{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:00:21Z","timestamp":1790118021633,"version":"4.0.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM202411023"],"award-info":[{"award-number":["SZSM202411023"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM202411013"],"award-info":[{"award-number":["SZSM202411013"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.phymed.2026.158126","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T16:55:00Z","timestamp":1774630500000},"page":"158126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Isobavachalcone exerts anti-gastric cancer effects by targeting dihydroorotate dehydrogenase to induce ROS release and activating the STING pathway"],"prefix":"10.1016","volume":"155","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7863-7728","authenticated-orcid":false,"given":"Yong","family":"Kuang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4293-6205","authenticated-orcid":false,"given":"Sachiyo","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6793-7119","authenticated-orcid":false,"given":"Jiahao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phymed.2026.158126_bib0001","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s43018-020-00136-x","article-title":"Immune-stimulating antibody conjugates elicit robust myeloid activation and durable antitumor immunity","volume":"2","author":"Ackerman","year":"2021","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.phymed.2026.158126_bib0002","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.phymed.2026.158126_bib0003","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neo.2022.01.001","article-title":"UALCAN: an update to the integrated cancer data analysis platform","volume":"25","author":"Chandrashekar","year":"2022","journal-title":"Neoplasia"},{"key":"10.1016\/j.phymed.2026.158126_bib0004","doi-asserted-by":"crossref","DOI":"10.1080\/14756366.2023.2292006","article-title":"Novel isobavachalcone derivatives induce apoptosis and necroptosis in human non-small cell lung cancer H1975 cells","volume":"39","author":"Chen","year":"2024","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.phymed.2026.158126_bib0005","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/s41423-021-00780-y","article-title":"Impact of intracellular innate immune receptors on immunometabolism","volume":"19","author":"Chou","year":"2022","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.phymed.2026.158126_bib0006","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jconrel.2023.09.024","article-title":"Mitochondrial-targeted brequinar liposome boosted mitochondrial-related ferroptosis for promoting checkpoint blockade immunotherapy in bladder cancer","volume":"363","author":"Ding","year":"2023","journal-title":"J. Control Release"},{"key":"10.1016\/j.phymed.2026.158126_bib0007","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jgg.2015.04.004","article-title":"Pyrimidine metabolism: dynamic and versatile pathways in pathogens and cellular development","volume":"42","author":"Garavito","year":"2015","journal-title":"J. Genet. Genom."},{"key":"10.1016\/j.phymed.2026.158126_bib0008","article-title":"Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors","volume":"5","author":"Gy\u0151rffy","year":"2024","journal-title":"Innov. (Camb.)"},{"key":"10.1016\/j.phymed.2026.158126_bib0009","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1002\/ptr.7054","article-title":"Isobavachalcone inhibits acute myeloid leukemia: potential role for ROS-dependent mitochondrial apoptosis and differentiation","volume":"35","author":"He","year":"2021","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2026.158126_bib0010","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1182\/blood.2024026040","article-title":"PSTK inhibition activates cGAS-STING, precipitating ferroptotic cell death in leukemic stem cells","volume":"145","author":"He","year":"2025","journal-title":"Blood"},{"key":"10.1016\/j.phymed.2026.158126_bib0011","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/s41467-024-54882-y","article-title":"Phenazine biosynthesis-like domain-containing protein (PBLD) and cedrelone promote antiviral immune response by activating NF-\u0138b","volume":"16","author":"Hou","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158126_bib0012","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3892\/etm.2015.2904","article-title":"Isobavachalcone induces the apoptosis of gastric cancer cells via inhibition of the Akt and Erk pathways","volume":"11","author":"Jin","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.phymed.2026.158126_bib0013","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.canlet.2010.01.035","article-title":"Abrogation of Akt signaling by Isobavachalcone contributes to its anti-proliferative effects towards human cancer cells","volume":"294","author":"Jing","year":"2010","journal-title":"Cancer Lett."},{"key":"10.1016\/j.phymed.2026.158126_bib0014","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1038\/s41590-024-01872-3","article-title":"The balance of STING signaling orchestrates immunity in cancer","volume":"25","author":"Lanng","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.phymed.2026.158126_bib0015","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1915828","article-title":"Isobavachalcone induces ROS-mediated apoptosis via targeting thioredoxin reductase 1 in human prostate cancer PC-3 cells","volume":"2018","author":"Li","year":"2018","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.phymed.2026.158126_bib0016","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1158\/0008-5472.CAN-17-0307","article-title":"TIMER: a web server for comprehensive analysis of tumor-infiltrating immune cells","volume":"77","author":"Li","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.phymed.2026.158126_bib0017","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41392-025-02141-x","article-title":"Energy metabolism in health and diseases","volume":"10","author":"Liu","year":"2025","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2026.158126_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102044","article-title":"An update on methods and approaches for interrogating mitochondrial reactive oxygen species production","volume":"45","author":"Mailloux","year":"2021","journal-title":"Redox. Biol."