{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:01:06Z","timestamp":1790118066838,"version":"4.0.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007847","name":"Jilin Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["20210101338JC"],"award-info":[{"award-number":["20210101338JC"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.phymed.2026.158107","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:54:27Z","timestamp":1774464867000},"page":"158107","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Scutellarin modulates Nrf2 to alleviate inflammation, pyroptosis, and ferroptosis in acetaminophen-induced hepatotoxicity"],"prefix":"10.1016","volume":"155","author":[{"given":"Rongli","family":"Pu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianxue","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanze","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.phymed.2026.158107_bib0001","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41580-019-0173-8","article-title":"Mitochondria as multifaceted regulators of cell death","volume":"21","author":"Bock","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158107_bib0002","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.1038\/s41467-023-39412-6","article-title":"USP25 regulates KEAP1-Nrf2 anti-oxidation axis and its inactivation protects acetaminophen-induced liver injury in male mice","volume":"14","author":"Cai","year":"2023","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.phymed.2026.158107_bib0003","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1631\/jzus.B2100977","article-title":"Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options","volume":"23","author":"Cai","year":"2022","journal-title":"J. Zhejiang Univ. Sci. B"},{"issue":"38","key":"10.1016\/j.phymed.2026.158107_bib0004","doi-asserted-by":"crossref","first-page":"42887","DOI":"10.1021\/acsami.2c10506","article-title":"Astaxanthin activated the Nrf2\/HO-1 pathway to enhance autophagy and inhibit ferroptosis, ameliorating acetaminophen-induced liver injury","volume":"14","author":"Cai","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"3","key":"10.1016\/j.phymed.2026.158107_bib0005","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.jhep.2022.10.028","article-title":"Hepatocyte-specific Mas activation enhances lipophagy and fatty acid oxidation to protect against acetaminophen-induced hepatotoxicity in mice","volume":"78","author":"Chen","year":"2023","journal-title":"J. Hepatol."},{"issue":"8","key":"10.1016\/j.phymed.2026.158107_bib0006","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1111\/nep.14069","article-title":"Scutellarin protects the kidney from ischemia\/reperfusion injury by targeting Nrf2","volume":"27","author":"Dai","year":"2022","journal-title":"Nephrology"},{"issue":"8","key":"10.1016\/j.phymed.2026.158107_bib0007","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1080\/15548627.2023.2179781","article-title":"Narirutin activates TFEB (transcription factor EB) to protect against acetaminophen-induced liver injury by targeting PPP3\/calcineurin","volume":"19","author":"Fang","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.phymed.2026.158107_bib0008","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.phrs.2016.02.020","article-title":"Acetaminophen from liver to brain: new insights into drug pharmacological action and toxicity","volume":"109","author":"Ghanem","year":"2016","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.phymed.2026.158107_bib0009","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.tibs.2024.12.010","article-title":"Regulating Nrf2 activity: ubiquitin ligases and signaling molecules in redox homeostasis","volume":"50","author":"Hayes","year":"2025","journal-title":"Trends Biochem. Sci."},{"issue":"4","key":"10.1016\/j.phymed.2026.158107_bib0010","doi-asserted-by":"crossref","DOI":"10.1111\/liv.16167","article-title":"Novel emerging mechanisms in acetaminophen (APAP) hepatotoxicity","volume":"45","author":"Hionides-Gutierrez","year":"2025","journal-title":"Liver Int."},{"issue":"12","key":"10.1016\/j.phymed.2026.158107_bib0011","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.1016\/j.apsb.2021.09.023","article-title":"Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls","volume":"11","author":"Jaeschke","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phymed.2026.158107_bib0012","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev-pathmechdis-051122-094016","article-title":"Acetaminophen hepatotoxicity: paradigm for understanding mechanisms of drug-induced liver injury","volume":"19","author":"Jaeschke","year":"2024","journal-title":"Annu. Rev. Pathol."},{"issue":"2","key":"10.1016\/j.phymed.2026.158107_bib0013","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/cmi.2015.95","article-title":"Molecular mechanisms regulating NLRP3 inflammasome activation","volume":"13","author":"Jo","year":"2016","journal-title":"Cell. Mol. Immunol."},{"issue":"6","key":"10.1016\/j.phymed.2026.158107_bib0014","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.jhep.2017.07.005","article-title":"Acetaminophen (APAP) hepatotoxicity-isn't it time for APAP to go away?","volume":"67","author":"Lee","year":"2017","journal-title":"J. Hepatol."},{"issue":"Pt A","key":"10.1016\/j.phymed.2026.158107_bib0015","article-title":"Sting mutation attenuates acetaminophen-induced acute liver injury by limiting NLRP3 activation","volume":"125","author":"Li","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2026.158107_bib0016","article-title":"Targeting antioxidant factor Nrf2 by raffinose ameliorates lipid dysmetabolism-induced pyroptosis, inflammation and fibrosis in NAFLD","volume":"130","author":"Liu","year":"2024","journal-title":"Phytomed. Int. J. Phytother. Phytopharmacol."