref","first-page":"12123","DOI":"10.1523\/JNEUROSCI.1751-17.2017","article-title":"The ubiquitin E3 ligase TRAF6 exacerbates ischemic stroke by ubiquitinating and activating Rac1","volume":"37","author":"Li","year":"2017","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.phymed.2026.158104_bib0018","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41419-022-05524-y","article-title":"TRAF6 regulates the abundance of RIPK1 and inhibits the RIPK1\/RIPK3\/MLKL necroptosis signaling pathway and affects the progression of colorectal cancer","volume":"14","author":"Lin","year":"2023","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.phymed.2026.158104_bib0019","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.7150\/ijbs.56800","article-title":"Genistein-3\u2019-sodium sulfonate attenuates neuroinflammation in stroke rats by down-regulating microglial M1 polarization through \u03b17nAChR-NF-\u03bab signaling pathway","volume":"17","author":"Liu","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.phymed.2026.158104_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109220","article-title":"Chrysophanol facilitates long-term neurological recovery through limiting microglia-mediated neuroinflammation after ischemic stroke in mice","volume":"112","author":"Liu","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"11","key":"10.1016\/j.phymed.2026.158104_bib0021","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1001\/jama.2020.26867","article-title":"Diagnosis and management of transient ischemic attack and acute ischemic stroke: a review","volume":"325","author":"Mendelson","year":"2021","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.phymed.2026.158104_bib0022","doi-asserted-by":"crossref","first-page":"6804","DOI":"10.1038\/s41467-023-42255-w","article-title":"Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization","volume":"14","author":"Meng","year":"2023","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.phymed.2026.158104_bib0023","doi-asserted-by":"crossref","first-page":"820","DOI":"10.4049\/jimmunol.1600334","article-title":"A20 ameliorates intracerebral hemorrhage-induced inflammatory injury by regulating TRAF6 polyubiquitination","volume":"198","author":"Meng","year":"2017","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.phymed.2026.158104_bib0024","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.molcel.2019.05.022","article-title":"TAM kinases promote necroptosis by regulating oligomerization of MLKL","volume":"75","author":"Najafov","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.phymed.2026.158104_bib0025","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41420-018-0067-0","article-title":"Phenotypic screening identifies a new oxazolone inhibitor of necroptosis and neuroinflammation","volume":"4","author":"Oliveira","year":"2018","journal-title":"Cell Death Discov."},{"issue":"1","key":"10.1016\/j.phymed.2026.158104_bib0026","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12974-020-01764-x","article-title":"DJ-1 exerts anti-inflammatory effects and regulates NLRX1-TRAF6 via SHP-1 in stroke","volume":"17","author":"Peng","year":"2020","journal-title":"J. Neuroinflamm."},{"issue":"5","key":"10.1016\/j.phymed.2026.158104_bib0027","doi-asserted-by":"crossref","first-page":"640","DOI":"10.4049\/jimmunol.2200603","article-title":"USP39 regulates NF-\u03bab-mediated inflammatory responses through deubiquitinating K48-linked i\u03bab\u03b1","volume":"210","author":"Quan","year":"2023","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158104_bib0028","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/cdd.2015.70","article-title":"Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis","volume":"23","author":"Rodriguez","year":"2016","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.phymed.2026.158104_bib0029","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.bbi.2020.10.015","article-title":"Lipopolysaccharide-induced sepsis-like state compromises post-ischemic neurological recovery, brain tissue survival and remodeling via mechanisms involving microvascular thrombosis and brain T cell infiltration","volume":"91","author":"Sardari","year":"2021","journal-title":"Brain Behav. Immun."},{"issue":"6","key":"10.1016\/j.phymed.2026.158104_bib0030","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/s12276-021-00634-7","article-title":"Necroptosis molecular mechanisms: recent findings regarding novel necroptosis regulators","volume":"53","author":"Seo","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.phymed.2026.158104_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102852","article-title":"Remote ischemic conditioning attenuates oxidative stress and inflammation via the Nrf2\/HO-1 pathway in MCAO mice","volume":"66","author":"Sun","year":"2023","journal-title":"Redox Biol"},{"issue":"1","key":"10.1016\/j.phymed.2026.158104_bib0032","first-page":"33","article-title":"China stroke surveillance report 2021","volume":"10","author":"Tu","year":"2023","journal-title":"Mil. Med. Res."},{"issue":"9","key":"10.1016\/j.phymed.2026.158104_bib0033","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1001\/jama.2022.1420","article-title":"What is acute ischemic stroke?","volume":"327","author":"Walter","year":"2022","journal-title":"JAMA"},{"issue":"7","key":"10.1016\/j.phymed.2026.158104_bib0034","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1007\/s12035-023-03728-7","article-title":"The role of necroptosis in cerebral ischemic stroke","volume":"61","author":"Wang","year":"2024","journal-title":"Mol. Neurobiol."