},{"key":"10.1016\/j.phymed.2026.158126_bib0019","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41586-021-03539-7","article-title":"DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer","volume":"593","author":"Mao","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2026.158126_bib0020","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41586-020-2475-6","article-title":"Mitochondrial ubiquinol oxidation is necessary for tumour growth","volume":"585","author":"Mart\u00ednez-Reyes","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2026.158126_bib0021","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.biochi.2017.02.003","article-title":"Dihydroorotate dehydrogenase (DHODH) inhibitors affect ATP depletion, endogenous ROS and mediate S-phase arrest in breast cancer cells","volume":"135","author":"Mohamad Fairus","year":"2017","journal-title":"Biochimie"},{"key":"10.1016\/j.phymed.2026.158126_bib0022","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrc2541","article-title":"Toll-like receptors and cancer","volume":"9","author":"Rakoff-Nahoum","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.phymed.2026.158126_bib0023","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature12445","article-title":"Pyrimidine homeostasis is accomplished by directed overflow metabolism","volume":"500","author":"Reaves","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2026.158126_bib0024","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1038\/s41598-023-50454-0","article-title":"Exploring the mechanism and phytochemicals in psoraleae fructus-induced hepatotoxicity based on RNA-seq, in vitro screening and molecular docking","volume":"14","author":"Shang","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phymed.2026.158126_bib0025","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.ccell.2025.02.014","article-title":"Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy","volume":"43","author":"Song","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.phymed.2026.158126_bib0026","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12122123","article-title":"Reactive oxygen species damage bovine endometrial epithelial cells via the cytochrome C-mPTP pathway","volume":"12","author":"Song","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.phymed.2026.158126_bib0027","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1038\/s41467-025-59307-y","article-title":"DHODH modulates immune evasion of cancer cells via CDP-choline dependent regulation of phospholipid metabolism and ferroptosis","volume":"16","author":"Teng","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.phymed.2026.158126_bib0028","doi-asserted-by":"crossref","first-page":"eadj3945","DOI":"10.1126\/sciimmunol.adj3945","article-title":"STING licensing of type I dendritic cells potentiates antitumor immunity","volume":"9","author":"Wang","year":"2024","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.phymed.2026.158126_bib0029","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.3324\/haematol.2018.188185","article-title":"Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells","volume":"103","author":"Wu","year":"2018","journal-title":"Haematologica"},{"key":"10.1016\/j.phymed.2026.158126_bib0030","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.freeradbiomed.2023.03.020","article-title":"Fighting cancer by triggering non-canonical mitochondrial permeability transition-driven necrosis through reactive oxygen species induction","volume":"202","author":"Xiao","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2026.158126_bib0031","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1002\/ptr.7520","article-title":"Isobavachalcone: a comprehensive review of its plant sources, pharmacokinetics, toxicity, pharmacological activities and related molecular mechanisms","volume":"36","author":"Xing","year":"2022","journal-title":"Phytother. Res."},{"key":"10.1016\/j.phymed.2026.158126_bib0032","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1186\/s12967-024-05588-8","article-title":"Blockade of the mitochondrial DNA release ameliorates hepatic ischemia-reperfusion injury through avoiding the activation of cGAS-Sting pathway","volume":"22","author":"Xiong","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.phymed.2026.158126_bib0033","article-title":"Mitochondrion-targeted type I photodynamic therapy for agonist independent cGAS-STING activation","author":"Xu","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.phymed.2026.158126_bib0034","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1111\/cas.13569","article-title":"Established gastric cancer cell lines transplantable into C57BL\/6 mice show fibroblast growth factor receptor 4 promotion of tumor growth","volume":"109","author":"Yamamoto","year":"2018","journal-title":"Cancer Sci."},{"key":"10.1016\/j.phymed.2026.158126_bib0035","article-title":"OMP38 of carbapenem-resistant acinetobacter baumannii-mediated mtDNA release activates the cGAS-STING signaling to induce inflammatory response","volume":"12","author":"Yang","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.phymed.2026.158126_bib0036","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/s12943-024-02186-6","article-title":"Nanomedicines harnessing cGAS-STING pathway: sparking immune revitalization to transform 'cold' tumors into 'hot' tumors","volume":"23","author":"Ying","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.phymed.2026.158126_bib0037","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2100225118","article-title":"TBK1 recruitment to STING activates both IRF3 and NF-\u03bab that mediate immune defense against tumors and viral infections","volume":"118","author":"Yum","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U S. A"},{"key":"10.1016\/j.phymed.2026.158126_bib0038","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41392-024-02097-4","article-title":"Digestive cancers: mechanisms, therapeutics and management","volume":"10","author":"Zhan","year":"2025","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.phymed.2026.158126_bib0039","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.freeradbiomed.2022.10.004","article-title":"Manganese induces tumor cell ferroptosis through type-I IFN dependent inhibition of mitochondrial dihydroorotate dehydrogenase","volume":"193","author":"Zhang","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.phymed.2026.158126_bib0040","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41577-024-01112-7","article-title":"Regulation of cGAS-STING signalling and its diversity of cellular outcomes","volume":"25","author":"Zhang","year":"2025","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phymed.2026.158126_bib0041","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41586-020-2749-z","article-title":"The molecular basis of tight nuclear tethering and inactivation of cGAS","volume":"587","author":"Zhao","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.phymed.2026.158126_bib0042","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","article-title":"Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol. Rev."}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326003612?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711326003612?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:00:40Z","timestamp":1790114440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711326003612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":42,"alternative-id":["S0944711326003612"],"URL":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158126","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isobavachalcone exerts anti-gastric cancer effects by targeting dihydroorotate dehydrogenase to induce ROS release and activating the STING pathway","name":"articletitle","label":"Article Title"},{"value":"Phytomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phymed.2026.158126","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier GmbH. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"158126"}}