},{"key":"10.1016\/j.phymed.2026.158107_bib0017","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3389\/fphar.2017.00975","article-title":"Scutellarin suppresses NLRP3 inflammasome activation in macrophages and protects mice against bacterial sepsis","volume":"8","author":"Liu","year":"2017","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158107_bib0018","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12964-018-0314-2","article-title":"Corilagin alleviates acetaminophen-induced hepatotoxicity via enhancing the AMPK\/GSK3\u03b2-Nrf2 signaling pathway","volume":"17","author":"Lv","year":"2019","journal-title":"Cell Commun. Signal. CCS"},{"issue":"5","key":"10.1016\/j.phymed.2026.158107_bib0019","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1021\/acs.jafc.3c05776","article-title":"The ameliorative role of Lico A on aflatoxin B(1)-triggered hepatotoxicity partially by activating Nrf2 signal pathway","volume":"72","author":"Lv","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phymed.2026.158107_bib0020","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.redox.2017.03.001","article-title":"Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK\/GSK3\u03b2-Nrf2 signal axis","volume":"12","author":"Lv","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.phymed.2026.158107_bib0021","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3389\/fphar.2018.00147","article-title":"Licochalcone A upregulates Nrf2 antioxidant pathway and thereby alleviates acetaminophen-induced hepatotoxicity","volume":"9","author":"Lv","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.phymed.2026.158107_bib0022","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41419-019-1543-z","article-title":"Nrf2 signaling and autophagy are complementary in protecting lipopolysaccharide\/d-galactosamine-induced acute liver injury by licochalcone A","volume":"10","author":"Lv","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.phymed.2026.158107_bib0023","article-title":"Enhanced Keap1-Nrf2\/trx-1 axis by daphnetin protects against oxidative stress-driven hepatotoxicity via inhibiting ASK1\/JNK and Txnip\/NLRP3 inflammasome activation","volume":"71","author":"Lv","year":"2020","journal-title":"Phytomed. Int. J. Phytother. Phytopharmacol."},{"issue":"4","key":"10.1016\/j.phymed.2026.158107_bib0024","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1080\/03602532.2020.1832112","article-title":"The development and hepatotoxicity of acetaminophen: reviewing over a century of progress","volume":"52","author":"McGill","year":"2020","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.phymed.2026.158107_bib0025","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.710692","article-title":"Protective property of scutellarin against liver injury induced by carbon tetrachloride in mice","volume":"12","author":"Miao","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158107_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121110","article-title":"Application of glutathione depletion in cancer therapy: enhanced ROS-based therapy, ferroptosis, and chemotherapy","volume":"277","author":"Niu","year":"2021","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.phymed.2026.158107_bib0027","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/s41419-020-03178-2","article-title":"Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-\u03bab\/NLRP3-mediated epithelial-mesenchymal transition and inflammation","volume":"11","author":"Peng","year":"2020","journal-title":"Cell Death Dis."},{"issue":"8","key":"10.1016\/j.phymed.2026.158107_bib0028","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.2174\/1570159X19666201230144109","article-title":"The multifaceted therapeutic role of N-acetylcysteine (NAC) in disorders characterized by oxidative stress","volume":"19","author":"Raghu","year":"2021","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.phymed.2026.158107_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114590","article-title":"Acetaminophen-induced hepatotoxicity predominantly via inhibiting Nrf2 antioxidative pathway and activating TLR4-NF-\u03bab-MAPK inflammatory response in mice","volume":"252","author":"Shen","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"24","key":"10.1016\/j.phymed.2026.158107_bib0030","doi-asserted-by":"crossref","first-page":"9682","DOI":"10.3390\/ijms21249682","article-title":"Cell death in liver diseases: a review","volume":"21","author":"Shojaie","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phymed.2026.158107_bib0031","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","article-title":"Oxidative stress: a concept in redox biology and medicine","volume":"4","author":"Sies","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.phymed.2026.158107_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106361","article-title":"Progress in the treatment of drug-induced liver injury with natural products","volume":"183","author":"Sun","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.phymed.2026.158107_bib0033","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s12272-019-01192-3","article-title":"Nrf2 in liver toxicology","volume":"43","author":"Taguchi","year":"2020","journal-title":"Arch. Pharm. Res."},{"issue":"5","key":"10.1016\/j.phymed.2026.158107_bib0034","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41580-022-00564-w","article-title":"Pore-forming proteins as drivers of membrane permeabilization in cell death pathways","volume":"24","author":"Vandenabeele","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.phymed.2026.158107_bib0035","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.freeradbiomed.2016.11.009","article-title":"Nrf2-mediated liver protection by esculentoside A against acetaminophen toxicity through the AMPK\/Akt\/GSK3\u03b2 pathway","volume":"101","author":"Wang","year":"2016","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.phymed.2026.158107_bib0036","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13790","article-title":"Scutellarin alleviates bone marrow mesenchymal stromal cellular senescence via the Ezh2-Nrf2 signalling axis in diabetes-induced bone loss","volume":"58","author":"Wang","year":"2025","journal-title":"Cell Prolif."