},{"issue":"8","key":"10.1016\/j.phymed.2026.158104_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110354","article-title":"K48\/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy","volume":"38","author":"Wang","year":"2022","journal-title":"Cell Rep"},{"issue":"2","key":"10.1016\/j.phymed.2026.158104_bib0036","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jcmgh.2019.10.002","article-title":"RIPK1 mediates TNF-induced intestinal crypt apoptosis during chronic NF-\u03bab activation","volume":"9","author":"Wong","year":"2020","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"issue":"12","key":"10.1016\/j.phymed.2026.158104_bib0037","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.clinbiochem.2013.05.059","article-title":"Identification of TLR downstream pathways in stroke patients","volume":"46","author":"Wu","year":"2013","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.phymed.2026.158104_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2022.114197","article-title":"Chrysophanol postconditioning attenuated cerebral ischemia-reperfusion injury induced NLRP3-related pyroptosis in a TRAF6-dependent manner","volume":"357","author":"Xia","year":"2022","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158104_bib0039","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1038\/s41467-022-29401-6","article-title":"USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy","volume":"13","author":"Xiong","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158104_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116140","article-title":"The role and therapeutic potential of nuclear factor \u03bab (NF-\u03baB) in ischemic stroke","volume":"171","author":"Xu","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"7343","key":"10.1016\/j.phymed.2026.158104_bib0041","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nature09853","article-title":"Crystal structure of inhibitor of \u03bab kinase \u03b2","volume":"472","author":"Xu","year":"2011","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.phymed.2026.158104_bib0042","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2183\/pjab.97.009","article-title":"TNF receptor-associated factor 6 (TRAF6) plays crucial roles in multiple biological systems through polyubiquitination-mediated NF-\u03bab activation","volume":"97","author":"Yamamoto","year":"2021","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"key":"10.1016\/j.phymed.2026.158104_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114672","article-title":"Cornuside protects against ischemic stroke in rats by suppressing the IL-17F\/TRAF6\/NF-\u03bab pathway via the brain-gut axis","volume":"373","author":"Yan","year":"2024","journal-title":"Exp. Neurol."},{"issue":"7","key":"10.1016\/j.phymed.2026.158104_bib0044","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1093\/cercor\/bhy089","article-title":"RIPK3\/MLKL-mediated neuronal necroptosis modulates the M1\/M2 polarization of microglia\/macrophages in the ischemic cortex","volume":"28","author":"Yang","year":"2018","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.phymed.2026.158104_bib0045","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s13578-023-01056-w","article-title":"TRIM67 alleviates cerebral ischemia\u2012reperfusion injury by protecting neurons and inhibiting neuroinflammation via targeting i\u03bab\u03b1 for K63-linked polyubiquitination","volume":"29","author":"Yu","year":"2023","journal-title":"Cell Biosci."},{"issue":"1","key":"10.1016\/j.phymed.2026.158104_bib0046","first-page":"25","article-title":"Activated Drp1 regulates p62-mediated autophagic flux and aggravates inflammation in cerebral ischemia-reperfusion via the ROS-RIP1\/RIP3-exosome axis","volume":"9","author":"Zeng","year":"2022","journal-title":"Mil. Med. Res."},{"issue":"1","key":"10.1016\/j.phymed.2026.158104_bib0047","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12943-024-01944-w","article-title":"ZNF460-mediated circRPPH1 promotes TNBC progression through ITGA5-induced FAK\/PI3K\/AKT activation in a ceRNA manner","volume":"23","author":"Zhang","year":"2024","journal-title":"Mol. Cancer"},{"issue":"7","key":"10.1016\/j.phymed.2026.158104_bib0048","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41419-020-02770-w","article-title":"Catalytically inactive RIP1 and RIP3 deficiency protect against acute ischemic stroke by inhibiting necroptosis and neuroinflammation","volume":"11","author":"Zhang","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2026.158104_bib0049","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2017.10.016","article-title":"Chrysophanol inhibits endoplasmic reticulum stress in cerebral ischemia and reperfusion mice","volume":"818","author":"Zhao","year":"2018","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158104_bib0050","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jphs.2018.08.002","article-title":"Chrysophanol attenuates nitrosative\/oxidative stress injury in a mouse model of focal cerebral ischemia\/reperfusion","volume":"138","author":"Zhao","year":"2018","journal-title":"J. Pharmacol. Sci."},{"issue":"1","key":"10.1016\/j.phymed.2026.158104_bib0051","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1186\/s12974-023-02968-7","article-title":"OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2","volume":"20","author":"Zheng","year":"2023","journal-title":"J. Neuroinflamm."},{"issue":"2","key":"10.1016\/j.phymed.2026.158104_bib0052","doi-asserted-by":"crossref","DOI":"10.1111\/cns.70242","article-title":"LncRNA-MEG3 mediated diabetic cerebral ischemia-reperfusion injury-induced apoptosis via modulating interaction between Annexin A2 and Akt in mitochondria","volume":"31","author":"Zhou","year":"2025","journal-title":"CNS Neurosci. Ther."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326003399?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326003399?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:03:46Z","timestamp":1790114626000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326003399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":52,"alternative-id":["S0944711326003399"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158104","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chrysophanol exerts neuroprotection against cerebral ischemia- reperfusion injury by regulating I\u03baB\u03b1-stabilized MLKL via ZNF460-TRAF6 axis","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158104","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"158104"}}