},{"key":"10.1016\/j.phymed.2026.158107_bib0037","article-title":"Peroxiredoxin 3 inhibits acetaminophen-induced liver pyroptosis through the regulation of mitochondrial ROS","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.phymed.2026.158107_bib0038","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20192501","article-title":"Scutellarin attenuates hypoxia\/reoxygenation injury in hepatocytes by inhibiting apoptosis and oxidative stress through regulating Keap1\/Nrf2\/ARE signaling","volume":"39","author":"Wu","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.phymed.2026.158107_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175979","article-title":"Scutellarin attenuates oxidative stress and neuroinflammation in cerebral ischemia\/reperfusion injury through PI3K\/Akt-mediated Nrf2 signaling pathways","volume":"957","author":"Xie","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phymed.2026.158107_bib0040","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.redox.2018.04.019","article-title":"Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions","volume":"17","author":"Yan","year":"2018","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.phymed.2026.158107_bib0041","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12964-023-01175-4","article-title":"Macrophage PTEN controls STING-induced inflammation and necroptosis through NICD\/Nrf2 signaling in APAP-induced liver injury","volume":"21","author":"Yang","year":"2023","journal-title":"Cell Commun. Signal. CCS"},{"issue":"4","key":"10.1016\/j.phymed.2026.158107_bib0042","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.3390\/ijms24043067","article-title":"The role of the NLRP3 inflammasome and programmed cell death in acute liver injury","volume":"24","author":"Yu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.phymed.2026.158107_bib0043","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3892\/mmr.2024.13185","article-title":"NLRP3 deficiency protects against acetaminophen induced liver injury by inhibiting hepatocyte pyroptosis","volume":"29","author":"Yuan","year":"2024","journal-title":"Mol. Med. Rep"},{"key":"10.1016\/j.phymed.2026.158107_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114132","article-title":"Scopoletin alleviates acetaminophen-induced hepatotoxicity through modulation of NLRP3 inflammasome activation and Nrf2\/HMGB1\/TLR4\/NF-\u03bab signaling pathway","volume":"148","author":"Yuan","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phymed.2026.158107_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102134","article-title":"The Nrf2-NLRP3-caspase-1 axis mediates the neuroprotective effects of Celastrol in Parkinson's disease","volume":"47","author":"Zhang","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.phymed.2026.158107_bib0046","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41573-025-01145-0","article-title":"Thirty years of Nrf2: advances and therapeutic challenges","volume":"24","author":"Zhang","year":"2025","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.phymed.2026.158107_bib0047","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1038\/s41401-025-01509-7","article-title":"FNDC5\/Irisin exacerbates APAP-induced acute liver injury through activating JNK\/NF-\u03bab and inflammatory response","volume":"46","author":"Zhang","year":"2025","journal-title":"Acta Pharmacol. Sin."},{"issue":"7","key":"10.1016\/j.phymed.2026.158107_bib0048","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1631\/jzus.B2200612","article-title":"Scutellarin prevents acute alcohol-induced liver injury via inhibiting oxidative stress by regulating the Nrf2\/HO-1 pathway and inhibiting inflammation by regulating the AKT, p38 MAPK\/NF-\u03bab pathways","volume":"24","author":"Zhang","year":"2023","journal-title":"J. Zhejiang Univ. Sci. B"},{"issue":"2","key":"10.1016\/j.phymed.2026.158107_bib0049","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1080\/10715762.2017.1422602","article-title":"Scutellarin ameliorates nonalcoholic fatty liver disease through the ppar\u03b3\/PGC-1\u03b1-Nrf2 pathway","volume":"52","author":"Zhang","year":"2018","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.phymed.2026.158107_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2025.154070","article-title":"Loss of Urat1 exacerbates APAP-induced liver injury in mice","volume":"511","author":"Zhao","year":"2025","journal-title":"Toxicology"},{"key":"10.1016\/j.phymed.2026.158107_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.116917","article-title":"Ammonium tetrathiomolybdate attenuates acetaminophen-induced acute liver failure by inhibiting the TRPV4\/calcium\/NF-\u03bab signaling pathway","volume":"237","author":"Zhong","year":"2025","journal-title":"Biochem. Pharmacol."},{"issue":"7329","key":"10.1016\/j.phymed.2026.158107_bib0052","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.phymed.2026.158107_bib0053","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.apsb.2020.06.016","article-title":"SIRT6 as a key event linking P53 and Nrf2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation","volume":"11","author":"Zhou","year":"2021","journal-title":"Acta Pharm. Sin. B"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326003429?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326003429?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:06:18Z","timestamp":1790114778000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326003429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":53,"alternative-id":["S0944711326003429"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158107","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Scutellarin modulates Nrf2 to alleviate inflammation, pyroptosis, and ferroptosis in acetaminophen-induced hepatotoxicity","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158107","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158107"}}